Genotoxic and cytostatic effects of 6-pentadecyl salicylic anacardic acid in transformed cell lines and peripheral blood mononuclear cells

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 777, Issue 1, 2015, Pages 43-53

  Alam Escamilla, David ^a   Estrada Muñiz, Elizabet ^a   Solís Villegas, Erik ^a   Elizondo, Guillermo ^a   Vega, Libia ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Anacardic acid; Antineoplastic agent; Cytostaticity; Cytotoxicity

Indexed keywords

6 PENTADECYL SALICYLIC ANACARDIC ACID; ANACARDIC ACID; CASPASE 8; CYTOSTATIC AGENT; PACLITAXEL; UNCLASSIFIED DRUG; MUTAGENIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CELL VIABILITY; COMET ASSAY; CONTROLLED STUDY; DNA STRAND BREAKAGE; DRUG CYTOTOXICITY; ERYTHROCYTE; FEMALE; GENOTOXICITY; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; K562 CELL LINE; LEUKEMIA CELL; LOW DRUG DOSE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; STOMACH CANCER; TRANSFORMED CELL LINE; ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; BONE MARROW CELL; CELL PROLIFERATION; CELL SURVIVAL; CYTOLOGY; DNA DENATURATION; DRUG EFFECTS; METABOLISM; MONONUCLEAR CELL; PATHOLOGY; STOMACH MUCOSA;

AMPHIPTERYGIUM ADSTRINGENS; HELICOBACTER PYLORI; MUS;

ANACARDIC ACIDS; ANIMALS; APOPTOSIS; BONE MARROW CELLS; CASPASE 8; CELL DIFFERENTIATION; CELL LINE, TRANSFORMED; CELL PROLIFERATION; CELL SURVIVAL; COMET ASSAY; CYTOSTATIC AGENTS; FEMALE; GASTRIC MUCOSA; HUMANS; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED BALB C; MUTAGENS; NUCLEIC ACID DENATURATION;

EID: 84916898795     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2014.11.008     Document Type: Article

References (24)

1. Navarrete A., Oliva I., Sanchez-Mendoza M.E., Arrieta J., Cruz-Antonio L., Castaneda-Hernandez G. Gastroprotection and effect of the simultaneous administration of Cuachalalate (Amphipterygium adstringens) on the pharmacokinetics and anti-inflammatory activity of diclofenac in rats. J. Pharm. Pharmacol. 2005, 57:1629-1636. 10.1211/jpp.57.12.0013.
2. Deciga-Campos M., Rivero-Cruz I., Arriaga-Alba M., Castaneda-Corral G., Angeles-Lopez G.E., Navarrete A., Mata R. Acute toxicity and mutagenic activity of Mexican plants used in traditional medicine. J. Ethnopharmacol. 2007, 110:334-342. 10.1016/j.jep.2006.10.001.
3. Rivero-Cruz B.E., Esturau N., Sanchez-Nieto S., Romero I., Castillo-Juarez I., Rivero-Cruz J.F. Isolation of the new anacardic acid 6-[16'Z-nonadecenyl]-salicylic acid and evaluation of its antimicrobial activity against Streptococcus mutans and Porphyromonas gingivalis. Nat. Prod. Res. 2011, 25:1282-1287.
4. Paramashivappa R., Phani Kumar P., Subba Rao P.V., Srinivasa Rao A. Synthesis of sildenafil analogues from anacardic acid and their phosphodiesterase-5 inhibition. J. Agric. Food Chem. 2002, 50:7709-7713.
5. Seong Y.A., Shin P.G., Kim G.D. Anacardic acid induces mitochondrial-mediated apoptosis in the A549 human lung adenocarcinoma cells. Int. J. Oncol. 2013, 42:1045-1051. 10.3892/ijo.2013.1763.
6. Vega L., Ostrosky-Wegman P., Fortoul T.I., Diaz C., Madrid V., Saavedra R. Sodium arsenite reduces proliferation of human activated T-cells by inhibition of the secretion of interleukin-2. Immunopharmacol. Immunot. 1999, 21:203-220. 10.3109/08923979909052758.
7. Soto-Pena G.A., Vega L. Arsenic interferes with the signaling transduction pathway of T cell receptor activation by increasing basal and induced phosphorylation of Lck and Fyn in spleen cells. Toxicol. Appl. Pharmacol. 2008, 230:216-226. 10.1016/j.taap.2008.02.029.
8. Esquivel-Senties M.S., Barrera I., Ortega A., Vega L. Organophosphorous pesticide metabolite (DEDTP) induces changes in the activation status of human lymphocytes by modulating the interleukin 2 receptor signal transduction pathway. Toxicol. Appl. Pharmacol. 2010, 248:122-133. 10.1016/j.taap.2010.07.017.
9. Bolognesi C., Fenech M. Micronucleus assay in human cells: lymphocytes and buccal cells. Methods Mol. Biol. 2013, 1044:191-207. 10.1007/978-1-62703-529-3_10.
10. Vega L., Valverde M., Elizondo G., Leyva J.F., Rojas E. Diethylthiophosphate and diethyldithiophosphate induce genotoxicity in hepatic cell lines when activated by further biotransformation via cytochrome p450. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 2009, 679:39-43.
11. Medina-Diaz I.M., Estrada-Muniz E., Reyes-Hernandez O.D., Ramirez P., Vega L., Elizondo G. Arsenite and its metabolites, MMA(III) and DMA(III), modify CYP3A4, PXR and RXR alpha expression in the small intestine of CYP3A4 transgenic mice. Toxicol. Appl. Pharmacol. 2009, 239:162-168. 10.1016/j.taap.2008.11.009.
12. Rea A.I., Schmidt J.M., Setzer W.N., Sibanda S., Taylor C., Gwebu E.T. Cytotoxic activity of Ozoroa insignis from Zimbabwe. Fitoterapia 2003, 74:732-735.
13. Kubo I.O.M., Vieira P.C., Komatsu S. Antitumor agents from the cashew (Anacardium occidentale) apple. J. Agric. Food Chem. 1993, 41:1012-1015.
14. Sukumari-Ramesh S., Singh N., Jensen M.A., Dhandapani K.M., Vender J.R. Anacardic acid induces caspase-independent apoptosis and radiosensitizes pituitary adenoma cells. J. Neurosurg. 2011, 114:1681-1690.
15. Acevedo H.R., Rojas M.D., Arceo S.D., Soto Hernandez M., Martinez Vazquez M., Terrazas T., del Toro G.V. Effect of 6-nonadecyl salicylic acid and its methyl ester on the induction of micronuclei in polychromatic erythrocytes in mouse peripheral blood. Mutat. Res. 2006, 609:43-46. 10.1016/j.mrgentox.2006.06.002.
16. Rosati E., Sabatini R., Rampino G., De Falco F., Di Ianni M., Falzetti F., Fettucciari K., Bartoli A., Screpanti I., Marconi P. Novel targets for endoplasmic reticulum stress-induced apoptosis in B-CLL. Blood 2010, 116:2713-2723. 10.1182/blood-2010-03-275628.
17. Seong Y.A., Shin P.G., Yoon J.S., Yadunandam A.K., Kim G.D. Induction of the endoplasmic reticulum stress and autophagy in human lung carcinoma A549 cells by anacardic acid. Cell Biochem. Biophys. 2014, 68:369-377. 10.1007/s12013-013-9717-2.
18. Castillo-Juarez I., Rivero-Cruz F., Celis H., Romero I. Anti-Helicobacter pylori activity of anacardic acids from Amphipterygium adstringens. J. Ethnopharmacol. 2007, 114:72-77. 10.1016/j.jep.2007.07.022.
19. Carvalho A.L., Annoni R., Silva P.R., Borelli P., Fock R.A., Trevisan M.T., Mauad T. Acute, subacute toxicity and mutagenic effects of anacardic acids from cashew (Anacardium occidentale Linn.) in mice. J. Ethnopharmacol. 2011, 135:730-736. 10.1016/j.jep.2011.04.002.
20. Paramashivappa R., Kumar P.P., Vithayathil P.J., Rao A.S. Novel method for isolation of major phenolic constituents from cashew (Anacardium occidentale L.) nut shell liquid. J. Agric. Food Chem. 2001, 49:2548-2551.
21. Philip J.Y., Da Cruz Francisco J., Dey E.S., Buchweishaija J., Mkayula L.L., Ye L. Isolation of anacardic acid from natural cashew nut shell liquid (CNSL) using supercritical carbon dioxide. J. Agric. Food Chem. 2008, 56:9350-9354.
22. van Beek T.A., Wintermans M.S. Preparative isolation and dual column high-performance liquid chromatography of ginkgolic acids from Ginkgo biloba. J. Chromatogr. A 2001, 930:109-117.
23. Ng'ang'a M.M., Hussain H., Chhabra S., Caroline L.-T., Krohn K. Chemical constituents from the root bark of Ozoroa insignis. Biochem. System Ecol. 2009, 37:116-119.
24. Lee S.J., Park W.H., Moon H.I. Bioassay-guided isolation of antiplasmodial anacardic acids derivatives from the whole plants of Viola websteri Hemsl. Parasitol. Res. 2009, 104:463-466.