The polyamine catabolic enzyme sat1 modulates tumorigenesis and radiation response in gbm

Cancer Research

Volumn 74, Issue 23, 2014, Pages 6925-6934

  Brett Morris, Adina ^a   Wright, Bradley M ^a   Seo, Yuji ^a,b   Pasupuleti, Vinay ^f   Zhang, Junran ^a   Lu, Jun ^c   Spina, Raffaella ^d   Bar, Eli E ^d   Gujrati, Maneesh ^e   Schur, Rebecca ^e   Lu, Zheng Rong ^e   Welford, Scott M ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OSAKA UNIVERSITY   (Japan)

^c AUCKLAND UNIVERSITY OF TECHNOLOGY   (New Zealand)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

^e Case Western Reserve University   (United States)

^f NONE

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H3; ORNITHINE DECARBOXYLASE; ORNITHINE DECARBOXYLASE 1; UNCLASSIFIED DRUG; ACYLTRANSFERASE; DIAMINE N-ACETYLTRANSFERASE; HISTONE; POLYAMINE; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER PROGNOSIS; CANCER SURVIVAL; CARCINOGENESIS; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; DNA REPAIR; ENZYME REGULATION; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOSS; GENETIC ASSOCIATION; GLIOBLASTOMA; HISTONE ACETYLATION; HOMOLOGOUS RECOMBINATION; IN VIVO STUDY; IONIZING RADIATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RADIOSENSITIVITY; SURVIVAL TIME; TUMOR SUPPRESSOR GENE; ANIMAL; BAGG ALBINO MOUSE; BRAIN NEOPLASMS; CELL CYCLE; CELL TRANSFORMATION; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; NUDE MOUSE; PATHOLOGY; RADIATION DOSE; TUMOR CELL LINE;

ACETYLTRANSFERASES; ANIMALS; BRAIN NEOPLASMS; CARCINOGENESIS; CELL CYCLE; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION; GLIOBLASTOMA; HISTONES; HOMOLOGOUS RECOMBINATION; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; POLYAMINES; RADIATION TOLERANCE; RADIATION, IONIZING; RNA, SMALL INTERFERING;

EID: 84917691027     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-1249     Document Type: Article

References (36)

1. Krex D, Klink B, Hartmann C, von Deimling A, Pietsch T, Simon M, et al. Long-term survival with glioblastoma multiforme. Brain 2007;130: 2596-606.
2. Wen PY, Kesari S. Malignant gliomas in adults. N Engl J Med 2008;359:492-507.
3. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352:987-96.
4. Chakravarti A, Zhai GG, Zhang M, Malhotra R, Latham DE, Delaney MA, et al. Survivin enhances radiation resistance in primary human glioblastoma cells via caspase-independent mechanisms. Oncogene 2004;23:7494-506.
5. Bao S,WuQ,McLendon RE, Hao Y, Shi Q, Hjelmeland AB, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006;444:756-60.
6. Hatanpaa KJ, Burma S, Zhao D, Habib AA. Epidermal growth factor receptor in glioma: signal transduction, neuropathology, imaging, and radioresistance. Neoplasia 2010;12:675-84.
7. Pegg AE. Spermidine/spermine-N(1)-acetyltransferase: a key metabolic regulator. Am J Physiol Endocrinol Metab 2008;294:E995-1010.
8. Chiu S, Oleinick NL. Radioprotection of cellular chromatin by the polyamines spermine and putrescine: preferential action against formation of DNA-protein crosslinks. Radiat Res 1998;149:543-9.
9. Warters RL, Newton GL, Olive PL, Fahey RC. Radioprotection of human cell nuclear DNA by polyamines: radiosensitivity of chromatin is infl uenced by tightly bound spermine. Radiat Res 1999;151: 354-62.
10. Sy D, Hugot S, Savoye C, Ruiz S, Charlier M, Spotheim-Maurizot M. Radioprotection ofDNAby spermine: a molecular modelling approach. Int J Radiat Biol 1999;75:953-61.
11. Murr R, Loizou JI, Yang YG, Cuenin C, Li H, Wang ZQ, et al. Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks. Nat Cell Biol 2006;8:91-9.
12. Sterner DE, Berger SL. Acetylation of histones and transcriptionrelated factors. Microbiol Mol Biol Rev 2000;64:435-59.
13. Masumoto H, Hawke D, Kobayashi R, Verreault A. A role for cell-cycleregulated histone H3 lysine 56 acetylation in the DNA damage response. Nature 2005;436:294-8.
14. Gujrati M, Malamas A, Shin T, Jin E, Sun Y, Lu ZR. Multifunctional cationic lipid-based nanoparticles facilitate endosomal escape and reduction-triggered cytosolic siRNA release. Mol Pharm 2014;11: 2734-44.
15. Krieg AJ, Hammond EM, Giaccia AJ. Functional analysis of p53 binding under differential stresses. Mol Cell Biol 2006;26:7030-45.
16. Kass EM, Helgadottir HR, Chen CC, Barbera M, Wang R, Westermark UK, et al. Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase. Proc Natl Acad Sci U S A 2013;110:5564-9.
17. Clark MJ, Homer N, O'Connor BD, Chen Z, Eskin A, Lee H, et al. U87MG decoded: the genomic sequence of a cytogenetically aberrant human cancer cell line. PLoS Genet 2010;6:e1000832.
18. Ishii N, Maier D, Merlo A, Tada M, Sawamura Y, Diserens AC, et al. Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines. Brain Pathol 1999;9: 469-79.
19. Galli R, Binda E, Orfanelli U, Cipelletti B, Gritti A, De Vitis S, et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 2004;64:7011-21.
20. Balasundaram D, Tyagi AK. Polyamine-DNA nexus: structural ramifications and biological implications. Mol Cell Biochem 1991;100: 129-40.
21. Casero RA, Pegg AE. Polyamine catabolism and disease. Biochem J 2009;421:323-38.
22. Barker CA, Powell SN. Enhancing radiotherapy through a greater understanding of homologous recombination. Semin Radiat Oncol 2010;20:267- 73 e3.
23. Litman R, Peng M, Jin Z, Zhang F, Zhang J, Powell S, et al. BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ. Cancer Cell 2005;8:255-65.
24. Rice JC, Futscher BW. Transcriptional repression of BRCA1 by aberrant cytosine methylation, histone hypoacetylation and chromatin condensation of the BRCA1 promoter. Nucleic Acids Res 2000; 28:3233-9.
25. Eisenberg T, Knauer H, Schauer A, Buttner S, Ruckenstuhl C, Car-mona- Gutierrez D, et al. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 2009;11:1305-14.
26. Pegg AE, Casero RA Jr. Current status of the polyamine research field. Methods Mol Biol 2011;720:3-35.
27. Ouameur AA, Tajmir-Riahi HA. Structural analysis of DNA interactions with biogenic polyamines and cobalt(III)hexamine studied by Fourier transform infrared and capillary electrophoresis. J Biol Chem 2004;279:42041-54.
28. Liu B, Sutton A, Sternglanz R. A yeast polyamine acetyltransferase. J Biol Chem 2005;280:16659-64.
29. Manna SK, Krausz KW, Bonzo JA, Idle JR, Gonzalez FJ. Metabolomics reveals aging-associated attenuation of noninvasive radiation biomarkers in mice: potential role of polyamine catabolism and incoherent DNA damage-repair. J Proteome Res 2013;12:2269-81.
30. deHart GW, Jin T, McCloskey DE, Pegg AE, Sheppard D. The alpha9- beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel. Proc Natl Acad Sci U S A 2008;105:7188-93.
31. Sampath V, Liu B, Tafrov S, Srinivasan M, Rieger R, Chen EI, et al. Biochemical characterization of Hpa2 and Hpa3, two small closely related acetyltransferases from Saccharomyces cerevisiae. J Biol Chem 2013;288:21506-13.
32. Seiler N. Thirty years of polyamine-related approaches to cancer therapy. Retrospect and prospect. Part 2. Structural analogues and derivatives. Curr Drug Targets 2003;4:565-85.
33. Seiler N. Thirty years of polyamine-related approaches to cancer therapy. Retrospect and prospect. Part 1. Selective enzyme inhibitors. Curr Drug Targets 2003;4:537-64.
34. Mandal S, Mandal A, Johansson HE, Orjalo AV, Park MH. Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells. Proc Natl Acad Sci U S A 2013;110:2169-74.
35. Venere M, Hamerlik P,WuQ, Rasmussen RD, Song LA, Vasanji A, et al. Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells. Cell Death Differ 2014;21:258-69.
36. Casero RA Jr, Marton LJ. Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases. Nat Rev Drug Discov 2007;6:373-90.