Hypertension increases contractile responses to hydrogen peroxide in resistance arteries through increased thromboxane a2,ca2+, and superoxide anion levels

Journal of Pharmacology and Experimental Therapeutics

Volumn 328, Issue 1, 2009, Pages 19-27

  García Redondo, Ana Beién ^a   Briones, Ana María ^a   Beltrán, Amada Elia ^a   Alonso, María Jesús ^b   Simonsen, Ulf ^c   Salaices, Mercedes ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b UNIVERSIDAD REY JUAN CARLOS   (Spain)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYLPYRAZOLE; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; APOCYNIN; CALCIUM ION; CYCLOOXYGENASE 1 INHIBITOR; FUREGRELATE; HYDROGEN PEROXIDE; INDOMETACIN; PROSTAGLANDIN SYNTHASE INHIBITOR; SC 58560; SUPEROXIDE; THROMBOXANE A2; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; THROMBOXANE SYNTHASE INHIBITOR; TIRON; UNCLASSIFIED DRUG; BENZOFURAN DERIVATIVE; CALCIUM; ENZYME INHIBITOR; ORGANIC COMPOUND; THROMBOXANE SYNTHASE;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL INJURY; BLOOD VESSEL REACTIVITY; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM; ENZYME IMMUNOASSAY; HYPERTENSION; MALE; MYOGRAPHY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; WISTAR KYOTO RAT; ANIMAL; DRUG ANTAGONISM; HEART CONTRACTION; MESENTERIC ARTERY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ANIMALS; BENZOFURANS; CALCIUM; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HYDROGEN PEROXIDE; HYPERTENSION; INDOMETHACIN; MALE; MESENTERIC ARTERIES; MYOCARDIAL CONTRACTION; ORGANIC CHEMICALS; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SUPEROXIDES; THROMBOXANE A2; THROMBOXANE-A SYNTHASE;

EID: 59149090569     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.144295     Document Type: Article

References (40)

1. Alvarez Y, Briones AM, Balfagón G, Alonso MJ, and Salaices M (2005) Hypertension increases the participation of vasoconstrictor prostanoids from cyclooxygenase-2 in phenylephrine responses. J Hypertens 23:767-777.
2. Alvarez Y, Perez-Girón JV, Hernanz R, Briones AM, García-Redondo A, Beltrán A, Alonso MJ, and Salaices M (2007) Losartan reduces the increased participation of cyclooxygenase-2-derived products in vascular responses of hypertensive rats. J Pharmacol Exp Ther 321:381-388.
3. Ardanaz N and Pagano PJ (2006) Hydrogen peroxide as a paracrine vascular mediator: regulation and signaling leading to dysfunction. Exp Biol Med (Maywood) 231:237-251.
4. Burke-Wolin T, Abate CJ, Wolin MS, and Gurtner GH (1991) Hydrogen peroxide-induced pulmonary vasodilation: role of guanosine 3′,5′- cyclic monophosphate. Am J Physiol 261:L393-L398.
5. Cogolludo A, Frazziano G, Cobeño L, Moreno L, Lodi F, Villamor E, Tamargo J, and Perez-Vizcaino F (2006) Role of reactive oxygen species in Kv channel inhibition and vasoconstriction induced by TP receptor activation in rat pulmonary arteries. Ann N Y Acad Sci 1091:41-51.
6. Cseko C, Bagi Z, and Koller A (2004) Biphasic effect of hydrogen peroxide on skeletal muscle arteriolar tone via activation of endothelial and smooth muscle signaling pathways. J Appl Physiol 97:1130-1137.
7. DeWitt DL, Day JS, Sonnenburg WK, and Smith WL (1983) Concentrations of prostaglandin endoperoxide synthase and prostaglandin I2 synthase in the endo-thelium and smooth muscle of bovine aorta. J Clin Invest 72:1882-1888.
8. Gao YJ and Lee RM (2001) Hydrogen peroxide induces a greater contraction in mesenteric arteries of spontaneously hypertensive rats through thromboxane A(2) production. Br J Pharmacol 134:1639-1646.
9. Gao YJ, Hirota S, Zhang DW, Janssen LJ, and Lee RM (2003) Mechanisms of hydrogen-peroxide-induced biphasic response in rat mesenteric artery. Br J Pharmacol 138:1085-1092.
10. Garcia-Cohen EC, Marin J, Diez-Picazo LD, Baena AB, Salaices M, and Rodriguez-Martinez MA (2000) Oxidative stress induced by tert-butyl hydroperoxide causes vasoconstriction in the aorta from hypertensive and aged rats: role of cyclooxygen-ase-2 isoform. J Pharmacol Exp Ther 293:75-81.
11. 2 in rat aorta. Vascul Pharmacol 43:128-138.
12. Hernanz R, Alonso MJ, Briones AM, Vila E, Simonsen U, and Salaices M (2003) Mechanisms involved in the early increase of serotonin contraction evoked by endotoxin in rat middle cerebral arteries. Br J Pharmacol 140:671-680.
13. Heumuller S, Wind S, Barbosa-Sicard E, Schmidt HH, Busse R, Schroder K, and Brandes RP (2008) Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension 51:211-217.
14. Iida Y and Katusic ZS (2000) Mechanisms of cerebral arterial relaxations to hydrogen peroxide. Stroke 31:2224-2230.
15. Institute of Laboratory Animal Resources (1996) Guide for the Care and Use of Laboratory Animals, 7th ed, Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, Washington DC.
16. i and force in rat resistance arteries. Pflugers Arch 420:536-543.
17. 2-induced contraction in pulmonary artery. Am J Physiol 272:H2686-H2692.
18. Kawka DW, Ouellet M, Hetu PO, Singer II, and Riendeau D (2007) Double-label expression studies of prostacyclin synthase, thromboxane synthase and COX iso-forms in normal aortic endothelium. Biochim Biophys Acta 1771:45-54.
19. Lacy F, Kailasam MT, O'Connor DT, Schmid-Schonbein GW, and Parmer RJ (2000) Plasma hydrogen peroxide production in human essential hypertension: role of heredity, gender, and ethnicity. Hypertension 36:878-884.
20. Lassègue B and Griendling KK (2004) Reactive oxygen species in hypertension: an update. Am J Hypertens 17:852-860.
21. 2 effects on cerebral prostanoids and pial arteriolar diameter in piglets. Am J Physiol 258:H1382-H1387.
22. 2 production by a non-phagocytic NAD(P)H oxidase causes oxidant injury. J Biol Chem 276:29251- 29256.
23. Lyle AN and Griendling KK (2006) Modulation of vascular smooth muscle signaling by reactive oxygen species. Physiology 21:269-280.
24. Mulvany MJ and Halpern W (1977) Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 41:19-26.
25. Muzaffar S, Shukla N, Lobo C, Angelini GD, and Jeremy JY (2004) Iloprost inhibits superoxide formation and gp91phox expression induced by the thromboxane A2 analogue U46619, 8-isoprostane F2alpha, prostaglandin F2alpha, cytokines and endotoxin in the pig pulmonary artery. Br J Pharmacol 141:488-496.
26. Osol G, Cipolla M, and Knutson S (1989) A new method for mechanically denuding the endothelium of small (50-150 microns) arteries with a human hair. Blood Vessels 26:320-324.
27. Paravicini TM and Touyz RM (2006) Redox signaling in hypertension. Cardiovasc Res 71:247-258.
28. 2-induced arterial muscle contraction. Am J Physiol Heart Circ Physiol 279:H1194-H1200.
29. Prieto D, Buus CL, Mulvany MJ, and Nilsson H (2000) Neuropeptide Y regulates intracellular calcium through different signalling pathways linked to a Y(1)-receptor in rat mesenteric small arteries. Br J Pharmacol 129:1689-1699.
30. Riganti C, Costamagna C, Doublier S, Miraglia E, Polimeni M, Bosia A, and Ghigo D (2008) The NADPH oxidase inhibitor apocynin induces nitric oxide synthesis via oxidative stress. Toxicol Appl Pharmacol 228:277-285.
31. Rodríguez-Martínez MA, García-Cohen EC, Baena AB, González R, Salaíces M, and Marín J (1998) Contractile responses elicited by hydrogen peroxide in aorta from normotensive and hypertensive rats: endothelial modulation and mechanism involved. Br J Pharmacol 125:1329-1335.
32. Seshiah PN, Weber DS, Rocic P, Valppu L, Taniyama Y, and Griendling KK (2002) Angiotensin II stimulation of NAD(P)H oxidase activity: upstream mediators. Circ Res 91:406-413.
33. Tabet F, Savoia C, Schiffrin EL, and Touyz RM (2004) Differential calcium regulation by hydrogen peroxide and superoxide in vascular smooth muscle cells from spontaneously hypertensive rats. J Cardiovasc Pharmacol 44:200-208.
34. Tang EH and Vanhoutte PM (2008) Gene expression changes of prostanoid syn-thases in endothelial cells and prostanoid receptors in vascular smooth muscle cells caused by aging and hypertension. Physiol Genomics 32:409-418.
35. Thakali K, Davenport L, Fink GD, and Watts SW (2007) Cyclooxygenase, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase MAPK, Rho kinase, and Src mediate hydrogen peroxide-induced contraction of rat thoracic aorta and vena cava. J Pharmacol Exp Ther 320:236-243.
36. Touyz RM (2003) Reactive oxygen species in vascular biology: role in arterial hypertension. Expert Rev Cardiovasc Ther 1:91-106.
37. 2+ sensitization to the alpha1-adrenergic vasoconstriction of rat penile small arteries. Am J Physiol Heart Circ Physiol 292:H1157-H1169.
38. Wei EP, Kontos HA, and Beckman JS (1996) Mechanisms ofcerebral vasodilation by superoxide, hydrogen peroxide, and peroxynitrite. Am J Physiol 271:H1262-H1266.
39. 2+]i in canine cerebral arterial smooth muscle: participation of cellular signaling pathways. Naunyn Schmiedebergs Arch Pharmacol 360:646-653.
40. Yang ZW, Zheng T, Zhang A, Altura BT, and Altura BM (1998) Mechanisms of hydrogen peroxide-induced contraction of rat aorta. Eur J Pharmacol 344:169-181.