Down-regulation of renal klotho expression by Shiga Toxin 2

Kidney and Blood Pressure Research

Volumn 39, Issue 5, 2014, Pages 441-449

  Feger, Martina ^a   Mia, Sobuj ^a   Pakladok, Tatsiana ^a   Nicolay, Jan P ^b,c   Alesutan, Ioana ^a   Schneider, Stefan W ^b   Voelkl, Jakob ^a   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

1,25(OH)2D3; 25 hydroxyvitamin D3 1 hydroxylase; FGF23; klotho; p38 MAPK; phosphate

Indexed keywords

1,25 DIHYDROXYERGOCALCIFEROL; CHOLESTANETRIOL 26 MONOOXYGENASE; COLECALCIFEROL 24 HYDROXYLASE; FIBROBLAST GROWTH FACTOR 23; KLOTHO PROTEIN; MESSENGER RNA; SOLVENT; TUMOR NECROSIS FACTOR ALPHA; UREA; VEROTOXIN 2; BETA GLUCURONIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; KIDNEY PARENCHYMA; MOUSE; NONHUMAN; PHOSPHATE BLOOD LEVEL; PHOSPHATE EXCRETION; PHOTOMETRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; URINE FLOW RATE; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; PHYSIOLOGY; URINE;

ANIMALS; DOWN-REGULATION; GENE EXPRESSION REGULATION; GLUCURONIDASE; MICE; MICE, INBRED C57BL; SHIGA TOXIN 2; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84917735420     PISSN: 14204096     EISSN: 14230143     Source Type: Journal    
DOI: 10.1159/000368457     Document Type: Article

References (56)

1. Hauswaldt S, Nitschke M, Sayk F, Solbach W, Knobloch JK: Lessons Learned From Outbreaks of Shiga Toxin Producing Escherichia coli. Curr Infect Dis Rep 2013;15:4-9
2. Karmali MA, Petric M, Lim C, Fleming PC, Steele BT: Escherichia coli cytotoxin, haemolytic-uraemic syndrome, and haemorrhagic colitis. Lancet 1983;2:1299-1300
3. Karmali MA, Steele BT, Petric M, Lim C: Sporadic cases of haemolytic-uraemic syndrome associated with faecal cytotoxin and cytotoxin-producing Escherichia coli in stools. Lancet 1983;1:619-620
4. Tarr PI, Gordon CA, Chandler WL: Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome. Lancet 2005;365:1073-1086
5. Moake JL: Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome. Arch Pathol Lab Med 2002;126:1430-1433
6. Corrigan JJ, Jr., Boineau FG: Hemolytic-uremic syndrome. Pediatr Rev 2001;22:365-369
7. Bitzan M, Bickford BB, Foster GH: Verotoxin (shiga toxin) sensitizes renal epithelial cells to increased heme toxicity: Possible implications for the hemolytic uremic syndrome. J Am Soc Nephrol 2004;15:2334-2343
8. Boyce TG, Swerdlow DL, Griffin PM: Escherichia coli O157:H7 and the hemolytic-uremic syndrome. N Engl J Med 1995;333:364-368
9. Hughes AK, Ergonul Z, Stricklett PK, Kohan DE: Molecular basis for high renal cell sensitivity to the cytotoxic effects of shigatoxin-1: Upregulation of globotriaosylceramide expression. J Am Soc Nephrol 2002;13:2239-2245
10. Te Loo DM, van Hinsbergh VW, van den Heuvel LP, Monnens LA: Detection of verocytotoxin bound to circulating polymorphonuclear leukocytes of patients with hemolytic uremic syndrome. J Am Soc Nephrol 2001;12:800-806
11. Kaper JB, Nataro JP, Mobley HL: Pathogenic Escherichia coli. Nat Rev Microbiol 2004;2:123-140
12. Porubsky S, Federico G, Muthing J, Jennemann R, Gretz N, Buttner S, Obermuller N, Jung O, Hauser IA, Grone E, Geiger H, Grone HJ, Betz C: Direct acute tubular damage contributes to Shigatoxin-mediated kidney failure. J Pathol 2014;234:120-133
13. Hu MC, Kuro-o M, Moe OW: The emerging role of Klotho in clinical nephrology. Nephrol Dial Transplant 2012;27:2650-2657
14. Drueke TB: Klotho, FGF23, and FGF receptors in chronic kidney disease: A yin-yang situation? Kidney Int 2010;78:1057-1060
15. Takeshita K, Fujimori T, Kurotaki Y, Honjo H, Tsujikawa H, Yasui K, Lee JK, Kamiya K, Kitaichi K, Yamamoto K, Ito M, Kondo T, Iino S, Inden Y, Hirai M, Murohara T, Kodama I, Nabeshima Y: Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression. Circulation 2004;109:1776-1782
16. Tsujikawa H, Kurotaki Y, Fujimori T, Fukuda K, Nabeshima Y: Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol 2003;17:2393-2403
17. Kuro-o M: Klotho in health and disease. Curr Opin Nephrol Hypertens 2012;21:362-368
18. Imura A, Iwano A, Tohyama O, Tsuji Y, Nozaki K, Hashimoto N, Fujimori T, Nabeshima Y: Secreted Klotho protein in sera and CSF: Implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett 2004;565:143-147
19. Akimoto T, Yoshizawa H, Watanabe Y, Numata A, Yamazaki T, Takeshima E, Iwazu K, Komada T, Otani N, Morishita Y, Ito C, Shiizaki K, Ando Y, Muto S, Kuro O, Kusano E: Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease. BMC Nephrol 2012;13:155
20. Dermaku-Sopjani M, Sopjani M, Saxena A, Shojaiefard M, Bogatikov E, Alesutan I, Eichenmuller M, Lang F: Downregulation of NaPi-IIa and NaPi-IIb Na-coupled phosphate transporters by coexpression of Klotho. Cell Physiol Biochem 2011;28:251-258
21. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI: Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997;390:45-51
22. Hu MC, Shi M, Zhang J, Quinones H, Griffith C, Kuro-o M, Moe OW: Klotho Deficiency Causes Vascular Calcification in Chronic Kidney Disease. J Am Soc Nephrol 2011;22:124-136
23. Kuro-o M: Klotho. Pflugers Arch 2010;459:333-343
24. Ohnishi M, Razzaque MS: Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging. FASEB J 2010;24:3562-3571
25. Moreno JA, Izquierdo MC, Sanchez-Nino MD, Suarez-Alvarez B, Lopez-Larrea C, Jakubowski A, Blanco J, Ramirez R, Selgas R, Ruiz-Ortega M, Egido J, Ortiz A, Sanz AB: The inflammatory cytokines TWEAK and TNFalpha reduce renal klotho expression through NFkappaB. J Am Soc Nephrol 2011;22:1315-1325
26. Tang C, Pathare G, Michael D, Fajol A, Eichenmuller M, Lang F: Downregulation of Klotho expression by dehydration. Am J Physiol Renal Physiol 2011;301:F745-F750
27. Tang R, Zhou QL, Ao X, Peng WS, Veeraragoo P, Tang TF: Fosinopril and losartan regulate klotho gene and nicotinamide adenine dinucleotide phosphate oxidase expression in kidneys of spontaneously hypertensive rats. Kidney Blood Press Res 2011;34:350-357
28. Yoon HE, Ghee JY, Piao S, Song JH, Han DH, Kim S, Ohashi N, Kobori H, M K-o, Yang CW: Angiotensin II blockade upregulates the expression of Klotho, the anti-Ageing gene, in an experimental model of chronic cyclosporine nephropathy. Nephrol Dial Transplant 2011;26:800-813
29. Alesutan I, Feger M, Pakladok T, Mia S, Ahmed MS, Voelkl J, Lang F: 25-hydroxyvitamin D3 1-Alphahydroxylase-dependent stimulation of renal klotho expression by spironolactone. Kidney Blood Press Res 2013;37:475-487
30. Doi S, Zou Y, Togao O, Pastor JV, John GB, Wang L, Shiizaki K, Gotschall R, Schiavi S, Yorioka N, Takahashi M, Boothman DA, Kuro-o M: Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem 2011;286:8655-8665
31. Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M: Suppression of aging in mice by the hormone Klotho. Science 2005;309:1829-1833
32. Panesso MC, Shi M, Cho HJ, Paek J, Ye J, Moe OW, Hu MC: Klotho has dual protective effects on cisplatininduced acute kidney injury. Kidney Int 2014;85:855-870
33. Haruna Y, Kashihara N, Satoh M, Tomita N, Namikoshi T, Sasaki T, Fujimori T, Xie P, Kanwar YS: Amelioration of progressive renal injury by genetic manipulation of Klotho gene. Proc Natl Acad Sci USA 2007;104:2331-2336
34. Ko GJ, Lee EA, Jeon US, Pyo HJ, Chin HJ, Chae DW, Kim S, Kwon YJ: The Association of Klotho Polymorphism with Disease Progression and Mortality in IgA Nephropathy. Kidney Blood Press Res 2012;36:191-199
35. Lim K, Lu TS, Molostvov G, Lee C, Lam FT, Zehnder D, Hsiao LL: Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23. Circulation 2012;125:2243-2255
36. Voelkl J, Alesutan I, Leibrock CB, Quintanilla-Martinez L, Kuhn V, Feger M, Mia S, Ahmed MS, Rosenblatt KP, Kuro-o M, Lang F: Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klothohypomorphic mice. J Clin Invest 2013;123:812-822
37. Xie J, Cha SK, An SW, Kuro-o M, Birnbaumer L, Huang CL: Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart. Nat Commun 2012;3:1238
38. Sauter KA, Melton-Celsa AR, Larkin K, Troxell ML, O'Brien AD, Magun BE: Mouse model of hemolytic-uremic syndrome caused by endotoxin-free Shiga toxin 2 (Stx2) and protection from lethal outcome by anti-Stx2 antibody. Infect Immun 2008;76:4469-4478
39. Pathare G, Foller M, Michael D, Walker B, Hierlmeier M, Mannheim JG, Pichler BJ, Lang F: Enhanced FGF23 serum concentrations and phosphaturia in gene targeted mice expressing WNK-resistant SPAK. Kidney Blood Press Res 2012;36:355-364
40. Pathare G, Foller M, Daryadel A, Mutig K, Bogatikov E, Fajol A, Almilaji A, Michael D, Stange G, Voelkl J, Wagner CA, Bachmann S, Lang F: OSR1-sensitive renal tubular phosphate reabsorption. Kidney Blood Press Res 2012;36:149-161
41. Feger M, Fajol A, Lebedeva A, Meissner A, Michael D, Voelkl J, Alesutan I, Schleicher E, Reichetzeder C, Hocher B, Qadri SM, Lang F: Effect of Carbon Monoxide Donor CORM-2 on Vitamin D3 Metabolism. Kidney Blood Press Res 2013;37:496-505
42. Sugatani J, Komiyama N, Mochizuki T, Hoshino M, Miyamoto D, Igarashi T, Hoshi S, Miwa M: Urinary concentrating defect in rats given Shiga toxin: Elevation in urinary AQP2 level associated with polyuria. Life Sci 2002;71:171-189
43. Carracedo J, Buendia P, Merino A, Madueno JA, Peralbo E, Ortiz A, Martin-Malo A, Aljama P, Rodriguez M, Ramirez R: Klotho modulates the stress response in human senescent endothelial cells. Mech Ageing Dev 2012;133:647-654
44. Hsieh CC, Kuro-o M, Rosenblatt KP, Brobey R, Papaconstantinou J: The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging. Aging (Albany NY) 2010;2:597-611
45. Zhou Q, Lin S, Tang R, Veeraragoo P, Peng W, Wu R: Role of Fosinopril and Valsartan on Klotho Gene Expression Induced by Angiotensin II in Rat Renal Tubular Epithelial Cells. Kidney Blood Press Res 2010;33:186-192
46. Fu XJ, Iijima K, Nozu K, Hamahira K, Tanaka R, Oda T, Yoshikawa N, Matsuo M: Role of p38 MAP kinase pathway in a toxin-induced model of hemolytic uremic syndrome. Pediatr Nephrol 2004;19:844-852
47. Ikeda M, Gunji Y, Yamasaki S, Takeda Y: Shiga toxin activates p38 MAP kinase through cellular Ca(2+) increase in Vero cells. FEBS Lett 2000;485:94-98
48. Peng T, Lu X, Lei M, Moe GW, Feng Q: Inhibition of p38 MAPK decreases myocardial TNF-Alpha expression and improves myocardial function and survival in endotoxemia. Cardiovasc Res 2003;59:893-900
49. Ramesh G, Brian Reeves W: Cisplatin increases TNF-Alpha mRNA stability in kidney proximal tubule cells. Ren Fail 2006;28:583-592
50. Nakamura A, Johns EJ, Imaizumi A, Yanagawa Y, Kohsaka T: Activation of beta(2)-Adrenoceptor prevents shiga toxin 2-induced TNF-Alpha gene transcription. J Am Soc Nephrol 2001;12:2288-2299
51. Yoshida T, Fujimori T, Nabeshima Y: Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene. Endocrinology 2002;143:683-689
52. Razzaque MS, Sitara D, Taguchi T, St Arnaud R, Lanske B: Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process. FASEB J 2006;20:720-722
53. Andrukhova O, Slavic S, Smorodchenko A, Zeitz U, Shalhoub V, Lanske B, Pohl EE, Erben RG: FGF23 regulates renal sodium handling and blood pressure. EMBO Mol Med 2014;6:744-759
54. Ikushima M, Rakugi H, Ishikawa K, Maekawa Y, Yamamoto K, Ohta J, Chihara Y, Kida I, Ogihara T: Antiapoptotic and anti-senescence effects of Klotho on vascular endothelial cells. Biochem Biophys Res Commun 2006;339:827-832
55. Kusaba T, Okigaki M, Matui A, Murakami M, Ishikawa K, Kimura T, Sonomura K, Adachi Y, Shibuya M, Shirayama T, Tanda S, Hatta T, Sasaki S, Mori Y, Matsubara H: Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+ channel to maintain endothelial integrity. Proc Natl Acad Sci USA 2010;107:19308-19313
56. Satoh M, Nagasu H, Morita Y, Yamaguchi TP, Kanwar YS, Kashihara N: Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling. Am J Physiol Renal Physiol 2012;303:F1641-F1651