Vaccarin attenuates the human EA.hy926 endothelial cell oxidative stress injury through inhibition of Notch signaling

International Journal of Molecular Medicine

Volumn 35, Issue 1, 2015, Pages 135-142

  Xie, Fengshan ^a   Cai, Weiwei ^a   Liu, Yanling ^a   Li, Yue ^a   Du, Bin ^b   Feng, Lei ^b   Qiu, Liying ^b  

^a Laboratory of Molecular Pharmacology   (China)

^b JIANGNAN UNIVERSITY   (China)

Author keywords

H2O2; Human EA.hy926 endothelial cells; Notch signaling pathway; Oxidative stress injury; Vaccarin

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; CASPASE 3; CYTOPROTECTIVE AGENT; FLAVONOID GLYCOSIDE; FLUORESCEIN ISOTHIOCYANATE; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; MALONALDEHYDE; NOTCH1 RECEPTOR; PROPIDIUM IODIDE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR HES 1; UNCLASSIFIED DRUG; VACCARIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; FLAVONOID; GLYCOSIDE; HES1 PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; NOTCH RECEPTOR; VACCARIN H;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL MIGRATION; CELL PROLIFERATION; CELL PROTECTION; CELL STRUCTURE; CELL SYNCHRONIZATION; CELL VIABILITY; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; OXIDATIVE STRESS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING; WOUND HEALING; CELL LINE; CELL MOTION; CELL SURVIVAL; DRUG EFFECTS; ENDOTHELIUM CELL; METABOLISM;

APOPTOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CASPASE 3; CELL LINE; CELL MOVEMENT; CELL SURVIVAL; ENDOTHELIAL CELLS; FLAVONOIDS; GLYCOSIDES; HOMEODOMAIN PROTEINS; HUMANS; HYDROGEN PEROXIDE; L-LACTATE DEHYDROGENASE; MALONDIALDEHYDE; OXIDATIVE STRESS; RECEPTOR, NOTCH1; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE;

EID: 84917706907     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2014.1977     Document Type: Article

References (51)

1. Beckman JA, Creager MA and Libby P: Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA 287: 2570-2581, 2002.
2. Malakul W, Thirawarapan S, Suvitayavat W and Woodman OL: Type 1 diabetes and hypercholesterolaemia reveal the contribution of endothelium-derived hyperpolarizing factor to endothelium-dependent relaxation of the rat aorta. Clin Exp Pharmacol Physiol 35: 192-200, 2008.
3. McNulty PH, Tulli MA, Robertson BJ, et al: Effect of simulated postprandial hyperglycemia on coronary blood flow in cardiac transplant recipients. Am J Physiol Heart Circ Physiol 293: H103-H108, 2007.
4. Vita JA: Endothelial function and clinical outcome. Heart 91: 1278-1279, 2005.
5. Schulz E, Dopheide J, Schuhmacher S, et al: Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction. Circulation 118: 1347-1357, 2008.
6. Yada T, Shimokawa H, Hiramatsu O, et al: Hydrogen peroxide, an endogenous endothelium-derived hyperpolarizing factor, plays an important role in coronary autoregulation in vivo. Circulation 107: 1040-1045, 2003.
7. West XZ, Malinin NL, Merkulova AA, et al: Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature 467: 972-976, 2010.
8. Chen CA, Wang TY, Varadharaj S, et al: S-glutathionylation uncouples eNOS and regulates its cellular and vascular function. Nature 468: 1115-1118, 2010.
9. Wu XG and Li L: Rosiglitazone suppresses lipopolysaccharide-induced matrix metalloproteinase-2 activity in rat aortic endothelial cells via Ras-MEK1/2 signaling. Int J Cardiol 158: 54-58, 2012.
10. Zanchetti A, Hennig M, Hollweck R, et al: Baseline values but not treatment-induced changes in carotid intima-media thickness predict incident cardiovascular events in treated hypertensive patients: findings in the European Lacidipine Study on Atherosclerosis (ELSA). Circulation 120: 1084-1090, 2009.
11. Yang Y, Duan WX, Liang ZX, et al: Curcumin attenuates endothelial cell oxidative stress injury through Notch signaling inhibition. Cell Signal 25: 615-629, 2013.
12. Rosenbaum MA, Miyazaki K and Graham LM: Hypercholesterolemia and oxidative stress inhibit endothelial cell healing after arterial injury. J Vasc Surg 55: 489-496, 2012.
13. Cook KM and Figg WD: Angiogenesis inhibitors: Current strategies and future prospects. CA Cancer J Clin 60: 222-243, 2010.
14. Ji X, Wang Z, Geamanu A, Sarkar FH and Gupta SV: Inhibition of cell growth and induction of apoptosis in non-small cell lung cancer cells by delta-tocotrienol is associated with notch-1 down-regulation. J Cell Biochem 112: 2773-2783, 2011.
15. Samon JB, Champhekar A, Minter LM, et al: Notch1 and TGFb1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells. Blood 112: 1813-1821, 2008.
16. Maciej J and Krzysztof S: Notch: A new player in MS mechanisms. J Neuroimmunol 218: 3-11, 2010.
17. Androutsellis-Theotokis A, Leker RR, Soldner F, et al: Notch signalling regulates stem cell numbers in vitro and in vivo. Nature 442: 823-826, 2006.
18. McCright B: Notch signaling in kidney development. Curr Opin Nephrol Hypertens 12: 5-10, 2003.
19. Archana VB, Karl DP, Pao LC, Yoon YS and Michael ED: Oxidative stress-induced Notch1 signaling promotes cardiogenic gene expression in mesenchymal stem cells. Stem Cell Res Ther 4: 2-15, 2013.
20. Campos J, Schmeda-Hirschmann G, Leiva E, et al: Lemon grass (Cymbopogon citratus (D.C) Stapf) polyphenols protect human umbilical vein endothelial cell (HUVECs) from oxidative damage induced by high glucose, hydrogen peroxide and oxidised low-density lipoprotein. Food Chem 151: 175-181, 2014.
21. Jin RG, Wang QJ and Yan TH: Protective effects of salidroside on human umbilical vein endothelial cells. Pharmacology and Clinics of Chinese Materia Medical 28: 41-44, 2012.
22. China Pharmacopoeia Committee. Chinese Pharmacopoeia: The 2010 edition. China Medical Science Press, Beijing, China: pp49-50, 2010.
23. Sang SM, Lao A and Chen ZL: Chemistry and bioactivity of the seeds of Vaccaria segetalis. Orient Foods Herbs 21: 279-291, 2000.
24. Li F and Liang JY: Research progress of Vaccaria segetalis. Straits Pharm J 3: 1-5, 2007.
25. Koike K, Jia ZH and Nikaido T: Triterpenoid saponins from Vaccaria segetalis. Phytochemistry 7: 1343, 1998.
26. Sang SM, Lao AN and Wang HC: A phenylpropanoid glycoside from Vaccaria segetalis. Phytochemistry 48: 569-571, 1998.
27. Sang S, Lao A and Wang H: Triterpenoid saponin from Vaccaria segetalis. J Asian Nat Prod Res, 1: 199-205, 1999.
28. Yun YS, Morita H, Takeya K, et al: Cyclic peptides from higher plants. 34. segetalins G and H, structures and estrogen-like activity of cyclic pentapeptides from Vaccaria segetalis. J Nat Prod 60: 216-218, 1997.
29. Morita H, Young SY, Takeya K, et al: A cyclic heptapeptide from Vaccaria segetalis. Phytochemistry 42: 439-441, 1996.
30. Dong Z and Chen N: Study on the TLC identification method of Wangbuliuxing tablets. China For Med Treat 30: 128, 2011.
31. Li N, Ma CH, Liu D, et al: Chemical constituents analysis of fried Vaccaria segetafis. Chin J Exptl Tradit Med Form 19: 73-75, 2013.
32. Sun YX, Liang HT, Zhang XT, et al: Structural elucidation and immunological activity of a polysaccharide from the fruiting body of Armillaria mellea. Biores Technol 100: 1860-1863, 2009.
33. Sun Y, Wang S, Li T, et al: Purification structure and immunobiological activity of a new water-soluble polysaccharide from the mycelium of Polyporus albicans (Imaz) Teng. Biores Technol 99: 900-904, 2008.
34. Meng H, Chen Y, Qin W, et al: Determination of vaccarin in Vaccariae Semen by HPLC. Zhongguo Zhong Yao Za Zhi 35: 2072-2074, 2010.
35. Xia MX, Feng L and Zhang LF: Isolation, Purification and Identification of Chemical Compound from Semen vaccariae to Inhibit Endothelial Cells. Biotechnology Bulletin 2: 93-97, 2009.
36. Cheong SM, Choi H, Hong BS, Gho YS and Han JK: Dab2 is pivotal for endothelial cell migration by mediating VEGF expression in cancer cells. Exp Cell Res 318: 550-557, 2012.
37. Liu HT, Li WM, Xu G, et al: Chitosan oligosaccharides attenuate hydrogen peroxide-induced stress injury in human umbilical vein endothelial cells. Pharmacol Res 59: 167-175, 2009.
38. Li B, Qiu T, Zhang P, Wang X, Yin Y and Li S: IKVAV regulates ERK1/2 and Akt signalling pathways in BMMSC population growth and proliferation. Cell Prolif 47: 133-145, 2014.
39. Liang KW, Lee WJ, Lee WL, Chen YT, Ting CT and Sheu WH: Diabetes exacerbates angiographic coronary lesion progression in subjects with metabolic syndrome independent of CRP levels. Clin Chim Acta 388: 41-45, 2008.
40. Dikalov SI, Dikalova AE, Bikineyeva AT, Schmidt HH, Harrison DG and Griendling KK: Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production. Free Radical Biol Med 45: 1340-1351, 2008.
41. Li JK, Ge R, Tang L and Li QS: Protective effects of farrerol against hydrogen-peroxide-induced apoptosis in human endothelium-derived EA.hy926 cells. Can J Physiol Pharmacol 91: 733-740, 2013.
42. Noseda M, McLean G, Niessen K, et al: Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation. Circ Res 94: 910-917, 2004.
43. Williams CK, Li JL, Murga M, Harris AL and Tosato G: Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood 107: 931-939, 2006.
44. MacKenzie F, Duriez P, Wong F, Noseda M and Karsan A: Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways. J Biol Chem 279: 11657-11663, 2004.
45. Ding X, Zhu F, Li T, Zhou Q, Hou FF and Nie J: Numb Protects Renal Proximal Tubular Cells from Puromycin Aminonucleoside-Induced Apoptosis through Inhibiting Notch Signaling Pathway. Int J Biol Sci 7: 269-278, 2011.
46. Stampfer MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B and Willett WC: Vitamin E consumption and the risk of coronary disease in women. N Engl J Med 328: 1444-1449, 1993.
47. Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA and Willett WC: Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 328: 1450-1456, 1993.
48. Chen SD, Yin JH, Hwang CS, Tang CM and Yang DI: Anti-apoptotic and anti-oxidative mechanisms of minocycline against sphingomyelinase/ceramide neurotoxicity: implication in Alzheimer's disease and cerebral ischemia. Free Radic Res 46: 940-950, 2012.
49. Luo P, Chen T, Zhao Y, et al: Protective effect of Homer 1a against hydrogen peroxide-induced oxidative stress in PC12 cells. Free Radic Res 46: 766-776, 2012.
50. Fan G, Ma X, Wong PY, Rodrigues CM and Steer CJ: p53 dephosphorylation and p21 (Cip1/Waf1) translocation correlate with caspase-3 activation in TGF-beta1-induced apoptosis of HuH-7 cells. Apoptosis 9: 211-221, 2004.
51. Duan W, Yang Y and Yi W: New Role of JAK2/STAT3 signaling in endothelial cell oxidative stress injury and protective effect of melatonin. PLoS One 8: 1-13, 2013.