Biochemical characterization of Hpa2 and Hpa3, two small closely related acetyltransferases from saccharomyces cerevisiae

Journal of Biological Chemistry

Volumn 288, Issue 30, 2013, Pages 21506-21513

  Sampath, Vinaya ^a   Liu, Bingsheng ^a   Tafrov, Stefan ^a,b   Srinivasan, Madhusudhan ^a   Rieger, Robert ^a   Chen, Emily I ^a   Sternglanz, Rolf ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLTRANSFERASES; BASIC PROTEINS; BIOCHEMICAL CHARACTERIZATION; DIFFERENT SUBSTRATES; POLYAMINES;

PROTEINS;

YEAST;

ACYLTRANSFERASE; BASIC PROTEIN; HISTONE H3; HISTONE H4; LYSINE; POLYAMINE; PROTEIN HPA2; PROTEIN HPA3; PROTEIN MET 1; PROTEIN MET 19; PROTEIN MET 27; SACCHAROMYCES CEREVISIAE PROTEIN; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SPECIFICITY; ESCHERICHIA COLI; GENE DELETION; IN VITRO STUDY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; TRANSLATION INITIATION; YEAST CELL;

ACETYLTRANSFERASE; HISTONE ACETYLASE; HISTONE MODIFICATION; MASS SPECTROMETRY (MS); POLYAMINES; TRANSLATION;

ACETYLATION; ACETYLTRANSFERASES; AMINO ACID SEQUENCE; AMINO ACIDS; AMINO-ACID N-ACETYLTRANSFERASE; CODON, INITIATOR; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HIGH MOBILITY GROUP PROTEINS; HISTONE ACETYLTRANSFERASES; HISTONES; ISOENZYMES; LYSINE; METHIONINE; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN MULTIMERIZATION; PUTRESCINE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPERMIDINE; SPERMINE; SUBSTRATE SPECIFICITY;

EID: 84881254916     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.486274     Document Type: Article

References (29)

1. Carrozza, M. J., Utley, R. T., Workman, J. L., and Côté, J. (2003) The diverse functions of histone acetyltransferase complexes. Trends Genet. 19, 321-329
2. Davies, J. (1994) Inactivation of antibiotics and the dissemination of resistance genes. Science 264, 375-382
3. Sterner, D. E., and Berger, S. L. (2000) Acetylation of histones and transcription-related factors. Microbiol. Mol. Biol. Rev. 64, 435-459
4. Baker, S. P., and Grant, P. A. (2007) The SAGA continues: expanding the cellular role of a transcriptional co-activator complex. Oncogene 26, 5329-5340
5. Parthun, M. R. (2007) Hat1: the emerging cellular roles of a type B histone acetyltransferase. Oncogene 26, 5319-5328
6. Doyon, Y., and Côté, J. (2004) The highly conserved and multifunctional NuA4 HAT complex. Curr. Opin. Genet. Dev. 14, 147-154
7. John, S., Howe, L., Tafrov, S. T., Grant, P. A., Sternglanz, R., and Workman, J. L. (2000) The something about silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)-FACT complex. Genes Dev. 14, 1196-1208
8. Angus-Hill, M. L., Dutnall, R. N., Tafrov, S. T., Sternglanz, R., and Ramakrishnan, V. (1999) Crystal structure of the histone acetyltransferase Hpa2: a tetrameric member of the Gcn5-related N-acetyltransferase superfamily. J. Mol. Biol. 294, 1311-1325
9. Yow, G. Y., Uo, T., Yoshimura, T., and Esaki, N. (2004) D-Amino acid N-acetyltransferase of Saccharomyces cerevisiae: a close homologue of histone acetyltransferase Hpa2p acting exclusively on free D-amino acids. Arch. Microbiol. 182, 396-403
10. Yow, G. Y., Uo, T., Yoshimura, T., and Esaki, N. (2006) Physiological role of D-amino acid-N-acetyltransferase of Saccharomyces cerevisiae: detoxification of D-amino acids. Arch. Microbiol. 185, 39-46
11. Rytka, J. (1975) Positive selection of general amino acid permease mutants in Saccharomyces cerevisiae. J. Bacteriol. 121, 562-570
12. Soutourina, J., Blanquet, S., and Plateau, P. (2000) D-tyrosyl-tRNATyr metabolism in Saccharomyces cerevisiae. J. Biol. Chem. 275, 11626-11630
13. Ausubel, F. M. (1988) Current Protocols in Molecular Biology, Wiley-Interscience, New York
14. Guthrie, C., and Fink, G. R. (1991) Guide to Yeast Genetics and Molecular Biology, Academic Press, San Diego
15. Mumberg, D., Müller, R., and Funk, M. (1995) Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. Gene 156, 119-122
16. Sutton, A., Heller, R. C., Landry, J., Choy, J. S., Sirko, A., and Sternglanz, R. (2001) A novel form of transcriptional silencing by Sum1-1 requires Hst1 and the origin recognition complex. Mol. Cell. Biol. 21, 3514-3522
17. Bartel, P. L., Chien, C., Sternglanz, R., and Fields, S. (1993) Using the two-hybrid system to detect protein-protein interactions. in Cellular Interactions in Development: A Practical Approach (Hartley, D. A., ed) p. xviii, IRL Press, Oxford
18. Gelperin, D. M., White, M. A., Wilkinson, M. L., Kon, Y., Kung, L. A., Wise, K. J., Lopez-Hoyo, N., Jiang, L., Piccirillo, S., Yu, H., Gerstein, M., Dumont, M. E., Phizicky, E. M., Snyder, M., and Grayhack, E. J. (2005) Biochemical and genetic analysis of the yeast proteome with a movable ORF collection. Genes Dev. 19, 2816-2826
19. Chien, C. T., Bartel, P. L., Sternglanz, R., and Fields, S. (1991) The twohybrid system: a method to identify and clone genes for proteins that interact with a protein of interest. Proc. Natl. Acad. Sci. U.S.A. 88, 9578-9582
20. Tabor, C. W., and Tabor, H. (1984) Polyamines. Annu. Rev. Biochem. 53, 749-790
21. Liu, B., Sutton, A., and Sternglanz, R. (2005) A yeast polyamine acetyltransferase. J. Biol. Chem. 280, 16659-16664
22. Libby, P. R. (1978) Calf liver nuclearN-acetyltransferases. Purification and properties of two enzymes with both spermidine acetyltransferase and histone acetyltransferase activities. J. Biol. Chem. 253, 233-237
23. Pollard, K. J., and Peterson, C. L. (1997) Role for ADA/GCN5 products in antagonizing chromatin-mediated transcriptional repression. Mol. Cell Biol. 17, 6212-6222
24. Kleff, S., Andrulis, E. D., Anderson, C. W., and Sternglanz, R. (1995) Identification of a gene encoding a yeast histone H4 acetyltransferase. J. Biol. Chem. 270, 24674-24677
25. Casero, R. A., Jr., and Pegg, A. E. (1993) Spermidine/spermine N1-acetyltransferase-the turning point in polyamine metabolism. FASEB J. 7, 653-661
26. Basu, A., Rose, K. L., Zhang, J., Beavis, R. C., Ueberheide, B., Garcia, B. A., Chait, B., Zhao, Y., Hunt, D. F., Segal, E., Allis, C. D., and Hake, S. B. (2009) Proteome-wide prediction of acetylation substrates. Proc. Natl. Acad. Sci. U.S.A. 106, 13785-13790
27. Yuan, H., and Marmorstein, R. (2013) Histone acetyltransferases: rising ancient counterparts to protein kinases. Biopolymers 99, 98-111
28. Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., and Weissman, J. S. (2003) Global analysis of protein expression in yeast. Nature 425, 737-741
29. Miura, F., Kawaguchi, N., Sese, J., Toyoda, A., Hattori, M., Morishita, S., and Ito, T. (2006) A large-scale full-length cDNA analysis to explore the budding yeast transcriptome. Proc. Natl. Acad. Sci. U.S.A. 103, 17846-17851