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Volumn 9, Issue 12, 2014, Pages

An NMR-based metabolomic approach to investigate the effects of supplementation with glutamic acid in piglets challenged with deoxynivalenol

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ALANINE; ARGININE; CASPASE 3; CHOLINE; CITRIC ACID; CREATININE; CYCLINE; FUMARIC ACID; GLUTAMIC ACID; GLUTATHIONE PEROXIDASE; GLYCINE; GLYCOPROTEIN; HIGH DENSITY LIPOPROTEIN; LACTIC ACID; LOW DENSITY LIPOPROTEIN; PROLINE; SUPEROXIDE DISMUTASE; TRIMETHYLAMINE OXIDE; UNSATURATED FATTY ACID; UREA; VOMITOXIN; TRICHOTHECENE DERIVATIVE;

EID: 84917696434     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0113687     Document Type: Article
Times cited : (32)

References (58)
  • 1
    • 77957802278 scopus 로고    scopus 로고
    • Deoxynivalenol: Mechanisms of action, human exposure, and toxicological relevance
    • Pestka JJ (2010) Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance. Archives of Toxicology 84: 663-679.
    • (2010) Archives of Toxicology , vol.84 , pp. 663-679
    • Pestka, J.J.1
  • 3
    • 0027586382 scopus 로고
    • Microbially Detoxified Vomitoxin-Contaminated Corn for Young-Pigs
    • He P, Young LG, Forsberg C (1993) Microbially Detoxified Vomitoxin-Contaminated Corn for Young-Pigs. Journal of Animal Science 71: 963-967.
    • (1993) Journal of Animal Science , vol.71 , pp. 963-967
    • He, P.1    Young, L.G.2    Forsberg, C.3
  • 6
    • 84903692603 scopus 로고    scopus 로고
    • Therapeutic effects of glutamic Acid in piglets challenged with deoxynivalenol
    • Wu M, Xiao H, Ren W, Yin J, Tan B, et al. (2014) Therapeutic effects of glutamic Acid in piglets challenged with deoxynivalenol. PLoS One 9: e100591.
    • (2014) PLoS One , vol.9 , pp. e100591
    • Wu, M.1    Xiao, H.2    Ren, W.3    Yin, J.4    Tan, B.5
  • 7
    • 0034062694 scopus 로고    scopus 로고
    • Glutamate: An amino acid of particular distinction
    • Young VR, Ajami AM (2000) Glutamate: an amino acid of particular distinction. J Nutr 130: 892S-900S.
    • (2000) J Nutr , vol.130 , pp. 892S-900S
    • Young, V.R.1    Ajami, A.M.2
  • 9
    • 84882705118 scopus 로고    scopus 로고
    • Amino acid sensing in the gastrointestinal tract
    • Gabriel AS, Uneyama H (2013) Amino acid sensing in the gastrointestinal tract. Amino Acids 45: 451-461.
    • (2013) Amino Acids , vol.45 , pp. 451-461
    • Gabriel, A.S.1    Uneyama, H.2
  • 10
    • 80052789930 scopus 로고    scopus 로고
    • Reduced expression of intestinal N-acetylglutamate synthase in suckling piglets: A novel molecular mechanism for arginine as a nutritionally essential amino acid for neonates
    • Geng M, Li T, Kong X, Song X, Chu W, et al. (2011) Reduced expression of intestinal N-acetylglutamate synthase in suckling piglets: a novel molecular mechanism for arginine as a nutritionally essential amino acid for neonates. Amino Acids 40: 1513-1522.
    • (2011) Amino Acids , vol.40 , pp. 1513-1522
    • Geng, M.1    Li, T.2    Kong, X.3    Song, X.4    Chu, W.5
  • 12
    • 67349185597 scopus 로고    scopus 로고
    • Metabolomic analysis of the response of growing pigs to dietary L-arginine supplementation
    • He Q, Kong X, Wu G, Ren P, Tang H, et al. (2009) Metabolomic analysis of the response of growing pigs to dietary L-arginine supplementation. Amino Acids 37: 199-208.
    • (2009) Amino Acids , vol.37 , pp. 199-208
    • He, Q.1    Kong, X.2    Wu, G.3    Ren, P.4    Tang, H.5
  • 14
    • 0043069547 scopus 로고    scopus 로고
    • Opinion: Understanding 'global' systems biology: Metabonomics and the continuum of metabolism
    • Nicholson JK, Wilson ID (2003) Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nat Rev Drug Discov 2: 668-676.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 668-676
    • Nicholson, J.K.1    Wilson, I.D.2
  • 15
    • 78449289396 scopus 로고    scopus 로고
    • Supplementing L-leucine to a low-protein diet increases tissue protein synthesis in weanling pigs
    • Yin Y, Yao K, Liu Z, Gong M, Ruan Z, et al. (2010) Supplementing L-leucine to a low-protein diet increases tissue protein synthesis in weanling pigs. Amino Acids 39: 1477-1486.
    • (2010) Amino Acids , vol.39 , pp. 1477-1486
    • Yin, Y.1    Yao, K.2    Liu, Z.3    Gong, M.4    Ruan, Z.5
  • 16
    • 0028304536 scopus 로고
    • Effects of low-level dietary deoxynivalenol on haematological and clinical parameters of the pig
    • Prelusky DB, Gerdes RG, Underhill KL, Rotter BA, Jui PY, et al. (1994) Effects of low-level dietary deoxynivalenol on haematological and clinical parameters of the pig. Nat Toxins 2: 97-104.
    • (1994) Nat Toxins , vol.2 , pp. 97-104
    • Prelusky, D.B.1    Gerdes, R.G.2    Underhill, K.L.3    Rotter, B.A.4    Jui, P.Y.5
  • 17
    • 0037713736 scopus 로고    scopus 로고
    • Role of inducible nitric oxide synthase expression in aberrant crypt foci-adenoma-carcinoma sequence
    • Xu MH, Deng CS, Zhu YQ, Lin J (2003) Role of inducible nitric oxide synthase expression in aberrant crypt foci-adenoma-carcinoma sequence. World Journal of Gastroenterology 9: 1246-1250.
    • (2003) World Journal of Gastroenterology , vol.9 , pp. 1246-1250
    • Xu, M.H.1    Deng, C.S.2    Zhu, Y.Q.3    Lin, J.4
  • 18
    • 84855477382 scopus 로고    scopus 로고
    • Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach
    • He QH, Ren PP, Kong XF, Wu YN, Wu GY, et al. (2012) Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach. Journal of Nutritional Biochemistry 23: 133-139.
    • (2012) Journal of Nutritional Biochemistry , vol.23 , pp. 133-139
    • He, Q.H.1    Ren, P.P.2    Kong, X.F.3    Wu, Y.N.4    Wu, G.Y.5
  • 19
    • 84884753781 scopus 로고    scopus 로고
    • Effects of composite antimicrobial peptides in weanling piglets challenged with deoxynivalenol: I. Growth performance, immune function, and antioxidation capacity
    • Xiao H, Wu MM, Tan BE, Yin YL, Li TJ, et al. (2013) Effects of composite antimicrobial peptides in weanling piglets challenged with deoxynivalenol: I. Growth performance, immune function, and antioxidation capacity. Journal of Animal Science 91: 4772-4780.
    • (2013) Journal of Animal Science , vol.91 , pp. 4772-4780
    • Xiao, H.1    Wu, M.M.2    Tan, B.E.3    Yin, Y.L.4    Li, T.J.5
  • 20
    • 84884754639 scopus 로고    scopus 로고
    • Effects of composite antimicrobial peptides in weanling piglets challenged with deoxynivalenol: II. Intestinal morphology and function
    • Xiao H, Tan BE, Wu MM, Yin YL, Li TJ, et al. (2013) Effects of composite antimicrobial peptides in weanling piglets challenged with deoxynivalenol: II. Intestinal morphology and function. Journal of Animal Science 91: 4750-4756.
    • (2013) Journal of Animal Science , vol.91 , pp. 4750-4756
    • Xiao, H.1    Tan, B.E.2    Wu, M.M.3    Yin, Y.L.4    Li, T.J.5
  • 22
    • 0032694577 scopus 로고    scopus 로고
    • 'Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson JK, Lindon JC, Holmes E (1999) 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29: 1181-1189.
    • (1999) Xenobiotica , vol.29 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 23
    • 54549091125 scopus 로고    scopus 로고
    • Systems biology - Metabonomics
    • Nicholson JK, Lindon JC (2008) Systems biology - Metabonomics. Nature 455: 1054-1056.
    • (2008) Nature , vol.455 , pp. 1054-1056
    • Nicholson, J.K.1    Lindon, J.C.2
  • 24
    • 2342520064 scopus 로고    scopus 로고
    • Application of nuclear magnetic resonance spectroscopy combined with principal component analysis in detecting inborn errors of metabolism using blood spots: A metabonomic approach
    • Constantinou MA, Papakonstantinou E, Benaki D, Spraul M, Shulpis K, et al. (2004) Application of nuclear magnetic resonance spectroscopy combined with principal component analysis in detecting inborn errors of metabolism using blood spots: a metabonomic approach. Analytica Chimica Acta 511:303-312.
    • (2004) Analytica Chimica Acta , vol.511 , pp. 303-312
    • Constantinou, M.A.1    Papakonstantinou, E.2    Benaki, D.3    Spraul, M.4    Shulpis, K.5
  • 25
    • 33644861299 scopus 로고    scopus 로고
    • A multi-analytical platform approach to the metabonomic analysis of plasma from normal and Zucker (fa/fa) obese rats
    • Williams R, Lenz EM, Wilson AJ, Granger J, Wilson ID, et al. (2006) A multi-analytical platform approach to the metabonomic analysis of plasma from normal and Zucker (fa/fa) obese rats. Mol Biosyst 2: 174-183.
    • (2006) Mol Biosyst , vol.2 , pp. 174-183
    • Williams, R.1    Lenz, E.M.2    Wilson, A.J.3    Granger, J.4    Wilson, I.D.5
  • 26
    • 70449450345 scopus 로고    scopus 로고
    • Human Serum Metabonomic Analysis Reveals Progression Axes for Glucose Intolerance and Insulin Resistance Statuses
    • Zhang XY, Wang YL, Hao FH, Zhou XH, Han XY, et al. (2009) Human Serum Metabonomic Analysis Reveals Progression Axes for Glucose Intolerance and Insulin Resistance Statuses. Journal of Proteome Research 8: 5188-5195.
    • (2009) Journal of Proteome Research , vol.8 , pp. 5188-5195
    • Zhang, X.Y.1    Wang, Y.L.2    Hao, F.H.3    Zhou, X.H.4    Han, X.Y.5
  • 29
    • 78650174720 scopus 로고    scopus 로고
    • Mycotoxin deoxynivalenol (DON) mediates biphasic cellular response in intestinal porcine epithelial cell lines IPEC-1 and IPEC-J2
    • Diesing AK, Nossol C, Panther P, Walk N, Post A, et al. (2011) Mycotoxin deoxynivalenol (DON) mediates biphasic cellular response in intestinal porcine epithelial cell lines IPEC-1 and IPEC-J2. Toxicology Letters 200: 8-18.
    • (2011) Toxicology Letters , vol.200 , pp. 8-18
    • Diesing, A.K.1    Nossol, C.2    Panther, P.3    Walk, N.4    Post, A.5
  • 30
    • 84898669954 scopus 로고    scopus 로고
    • Dietary arginine supplementation enhances intestinal expression of SLC7A7 and SLC7A1 and ameliorates growth depression in mycotoxin-challenged pigs
    • Yin J, Ren W, Duan J, Wu L, Chen S, et al. (2014) Dietary arginine supplementation enhances intestinal expression of SLC7A7 and SLC7A1 and ameliorates growth depression in mycotoxin-challenged pigs. Amino Acids 46: 883-892.
    • (2014) Amino Acids , vol.46 , pp. 883-892
    • Yin, J.1    Ren, W.2    Duan, J.3    Wu, L.4    Chen, S.5
  • 32
    • 79956353020 scopus 로고    scopus 로고
    • Adapted response of the antioxidant defense system to oxidative stress induced by deoxynivalenol in Hek-293 cells
    • Dinu D, Bodea GO, Ceapa CD, Munteanu MC, Roming FI, et al. (2011) Adapted response of the antioxidant defense system to oxidative stress induced by deoxynivalenol in Hek-293 cells. Toxicon 57: 1023-1032.
    • (2011) Toxicon , vol.57 , pp. 1023-1032
    • Dinu, D.1    Bodea, G.O.2    Ceapa, C.D.3    Munteanu, M.C.4    Roming, F.I.5
  • 33
    • 23944513331 scopus 로고    scopus 로고
    • Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2
    • Kouadio JH, Mobio TA, Baudrimont I, Moukha S, Dano SD, et al. (2005) Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2. Toxicology 213: 56-65.
    • (2005) Toxicology , vol.213 , pp. 56-65
    • Kouadio, J.H.1    Mobio, T.A.2    Baudrimont, I.3    Moukha, S.4    Dano, S.D.5
  • 34
    • 77956905668 scopus 로고    scopus 로고
    • Comparative hepatotoxicity of deoxynivalenol in rat, mouse and human liver cells in culture
    • Sahu SC, O'Donnell MW, Wiesenfeld PL (2010) Comparative hepatotoxicity of deoxynivalenol in rat, mouse and human liver cells in culture. Journal of Applied Toxicology 30: 566-573.
    • (2010) Journal of Applied Toxicology , vol.30 , pp. 566-573
    • Sahu, S.C.1    O'Donnell, M.W.2    Wiesenfeld, P.L.3
  • 35
    • 70349578566 scopus 로고    scopus 로고
    • Metabolism and functions of L-glutamate in the epithelial cells of the small and large intestines
    • Blachier F, Boutry C, Bos C, Tome D (2009) Metabolism and functions of L-glutamate in the epithelial cells of the small and large intestines. American Journal of Clinical Nutrition 90: 814s-821s.
    • (2009) American Journal of Clinical Nutrition , vol.90 , pp. 814s-821s
    • Blachier, F.1    Boutry, C.2    Bos, C.3    Tome, D.4
  • 36
    • 84862509596 scopus 로고    scopus 로고
    • Chronic ingestion of deoxynivalenol and fumonisin, alone or in interaction, induces morphological and immunological changes in the intestine of piglets
    • Bracarense APFL, Lucioli J, Grenier B, Pacheco GD, Moll WD, et al. (2012) Chronic ingestion of deoxynivalenol and fumonisin, alone or in interaction, induces morphological and immunological changes in the intestine of piglets. British Journal of Nutrition 107: 1776-1786.
    • (2012) British Journal of Nutrition , vol.107 , pp. 1776-1786
    • Bracarense, A.P.F.L.1    Lucioli, J.2    Grenier, B.3    Pacheco, G.D.4    Moll, W.D.5
  • 37
    • 0031045565 scopus 로고    scopus 로고
    • PCNA: Structure, functions and interactions
    • Kelman Z (1997) PCNA: structure, functions and interactions. Oncogene 14: 629-640.
    • (1997) Oncogene , vol.14 , pp. 629-640
    • Kelman, Z.1
  • 38
    • 79956150420 scopus 로고    scopus 로고
    • Proliferating cell nuclear antigen (PCNA): A key factor in DNA replication and cell cycle regulation
    • Strzalka W, Ziemienowicz A (2011) Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation. Ann Bot 107: 1127-1140.
    • (2011) Ann Bot , vol.107 , pp. 1127-1140
    • Strzalka, W.1    Ziemienowicz, A.2
  • 39
    • 84871757456 scopus 로고    scopus 로고
    • Reactive oxygen species-induced cytotoxic effects of zinc oxide nanoparticles in rat retinal ganglion cells
    • Guo D, Bi H, Liu B, Wu Q, Wang D, et al. (2013) Reactive oxygen species-induced cytotoxic effects of zinc oxide nanoparticles in rat retinal ganglion cells. Toxicol In Vitro 27: 731-738.
    • (2013) Toxicol in Vitro , vol.27 , pp. 731-738
    • Guo, D.1    Bi, H.2    Liu, B.3    Wu, Q.4    Wang, D.5
  • 42
    • 84867572064 scopus 로고    scopus 로고
    • Decreased glutamate, glutamine and citrulline concentrations in plasma and muscle in endotoxemia cannot be reversed by glutamate or glutamine supplementation: A primary intestinal defect?
    • Boutry C, Matsumoto H, Bos C, Moinard C, Cynober L, et al. (2012) Decreased glutamate, glutamine and citrulline concentrations in plasma and muscle in endotoxemia cannot be reversed by glutamate or glutamine supplementation: a primary intestinal defect? Amino Acids 43: 1485-1498.
    • (2012) Amino Acids , vol.43 , pp. 1485-1498
    • Boutry, C.1    Matsumoto, H.2    Bos, C.3    Moinard, C.4    Cynober, L.5
  • 43
    • 46549086167 scopus 로고    scopus 로고
    • Citrulline as a biomarker of intestinal failure due to enterocyte mass reduction
    • Crenn P, Messing B, Cynober L (2008) Citrulline as a biomarker of intestinal failure due to enterocyte mass reduction. Clinical Nutrition 27: 328-339.
    • (2008) Clinical Nutrition , vol.27 , pp. 328-339
    • Crenn, P.1    Messing, B.2    Cynober, L.3
  • 44
    • 0037622076 scopus 로고    scopus 로고
    • Plasma citrulline: A marker of enterocyte mass in villous atrophy-associated small bowel disease
    • Crenn P, Vahedi K, Lavergne-Slove A, Cynober L, Matuchansky C, et al. (2003) Plasma citrulline: A marker of enterocyte mass in villous atrophy-associated small bowel disease. Gastroenterology 124: 1210-1219.
    • (2003) Gastroenterology , vol.124 , pp. 1210-1219
    • Crenn, P.1    Vahedi, K.2    Lavergne-Slove, A.3    Cynober, L.4    Matuchansky, C.5
  • 45
    • 0034464238 scopus 로고    scopus 로고
    • Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans
    • Crenn P, Coudray-Lucas C, Thuillier F, Cynober L, Messing B (2000) Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans. Gastroenterology 119: 1496-1505.
    • (2000) Gastroenterology , vol.119 , pp. 1496-1505
    • Crenn, P.1    Coudray-Lucas, C.2    Thuillier, F.3    Cynober, L.4    Messing, B.5
  • 46
    • 20144389668 scopus 로고    scopus 로고
    • Serum citrulline levels correlate with enteral tolerance and bowel length in infants with short bowel syndrome
    • Rhoads JM, Plunkett E, Galanko J, Lichtman S, Taylor L, et al. (2005) Serum citrulline levels correlate with enteral tolerance and bowel length in infants with short bowel syndrome. J Pediatr 146: 542-547.
    • (2005) J Pediatr , vol.146 , pp. 542-547
    • Rhoads, J.M.1    Plunkett, E.2    Galanko, J.3    Lichtman, S.4    Taylor, L.5
  • 47
    • 84891813464 scopus 로고    scopus 로고
    • A systematic approach to obtain validated partial least square models for predicting lipoprotein subclasses from serum NMR spectra
    • Mihaleva VV, van Schalkwijk DB, de Graaf AA, van Duynhoven J, van Dorsten FA, et al. (2014) A systematic approach to obtain validated partial least square models for predicting lipoprotein subclasses from serum NMR spectra. Anal Chem 86: 543-550.
    • (2014) Anal Chem , vol.86 , pp. 543-550
    • Mihaleva, V.V.1    Van Schalkwijk, D.B.2    De Graaf, A.A.3    Van Duynhoven, J.4    Van Dorsten, F.A.5
  • 48
    • 33846639147 scopus 로고    scopus 로고
    • Value of low-density lipoprotein particle number and size as predictors of coronary artery disease in apparently healthy men and women - The EPIC-Norfolk Prospective Population study
    • El Harchaoui K, van der Steeg WA, Stroes ESG, Kuivenhoven JA, Otvos JD, et al. (2007) Value of low-density lipoprotein particle number and size as predictors of coronary artery disease in apparently healthy men and women - The EPIC-Norfolk Prospective Population study. Journal of the American College of Cardiology 49: 547-553.
    • (2007) Journal of the American College of Cardiology , vol.49 , pp. 547-553
    • El Harchaoui, K.1    Van Der Steeg, W.A.2    Stroes, E.S.G.3    Kuivenhoven, J.A.4    Otvos, J.D.5
  • 49
    • 0037317156 scopus 로고    scopus 로고
    • Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance
    • Garvey WT, Kwon S, Zheng D, Shaughnessy S, Wallace P, et al. (2003) Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance. Diabetes 52: 453-462.
    • (2003) Diabetes , vol.52 , pp. 453-462
    • Garvey, W.T.1    Kwon, S.2    Zheng, D.3    Shaughnessy, S.4    Wallace, P.5
  • 50
    • 33747343156 scopus 로고    scopus 로고
    • H-1 NMR spectroscopy for the prediction of therapeutic outcome in patients with fulminant hepatic failure
    • Saxena V, Gupta A, Gowda GAN, Saxena R, Yachha SK, et al. (2006) H-1 NMR spectroscopy for the prediction of therapeutic outcome in patients with fulminant hepatic failure. Nmr in Biomedicine 19: 521-526.
    • (2006) Nmr in Biomedicine , vol.19 , pp. 521-526
    • Saxena, V.1    Gupta, A.2    Gowda, G.A.N.3    Saxena, R.4    Yachha, S.K.5
  • 51
    • 20844461344 scopus 로고    scopus 로고
    • H-1-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants
    • Serkova N, Fuller TF, Klawitter J, Freise CE, Niemann CU (2005) H-1-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants. Kidney International 67: 1142-1151.
    • (2005) Kidney International , vol.67 , pp. 1142-1151
    • Serkova, N.1    Fuller, T.F.2    Klawitter, J.3    Freise, C.E.4    Niemann, C.U.5
  • 52
    • 0033863308 scopus 로고    scopus 로고
    • Influence of retrieval conditions on renal medulla injury: Evaluation by proton NMR spectroscopy in an isolated perfused pig kidney model
    • Hauet T, Gibelin H, Richer JP, Godart C, Eugene M, et al. (2000) Influence of retrieval conditions on renal medulla injury: Evaluation by proton NMR spectroscopy in an isolated perfused pig kidney model. Journal of Surgical Research 93: 1-8.
    • (2000) Journal of Surgical Research , vol.93 , pp. 1-8
    • Hauet, T.1    Gibelin, H.2    Richer, J.P.3    Godart, C.4    Eugene, M.5
  • 54
    • 0029810668 scopus 로고    scopus 로고
    • Nuclear magnetic resonance and high-performance liquid chromatography nuclear magnetic resonance studies on the toxicity and metabolism of ifosfamide
    • Foxall PJD, Lenz EM, Lindon JC, Neild GH, Wilson ID, et al. (1996) Nuclear magnetic resonance and high-performance liquid chromatography nuclear magnetic resonance studies on the toxicity and metabolism of ifosfamide. Therapeutic Drug Monitoring 18: 498-505.
    • (1996) Therapeutic Drug Monitoring , vol.18 , pp. 498-505
    • Foxall, P.J.D.1    Lenz, E.M.2    Lindon, J.C.3    Neild, G.H.4    Wilson, I.D.5
  • 55
    • 0142138236 scopus 로고    scopus 로고
    • Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis
    • Griffin JL (2003) Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis. Current Opinion in Chemical Biology 7: 648-654.
    • (2003) Current Opinion in Chemical Biology , vol.7 , pp. 648-654
    • Griffin, J.L.1
  • 56
    • 0028983919 scopus 로고
    • An Analysis of Predictors of Long-Term Cadaveric Renal-Allograft Survival
    • Cole E, Naimark D, Aprile M, Wade J, Cattran D, et al. (1995) An Analysis of Predictors of Long-Term Cadaveric Renal-Allograft Survival. Clinical Transplantation 9: 282-288.
    • (1995) Clinical Transplantation , vol.9 , pp. 282-288
    • Cole, E.1    Naimark, D.2    Aprile, M.3    Wade, J.4    Cattran, D.5
  • 57
    • 34547680472 scopus 로고    scopus 로고
    • Enhancement of intestinal absorption of macromolecules by spermine in rats
    • Sugita Y, Takao K, Toyama Y, Shirahata A (2007) Enhancement of intestinal absorption of macromolecules by spermine in rats. Amino Acids 33: 253-260.
    • (2007) Amino Acids , vol.33 , pp. 253-260
    • Sugita, Y.1    Takao, K.2    Toyama, Y.3    Shirahata, A.4
  • 58
    • 34547114974 scopus 로고    scopus 로고
    • A unified hypothesis of coeliac disease with implications for management of patients
    • Cornell HJ, Stelmasiak T (2007) A unified hypothesis of coeliac disease with implications for management of patients. Amino Acids 33: 43-49.
    • (2007) Amino Acids , vol.33 , pp. 43-49
    • Cornell, H.J.1    Stelmasiak, T.2


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