Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding

Biochemical Journal

Volumn 465, Issue , 2015, Pages 149-161

  Visperas, Patrick R ^a   Winger, Jonathan A ^a   Horton, Timothy M ^a   Shah, Neel H ^a   Aum, Diane J ^a   Tao, Alyssa ^a   Barros, Tiago ^a   Yan, Qingrong ^a   Wilson, Christopher G ^b   Arkin, Michelle R ^b   Weiss, Arthur ^b   Kuriyan, John ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

B cell; Covalent small molecule inhibitor; Hydrogen peroxide (H2O2); Immunoreceptor tyrosine based activation motif (ITAM); T cell

Indexed keywords

CYSTEINE; HYDROGEN PEROXIDE; PEROXIREDOXIN; PHOSPHOTYROSINE; PROTEIN KINASE SYK; PROTEIN KINASE ZAP 70; PROTEIN SH2; REACTIVE OXYGEN METABOLITE; TYROSINE; WATER; MOLECULAR LIBRARY; PHOSPHOPEPTIDE; PROTEIN BINDING; PROTEIN TYROSINE KINASE; SIGNAL PEPTIDE; THIOL DERIVATIVE; ZAP70 PROTEIN, HUMAN;

ARTICLE; ENZYME PHOSPHORYLATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; IMMUNORECEPTOR TYROSINE BASED ACTIVATION MOTIF; OXIDATION; PROTEIN BINDING; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HUMAN; METABOLISM; MOLECULAR LIBRARY; OXIDATION REDUCTION REACTION; PHARMACOLOGY; PHOSPHORYLATION; PROTEIN MOTIF; SRC HOMOLOGY DOMAIN;

AMINO ACID MOTIFS; BINDING SITES; CYSTEINE; HUMANS; HYDROGEN PEROXIDE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, MOLECULAR; OXIDATION-REDUCTION; PHOSPHOPEPTIDES; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; SMALL MOLECULE LIBRARIES; SRC HOMOLOGY DOMAINS; SULFHYDRYL COMPOUNDS; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 84918502931     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20140793     Document Type: Article

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