Diethylthiophosphate and diethyldithiophosphate induce genotoxicity in hepatic cell lines when activated by further biotransformation via Cytochrome P450

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 679, Issue 1-2, 2009, Pages 39-43

  Vega, L ^a   Valverde, M ^b   Elizondo, G ^c   Leyva, J F ^b   Rojas, E ^b  

^a Departamento de Toxicología   (Mexico)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS   (Mexico)

^c Insituto Nacional de Cardiología Ignacio Chávez   (Mexico)

Author keywords

DNA damage; Hepatic cell lines; Organophosphorous pesticide metabolites; Oxidative damage; Sulconazole

Indexed keywords

CYTOCHROME P450; DIETHYLTHIOPHOSPHATE; PHOSPHORODITHIOIC ACID O,O DIETHYL ESTER; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; CELL LINE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; GENOTOXICITY; HUMAN; HUMAN CELL; LIVER CELL; OXIDATIVE STRESS; PRIORITY JOURNAL;

BIOTRANSFORMATION; CELL LINE; COMET ASSAY; CYTOCHROME P-450 ENZYME SYSTEM; DNA DAMAGE; HUMANS; LIVER; MUTAGENS; ORGANOPHOSPHORUS COMPOUNDS; ORGANOTHIOPHOSPHORUS COMPOUNDS; PESTICIDES;

EID: 70249132104     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2009.07.009     Document Type: Article

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