Leishmaniasis in travelers: A literature review

Travel Medicine and Infectious Disease

Volumn 12, Issue 6, 2014, Pages 563-581

  Mansueto, Pasquale ^a   Seidita, Aurelio ^a   Vitale, Giustina ^a   Cascio, Antonio ^b  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

Cutaneous leishmaniasis; Mucosal leishmaniasis; Travelers; Visceral leishmaniasis

Indexed keywords

AMPHOTERICIN B; ANTILEISHMANIAL AGENT; AZITHROMYCIN; IMIDAZOLE DERIVATIVE; MILTEFOSINE; PENTAMIDINE; PENTAVALENT ANTIMONIAL DERIVATIVE; UNCLASSIFIED DRUG; ANTIPROTOZOAL AGENT;

ABDOMINAL DISTENSION; ACUTE HEPATITIS; ANOREXIA; ASCITES; BACTERIAL SUPERINFECTION; BONE MARROW BIOPSY; CHOLECYSTITIS; EMPORIATRICS; ENZYME LINKED IMMUNOSORBENT ASSAY; EPISTAXIS; FEVER; GINGIVA BLEEDING; GRANULOMATOSIS; GUILLAIN BARRE SYNDROME; HEMOPHAGOCYTIC SYNDROME; HEPATOSPLENOMEGALY; HUMAN; IMMIGRANT; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; LEISHMANIA; LEISHMANIA INFANTUM; LEISHMANIA MAJOR; LEISHMANIA MEXICANA; LEISHMANIA PANAMENSIS; LEISHMANIA TROPICA; LEISHMANIASIS; LEISHMANIN SKIN TEST; LOCAL THERAPY; LYMPHADENOPATHY; MALNUTRITION; MICROSCOPY; MUCOSAL DISEASE; MUCOSAL LEISHMANIASIS; NONHUMAN; NOSE SEPTUM PERFORATION; PALLOR; PAPULE; PERIPHERAL EDEMA; POLYMERASE CHAIN REACTION; PUNCH BIOPSY; REVIEW; SEROLOGY; SKIN BIOPSY; SKIN DEFECT; SKIN LEISHMANIASIS; SKIN MANIFESTATION; SKIN NODULE; SKIN ULCER; SOLDIER; SYSTEMATIC REVIEW; TOURISM; TRAVEL ACQUIRED LEISHMANIASIS; VISCERAL LEISHMANIASIS; WEAKNESS; WEIGHT REDUCTION; ANIMAL; DISEASE CARRIER; MIGRANT; PARASITOLOGY; PATHOPHYSIOLOGY; PSYCHODIDAE; SOUTH AMERICA; SOUTHERN EUROPE; TRAVEL;

ANIMALS; ANTIPROTOZOAL AGENTS; EMIGRANTS AND IMMIGRANTS; HUMANS; INSECT VECTORS; LEISHMANIA; LEISHMANIASIS; MEDITERRANEAN REGION; MILITARY PERSONNEL; PSYCHODIDAE; SOUTH AMERICA; TRAVEL;

EID: 84916879989     PISSN: 14778939     EISSN: 18730442     Source Type: Journal    
DOI: 10.1016/j.tmaid.2014.09.007     Document Type: Review

References (181)

1. P. Ready Sand fly evolution and its relationship to Leishmania transmission Memorias do Inst Oswaldo Cruz 95 2000 589 590
2. H.C. Maltezou Leishmaniasis H.C. Maltezou, A. Gikas, Tropical and emerging infectious diseases 2010 Research Signpost Kerala, India 163 185
3. P.A. Bates Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies Int J Parasitol 37 2007 1097 1106
4. V.S. Belo, G.L. Werneck, D.S. Barbosa, T.C. Simoes, B.W. Nascimento, and E.S. da Silva Factors associated with visceral leishmaniasis in the americas: a systematic review and meta-analysis PLoS Negl Trop Dis 7 2013 e2182
5. R.W. Sutherst Global change and human vulnerability to vector-borne diseases Clin Microbiol Rev 17 2004 136 173
6. R. Shafiei, M. Mohebali, B. Akhoundi, M.S. Galian, F. Kalantar, and S. Ashkan Emergence of co-infection of visceral leishmaniasis in HIV-positive patients in northeast Iran: a preliminary study Travel Med Infect Dis 12 2014 173 178
7. J. Alvar, P. Aparicio, A. Aseffa, M. Den Boer, C. Canavate, and J.P. Dedet The relationship between leishmaniasis and AIDS: the second 10 years Clin Microbiol Rev 21 2008 334 359 [table of contents]
8. P. Desjeux, and J. Alvar Leishmania/HIV co-infections: epidemiology in Europe Ann Trop Med Parasitol 97 Suppl. 1 2003 3 15
9. A. Pavli, and H.C. Maltezou Leishmaniasis, an emerging infection in travelers Int J Infect Dis - IJID - Off Publ Int Soc Infect Dis 14 2010 e1032 e1039
10. T.C. Jones, W.D. Johnson Jr., A.C. Barretto, E. Lago, R. Badaro, and B. Cerf Epidemiology of American cutaneous leishmaniasis due to Leishmania braziliensis braziliensis J Infect Dis 156 1987 73 83
11. A.E. Paniz Mondolfi, G.B. Duffey, L.E. Horton, M. Tirado, O. Reyes Jaimes, and A. Perez-Alvarez Intermediate/borderline disseminated cutaneous leishmaniasis Int J Dermatol 52 2013 446 455
12. F.T. Silveira, R. Lainson, and C.E. Corbett Clinical and immunopathological spectrum of American cutaneous leishmaniasis with special reference to the disease in Amazonian Brazil: a review Memorias do Inst Oswaldo Cruz 99 2004 239 251
13. C.M. Lucas, E.D. Franke, M.I. Cachay, A. Tejada, M.E. Cruz, and R.D. Kreutzer Geographic distribution and clinical description of leishmaniasis cases in Peru Am J Trop Med Hyg 59 1998 312 317
14. M.L. Turetz, P.R. Machado, A.I. Ko, F. Alves, A. Bittencourt, and R.P. Almeida Disseminated leishmaniasis: a new and emerging form of leishmaniasis observed in northeastern Brazil J Infect Dis 186 2002 1829 1834
15. J.M. Blackwell Tumour necrosis factor alpha and mucocutaneous leishmaniasis Parasitol Today 15 1999 73 75
16. C. Ronet, S.M. Beverley, and N. Fasel Muco-cutaneous leishmaniasis in the New World: the ultimate subversion Virulence 2 2011 547 552
17. J. Alvar, I.D. Velez, C. Bern, M. Herrero, P. Desjeux, and J. Cano Leishmaniasis worldwide and global estimates of its incidence PloS One 7 2012 e35671
18. A. Perez-Ayala, F. Norman, J.A. Perez-Molina, J.M. Herrero, B. Monge, and R. Lopez-Velez Imported leishmaniasis: a heterogeneous group of diseases J Travel Med 16 2009 395 401
19. D.A. Kafetzis, and H.C. Maltezou Visceral leishmaniasis in paediatrics Curr Opin Infect Dis 15 2002 289 294
20. D. Basset, F. Faraut, P. Marty, J. Dereure, E. Rosenthal, and C. Mary Visceral leishmaniasis in organ transplant recipients: 11 new cases and a review of the literature Microbes Infection - Institut Pasteur 7 2005 1370 1375
21. I.D. Xynos, M.G. Tektonidou, D. Pikazis, and N.V. Sipsas Leishmaniasis, autoimmune rheumatic disease, and anti-tumor necrosis factor therapy, Europe Emerg Infect Dis 15 2009 956 959
22. W. Coura-Vital, M.J. Marques, V.M. Veloso, B.M. Roatt, R.D. Aguiar-Soares, and L.E. Reis Prevalence and factors associated with Leishmania infantum infection of dogs from an urban area of Brazil as identified by molecular methods PLoS Negl Trop Dis 5 2011 e1291
23. J.C. Dujardin, L. Campino, C. Canavate, J.P. Dedet, L. Gradoni, and K. Soteriadou Spread of vector-borne diseases and neglect of Leishmaniasis, Europe Emerg Infect Dis 14 2008 1013 1018
24. S. Antinori, E. Gianelli, S. Calattini, E. Longhi, M. Gramiccia, and M. Corbellino Cutaneous Leishmaniasis: an increasing threat for travellers Clin Microbiol Infect - Off Publ Eur Soc Clin Microbiol Infect Dis 11 2005 343 346
25. E. Caumes, J. Carriere, G. Guermonprez, F. Bricaire, M. Danis, and M. Gentilini Dermatoses associated with travel to tropical countries: a prospective study of the diagnosis and management of 269 patients presenting to a tropical disease unit Clin Infect Dis - Off Publ Infect Dis Soc Am 20 1995 542 548
26. S.D. Lawn, J. Whetham, P.L. Chiodini, J. Kanagalingam, J. Watson, and R.H. Behrens New World mucosal and cutaneous Leishmaniasis: an emerging health problem among British travellers QJM - Mon J Assoc Phys 97 2004 781 788
27. G. Morizot, P. Delgiudice, E. Caumes, E. Laffitte, P. Marty, and A. Dupuy Healing of Old world cutaneous Leishmaniasis in travelers treated with fluconazole: drug effect or spontaneous evolution? Am J Trop Med Hyg 76 2007 48 52
28. D. Stark, S. van Hal, R. Lee, D. Marriott, and J. Harkness Leishmaniasis, an emerging imported infection: report of 20 cases from Australia J Travel Med 15 2008 351 354
29. A.N. Malik, L. John, A.D. Bruceson, and D.N. Lockwood Changing pattern of visceral leishmaniasis, United Kingdom, 1985-2004 Emerg Infect Dis 12 2006 1257 1259
30. B.L. Herwaldt, S.L. Stokes, and D.D. Juranek American cutaneous leishmaniasis in U.S. travelers Ann Intern Med 118 1993 779 784
31. Update: cutaneous leishmaniasis in U.S. military personnel-Southwest/Central Asia, 2002-2004 MMWR Morb Mortal Wkly Rep 53 2004 264 265
32. S. Ahluwalia, S.D. Lawn, J. Kanagalingam, H. Grant, and D.N. Lockwood Mucocutaneous leishmaniasis: an imported infection among travellers to central and South America BMJ 329 2004 842 844
33. Centers for Disease C Viscerotropic leishmaniasis in persons returning from operation desert storm-1990-1991 MMWR Morb Mortal Wkly Rep 41 1992 131 134
34. G. Bezold, M. Lange, K. Gethoffer, H. Pillekamp, H. Reindl, and C. Richter Competitive polymerase chain reaction used to diagnose cutaneous leishmaniasis in German soldiers infected during military exercises in French Guiana Eur J Clin Microbiol Infect Dis - Off Publ Eur Soc Clin Microbiol 20 2001 421 424
35. Cutaneous leishmaniasis in U.S. military personnel-Southwest/Central Asia, 2002-2003 MMWR Morb Mortal Wkly Rep 52 2003 1009 1012
36. S. Haider, O. Boutross-Tadross, J. Radhi, and N. Momar Cutaneous ulcer in a man returning from Central America CMAJ - Can Med Assoc J - J de l'Assoc Med Can 168 2003 590 591
37. G. Harms, G. Schonian, and H. Feldmeier Leishmaniasis in Germany Emerg Infect Dis 9 2003 872 875
38. A. Scope, H. Trau, G. Anders, A. Barzilai, Y. Confino, and E. Schwartz Experience with New World cutaneous leishmaniasis in travelers J Am Acad Dermatol 49 2003 672 678
39. A. Scope, H. Trau, M. Bakon, N. Yarom, A. Nasereddin, and E. Schwartz Imported mucosal leishmaniasis in a traveler Clin Infect Dis - Off Publ Infect Dis Soc Am 37 2003 e83 e837
40. Two cases of visceral leishmaniasis in U.S. military personnel-Afghanistan, 2002-2004 MMWR Morb Mortal Wkly Rep 53 2004 265 268
41. L. El Hajj, M. Thellier, J. Carriere, F. Bricaire, M. Danis, and E. Caumes Localized cutaneous leishmaniasis imported into Paris: a review of 39 cases Int J Dermatol 43 2004 120 125
42. O. Ju, D.I. Grove, W.J. Jaksic, and G.W. Dart Visceral leishmaniasis: a trip to the Greek Islands is not always idyllic Med J Aust 181 2004 446 447
43. T. Weitzel, N. Muhlberger, T. Jelinek, M. Schunk, S. Ehrhardt, and C. Bogdan Imported leishmaniasis in Germany 2001-2004: data of the SIMPID surveillance network Eur J Clin Microbiol Infect Dis - Off Publ Eur Soc Clin Microbiol 24 2005 471 476
44. R.J. Willard, A.M. Jeffcoat, P.M. Benson, and D.S. Walsh Cutaneous leishmaniasis in soldiers from Fort Campbell, Kentucky returning from operation Iraqi freedom highlights diagnostic and therapeutic options J Am Acad Dermatol 52 2005 977 987
45. J.J. Scarisbrick, P.L. Chiodini, J. Watson, A. Moody, M. Armstrong, and D. Lockwood Clinical features and diagnosis of 42 travellers with cutaneous leishmaniasis Travel Med Infect Dis 4 2006 14 21
46. J.P. Woodrow, J.D. Hartzell, J. Czarnik, D.M. Brett-Major, and G. Wortmann Cutaneous and presumed visceral leishmaniasis in a soldier deployed to Afghanistan MedGenMed - Medscape Gen Med 8 2006 43
47. J.M. Vinetz, and L. Soong Leishmania mexicana infection of the eyelid in a traveler to Belize Braz J Infect Dis - Off Publ Braz Soc Infect Dis 11 2007 149 152
48. M. Solomon, S. Baum, A. Barzilai, A. Scope, H. Trau, and E. Schwartz Liposomal amphotericin B in comparison to sodium stibogluconate for cutaneous infection due to Leishmania Braziliensis J Am Acad Dermatol 56 2007 612 616
49. O. Delgado, S. Silva, V. Coraspe, M.A. Rivas, A.J. Rodriguez-Morales, and P. Navarro Cutaneous leishmaniasis imported from Colombia to Northcentral Venezuela: implications for travel advice Travel Med Infect Dis 6 2008 376 379
50. N. Berens-Riha, E. Fleischmann, F. Pratlong, G. Bretzel, F. von Sonnenburg, and T. Loscher Cutaneous leishmaniasis (Leishmania tropica) in a German tourist after travel to Greece J Travel Med 16 2009 220 222
51. V. Leitner, J. Weingast, K. Harmankaya, J. Walochnik, H. Pehamberger, and P. Petzelbauer Leishmaniasis in the tongue of an immunocompetent man Am J Trop Med Hyg 82 2010 597 599
52. S.A. Mazumder, S. Pandey, S.C. Brewer, V.S. Baselski, P.J. Weina, and M.A. Land Lingual Leishmaniasis complicating visceral disease J Travel Med 17 2010 212 214
53. A.P. Cannella, B.M. Nguyen, C.D. Piggott, R.A. Lee, J.M. Vinetz, and S.R. Mehta A cluster of cutaneous Leishmaniasis associated with human smuggling Am J Trop Med Hyg 84 2011 847 850
54. C.H. Costa, and I.K. de Miranda-Santos Aircraft and risk of importing a new vector of visceral Leishmaniasis Emerg Infect Dis 17 2011 1333 1334
55. M. Solomon, S. Benenson, S. Baum, and E. Schwartz Tropical skin infections among Israeli travelers Am J Trop Med Hyg 85 2011 868 872
56. P.P. van Thiel, J.E. Zeegelaar, T. van Gool, W.R. Faber, and P.A. Kager Cutaneous Leishmaniasis in three Dutch military cohorts following jungle training in Belize Travel Med Infect Dis 9 2011 153 160
57. P. Zanger, I. Kotter, A. Raible, T. Gelanew, G. Schonian, and P.G. Kremsner Case report: successful treatment of cutaneous leishmaniasis caused by Leishmania aethiopica with liposomal amphothericin B in an immunocompromised traveler returning from Eritrea Am J Trop Med Hyg 84 2011 692 694
58. P. Kelly, T. Baudry, and F. Peyron Imported cutaneous leishmaniasis in a short-term traveler returning from Central Mali - the role of PCR Travel Med Infect Dis 10 2012 97 100
59. D. Terhorst, U. Blume-Peytavi, G. Schonian, C. Schewe, N. Haas, and G.J. Burbach Leishmaniasis: a reminder in the face of forgotten travel J Pediatr 161 2012 966
60. E.C. Wall, J. Watson, M. Armstrong, P.L. Chiodini, and D.N. Lockwood Epidemiology of imported cutaneous leishmaniasis at the Hospital for Tropical Diseases, London, United Kingdom: use of polymerase chain reaction to identify the species Am J Trop Med Hyg 86 2012 115 118
61. A. Bart, P.P. van Thiel, H.J. de Vries, C.J. Hodiamont, and T. Van Gool Imported Leishmaniasis in the Netherlands from 2005 to 2012: epidemiology, diagnostic techniques and sequence-based species typing from 195 patients Euro surveill bull Eur les mal transm - Eur Commun Dis Bull 18 2013 20544
62. E. Demers, D.M. Forrest, and G.E. Weichert Cutaneous Leishmaniasis in a returning traveller CMAJ - Can Med Assoc J - J de l'Assoc Med Can 185 2013 681 683
63. S. Larreche, G. Launay, C. Weibel Galluzzo, A. Bousquet, G. Eperon, and J.E. Pilo Cluster of zoonotic cutaneous Leishmaniasis (Leishmania major) in European travelers returning from Turkmenistan J Travel Med 20 2013 400 402
64. J. Moore, and K. Brown Sun, sangria and sandflies: Leishmaniasis in an immunosuppressed patient returning from Spain Travel Med Infect Dis 11 2013 119 122
65. W. Poeppl, C. Oeser, K. Grabmeier-Pfistershammer, J. Walochnik, and H. Burgmann Clinical findings and management of imported cutaneous Leishmaniasis: report of 14 cases from Austria Travel Med Infect Dis 11 2013 90 94
66. V. Field, P. Gautret, P. Schlagenhauf, G.D. Burchard, E. Caumes, and M. Jensenius Travel and migration associated infectious diseases morbidity in Europe, 2008 BMC Infect Dis 10 2010 330
67. S. Odolini, P. Parola, E. Gkrania-Klotsas, E. Caumes, P. Schlagenhauf, and R. Lopez-Velez Travel-related imported infections in Europe, EuroTravNet 2009 Clin Microbiol Infect - Off Publ Eur Soc Clin Microbiol Infect Dis 18 2012 468 474
68. Organization WT. Tourism 2020 vision.
69. Association TI. Travel market segments.
70. E.E. Bejarano, S. Uribe, W. Rojas, and I. Dario Velez Phlebotomine sand flies (Diptera: Psychodidae) associated with the appearance of urban Leishmaniasis in the city of Sincelejo, Colombia Memorias do Inst Oswaldo Cruz 97 2002 645 647
71. J.E. Zeegelaar, W.H. Steketee, P.P. van Thiel, J.C. Wetsteyn, P.A. Kager, and W.R. Faber Changing pattern of imported cutaneous Leishmaniasis in the Netherlands Clin Exp Dermatol 30 2005 1 5
72. U. Ehehalt, M. Schunk, M. Jensenius, P.J. van Genderen, E. Gkrania-Klotsas, and F. Chappuis Leishmaniasis acquired by travellers to endemic regions in Europe: a EuroTravNet multi-centre study Travel Med Infect Dis 12 2014 167 172
73. D.O. Freedman, L.H. Weld, P.E. Kozarsky, T. Fisk, R. Robins, and F. von Sonnenburg Spectrum of disease and relation to place of exposure among ill returned travelers N Engl J Med 354 2006 119 130
74. F.A. Kiiamov, L.S. Orlova, A. Topchin Iu, and G.A. Shalabaev Cases of cutaneous leishmaniasis infection resulting from the importation of sandflies via transportation means Meditsinskaia Parazitol I Parazit bolezni 1990 40 41
75. M. Hardiman, and A. Wilder-Smith The revised international health regulations and their relevance to travel medicine J Travel Med 14 2007 141 144
76. J. Blum, T. Junghanss, and C. Hatz Erroneous tracks in the diagnosis of cutaneous and mucocutaneous leishmaniasis Schweiz Rundsch Fur Med Prax - Rev Suisse Med Prax 83 1994 1025 1029
77. P.J. Lohuis, M.M. Lipovsky, A.I. Hoepelman, G.J. Hordijk, and E.H. Huizing Leishmania Braziliensis presenting as a granulomatous lesion of the nasal septum mucosa J Laryngol Otol 111 1997 973 975
78. J.L. Rosbotham, E.L. Corbett, H.R. Grant, R.J. Hay, and A.D. Bryceson Imported mucocutaneous Leishmaniasis Clin Exp Dermatol 21 1996 288 290
79. T. Herremans, E. Pinelli, M. Casparie, N. Nozari, J. Roelfsema, and L. Kortbeek Increase of imported Leishmaniasis in the Netherlands: a twelve year overview (1996-2007) Int Health 2 2010 42 46
80. M.J. van Vliet, H. Veeken, W. Hart, and R.Y. Tamminga Clinical reasoning and decision-making in practice. A young boy with fever, pancytopenia and an enlarged spleen Ned Tijdschr Geneeskd 150 2006 1662 1668
81. E. Schwartz, C. Hatz, and J. Blum New World cutaneous Leishmaniasis in travellers Lancet Infect Dis 6 2006 342 349
82. O.E. Akilov, A. Khachemoune, and T. Hasan Clinical manifestations and classification of Old World cutaneous leishmaniasis Int J Dermatol 46 2007 132 142
83. J. Richter, I. Hanus, D. Haussinger, T. Loscher, and G. Harms Mucosal Leishmania infantum infection Parasitol Res 109 2011 959 962
84. K. Grabmeier-Pfistershammer, W. Poeppl, P.M. Brunner, K. Rappersberger, and A. Rieger Clinical challenges in the management of Leishmania/HIV coinfection in a nonendemic area: a case report Case Reports Infect Dis 2012 2012 787305
85. A.L. Neumayr, C. Walter, M. Stoeckle, N. Braendle, K. Glatz, and J.A. Blum Successful treatment of imported mucosal Leishmania infantum leishmaniasis with miltefosine after severe hypokalemia under meglumine antimoniate treatment J Travel Med 19 2012 124 126
86. E.T. Ryan, M.E. Wilson, and K.C. Kain Illness after international travel N Engl J Med 347 2002 505 516
87. V. Rastogi, and P.S. Nirwan Cutaneous leishmaniasis: an emerging infection in a non-endemic area and a brief update Indian J Med Microbiol 25 2007 272 275
88. M. Calvopina, E.A. Gomez, H. Sindermann, P.J. Cooper, and Y. Hashiguchi Relapse of New World diffuse cutaneous leishmaniasis caused by Leishmania (Leishmania) mexicana after miltefosine treatment Am J Trop Med Hyg 75 2006 1074 1077
89. M. Rhajaoui, A. Nasereddin, H. Fellah, K. Azmi, F. Amarir, and A. Al-Jawabreh New clinico-epidemiologic profile of cutaneous leishmaniasis, Morocco Emerg Infect Dis 13 2007 1358 1360
90. Q. Sousa Ade, M.E. Parise, M.M. Pompeu, J.M. Coehlo Filho, I.A. Vasconcelos, and J.W. Lima Bubonic leishmaniasis: a common manifestation of Leishmania (Viannia) braziliensis infection in Ceara, Brazil Am J Trop Med Hyg 53 1995 380 385
91. A. Barral, M. Barral-Netto, R. Almeida, A.R. de Jesus, G. Grimaldi Junior, and E.M. Netto Lymphadenopathy associated with Leishmania braziliensis cutaneous infection Am J Trop Med Hyg 47 1992 587 592
92. T.R. Navin, B.A. Arana, F.E. Arana, J.D. Berman, and J.F. Chajon Placebo-controlled clinical trial of sodium stibogluconate (Pentostam) versus ketoconazole for treating cutaneous leishmaniasis in Guatemala J Infect Dis 165 1992 528 534
93. Y. Gutierrez, G.H. Salinas, G. Palma, L.B. Valderrama, C.V. Santrich, and N.G. Saravia Correlation between histopathology, immune response, clinical presentation, and evolution in Leishmania braziliensis infection Am J Trop Med Hyg 45 1991 281 289
94. M.P. Oliveira-Neto, C. Pirmez, E. Rangel, A. Schubach, and G. Grimaldi Junior An outbreak of American cutaneous leishmaniasis (Leishmania braziliensis braziliensis) in a periurban area of Rio de Janeiro city, Brazil: clinical and epidemiological studies Mem Inst Oswaldo Cruz 83 1988 427 435
95. C. David, L. Dimier-David, F. Vargas, M. Torrez, and J.P. Dedet Fifteen years of cutaneous and mucocutaneous leishmaniasis in Bolivia: a retrospective study Trans R Soc Trop Med Hyg 87 1993 7 9
96. G.L. Machado-Coelho, W.T. Caiaffa, O. Genaro, P.A. Magalhaes, and W. Mayrink Risk factors for mucosal manifestation of American cutaneous leishmaniasis Trans R Soc Trop Med Hyg 99 2005 55 61
97. M.L. Petzl-Erler, M.P. Belich, and F. Queiroz-Telles Association of mucosal leishmaniasis with HLA Hum Immunol 32 1991 254 260
98. A. Alcais, L. Abel, C. David, M.E. Torrez, P. Flandre, and J.P. Dedet Risk factors for onset of cutaneous and mucocutaneous leishmaniasis in Bolivia Am J Trop Med Hyg 57 1997 79 84
99. D. Argaw, A. Mulugeta, M. Herrero, N. Nombela, T. Teklu, and T. Tefera Risk factors for visceral leishmaniasis among residents and migrants in Kafta-Humera, Ethiopia PLoS Negl Trop Dis 7 2013 e2543
100. A. MN, and A. MI Visceral leishmaniasis: clinical and demographic features in an African population Pak J Med Sci 29 2013 485 489
101. R.N. Harizanov, I.T. Kaftandjiev, D.P. Jordanova, I.B. Marinova, and N.D. Tsvetkova Clinical features, diagnostic tools, and treatment regimens for visceral leishmaniasis in Bulgaria Pathog Glob Health 107 2013 260 266
102. N. Kumar, K. Pandey, V.N. Das, P.K. Sinha, R.K. Topno, and C.S. Lal HIV infection, visceral leishmaniasis and Guillain-Barre syndrome in the same patient: a case report Ann Trop Med Parasitol 102 2008 185 188
103. H.C. Maltezou, C. Siafas, M. Mavrikou, P. Spyridis, C. Stavrinadis, and T. Karpathios Visceral leishmaniasis during childhood in southern Greece Clin Infect Dis - Off Publ Infect Dis Soc Am 31 2000 1139 1143
104. P. Desjeux Leishmaniasis: current situation and new perspectives Comp Immunol Microbiol Infect Dis 27 2004 305 318
105. Y. Mueller, D.B. Mbulamberi, P. Odermatt, A. Hoffmann, L. Loutan, and F. Chappuis Risk factors for in-hospital mortality of visceral leishmaniasis patients in eastern Uganda Trop Med Int health - TM IH 14 2009 910 917
106. G. Cenderello, A. Pasa, A. Dusi, C. Dentone, F. Toscanini, and N. Bobbio Varied spectrum of clinical presentation and mortality in a prospective registry of visceral leishmaniasis in a low endemicity area of Northern Italy BMC Infect Dis 13 2013 248
107. K. Ritmeijer, A. Dejenie, Y. Assefa, T.B. Hundie, J. Mesure, and G. Boots A comparison of miltefosine and sodium stibogluconate for treatment of visceral leishmaniasis in an Ethiopian population with high prevalence of HIV infection Clin Infect Dis - Off Publ Infect Dis Soc Am 43 2006 357 364
108. I. Molina, V. Falco, M. Crespo, C. Riera, E. Ribera, and A. Curran Efficacy of liposomal amphotericin B for secondary prophylaxis of visceral leishmaniasis in HIV-infected patients J Antimicrob Chemother 60 2007 837 842
109. A.J. Magill, M. Grogl, R.A. Gasser Jr., W. Sun, and C.N. Oster Visceral infection caused by Leishmania tropica in veterans of operation desert storm N Engl J Med 328 1993 1383 1387
110. T.R. Navin, F.E. Arana, A.M. de Merida, B.A. Arana, A.L. Castillo, and D.N. Silvers Cutaneous leishmaniasis in Guatemala: comparison of diagnostic methods Am J Trop Med Hyg 42 1990 36 42
111. K.A. Weigle, M. de Davalos, P. Heredia, R. Molineros, N.G. Saravia, and A. D'Alessandro Diagnosis of cutaneous and mucocutaneous leishmaniasis in Colombia: a comparison of seven methods Am J Trop Med Hyg 36 1987 489 496
112. C.I. de Oliveira, A. Bafica, F. Oliveira, C.B. Favali, T. Correa, and L.A. Freitas Clinical utility of polymerase chain reaction-based detection of Leishmania in the diagnosis of American cutaneous leishmaniasis Clin Infect Dis - Off Publ Infect Dis Soc Am 37 2003 e149 e153
113. W.H. Markle, and K. Makhoul Cutaneous leishmaniasis: recognition and treatment Am Fam Phys 69 2004 1455 1460
114. K.M. Blonski, N. Blodorn-Schlicht, T.M. Falk, R.S. Faye, and O.P. Clausen Increased detection of cutaneous leishmaniasis in Norway by use of polymerase chain reaction APMIS - Acta Pathol Microbiol Immunol Scand 120 2012 591 596
115. R. Reithinger, J.C. Dujardin, H. Louzir, C. Pirmez, B. Alexander, and S. Brooker Cutaneous leishmaniasis Lancet Infect Dis 7 2007 581 596
116. J. Blum, P. Desjeux, E. Schwartz, B. Beck, and C. Hatz Treatment of cutaneous leishmaniasis among travellers J Antimicrob Chemother 53 2004 158 166
117. P. Desjeux, S. Mollinedo, F. Le Pont, A. Paredes, and G. Ugarte Cutaneous leishmaniasis in Bolivia. A study of 185 human cases from Alto Beni (La Paz Department). Isolation and isoenzyme characterization of 26 strains of Leishmania braziliensis braziliensis [corrected] Trans R Soc Trop Med Hyg 81 1987 742 746
118. J.P. Gangneux, J. Menotti, F. Lorenzo, C. Sarfati, H. Blanche, and H. Bui Prospective value of PCR amplification and sequencing for diagnosis and typing of old world Leishmania infections in an area of nonendemicity J Clin Microbiol 41 2003 1419 1422
119. C. Cassagne, F. Pratlong, F. Jeddi, R. Benikhlef, K. Aoun, and A.C. Normand Identification of Leishmania at the species level with matrix-assisted laser desorption ionization time-of-flight mass spectrometry Clin Microbiol Infect - Off Publ Eur Soc Clin Microbiol Infect Dis 2013
120. M.C. Boite, I.L. Mauricio, M.A. Miles, and E. Cupolillo New insights on taxonomy, phylogeny and population genetics of Leishmania (Viannia) parasites based on multilocus sequence analysis PLoS Negl Trop Dis 6 2012 e1888
121. W.R. Faber, L. Oskam, T. van Gool, N.C. Kroon, K.J. Knegt-Junk, and H. Hofwegen Value of diagnostic techniques for cutaneous leishmaniasis J Am Acad Dermatol 49 2003 70 74
122. M.E. de Almeida, F.J. Steurer, O. Koru, B.L. Herwaldt, N.J. Pieniazek, and A.J. da Silva Identification of Leishmania spp. by molecular amplification and DNA sequencing analysis of a fragment of rRNA internal transcribed spacer 2 J Clin Microbiol 49 2011 3143 3149
123. J.G. Oliveira, F.O. Novais, C.I. de Oliveira, A.C. da Cruz Junior, L.F. Campos, and A.V. da Rocha Polymerase chain reaction (PCR) is highly sensitive for diagnosis of mucosal leishmaniasis Acta Trop 94 2005 55 59
124. C.V. David, and N. Craft Cutaneous and mucocutaneous leishmaniasis Dermatol Ther 22 2009 491 502
125. M. Ameen Cutaneous leishmaniasis: advances in disease pathogenesis, diagnostics and therapeutics Clin Exp Dermatol 35 2010 699 705
126. F. de Monbrison, I. Mihoubi, and S. Picot Real-time PCR assay for the identification of cutaneous Leishmania parasite species in constantine region of Algeria Acta trop 102 2007 79 83
127. A.K. Boggild, B.M. Valencia, D. Espinosa, N. Veland, A.P. Ramos, and J. Arevalo Detection and species identification of Leishmania DNA from filter paper lesion impressions for patients with American cutaneous leishmaniasis Clin Infect Dis - Off Publ Infect Dis Soc Am 50 2010 e1 e6
128. M. Boelaert, S.K. Bhattacharya, F. Chappuis, S.H. El Safi, A. Hailu, and D. Mondal Evaluation of rapid diagnostic tests: visceral leishmaniasis Nat Rev Micro 5 2007 S30 S39
129. (OIE) WOfAH Manual of diagnostic tests and vaccines for terrestrial animals 2013 2013
130. W. van der Meide, J. Guerra, G. Schoone, M. Farenhorst, L. Coelho, and W. Faber Comparison between quantitative nucleic acid sequence-based amplification, real-time reverse transcriptase PCR, and real-time PCR for quantification of Leishmania parasites J Clin Microbiol 46 2008 73 78
131. C.J. Hodiamont, P.A. Kager, A. Bart, H.J. de Vries, P.P. van Thiel, and T. Leenstra Species-directed therapy for leishmaniasis in returning travellers: a comprehensive guide PLoS Negl Trop Dis 8 2014 e2832
132. J.A. Blum, and C.F. Hatz Treatment of cutaneous leishmaniasis in travelers 2009 J Travel Med 16 2009 123 131
133. H.W. Murray, J.D. Berman, C.R. Davies, and N.G. Saravia Advances in leishmaniasis Lancet 366 2005 1561 1577
134. H. Goto, and J.A. Lindoso Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis Expert Rev Anti Infect Ther 8 2010 419 433
135. B. Monge-Maillo, and R. Lopez-Velez Therapeutic options for visceral leishmaniasis Drugs 73 2013 1863 1888
136. B.L. Herwaldt, and J.D. Berman Recommendations for treating leishmaniasis with sodium stibogluconate (Pentostam) and review of pertinent clinical studies Am J Trop Med Hyg 46 1992 296 306
137. V. Amato, J. Amato, A. Nicodemo, D. Uip, V. Amato-Neto, and M. Duarte Treatment of mucocutaneous leishmaniasis with pentamidine isothionate Ann de Dermatol de Venereol 125 1998 492 495
138. V.S. Amato, F.F. Tuon, A.M. Siqueira, A.C. Nicodemo, and V.A. Neto Treatment of mucosal leishmaniasis in Latin America: systematic review Am J Trop Med Hyg 77 2007 266 274
139. N.E. Aronson, G.W. Wortmann, S.C. Johnson, J.E. Jackson, R.A. Gasser Jr., and A.J. Magill Safety and efficacy of intravenous sodium stibogluconate in the treatment of leishmaniasis: recent U.S. military experience Clin Infect Dis - Off Publ Infect Dis Soc Am 27 1998 1457 1464
140. N.C. Hepburn, I. Siddique, A.F. Howie, G.J. Beckett, and P.C. Hayes Hepatotoxicity of sodium stibogluconate in leishmaniasis Lancet 342 1993 238 239
141. R.A. Gasser Jr., A.J. Magill, C.N. Oster, E.D. Franke, M. Grogl, and J.D. Berman Pancreatitis induced by pentavalent antimonial agents during treatment of leishmaniasis Clin Infect Dis - Off Publ Infect Dis Soc Am 18 1994 83 90
142. R.N. Davidson Practical guide for the treatment of leishmaniasis Drugs 56 1998 1009 1018
143. M.O. McBride, M. Linney, R.N. Davidson, and J.N. Weber Pancreatic necrosis following treatment of leishmaniasis with sodium stibogluconate Clin Infect Dis - Off Publ Infect Dis Soc Am 21 1995 710
144. G. Antezana, R. Zeballos, C. Mendoza, P. Lyevre, L. Valda, and F. Cardenas Electrocardiographic alterations during treatment of mucocutaneous leishmaniasis with meglumine antimoniate and allopurinol Trans R Soc Trop Med Hyg 86 1992 31 33
145. A.L. Ribeiro, J.B. Drummond, A.C. Volpini, A.C. Andrade, and V.M. Passos Electrocardiographic changes during low-dose, short-term therapy of cutaneous leishmaniasis with the pentavalent antimonial meglumine Braz J Med Biol Res - Revista Brasileira de Pesquisas Medicas E Biologicas Sociedade Brasileira de Biofisica [et al] 32 1999 297 301
146. S.D. Lawn, M. Armstrong, D. Chilton, and C.J. Whitty Electrocardiographic and biochemical adverse effects of sodium stibogluconate during treatment of cutaneous and mucosal leishmaniasis among returned travellers Trans R Soc Trop Med Hyg 100 2006 264 269
147. A.J. Krolewiecki, H.D. Romero, S.P. Cajal, D. Abraham, T. Mimori, and T. Matsumoto A randomized clinical trial comparing oral azithromycin and meglumine antimoniate for the treatment of American cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis Am J Trop Med Hyg 77 2007 640 646
148. F.F. Tuon, V.S. Amato, M.E. Graf, A.M. Siqueira, A.C. Nicodemo, and V. Amato Neto Treatment of New World cutaneous leishmaniasis-a systematic review with a meta-analysis Int J Dermatol 47 2008 109 124
149. I. Hellier, O. Dereure, I. Tournillac, F. Pratlong, B. Guillot, and J.P. Dedet Treatment of old world cutaneous leishmaniasis by pentamidine isethionate. An open study of 11 patients Dermatol 200 2000 120 123
150. B. Naafs Pentamidine-induced diabetes mellitus Trans R Soc Trop Med Hyg 79 1985 141
151. J. Soto, and J. Berman Treatment of New World cutaneous leishmaniasis with miltefosine Trans R Soc Trop Med Hyg 100 Suppl. 1 2006 S34 S40
152. O. Zerpa, M. Ulrich, B. Blanco, M. Polegre, A. Avila, and N. Matos Diffuse cutaneous leishmaniasis responds to miltefosine but then relapses Br J Dermatol 156 2007 1328 1335
153. J. Soto, J. Rea, M. Balderrama, J. Toledo, P. Soto, and L. Valda Efficacy of miltefosine for Bolivian cutaneous leishmaniasis Am J Trop Med Hyg 78 2008 210 211
154. S. Sundar, T.K. Jha, C.P. Thakur, S.K. Bhattacharya, and M. Rai Oral miltefosine for the treatment of Indian visceral leishmaniasis Trans R Soc Trop Med Hyg 100 Suppl. 1 2006 S26 S33
155. A.A. Alrajhi, E.A. Ibrahim, E.B. De Vol, M. Khairat, R.M. Faris, and J.H. Maguire Fluconazole for the treatment of cutaneous leishmaniasis caused by Leishmania major N Engl J Med 346 2002 891 895
156. M. Emad, F. Hayati, M.K. Fallahzadeh, and M.R. Namazi Superior efficacy of oral fluconazole 400 mg daily versus oral fluconazole 200 mg daily in the treatment of cutaneous leishmania major infection: a randomized clinical trial J Am Acad Dermatol 64 2011 606 608
157. A.C. Teixeira, M.G. Paes, O. Guerra Jde, A. Prata, and M.L. Silva-Vergara Low efficacy of azithromycin to treat cutaneous leishmaniasis in Manaus, AM, Brazil Rev Inst Med Trop Sao Paulo 49 2007 235 238
158. M.L. Silva-Vergara, A. Silva Lde, F.R. Maneira, A.G. da Silva, and A. Prata Azithromycin in the treatment of mucosal leishmaniasis Rev Inst Med Trop Sao Paulo 46 2004 175 177
159. S.A. Sampaio, J.T. Godoy, L. Paiva, N.L. Dillon, and L.C. da The treatment of American (mucocutaneous) leishmaniasis with amphotericin B Arch Dermatol 82 1960 627 635
160. H.A. Lessa, P. Machado, F. Lima, A.A. Cruz, O. Bacellar, and J. Guerreiro Successful treatment of refractory mucosal leishmaniasis with pentoxifylline plus antimony Am J Trop Med Hyg 65 2001 87 89
161. A. Asilian, A. Sadeghinia, G. Faghihi, and A. Momeni Comparative study of the efficacy of combined cryotherapy and intralesional meglumine antimoniate (Glucantime) vs. cryotherapy and intralesional meglumine antimoniate (Glucantime) alone for the treatment of cutaneous leishmaniasis Int J Dermatol 43 2004 281 283
162. A. Khatami, A. Firooz, F. Gorouhi, and Y. Dowlati Treatment of acute Old World cutaneous leishmaniasis: a systematic review of the randomized controlled trials J Am Acad Dermatol 57 335 2007 e1 e29
163. B.A. Arana, C.E. Mendoza, N.R. Rizzo, and A. Kroeger Randomized, controlled, double-blind trial of topical treatment of cutaneous leishmaniasis with paromomycin plus methylbenzethonium chloride ointment in Guatemala Am J Trop Med Hyg 65 2001 466 470
164. G. Sadeghian, and M.A. Nilforoushzadeh Effect of combination therapy with systemic glucantime and pentoxifylline in the treatment of cutaneous leishmaniasis Int J Dermatol 45 2006 819 821
165. A.J. Junaid Treatment of cutaneous leishmaniasis with infrared heat Int J Dermatol 25 1986 470 472
166. O. al-Majali, H.B. Routh, O. Abuloham, K.R. Bhowmik, M. Muhsen, and H. Hebeheba A 2-year study of liquid nitrogen therapy in cutaneous leishmaniasis Int J Dermatol 36 1997 460 462
167. A. Asilian, A. Sharif, G. Faghihi, S. Enshaeieh, F. Shariati, and A.H. Siadat Evaluation of CO laser efficacy in the treatment of cutaneous leishmaniasis Int J Dermatol 43 2004 736 738
168. V. Leibovici, and H. Aram Cryotherapy in acute cutaneous leishmaniasis Int J Dermatol 25 1986 473 475
169. H.C. Maltezou Visceral leishmaniasis: advances in treatment Recent Pat Anti Infect Drug Discov 3 2008 192 198
170. M.E. Raguenaud, A. Jansson, V. Vanlerberghe, S. Deborggraeve, J.C. Dujardin, and G. Orfanos Epidemiology and clinical features of patients with visceral leishmaniasis treated by an MSF clinic in Bakool region, Somalia, 2004-2006 PLoS Negl Trop Dis 1 2007 e85
171. P. Minodier, R. Piarroux, J.M. Garnier, D. Unal, H. Perrimond, and H. Dumon Pediatric visceral leishmaniasis in southern France Pediatr Infect Dis J 17 1998 701 704
172. S. Sundar, J. Chakravarty, V.K. Rai, N. Agrawal, S.P. Singh, and V. Chauhan Amphotericin B treatment for Indian visceral leishmaniasis: response to 15 daily versus alternate-day infusions Clin Infect Dis - Off Publ Infect Dis Soc Am 45 2007 556 561
173. P.L. Olliaro, P.J. Guerin, S. Gerstl, A.A. Haaskjold, J.A. Rottingen, and S. Sundar Treatment options for visceral leishmaniasis: a systematic review of clinical studies done in India, 1980-2004 Lancet Infect Dis 5 2005 763 774
174. C. Bern, J. Adler-Moore, J. Berenguer, M. Boelaert, M. den Boer, and R.N. Davidson Liposomal amphotericin B for the treatment of visceral leishmaniasis Clin Infect Dis - Off Publ Infect Dis Soc Am 43 2006 917 924
175. P.K. Sinha, J. van Griensven, K. Pandey, N. Kumar, N. Verma, and R. Mahajan Liposomal amphotericin B for visceral leishmaniasis in human immunodeficiency virus-coinfected patients: 2-year treatment outcomes in Bihar, India Clin Infect Dis - Off Publ Infect Dis Soc Am 53 2011 e91 e98
176. S. Sundar, T.K. Jha, C.P. Thakur, P.K. Sinha, and S.K. Bhattacharya Injectable paromomycin for visceral leishmaniasis in India N Engl J Med 356 2007 2571 2581
177. S.K. Bhattacharya, P.K. Sinha, S. Sundar, C.P. Thakur, T.K. Jha, and K. Pandey Phase 4 trial of miltefosine for the treatment of Indian visceral leishmaniasis J Infect Dis 196 2007 591 598
178. S. Sundar, A. Singh, M. Rai, V.K. Prajapati, A.K. Singh, and B. Ostyn Efficacy of miltefosine in the treatment of visceral leishmaniasis in India after a decade of use Clin Infect Dis - Off Publ Infec Dis Soc Am 55 2012 543 550
179. I.L. Bauer Knowledge and behavior of tourists to Manu National Park, Peru, in relation to Leishmaniasis J Travel Med 9 2002 173 179
180. J. Soto, F. Medina, N. Dember, and J. Berman Efficacy of permethrin-impregnated uniforms in the prevention of malaria and leishmaniasis in Colombian soldiers Clin Infect Dis - Off Publ Infect Dis Soc Am 21 1995 599 602
181. A. Kroeger, E.V. Avila, and L. Morison Insecticide impregnated curtains to control domestic transmission of cutaneous leishmaniasis in Venezuela: cluster randomised trial BMJ 325 2002 810 813