Methylation of mir-129-5p cpg island modulates multi-drug resistance in gastric cancer by targeting abc transporters

Oncotarget

Volumn 5, Issue 22, 2014, Pages 11552-11563

  Wu, Qiong ^a   Yang, Zhiping ^a   Xia, Lin ^a   Nie, Yongzhan ^a   Wu, Kaichun ^a   Fan, Yongquan Shi Daiming ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

ABC transporters; Drug resistance; Gastric cancer; Mir 129 5p

Indexed keywords

ABC TRANSPORTER G1; MICRORNA; MICRORNA 129 5P; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 5; UNCLASSIFIED DRUG; 5-AZA-2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE; ABC TRANSPORTER; ABCB1 PROTEIN, HUMAN; ABCC5 PROTEIN, HUMAN; ABCG1 PROTEIN, HUMAN; AZACITIDINE; MIRN129 MICRORNA, HUMAN; MULTIDRUG RESISTANCE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER RESISTANCE; CONTROLLED STUDY; CPG ISLAND; DRUG TARGETING; GASTRIC CANCER CELL LINE; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; RNA METHYLATION; STOMACH CANCER; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DNA METHYLATION; DNA MICROARRAY; DRUG RESISTANCE; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; REPORTER GENE; STOMACH TUMOR; TUMOR CELL LINE;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; AZACITIDINE; BASE SEQUENCE; CELL LINE, TUMOR; CPG ISLANDS; DNA METHYLATION; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GENE SILENCING; GENES, REPORTER; HUMANS; MICE; MICE, INBRED BALB C; MICRORNAS; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; P-GLYCOPROTEINS; STOMACH NEOPLASMS; TRANSFECTION;

EID: 84917707327     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2594     Document Type: Article

References (35)

1. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004; 116(2):281-297.
2. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009; 136(2):215-233.
3. Croce CM. Causes and consequences of microRNA dysregulation in cancer. Nature reviews Genetics. 2009; 10(10):704-714.
4. Wang Z, Wang N, Liu P, Chen Q, Situ H, Xie T, Zhang J, Peng C, Lin Y and Chen J. MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin. Oncotarget. 2014; 5(16):7013-7026.
5. Wagner KW, Alam H, Dhar SS, Giri U, Li N, Wei Y, Giri D, Cascone T, Kim JH, Ye Y, Multani AS, Chan CH, Erez B, Saigal B, Chung J, Lin HK, et al. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. The Journal of clinical investigation. 2013; 123(12):5231-5246.
6. Sarkar S, Horn G, Moulton K, Oza A, Byler S, Kokolus S and Longacre M. Cancer development, progression, and therapy: an epigenetic overview. International journal of molecular sciences. 2013; 14(10):21087-21113.
7. Wong KY, Yu L and Chim CS. DNA methylation of tumor suppressor miRNA genes: a lesson from the miR-34 family. Epigenomics. 2011; 3(1):83-92.
8. Yan JW, Lin JS and He XX. The emerging role of miR-375 in cancer. International journal of cancer Journal international du cancer. 2014; 135(5):1011-1018.
9. Baer C, Claus R and Plass C. Genome-wide epigenetic regulation of miRNAs in cancer. Cancer research. 2013; 73(2):473-477.
10. Wilting SM, Verlaat W, Jaspers A, Makazaji NA, Agami R, Meijer CJ, Snijders PJ and Steenbergen RD. Methylationmediated transcriptional repression of microRNAs during cervical carcinogenesis. Epigenetics: official journal of the DNA Methylation Society. 2013; 8(2):220-228.
11. Wang P, Chen L, Zhang J, Chen H, Fan J, Wang K, Luo J, Chen Z, Meng Z and Liu L. Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1. Oncogene. 2014; 33(4):514-524.
12. Majid S, Dar AA, Saini S, Shahryari V, Arora S, Zaman MS, Chang I, Yamamura S, Tanaka Y, Chiyomaru T, Deng G and Dahiya R. miRNA-34b inhibits prostate cancer through demethylation, active chromatin modifications, and AKT pathways. Clinical cancer research: an official journal of the American Association for Cancer Research. 2013; 19(1):73-84.
13. Katada T, Ishiguro H, Kuwabara Y, Kimura M, Mitui A, Mori Y, Ogawa R, Harata K and Fujii Y. microRNA expression profile in undifferentiated gastric cancer. International journal of oncology. 2009; 34(2):537-542.
14. Dyrskjot L, Ostenfeld MS, Bramsen JB, Silahtaroglu AN, Lamy P, Ramanathan R, Fristrup N, Jensen JL, Andersen CL, Zieger K, Kauppinen S, Ulhoi BP, Kjems J, Borre M and Orntoft TF. Genomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro. Cancer research. 2009; 69(11):4851-4860.
15. Chen X, Zhang L, Zhang T, Hao M, Zhang X, Zhang J, Xie Q, Wang Y, Guo M, Zhuang H and Lu F. Methylationmediated repression of microRNA 129-2 enhances oncogenic SOX4 expression in HCC. Liver international: official journal of the International Association for the Study of the Liver. 2013; 33(3):476-486.
16. Kang M, Li Y, Liu W, Wang R, Tang A, Hao H, Liu Z and Ou H. miR-129-2 suppresses proliferation and migration of esophageal carcinoma cells through downregulation of SOX4 expression. International journal of molecular medicine. 2013; 32(1):51-58.
17. Yu X, Song H, Xia T, Han S, Xiao B, Luo L, Xi Y and Guo J. Growth inhibitory effects of three miR-129 family members on gastric cancer. Gene. 2013; 532(1):87-93.
18. Bandres E, Agirre X, Bitarte N, Ramirez N, Zarate R, Roman-Gomez J, Prosper F and Garcia-Foncillas J. Epigenetic regulation of microRNA expression in colorectal cancer. International journal of cancer Journal international du cancer. 2009; 125(11):2737-2743.
19. Chen X, Hu H, Guan X, Xiong G, Wang Y, Wang K, Li J, Xu X, Yang K and Bai Y. CpG island methylation status of miRNAs in esophageal squamous cell carcinoma. International journal of cancer Journal international du cancer. 2012; 130(7):1607-1613.
20. Anwar SL, Albat C, Krech T, Hasemeier B, Schipper E, Schweitzer N, Vogel A, Kreipe H and Lehmann U. Concordant hypermethylation of intergenic microRNA genes in human hepatocellular carcinoma as new diagnostic and prognostic marker. International journal of cancer Journal international du cancer. 2013; 133(3):660-670.
21. Lu CY, Lin KY, Tien MT, Wu CT, Uen YH and Tseng TL. Frequent DNA methylation of MiR-129-2 and its potential clinical implication in hepatocellular carcinoma. Genes, chromosomes & cancer. 2013; 52(7):636-643.
22. He Y, Huang C, Zhang L and Li J. Epigenetic Repression ofmiR-129-2 in Cancer. Liver international: official journal of the International Association for the Study of the Liver. 2014; 34(4):646.
23. Tsai KW, Wu CW, Hu LY, Li SC, Liao YL, Lai CH, Kao HW, Fang WL, Huang KH, Chan WC and Lin WC. Epigenetic regulation of miR-34b and miR-129 expression in gastric cancer. International journal of cancer Journal international du cancer. 2011; 129(11):2600-2610.
24. Huang YW, Liu JC, Deatherage DE, Luo J, Mutch DG, Goodfellow PJ, Miller DS and Huang TH. Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 oncogene in endometrial cancer. Cancer research. 2009; 69(23):9038-9046.
25. Karaayvaz M, Zhai H and Ju J. miR-129 promotes apoptosis and enhances chemosensitivity to 5-fluorouracil in colorectal cancer. Cell death & disease. 2013; 4:e659.
26. Scapoli L, Palmieri A, Lo Muzio L, Pezzetti F, Rubini C, Girardi A, Farinella F, Mazzotta M and Carinci F. MicroRNA expression profiling of oral carcinoma identifies new markers of tumor progression. International journal of immunopathology and pharmacology. 2010; 23(4):1229-1234.
27. Ogawa R, Ishiguro H, Kuwabara Y, Kimura M, Mitsui A, Katada T, Harata K, Tanaka T and Fujii Y. Expression profiling of micro-RNAs in human esophageal squamous cell carcinoma using RT-PCR. Medical molecular morphology. 2009; 42(2):102-109.
28. Shen YL, Jiang YG, Greenlee AR, Zhou LL and Liu LH. MicroRNA expression profiles and miR-10a target in antibenzo[a] pyrene-7, 8-diol-9, 10-epoxide-transformed human 16HBE cells. Biomedical and environmental sciences: BES. 2009; 22(1):14-21.
29. Zhao JJ, Yang J, Lin J, Yao N, Zhu Y, Zheng J, Xu J, Cheng JQ, Lin JY and Ma X. Identification of miRNAs associated with tumorigenesis of retinoblastoma by miRNA microarray analysis. Child's nervous system: ChNS: official journal of the International Society for Pediatric Neurosurgery. 2009; 25(1):13-20.
30. Gillet JP, Efferth T and Remacle J. Chemotherapy-induced resistance by ATP-binding cassette transporter genes. Biochimica et biophysica acta. 2007; 1775(2):237-262.
31. Lage H. ABC-transporters: implications on drug resistance from microorganisms to human cancers. International journal of antimicrobial agents. 2003; 22(3):188-199.
32. Du J, Pan Y, Shi Y, Guo C, Jin X, Sun L, Liu N, Qiao T and Fan D. Overexpression and significance of prion protein in gastric cancer and multidrug-resistant gastric carcinoma cell line SGC7901/ADR. International journal of cancer Journal international du cancer. 2005; 113(2):213-220.
33. Yin F, Shi YQ, Zhao WP, Xiao B, Miao JY and Fan DM. Suppression of P-gp induced multiple drug resistance in a drug resistant gastric cancer cell line by overexpression of Fas. World journal of gastroenterology: WJG. 2000; 6(5):664-670.
34. Shang Y, Zhang Z, Liu Z, Feng B, Ren G, Li K, Zhou L, Sun Y, Li M, Zhou J, An Y, Wu K, Nie Y and Fan D. miR-508-5p regulates multidrug resistance of gastric cancer by targeting ABCB1 and ZNRD1. Oncogene. 2014; 33(25):3267-3276.
35. Wu Q, Yang Z, Wang F, Hu S, Yang L, Shi Y and Fan D. MiR-19b/20a/92a regulates the self-renewal and proliferation of gastric cancer stem cells. Journal of cell science. 2013; 126(Pt 18):4220-4229.