Synthesis of sildenafil analogues from anacardic acid and their phosphodiesterase-5 inhibition

Journal of Agricultural and Food Chemistry

Volumn 50, Issue 26, 2002, Pages 7709-7713

  Paramashivappa, R ^a   Phani Kumar, P ^a   Subba Rao, P V ^a   Srinivasa Rao, A ^a  

^a JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

Anacardic acid; Cashew nut shell liquid; Erectile dysfunction; PDEs inhibitor; Sildenafil

Indexed keywords

5 (2 ETHOXY 6 PENTADECYLPHENYL) 1 METHYL 3 N PROPYL 1,6 DIHYDRO 7H PYRAZOLO[4,3 D]PYRIMIDIN 7 ONE; 5 [2 ETHOXY 5 (4 METHYLPIPERAZIN 1 YLSULFONYL) 6 PENTADECYLPHENYL] 1,6 DIHYDRO 7H PYRAZOLO[4,3 D]PYRIMIDIN 7 ONE; 5 [2 METHOXY 5 (4 METHYLPIPERAZIN 1 YLSULFONYL) 6 PENTADECYLPHENYL] 1,6 DIHYDRO 7H PYRAZOLO[4,3 D]PYRIMIDIN 7 ONE; ANACARDIC ACID; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE V; PIPERAZINE DERIVATIVE; SALICYLIC ACID DERIVATIVE; SILDENAFIL; UNCLASSIFIED DRUG;

ACCIDENT PREVENTION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CASHEW NUT; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; ENZYME INHIBITION; MASS SPECTROMETRY; METABOLISM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTECTIVE EQUIPMENT; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; VASCULAR SMOOTH MUSCLE;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANACARDIC ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PIPERAZINES; SALICYLIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANACARDIUM OCCIDENTALE;

EID: 0037132570     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf0258050     Document Type: Article

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