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Volumn 33, Issue 1, 2015, Pages 77-87

C-Src, ERK1/2 and Rho kinasemediate hydrogen peroxide-induced vascular contraction in hypertension: Role ofTXA2, NAD(P)H oxidase andmitochondria

Author keywords

C Src; ERK1 2; H2O2; Mesenteric resistance arteries; Mitochondria; NAD(P)H oxidase; Rho kinase; Spontaneously hypertensive rats

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; CSK TYROSINE-PROTEIN KINASE; HYDROGEN PEROXIDE; PROTEIN TYROSINE KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RHO KINASE; THROMBOXANE A2; VASOCONSTRICTOR AGENT;

EID: 84916928817     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0000000000000383     Document Type: Article
Times cited : (36)

References (47)
  • 1
    • 33644681926 scopus 로고    scopus 로고
    • Hydrogen peroxide as a paracrine vascular mediator: Regulation and signaling leading to dysfunction
    • Ardanaz N, Pagano PJ. Hydrogen peroxide as a paracrine vascular mediator: Regulation and signaling leading to dysfunction. Exp Biol Med (Maywood) 2006; 231: 237-251.
    • (2006) Exp Biol Med (Maywood). , vol.231 , pp. 237-251
    • Ardanaz, N.1    Pagano, P.J.2
  • 2
    • 79957890939 scopus 로고    scopus 로고
    • Combating oxidative stress in vascular disease: NAD(P)H oxidases as therapeutic targets
    • Drummond GR, Selemidis S, Griendling KK, Sobey CG. Combating oxidative stress in vascular disease: NAD(P)H oxidases as therapeutic targets. Nat Rev Drug Discov 2011; 10: 453-471.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 453-471
    • Drummond, G.R.1    Selemidis, S.2    Griendling, K.K.3    Sobey, C.G.4
  • 3
    • 77953535497 scopus 로고    scopus 로고
    • Oxidative stress and hypertension: Current concepts
    • Briones AM, Touyz RM. Oxidative stress and hypertension: Current concepts. Curr Hypertens Rep 2010; 12: 135-142.
    • (2010) Curr Hypertens Rep , vol.12 , pp. 135-142
    • Briones, A.M.1    Touyz, R.M.2
  • 4
    • 0035671492 scopus 로고    scopus 로고
    • Hydrogen peroxide induces a greater contraction in mesenteric arteries of spontaneously hypertensive rats through thromboxane A(2) production
    • Gao YJ, Lee RM. Hydrogen peroxide induces a greater contraction in mesenteric arteries of spontaneously hypertensive rats through thromboxane A(2) production. Br J Pharmacol 2001; 134: 1639-1646.
    • (2001) Br J Pharmacol , vol.134 , pp. 1639-1646
    • Gao, Y.J.1    Lee, R.M.2
  • 5
    • 4344624411 scopus 로고    scopus 로고
    • Biphasic effect of hydrogen peroxide on skeletal muscle arteriolar tone via activation of endothelial and smooth muscle signaling pathways
    • Cseko C, Bagi Z, Koller A. Biphasic effect of hydrogen peroxide on skeletal muscle arteriolar tone via activation of endothelial and smooth muscle signaling pathways. J Appl Physiol 2004; 97: 1130-1137.
    • (2004) J Appl Physiol , vol.97 , pp. 1130-1137
    • Cseko, C.1    Bagi, Z.2    Koller, A.3
  • 7
    • 73249116181 scopus 로고    scopus 로고
    • Losartan and tempol treatments normalize the increased response to hydrogen peroxide in resistance arteries from hypertensive rats
    • García-Redondo AB, Briones AM, Avendaño MS, Hernanz R, Alonso MJ, Salaices M. Losartan and tempol treatments normalize the increased response to hydrogen peroxide in resistance arteries from hypertensive rats. J Hypertens 2009; 27: 1814-1822.
    • (2009) J Hypertens , vol.27 , pp. 1814-1822
    • García-Redondo, A.B.1    Briones, A.M.2    Avendaño, M.S.3    Hernanz, R.4    Alonso, M.J.5    Salaices, M.6
  • 8
    • 0033695425 scopus 로고    scopus 로고
    • Plasmahydrogen peroxide production in human essential hypertension: Role of heredity, gender, and ethnicity
    • Lacy F, Kailasam MT, O'Connor DT, Schmid-Schönbein GW, Parmer RJ. Plasmahydrogen peroxide production in human essential hypertension: Role of heredity, gender, and ethnicity. Hypertension 2000; 36: 878-884.
    • (2000) Hypertension , vol.36 , pp. 878-884
    • Lacy, F.1    Kailasam, M.T.2    O'Connor, D.T.3    Schmid-Schönbein, G.W.4    Parmer, R.J.5
  • 9
    • 84866325854 scopus 로고    scopus 로고
    • NOX4-dependent hydrogen peroxide overproduction in human atrial fibrillation and HL-1 atrial cells: Relationship to hypertension
    • Zhang J, Youn JY, Kim AY, Ramirez RJ, Gao L, Ngo D, et al. NOX4-dependent hydrogen peroxide overproduction in human atrial fibrillation and HL-1 atrial cells: Relationship to hypertension. Front Physiol 2012; 3: 140.
    • (2012) Front Physiol , vol.3 , pp. 140
    • Zhang, J.1    Youn, J.Y.2    Kim, A.Y.3    Ramirez, R.J.4    Gao, L.5    Ngo, D.6
  • 10
    • 0031772807 scopus 로고    scopus 로고
    • Contractile responses elicited by hydrogen peroxide in aorta from normotensive and hypertensive rats. Endothelial modulation and mechanism involved
    • Rodríguez-Martínez MA, García-Cohen EC, Baena AB, González R, Salaices M, Marín J. Contractile responses elicited by hydrogen peroxide in aorta from normotensive and hypertensive rats. Endothelial modulation and mechanism involved. Br J Pharmacol 1998; 125: 1329-1335.
    • (1998) Br J Pharmacol , vol.125 , pp. 1329-1335
    • Rodríguez-Martínez, M.A.1    García-Cohen, E.C.2    Baena, A.B.3    González, R.4    Salaices, M.5    Marín, J.6
  • 11
    • 33644969084 scopus 로고    scopus 로고
    • Pleiotropic effects of hydrogen peroxide in arteries and veins from normotensive and hypertensive rats
    • Thakali K, Davenport L, Fink GD, Watts SW. Pleiotropic effects of hydrogen peroxide in arteries and veins from normotensive and hypertensive rats. Hypertension 2006; 47: 482-487.
    • (2006) Hypertension , vol.47 , pp. 482-487
    • Thakali, K.1    Davenport, L.2    Fink, G.D.3    Watts, S.W.4
  • 12
    • 84884194246 scopus 로고    scopus 로고
    • Angiotensin II-induced production of mitochondrial reactive oxygen species: Potential mechanisms and relevance for cardiovascular disease
    • Dikalov SI, Nazarewicz RR. Angiotensin II-induced production of mitochondrial reactive oxygen species: Potential mechanisms and relevance for cardiovascular disease. Antioxid Redox Signal 2013; 19: 1085-1094.
    • (2013) Antioxid Redox Signal , vol.19 , pp. 1085-1094
    • Dikalov, S.I.1    Nazarewicz, R.R.2
  • 15
    • 84891758878 scopus 로고    scopus 로고
    • Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension
    • Dikalov SI, Nazarewicz RR, Bikineyeva A, Hilenski L, Lassègue B, Griendling KK, et al. Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension. Antioxid Redox Signal 2014; 20: 281-294.
    • (2014) Antioxid Redox Signal , vol.20 , pp. 281-294
    • Dikalov, S.I.1    Nazarewicz, R.R.2    Bikineyeva, A.3    Hilenski, L.4    Lassègue, B.5    Griendling, K.K.6
  • 16
    • 0344125376 scopus 로고    scopus 로고
    • Mechanisms of hydrogen-peroxide-induced biphasic response in rat mesenteric artery
    • Gao YJ, Hirota S, Zhang DW, Janssen LJ, Lee RM. Mechanisms of hydrogen-peroxide-induced biphasic response in rat mesenteric artery. Br J Pharmacol 2003; 138: 1085-1092.
    • (2003) Br J Pharmacol , vol.138 , pp. 1085-1092
    • Gao, Y.J.1    Hirota, S.2    Zhang, D.W.3    Janssen, L.J.4    Lee, R.M.5
  • 17
    • 0036375234 scopus 로고    scopus 로고
    • P38 mitogen-Activated protein kinase activation is required for thromboxane-induced contraction in perfused and pressurized rat mesenteric resistance arteries
    • Bolla M, Matrougui K, Loufrani L, Maclouf J, Levy B, Levy-Toledano S, et al. p38 mitogen-Activated protein kinase activation is required for thromboxane-induced contraction in perfused and pressurized rat mesenteric resistance arteries. J Vasc Res 2002; 39: 353-360.
    • (2002) J Vasc Res , vol.39 , pp. 353-360
    • Bolla, M.1    Matrougui, K.2    Loufrani, L.3    Maclouf, J.4    Levy, B.5    Levy-Toledano, S.6
  • 18
    • 35548967033 scopus 로고    scopus 로고
    • 2-induced vasoconstriction in the abdominal aorta and mesenteric artery of the mouse
    • 2-induced vasoconstriction in the abdominal aorta and mesenteric artery of the mouse. Vascul Pharmacol 2007; 47: 288-294.
    • (2007) Vascul Pharmacol , vol.47 , pp. 288-294
    • Ardanaz, N.1    Beierwaltes, W.H.2    Pagano, P.J.3
  • 19
    • 33845892562 scopus 로고    scopus 로고
    • Cyclooxygenase, p38 mitogen-Activated protein kinase (MAPK), extracellular signalregulated kinase MAPK, Rho Kinase, and Src mediate hydrogen peroxide-induced contraction of rat thoracic aorta and vena cava
    • Thakali K, Davenport L, Fink GD, Watts SW. Cyclooxygenase, p38 mitogen-Activated protein kinase (MAPK), extracellular signalregulated kinase MAPK, Rho Kinase, and Src mediate hydrogen peroxide-induced contraction of rat thoracic aorta and vena cava. J Pharmacol Exp Ther 2007; 320: 236-243.
    • (2007) J Pharmacol Exp Ther , vol.320 , pp. 236-243
    • Thakali, K.1    Davenport, L.2    Fink, G.D.3    Watts, S.W.4
  • 20
    • 77951841400 scopus 로고    scopus 로고
    • RhoA-Rho Kinase signaling mediates endothelium-And endoperoxide-dependent contractile activities characteristic of hypertensive vascular dysfunction
    • Denniss SG, Jeffery AJ, Rush JW. RhoA-Rho Kinase signaling mediates endothelium-And endoperoxide-dependent contractile activities characteristic of hypertensive vascular dysfunction. Am J Physiol Heart Circ Physiol 2010; 298: H1391-H1405.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298 , pp. H1391-H1405
    • Denniss, S.G.1    Jeffery, A.J.2    Rush, J.W.3
  • 21
    • 79961191673 scopus 로고    scopus 로고
    • Redox regulation of protein kinases as a modulator of vascular function
    • Knock GA, Ward JP. Redox regulation of protein kinases as a modulator of vascular function. Antioxid Redox Signal 2011; 15: 1531-1547.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 1531-1547
    • Knock, G.A.1    Ward, J.P.2
  • 23
    • 29244467700 scopus 로고    scopus 로고
    • Mitogen-Activated protein kinase activation by hydrogen peroxide is mediated through tyrosine kinase-dependent, protein kinase C-independent pathways in vascular smooth muscle cells: Upregulation in spontaneously hypertensive rats
    • Tabet F, Schiffrin EL, Touyz RM. Mitogen-Activated protein kinase activation by hydrogen peroxide is mediated through tyrosine kinase-dependent, protein kinase C-independent pathways in vascular smooth muscle cells: Upregulation in spontaneously hypertensive rats. J Hypertens 2005; 23: 2005-2012.
    • (2005) J Hypertens , vol.23 , pp. 2005-2012
    • Tabet, F.1    Schiffrin, E.L.2    Touyz, R.M.3
  • 24
    • 0017702173 scopus 로고
    • Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats
    • Mulvany MJ, Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 1977; 41: 19-26.
    • (1977) Circ Res , vol.41 , pp. 19-26
    • Mulvany, M.J.1    Halpern, W.2
  • 25
    • 33646763902 scopus 로고    scopus 로고
    • Rho Kinases in cardiovascular physiology and pathophysiology
    • Loirand G, Guérin P, Pacaud P. Rho Kinases in cardiovascular physiology and pathophysiology. Circ Res 2006; 98: 322-334.
    • (2006) Circ Res , vol.98 , pp. 322-334
    • Loirand, G.1    Guérin, P.2    Pacaud, P.3
  • 26
    • 0034711209 scopus 로고    scopus 로고
    • 2-mediated injury of human endothelial cells
    • 2-mediated injury of human endothelial cells. J Biol Chem 2000; 275: 37187-37193.
    • (2000) J Biol Chem , vol.275 , pp. 37187-37193
    • Li, Y.1    Liu, J.2    Zhan, X.3
  • 27
    • 0037160074 scopus 로고    scopus 로고
    • Ligand-independent trans-Activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src
    • Saito S, Frank GD, Mifune M, Ohba M, Utsunomiya H, Motley ED, et al. Ligand-independent trans-Activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src. J Biol Chem 2002; 277: 44695-44700.
    • (2002) J Biol Chem , vol.277 , pp. 44695-44700
    • Saito, S.1    Frank, G.D.2    Mifune, M.3    Ohba, M.4    Utsunomiya, H.5    Motley, E.D.6
  • 28
    • 51449095730 scopus 로고    scopus 로고
    • Low-power laser irradiation activates Src tyrosine kinase through reactive oxygen species-mediated signaling pathway
    • Zhang J, Xing D, Gao X. Low-power laser irradiation activates Src tyrosine kinase through reactive oxygen species-mediated signaling pathway. J Cell Physiol 2008; 217: 518-528.
    • (2008) J Cell Physiol , vol.217 , pp. 518-528
    • Zhang, J.1    Xing, D.2    Gao, X.3
  • 29
    • 78649725403 scopus 로고    scopus 로고
    • Epidermal growth factor receptor transactivation by endogenous vasoactive peptides contributes to hyperproliferation of vascular smooth muscle cells of SHR
    • Li Y, Lévesque LO, Anand-Srivastava MB. Epidermal growth factor receptor transactivation by endogenous vasoactive peptides contributes to hyperproliferation of vascular smooth muscle cells of SHR. Am J Physiol Heart Circ Physiol 2010; 299: H1959-H1967.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299 , pp. H1959-H1967
    • Li, Y.1    Lévesque, L.O.2    Anand-Srivastava, M.B.3
  • 31
    • 0037783377 scopus 로고    scopus 로고
    • Schiffrin EL. C-Src induces phosphorylation and translocation of p47phox: Role in superoxide generation by angiotensin II in human vascular smooth muscle cells
    • Touyz RM, Yao G, Schiffrin EL. c-Src induces phosphorylation and translocation of p47phox: Role in superoxide generation by angiotensin II in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2003; 23: 981-987.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 981-987
    • Touyz, R.M.1    Yao, G.2
  • 32
    • 77956228328 scopus 로고    scopus 로고
    • Vascular superoxide production by endothelin-1 requires Src nonreceptor protein tyrosine kinase and MAPK activation
    • Romero M, Jiménez R, Sánchez M, López-Sepúlveda R, Zarzuelo A, Tamargo J, et al. Vascular superoxide production by endothelin-1 requires Src nonreceptor protein tyrosine kinase and MAPK activation. Atherosclerosis 2010; 212: 78-85.
    • (2010) Atherosclerosis , vol.212 , pp. 78-85
    • Romero, M.1    Jiménez, R.2    Sánchez, M.3    López-Sepúlveda, R.4    Zarzuelo, A.5    Tamargo, J.6
  • 33
    • 0035800828 scopus 로고    scopus 로고
    • H(2)O(2)-induced O(2) production by a nonphagocytic NAD(P)H Oxidase causes oxidant injury
    • Li WG, Miller FJ Jr, Zhang HJ, Spitz DR, Oberley LW, Weintraub NL. H(2)O(2)-induced O(2) production by a nonphagocytic NAD(P)H Oxidase causes oxidant injury. J Biol Chem 2001; 276: 29251-29256.
    • (2001) J Biol Chem , vol.276 , pp. 29251-29256
    • Li, W.G.1    Miller, F.J.2    Zhang, H.J.3    Spitz, D.R.4    Oberley, L.W.5    Weintraub, N.L.6
  • 34
    • 84862540969 scopus 로고    scopus 로고
    • Pregnancy reduces RhoA/Rho kinase and protein kinase C signaling pathways downstream of thromboxane receptor activation in the rat uterine artery
    • Goulopoulou S, Hannan JL, Matsumoto T, Webb RC. Pregnancy reduces RhoA/Rho kinase and protein kinase C signaling pathways downstream of thromboxane receptor activation in the rat uterine artery. Am J Physiol Heart Circ Physiol 2012; 302: H2477-H2488.
    • (2012) Am J Physiol Heart Circ Physiol , vol.302 , pp. H2477-H2488
    • Goulopoulou, S.1    Hannan, J.L.2    Matsumoto, T.3    Webb, R.C.4
  • 35
    • 34447518891 scopus 로고    scopus 로고
    • ERK activation contributes to regulation of spontaneous contractile tone via superoxide anion in isolated rat aorta of angiotensin II-induced hypertension
    • Ding L, Chapman A, Boyd R, Wang HD. ERK activation contributes to regulation of spontaneous contractile tone via superoxide anion in isolated rat aorta of angiotensin II-induced hypertension. Am J Physiol Heart Circ Physiol 2007; 292: H2997-3005.
    • (2007) Am J Physiol Heart Circ Physiol , vol.292 , pp. H2997-3005
    • Ding, L.1    Chapman, A.2    Boyd, R.3    Wang, H.D.4
  • 36
    • 0141751697 scopus 로고    scopus 로고
    • 2+ sensitivity of smooth muscle and nonmuscle myosin II: Modulated by G proteins, kinases, and myosin phosphatase
    • 2+ sensitivity of smooth muscle and nonmuscle myosin II: Modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 2003; 83: 1325-1358.
    • (2003) Physiol Rev , vol.83 , pp. 1325-1358
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 37
    • 0035316139 scopus 로고    scopus 로고
    • Involvement of Rho-kinase in hypertensive vascular disease: A novel therapeutic target in hypertension
    • Mukai Y, Shimokawa H, Matoba T, Kandabashi T, Satoh S, Hiroki J, et al. Involvement of Rho-kinase in hypertensive vascular disease: A novel therapeutic target in hypertension. FASEB J 2001; 15: 1062-1064.
    • (2001) FASEB J , vol.15 , pp. 1062-1064
    • Mukai, Y.1    Shimokawa, H.2    Matoba, T.3    Kandabashi, T.4    Satoh, S.5    Hiroki, J.6
  • 38
    • 0035860840 scopus 로고    scopus 로고
    • Increased expression and activity of RhoA are associated with increased DNA synthesis and reduced p27(Kip1) expression in the vasculature of hypertensive rats
    • Seasholtz TM, Zhang T, Morissette MR, Howes AL, Yang AH, Brown JH. Increased expression and activity of RhoA are associated with increased DNA synthesis and reduced p27(Kip1) expression in the vasculature of hypertensive rats. Circ Res 2001; 89: 488-495.
    • (2001) Circ Res , vol.89 , pp. 488-495
    • Seasholtz, T.M.1    Zhang, T.2    Morissette, M.R.3    Howes, A.L.4    Yang, A.H.5    Brown, J.H.6
  • 39
    • 78149469722 scopus 로고    scopus 로고
    • RhoA/Rho-kinase and vascular diseases: What is the link?
    • Nunes KP, Rigsby CS, Webb RC. RhoA/Rho-kinase and vascular diseases: What is the link? Cell Mol Life Sci 2010; 67: 3823-3836.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 3823-3836
    • Nunes, K.P.1    Rigsby, C.S.2    Webb, R.C.3
  • 40
    • 4744347777 scopus 로고    scopus 로고
    • Activation of Rho/Rho Kinase signaling pathway by reactive oxygen species in rat aorta
    • Jin L, Ying Z, Webb RC. Activation of Rho/Rho Kinase signaling pathway by reactive oxygen species in rat aorta. Am J Physiol Heart Circ Physiol 2004; 287: H1495-H1500.
    • (2004) Am J Physiol Heart Circ Physiol , vol.287 , pp. H1495-H1500
    • Jin, L.1    Ying, Z.2    Webb, R.C.3
  • 43
    • 0037278876 scopus 로고    scopus 로고
    • Comparison of inhibitory effects of Y-27632, a Rho Kinase inhibitor, in strips of small and large mesenteric arteries from spontaneously hypertensive and normotensive Wistar-Kyoto rats
    • Asano M, Nomura Y. Comparison of inhibitory effects of Y-27632, a Rho Kinase inhibitor, in strips of small and large mesenteric arteries from spontaneously hypertensive and normotensive Wistar-Kyoto rats. Hypertens Res 2003; 26: 97-106.
    • (2003) Hypertens Res , vol.26 , pp. 97-106
    • Asano, M.1    Nomura, Y.2
  • 45
    • 79961067803 scopus 로고    scopus 로고
    • Rho-kinase: Important new therapeutic target in cardiovascular diseases
    • Satoh K, Fukumoto Y, Shimokawa H. Rho-kinase: Important new therapeutic target in cardiovascular diseases. Am J Physiol Heart Circ Physiol 2011; 301: H287-H296.
    • (2011) Am J Physiol Heart Circ Physiol , vol.301 , pp. H287-H296
    • Satoh, K.1    Fukumoto, Y.2    Shimokawa, H.3
  • 46
    • 0142120102 scopus 로고    scopus 로고
    • Long-Term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: Effect on endothelial NAD(P)H oxidase system
    • Higashi M, Shimokawa H, Hattori T, Hiroki J, Mukai Y, Morikawa K, et al. Long-Term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: Effect on endothelial NAD(P)H oxidase system. Circ Res 2003; 93: 767-775.
    • (2003) Circ Res , vol.93 , pp. 767-775
    • Higashi, M.1    Shimokawa, H.2    Hattori, T.3    Hiroki, J.4    Mukai, Y.5    Morikawa, K.6
  • 47
    • 0035569024 scopus 로고    scopus 로고
    • Src is an important mediator of extracellular signal-regulated kinase 1/2-dependent growth signaling by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients
    • Touyz RM, He G, Wu XH, Park JB, Mabrouk ME, Schiffrin EL. Src is an important mediator of extracellular signal-regulated kinase 1/2-dependent growth signaling by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients. Hypertension 2001; 38: 56-64.
    • (2001) Hypertension , vol.38 , pp. 56-64
    • Touyz, R.M.1    He, G.2    Wu, X.H.3    Park, J.B.4    Mabrouk, M.E.5    Schiffrin, E.L.6


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