Can supplementation with vitamin C and E alter physiological adaptations to strength training?

BMC Sports Science, Medicine and Rehabilitation

Volumn 6, Issue 1, 2014, Pages

  Paulsen, Gøran ^a,b   Cumming, Kristoffer T ^a   Hamarsland, Håvard ^a   Børsheim, Elisabet ^c   Berntsen, Sveinung ^d   Raastad, Truls ^a  

^a NORWEGIAN SCHOOL OF SPORT SCIENCES   (Norway)

^b Norwegian Olympic Sports Center   (Norway)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d UNIVERSITY OF AGDER   (Norway)

Author keywords

1 repetition maximum; Antioxidants; Muscle mass; Muscle strength; Protocol paper

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; PLACEBO;

ADAPTATION; ADULT; AGED; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG MEGADOSE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; HEALTH STATUS; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; MUSCLE MASS; MUSCLE STRENGTH; NORMAL HUMAN; NUTRITIONAL ASSESSMENT; PHYSICAL ACTIVITY; PHYSICAL PERFORMANCE; PROTEIN SYNTHESIS; RANDOMIZED CONTROLLED TRIAL; RESISTANCE TRAINING; VITAMIN SUPPLEMENTATION;

EID: 84916636626     PISSN: None     EISSN: 20521847     Source Type: Journal    
DOI: 10.1186/2052-1847-6-28     Document Type: Article

References (76)

1. Holloszy JO, Coyle EF: Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol 1984, 56:831-838.
2. Costill DL, Coyle EF, Fink WF, Lesmes GR, Witzmann FA: Adaptations in skeletal muscle following strength training. J Appl Physiol 1979, 46:96-99.
3. Pollock ML: The quantification of endurance training programs. Exerc Sport Sci Rev 1973, 1:155-188.
4. Deschenes MR, Kraemer WJ: Performance and physiologic adaptations to resistance training. Am J Phys Med Rehabil 2002, 81:S3-16.
5. Hawley JA, Tipton KD, Millard-Stafford ML: Promoting training adaptations through nutritional interventions. J Sports Sci 2006, 24:709-721.
6. Hulmi JJ, Lockwood CM, Stout JR: Effect of protein/essential amino acids and resistance training on skeletal muscle hypertrophy: a case for whey protein. Nutr Metab (Lond) 2010, 7:51.
7. Bemben MG, Lamont HS: Creatine supplementation and exercise performance: recent findings. Sports Med 2005, 35:107-125.
8. Rodriguez NR, Di Marco NM, Langley S: American college of sports medicine position stands nutrition and athletic performance. Med Sci Sports Exerc 2009, 41:709-731.
9. Clarkson PM, Thompson HS: Antioxidants: what role do they play in physical activity and health? Am J Clin Nutr 2000, 72:637S-646S.
10. Peternelj TT, Coombes JS: Antioxidant supplementation during exercise training: beneficial or detrimental? Sports Med 2011, 41:1043-1069.
11. Vina J, Gomez-Cabrera MC, Borras C: Fostering antioxidant defences: up-regulation of antioxidant genes or antioxidant supplementation? Br J Nutr 2007, 98(Suppl 1):S36-S40.
12. Peake JM, Suzuki K, Coombes JS: The influence of antioxidant supplementation on markers of inflammation and the relationship to oxidative stress after exercise. J Nutr Biochem 2007, 18:357-371.
13. Ristow M, Zarse K: How increased oxidative stress promotes longevity and metabolic health: the concept of mitochondrial hormesis (mitohormesis). Exp Gerontol 2010, 45:410-418.
14. Braakhuis AJ: Effect of vitamin C supplements on physical performance. Curr Sports Med Rep 2012, 11:180-184.
15. Nikolaidis MG, Kerksick CM, Lamprecht M, McAnulty SR: Does vitamin C and E supplementation impair the favorable adaptations of regular exercise? Oxid Med Cell Longev 2012, 2012:707941.
16. Fisher-Wellman K, Bloomer RJ: Acute exercise and oxidative stress: a 30 year history. Dyn Med 2009, 8:1.
17. Warren JA, Jenkins RR, Packer L, Witt EH, Armstrong RB: Elevated muscle vitamin E does not attenuate eccentric exercise-induced muscle injury. J Appl Physiol 1992, 72:2168-2175.
18. Hawley JA, Burke LM, Phillips SM, Spriet LL: Nutritional modulation of training-induced skeletal muscle adaptations. J Appl Physiol 2011, 110:834-845.
19. Makanae Y, Kawada S, Sasaki K, Nakazato K, Ishii N: Vitamin C administration attenuates overload-induced skeletal muscle hypertrophy in rats. Acta Physiol (Oxf) 2013, 208:57-65.
20. Morales-Alamo D, Ponce-Gonzalez JG, Guadalupe-Grau A, Rodriguez-Garcia L, Santana A, Cusso MR, Guerrero M, Guerra B, Dorado C, Calbet JA: Increased oxidative stress and anaerobic energy release, but blunted Thr172-AMPKalpha phosphorylation, in response to sprint exercise in severe acute hypoxia in humans. J Appl Physiol 2012, 113:917-928.
21. Malm C, Svensson M, Ekblom B, Sjodin B: Effects of ubiquinone-10 supplementation and high intensity training on physical performance in humans. Acta Physiol Scand 1997, 161:379-384.
22. Braakhuis AJ, Hopkins WG, Lowe TE: Effects of dietary antioxidants on training and performance in female runners. Eur J Sport Sci 2014, 14:160-168.
23. Bobeuf F, Labonte M, Dionne IJ, Khalil A: Combined effect of antioxidant supplementation and resistance training on oxidative stress markers, muscle and body composition in an elderly population. J Nutr Health Aging 2011, 15:883-889.
24. Chuin A, Labonte M, Tessier D, Khalil A, Bobeuf F, Doyon CY, Rieth N, Dionne IJ: Effect of antioxidants combined to resistance training on BMD in elderly women: a pilot study. Osteoporos Int 2009, 20:1253-1258.
25. Theodorou AA, Nikolaidis MG, Paschalis V, Koutsias S, Panayiotou G, Fatouros IG, Koutedakis Y, Jamurtas AZ: No effect of antioxidant supplementation on muscle performance and blood redox status adaptations to eccentric training. Am J Clin Nutr 2011, 93:1373-1383.
26. Ryan MJ, Dudash HJ, Docherty M, Geronilla KB, Baker BA, Haff GG, Cutlip RG, Always SE: Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats. Exp Gerontol 2010, 45:882-895.
27. Peake J, Della GP, Cameron-Smith D: Aging and its effects on inflammation in skeletal muscle at rest and following exercise-induced muscle injury. Am J Physiol Regul Integr Comp Physiol 2010, 298:R1485-R1495.
28. Gianni P, Jan KJ, Douglas MJ, Stuart PM, Tarnopolsky MA: Oxidative stress and the mitochondrial theory of aging in human skeletal muscle. Exp Gerontol 2004, 39:1391-1400.
29. Gomez-Cabrera MC, Ferrando B, Brioche TS-GF, Vina J: Exercise and antioxidant supplements in the elderly. Journal of Sport and Health Science 2013, 2:94-100.
30. Padayatty SJ, Levine M: New insights into the physiology and pharmacology of vitamin C. CMAJ 2001, 164:353-355.
31. Lodge JK: Vitamin E bioavailability in humans. J Plant Physiol 2005, 162:790-796.
32. Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, Katz A, Wesley RA, Levine M: Vitamin C pharmacokinetics: implications for oral and intravenous use. Ann Intern Med 2004, 140:533-537.
33. Black AE, Goldberg GR, Jebb SA, Livingstone MB, Cole TJ, Prentice AM: Critical evaluation of energy intake data using fundamental principles of energy physiology: 2. Evaluating the results of published surveys. Eur J Clin Nutr 1991, 45:583-599.
34. Andersen LF, Pollestad ML, Jacobs DR Jr, Lovo A, Hustvedt BE: Validation of a pre-coded food diary used among 13-year-olds: comparison of energy intake with energy expenditure. Public Health Nutr 2005, 8:1315-1321.
35. Borg G: Perceived exertion as an indicator of somatic stress. Scand J Rehabil Med 1970, 2:92-98.
36. Anderson LJ, Erceg DN, Schroeder ET: Utility of multifrequency bioelectrical impedance compared with dual-energy x-ray absorptiometry for assessment of total and regional body composition varies between men and women. Nutr Res 2012, 32:479-485.
37. Berntsen S, Hageberg R, Aandstad A, Mowinckel P, Anderssen SA, Carlsen KH, Andersen LB: Validity of physical activity monitors in adults participating in free-living activities. Br J Sports Med 2010, 44:657-664.
38. Paulsen G, Vissing K, Kalhovde JM, Ugelstad I, Bayer ML, Kadi F, Schjerling P, Hallen J, Raastad T: Maximal eccentric exercise induces a rapid accumulation of small heat shock proteins on myofibrils and a delayed HSP70 response in humans. Am J Physiol Regul Integr Comp Physiol 2007, 293:R844-R853.
39. Hanssen KE, Kvamme NH, Nilsen TS, Ronnestad B, Ambjornsen IK, Norheim F, Kadi F, Hallen J, Drevon CA, Raastad T: The effect of strength training volume on satellite cells, myogenic regulatory factors, and growth factors. Scand J Med Sci Sports 2012, 23:728-739.
40. Mackey AL, Kjaer M, Charifi N, Henriksson J, Bojsen-Moller J, Holm L, Kadi F: Assessment of satellite cell number and activity status in human skeletal muscle biopsies. Muscle Nerve 2009, 40:455-465.
41. Paulsen G, Lauritzen F, Bayer ML, Kalhovde JM, Ugelstad I, Owe SG, Hallen J, Bergersen LH, Raastad T: Subcellular movement and expression of HSP27, alphaB-crystallin, and HSP70 after two bouts of eccentric exercise in humans. J Appl Physiol 2009, 107:570-582.
42. Sakhi AK, Russnes KM, Smeland S, Blomhoff R, Gundersen TE: Simultaneous quantification of reduced and oxidized glutathione in plasma using a two-dimensional chromatographic system with parallel porous graphitized carbon columns coupled with fluorescence and coulometric electrochemical detection. J Chromatogr A 2006, 1104:179-189.
43. Zhang XJ, Chinkes DL, Wolfe RR: Measurement of muscle protein fractional synthesis and breakdown rates from a pulse tracer injection. Am J Physiol Endocrinol Metab 2002, 283:E753-E764.
44. Niess AM, Simon P: Response and adaptation of skeletal muscle to exercise- the role of reactive oxygen species. Front Biosci 2007, 12:4826-4838.
45. Powers SK, Lennon SL: Analysis of cellular responses to free radicals: focus on exercise and skeletal muscle. Proc Nutr Soc 1999, 58:1025-1033.
46. Diplock AT: Safety of antioxidant vitamins and beta-carotene. Am J Clin Nutr 1995, 62:1510S-1516S.
47. Garewal HS, Diplock AT: How 'safe' are antioxidant vitamins? Drug Saf 1995, 13:8-14.
48. Novotny JA, Fadel JG, Holstege DM, Furr HC, Clifford AJ: This kinetic, bioavailability, and metabolism study of RRR-alpha-tocopherol in healthy adults suggests lower intake requirements than previous estimates. J Nutr 2012, 142:2105-2111.
49. Yfanti C, Akerstrom T, Nielsen S, Nielsen AR, Mounier R, Mortensen OH, Lykkesfeldt J, Rose AJ, Fischer CP, Pedersen BK: Antioxidant supplementation does not alter endurance training adaptation. Med Sci Sports Exerc 2010, 42:1388-1395.
50. Roberts LA, Beattie K, Close GL, Morton JP: Vitamin C consumption does not impair training-induced improvements in exercise performance. Int J Sports Physiol Perform 2011, 6:58-69.
51. Ristow M, Zarse K, Oberbach A, Kloting N, Birringer M, Kiehntopf M, Stumvoll M, Kahn CR, Bluher M: Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci U S A 2009, 106:8665-8670.
52. Aguilo A, Tauler P, Sureda A, Cases N, Tur J, Pons A: Antioxidant diet supplementation enhances aerobic performance in amateur sportsmen. J Sports Sci 2007, 25:1203-1210.
53. Gomez-Cabrera MC, Domenech E, Romagnoli M, Arduini A, Borras C, Pallardo FV, Sastre J, Vina J: Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr 2008, 87:142-149.
54. Zoppi CC, Hohl R, Silva FC, Lazarim FL, Neto JM, Stancanneli M, Macedo DV: Vitamin C and e supplementation effects in professional soccer players under regular training. J Int Soc Sports Nutr 2006, 3:37-44.
55. Hunter GR, McCarthy JP, Bamman MM: Effects of resistance training on older adults. Sports Med 2004, 34:329-348.
56. Kosek DJ, Kim JS, Petrella JK, Cross JM, Bamman MM: Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults. J Appl Physiol 2006, 101:531-544.
57. Kraemer WJ, Fleck SJ, Evans WJ: Strength and power training: physiological mechanisms of adaptation. Exerc Sport Sci Rev 1996, 24:363-397.
58. Seynnes OR, De Boer M, Narici MV: Early skeletal muscle hypertrophy and architectural changes in response to high-intensity resistance training. J Appl Physiol 2007, 102:368-373.
59. Lorenz DS, Reiman MP, Walker JC: Periodization: current review and suggested implementation for athletic rehabilitation. Sports Health 2010, 2:509-518.
60. Fleck SJ: Periodized strength training: a critical review. J Strength Cond Res 1999, 13:82-89.
61. Burton GW, Traber MG, Acuff RV, Walters DN, Kayden H, Hughes L, Ingold KU: Human plasma and tissue alpha-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E. Am J Clin Nutr 1998, 67:669-684.
62. Traber MG, Ramakrishnan R, Kayden HJ: Human plasma vitamin E kinetics demonstrate rapid recycling of plasma RRR-alpha-tocopherol. Proc Natl Acad Sci U S A 1994, 91:10005-10008.
63. Mazzetti SA, Kraemer WJ, Volek JS, Duncan ND, Ratamess NA, Gomez AL, Newton RU, Hakkinen K, Fleck SJ: The influence of direct supervision of resistance training on strength performance. Med Sci Sports Exerc 2000, 32:1175-1184.
64. Staron RS, Karapondo DL, Kraemer WJ, Fry AC, Gordon SE, Falkel JE, Hagerman FC, Hikida RS: Skeletal muscle adaptations during early phase of heavy-resistance training in men and women. J Appl Physiol 1994, 76:1247-1255.
65. Wretman C, Lionikas A, Widegren U, Lannergren J, Westerblad H, Henriksson J: Effects of concentric and eccentric contractions on phosphorylation of MAPK(erk1/2) and MAPK(p38) in isolated rat skeletal muscle. J Physiol 2001, 535:155-164.
66. Maughan RJ, Depiesse F, Geyer H: The use of dietary supplements by athletes. J Sports Sci 2007, 25(Suppl 1):S103-S113.
67. Sobal J, Marquart LF: Vitamin/mineral supplement use among athletes: a review of the literature. Int J Sport Nutr 1994, 4:320-334.
68. Kennedy ET, Luo H, Houser RF: Dietary supplement use pattern of U.S. adult population in the 2007-2008 National Health and Nutrition Examination Survey (NHANES). Ecol Food Nutr 2013, 2013(52):76-84.
69. Stewart ML, McDonald JT, Levy AS, Schucker RE, Henderson DP: Vitamin/mineral supplement use: a telephone survey of adults in the United States. J Am Diet Assoc 1985, 85:1585-1590.
70. Braun H, Koehler K, Geyer H, Kleiner J, Mester J, Schanzer W: Dietary supplement use among elite young German athletes. Int J Sport Nutr Exerc Metab 2009, 19:97-109.
71. Maughan RJ, Greenhaff PL, Hespel P: Dietary supplements for athletes: emerging trends and recurring themes. J Sports Sci 2011, 29(Suppl 1):S57-S66.
72. Hemila H, Chalker E: Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 2013, 1:CD000980.
73. Wintergerst ES, Maggini S, Hornig DH: Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab 2007, 51:301-323.
74. Sebastian RS, Cleveland LE, Goldman JD, Moshfegh AJ: Older adults who use vitamin/mineral supplements differ from nonusers in nutrient intake adequacy and dietary attitudes. J Am Diet Assoc 2007, 107:1322-1332.
75. Bloomer RJ: The role of nutritional supplements in the prevention and treatment of resistance exercise-induced skeletal muscle injury. Sports Med 2007, 37:519-532.
76. Evans WJ: Vitamin E, vitamin C, and exercise. Am J Clin Nutr 2000, 72:647S-652S.