Urinary concentrating defect in rats given Shiga toxin: Elevation in urinary AQP2 level associated with polyuria

Life Sciences

Volumn 71, Issue 2, 2002, Pages 171-189

  Sugatani, Junko ^a   Komiyama, Naoko ^a   Mochizuki, Toru ^a   Hoshino, Minoru ^a   Miyamoto, Daisei ^a   Igarashi, Takashi ^b   Hoshi, Shoji ^c   Miwa, Masao ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c Shizuoka Saiseikai Renual Hospital   (Japan)

Author keywords

Aquaporin 2 (AQP2); Hemolytic uremic syndrome (HUS); Renal tubular impairment; Shiga toxin 1 (Stx1); Shiga toxin 2 (Stx2)

Indexed keywords

AQUAPORIN; AQUAPORIN 1; AQUAPORIN 2; AQUAPORIN 3; AQUAPORIN 4; AQUAPORIN 5; BETA 2 MICROGLOBULIN; N ACETYL BETA GLUCOSAMINIDASE; SHIGA TOXIN; UNCLASSIFIED DRUG; VASOPRESSIN;

ANIMAL MODEL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ELECTROIMMUNOASSAY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KIDNEY CONCENTRATING CAPACITY; KIDNEY FUNCTION; KIDNEY TUBULE; KIDNEY TUBULE DISORDER; MALE; MORPHOLOGY; NONHUMAN; POLYURIA; PROTEIN EXPRESSION; RAT; URINALYSIS; URINE OSMOLALITY;

ACETYLGLUCOSAMINIDASE; ANIMALS; AQUAPORIN 2; AQUAPORIN 6; AQUAPORINS; BETA 2-MICROGLOBULIN; CELL MEMBRANE; DISEASE MODELS, ANIMAL; KIDNEY FAILURE; KIDNEY FUNCTION TESTS; MALE; POLYURIA; RATS; RATS, WISTAR; SHIGA TOXIN; SHIGA-LIKE TOXIN I; SHIGA-LIKE TOXIN II;

ESCHERICHIA COLI;

EID: 0037205120     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(02)01618-1     Document Type: Article

References (41)

1. Sporadic cases of haemolytic-uremic syndrome associated with faecal cytotoxin and cytotoxin-producing Esherichia coli in stools
2. Esherichia coli O157:H7 and the hemolytic-uremic syndrome
3. Human renal microvascular endothelial cells as a potential target in the development of the hemolytic uremic syndrome as related to fibrinolysis factor expression, in vitro
4. Impairment by verotoxin of tubular function contributes to the renal damage seen in haemolytic uremic syndrome
5. The detection of Shiga toxins in the kidney of a patient with hemolytic uremic syndrome
6. Apoptosis induced in Burkitt's lymphoma cells via Gb3/CD77, a glycolipid antigen
7. Verotoxin-binding in human renal sections
8. Acute renal tubular necrosis and death of mice orally infected with Esherichia coli strains that produce Shiga-like toxin type II
9. Cloning and expression of apical membrane water channel of rat kidney collecting tubule
10. Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney
11. CAMP-dependent phosphorylation stimulates water permeability of aquaporin-collecting duct water channel protein expressed in Xenopus oocytes
12. Long-term regulation of aquaporins in the kidney
13. Downregulation of aquaporin-2 parallels changes in renal water excretion in unilateral ureteral obstruction
14. Role of water channel AQP-CD in water retention in SIADH and cirrhotic rats
15. Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla
16. Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex
17. Vasopressin-elicited water and urea permeabilities are altered in IMCD in hypercalcemic rats
18. Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2 water channel in collecting duct
19. Upregulation of aquaporin-2 water channel expression in chronic heart failure rat
20. Purification and some properties of Shiga-like toxin from Escherichia coli O157: H7 that is immunologically identical to Shiga toxin
21. Purification and some properties of a Vero toxin from Esherichia coli O157:H7 that is immunologically unrelated to Shiga toxin
22. Cloning, characterization, and chromosomal mapping of human aquaporin of collecting duct
23. Aquaporins in complex tissues: Distribution of aquaporins 1-5 in human and rat eye
24. Quantitation of aquaporin-2 abundance in microdissected collecting ducts: Axial distribution and control by AVP
25. Neuronal and vascular pathology produced by verocytotoxin 2 in the rabbit central nervous system
26. The nucleotide sequence of the rat cytoplasmic β-actin gene
27. The serum level and urinary excretion of beta 2-microglobulin in health and renal disease
28. Toxin genotypes and plasmid profiles as determinants of systemic sequelae in Esherichia coli O157:H7 infections
29. Verotoxins induce apoptosis in human renal tubular epithelium derived cells
30. Shiga toxin induces medullary tubular injury in isolated perfused rat kidneys
31. Shiga toxin-induced tubular injury in hemolytic uremic syndrome
32. Characterization of the baboon responses to Shiga-like toxin: Descriptive study of a new primate model of toxic responses to Stx-1
33. Activation of coagulation in C57BL/6 mice given verotoxin 2 (VT2) and the effect of co-administration of LPS with VT2
34. Induction of glomerular lesions in the kidneys of mice infected with vero toxin-producin Escherichia coli by lipopolysaccharide injection
35. Case records of the Massachusetts General Hospital
36. Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine
37. Reduced abundance of aquaporins in rats with bilateral ischemia-induced acute renal failure: Prevention by α-MSH
38. Urinary excretion of aquaporin-2 in rat is mediated by a vasopressin-dependent apical pathway
39. Urinary excretion of aquaporin-2 in patients with diabetes insipidus
40. Urinary excretion of aquaporin-2 water channel protein in human and rat
41. Alteration in water channel AQP-2 by removal of AVP stimulation in collecting duct cells of dehydrated rats