Does vitamin C and e supplementation impair the favorable adaptations of regular exercise?

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2012, Pages

  Nikolaidis, Michalis G ^a   Kerksick, Chad M ^b   Lamprecht, Manfred ^c   McAnulty, Steven R ^d  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b UNIVERSITY OF NEW MEXICO   (United States)

^c MEDICAL UNIVERSITY OF GRAZ   (Austria)

^d APPALACHIAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT NUTRIENT; EXERCISE TRAINING; FREE RADICAL PRODUCTIONS; HUMAN MODEL; PHYSIOLOGICAL ADAPTATIONS; POTENTIAL OUTCOMES; VITAMIN C;

FREE RADICALS; NUTRIENTS; PHYSIOLOGY;

VITAMINS;

ALPHA TOCOPHEROL; ASCORBIC ACID; COPPER ZINC SUPEROXIDE DISMUTASE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ADAPTATION; ANTIOXIDANT ACTIVITY; ENZYME ACTIVITY; EXERCISE; HUMAN; INSULIN SENSITIVITY; METHODOLOGY; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; REVIEW; STUDY DESIGN; VITAMIN SUPPLEMENTATION; ANIMAL; ANIMAL EXPERIMENT; DIET SUPPLEMENTATION; DRUG EFFECT; PHYSIOLOGY;

ANIMALIA;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ASCORBIC ACID; DIETARY SUPPLEMENTS; EXERCISE; HUMANS; PHYSICAL CONDITIONING, ANIMAL; VITAMIN E;

EID: 84866157093     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2012/707941     Document Type: Review

References (60)

1. Bradshaw M. P., Barril C., Clark A. C., Prenzler P. D., Scollary G. R., Ascorbic acid: a review of its chemistry and reactivity in relation to a wine environment. Critical Reviews in Food Science and Nutrition 2011 51 6 479 498 2-s2.0-79954987184 10.1080/10408391003690559
2. Jiang Z., Yin X., Jiang Q., Natural forms of vitamin E and 13′-carboxychromanol, a long-chain vitamin E metabolite, inhibit leukotriene generation from stimulated neutrophils by blocking calcium influx and suppressing 5-lipoxygenase activity, respectively. Journal of Immunology 2011 186 2 1173 1179 2-s2.0-79251568317 10.4049/jimmunol.1002342
3. Jackson M. J., Pye D., Palomero J., The production of reactive oxygen and nitrogen species by skeletal muscle. Journal of Applied Physiology 2007 102 4 1664 1670 2-s2.0-34147142547 10.1152/japplphysiol.01102.2006 (Pubitemid 46571066)
4. Powers S. K., Duarte J., Kavazis A. N., Talbert E. E., Reactive oxygen species are signalling molecules for skeletal muscle adaptation. Experimental Physiology 2010 95 1 1 9 2-s2.0-74049129489 10.1113/expphysiol.2009.050526
5. Bloomer R. J., Smith W. A., Oxidative stress in response to aerobic and anaerobic power testing: influence of exercise training and carnitine supplementation. Research in Sports Medicine 2009 17 1 1 16 2-s2.0-61949094459 10.1080/15438620802678289
6. Peternelj T. T., Coombes J. S., Antioxidant supplementation during exercise training: beneficial or detrimental? Sports Medicine 2011 41 12 1043 1069 10.2165/11594400-000000000-00000
7. Powers S. K., Ji L. L., Leeuwenburgh C., Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review. Medicine and Science in Sports and Exercise 1999 31 7 987 997 2-s2.0-0344298914 10.1097/00005768-199907000-00011 (Pubitemid 29316195)
8. Sobal J., Marquart L. F., Vitamin/mineral supplement use among athletes: a review of the literature. International Journal of Sport Nutrition 1994 4 4 320 334 2-s2.0-0028722472
9. Gomez-Cabrera M. C., Domenech E., Romagnoli M., Arduini A., Borras C., Pallardo F. V., Sastre J., Via J., Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. American Journal of Clinical Nutrition 2008 87 1 142 149 2-s2.0-38149131289
10. Ristow M., Zarse K., Oberbach A., Klöting N., Birringer M., Kiehntopf M., Stumvoll M., Kahn C. R., Blüher M., Antioxidants prevent health-promoting effects of physical exercise in humans. Proceedings of the National Academy of Sciences of the United States of America 2009 106 21 8665 8670 2-s2.0-66649109663 10.1073/pnas.0903485106
11. Higashida K., Kim S. H., Higuchi M., Holloszy J. O., Han D. H., Normal adaptations to exercise despite protection against oxidative stress. American Journal of Physiology Endocrinology and Metabolism 2011 301 5 E779 E784 10.1152/ajpendo.00655.2010
12. Roberts L. A., Beattie K., Close G. L., Morton J. P., Vitamin C consumption does not impair training-induced improvements in exercise performance. International Journal of Sports Physiology and Performance 2011 6 1 58 69 2-s2.0-79952947280
13. Ryan M. J., Dudash H. J., Docherty M., Geronilla K. B., Baker B. A., Haff G. G., Cutlip R. G., Alway S. E., Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats. Experimental Gerontology 2010 45 11 882 895 2-s2.0-77957847517 10.1016/j.exger.2010.08.002
14. Theodorou A. A., Nikolaidis M. G., Paschalis V., Koutsias S., Panayiotou G., Fatouros I. G., Koutedakis Y., Jamurtas A. Z., No effect of antioxidant supplementation on muscle performance and blood redox status adaptations to eccentric training. American Journal of Clinical Nutrition 2011 93 6 1373 1383 2-s2.0-79956334155 10.3945/ajcn.110.009266
15. Yfanti C., Åkerström T., Nielsen S., Nielsen A. R., Mounier R., Mortensen O. H., Lykkesfeldt J., Rose A. J., Fischer C. P., Pedersen B. K., Antioxidant supplementation does not alter endurance training adaptation. Medicine and Science in Sports and Exercise 2010 42 7 1388 1395 2-s2.0-77954038773 10.1249/MSS.0b013e3181cd76be
16. Yfanti C., Fischer C. P., Nielsen S., Akerstrom T., Nielsen A. R., Veskoukis A. S., Role of vitamin C and E supplementation on IL-6 in response to training. Journal of Applied Physiology 2012 112 6 990 1000 10.1152/ japplphysiol.01027.2010
17. Yfanti C., Nielsen A. R., Åkerström T., Nielsen S., Rose A. J., Richter E. A., Lykkesfeldt J., Fischer C. P., Pedersen B. K., Effect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training. American Journal of Physiology 2011 300 5 E761 E770 2-s2.0-79955562738 10.1152/ajpendo.00207.2010
18. Bailey D. M., Williams C., Betts J. A., Thompson D., Hurst T. L., Oxidative stress, inflammation and recovery of muscle function after damaging exercise: effect of 6-week mixed antioxidant supplementation. European Journal of Applied Physiology 2011 111 6 925 936 2-s2.0-79958175116 10.1007/s00421-010- 1718-x
19. Coombes J. S., Powers S. K., Rowell B., Hamilton K. L., Dodd S. L., Shanely R. A., Sen C. K., Packer L., Effects of vitamin E and α -lipoic acid on skeletal muscle contractile properties. Journal of Applied Physiology 2001 90 4 1424 1430 2-s2.0-0035100174 (Pubitemid 32220928)
20. Dumke C. L., Nieman D. C., Utter A. C., Rigby M. D., Quindry J. C., Triplett N. T., McAnulty S. R., McAnulty L. S., Quercetin's effect on cycling efficiency and substrate utilization. Applied Physiology, Nutrition and Metabolism 2009 34 6 993 1000 2-s2.0-77950899867 10.1139/H09-099
21. Gomez-Cabrera M. C., Martínez A., Santangelo G., Pallardó F. V., Sastre J., Via J., Oxidative stress in marathon runners: interest of antioxidant supplementation. The British Journal of Nutrition 2006 96 supplement 1 S31 33 2-s2.0-33750736364
22. Malm C., Svensson M., Ekblom B., Sjödin B., Effects of ubiquinone-10 supplementation and high intensity training on physical performance in humans. Acta Physiologica Scandinavica 1997 161 3 379 384 2-s2.0-0031408823 (Pubitemid 28092026)
23. Malm C., Svensson M., Sjöberg B., Ekblom B., Sjödin B., Supplementation with ubiquinone-10 causes cellular damage during intense exercise. Acta Physiologica Scandinavica 1996 157 4 511 512 2-s2.0-0029739888 (Pubitemid 26258991)
24. Nieman D. C., Henson D. A., Maxwell K. R., Williams A. S., Mcanulty S. R., Jin F., Shanely R. A., Lines T. C., Effects of quercetin and EGCG on mitochondrial biogenesis and immunity. Medicine and Science in Sports and Exercise 2009 41 7 1467 1475 2-s2.0-67650033132 10.1249/MSS.0b013e318199491f
25. Wray D. W., Uberoi A., Lawrenson L., Bailey D. M., Richardson R. S., Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome. Clinical Science 2009 116 5 433 441 2-s2.0-63449106961 10.1042/CS20080337
26. Njus D., Kelley P. M., Vitamins C and E donate single hydrogen atoms in vivo. FEBS Letters 1991 284 2 147 151 2-s2.0-0025803598 10.1016/0014-5793(91) 80672-P
27. Buettner G. R., The pecking order of free radicals and antioxidants: lipid peroxidation, α -tocopherol, and ascorbate. Archives of Biochemistry and Biophysics 1993 300 2 535 543 2-s2.0-0027251053 10.1006/abbi.1993.1074 (Pubitemid 23232908)
28. Halliwell B., Gutteridge J., Free Radicals in Biology and Medicine 2007 New York, NY, USA Oxford University Press
29. Asha Devi S., Prathima S., Subramanyam M. V., Dietary vitamin E and physical exercise: I. Altered endurance capacity and plasma lipid profile in ageing rats. Experimental Gerontology 2003 38 3 285 290 2-s2.0-0037361131 10.1016/S0531-5565(02)00206-1 (Pubitemid 36170323)
30. Asha Devi S., Prathima S., Subramanyam M. V., Dietary vitamin E and physical exercise: II. Antioxidant status and lipofuscin-like substances in aging rat heart. Experimental Gerontology 2003 38 3 291 297 2-s2.0-0037359647 10.1016/S0531-5565(02)00207-3 (Pubitemid 36170324)
31. Holloszy J. O., Higashida K., Kim S. H., Higuchi M., Han D. H., Response to letter to the editor by Gomez-Cabrera et al. American Journal of Physiology Endocrinology and Metabolism 2012 302 E478 E479 10.1152/ajpendo.00596.2011
32. Nikolaidis M. G., Jamurtas A. Z., Paschalis V., Fatouros I. G., Koutedakis Y., Kouretas D., The effect of muscle-damaging exercise on blood and skeletal muscle oxidative stress: magnitude and time-course considerations. Sports Medicine 2008 38 7 579 606 2-s2.0-45549092340 10.2165/00007256-200838070- 00005 (Pubitemid 351861946)
33. Nikolaidis M. G., Kyparos A., Spanou C., Paschalis V., Theodorou A. A., Vrabas I. S., Redox biology of exercise: an integrative and comparative consideration of some overlooked issues. The Journal of Experimental Biology 2012 215 10 1615 1625 10.1242/jeb.067470
34. Nikolaidis M. G., Paschalis V., Giakas G., Fatouros I. G., Koutedakis Y., Kouretas D., Jamurtas A. Z., Decreased blood oxidative stress after repeated muscle-damaging exercise. Medicine and Science in Sports and Exercise 2007 39 7 1080 1089 2-s2.0-34347363142 10.1249/mss.0b013e31804ca10c (Pubitemid 47014136)
35. Buettner G. R., The pecking order of free radicals and antioxidants: lipid peroxidation, α -tocopherol, and ascorbate. Archives of Biochemistry and Biophysics 1993 300 2 535 543 2-s2.0-0027251053 10.1006/abbi.1993.1074 (Pubitemid 23232908)
36. Gaeini A. A., Rahnama N., Hamedinia M. R., Effects of vitamin E supplementation on oxidative stress at rest and after exercise to exhaustion in athletic students. Journal of Sports Medicine and Physical Fitness 2006 46 3 458 461 2-s2.0-33750214346 (Pubitemid 44606457)
37. Nieman D. C., Henson D. A., McAnulty S. R., McAnulty L., Swick N. S., Utter A. C., Vinci D. M., Opiela S. J., Morrow J. D., Influence of vitamin C supplementation on oxidative and immune changes after an ultramarathon. Journal of Applied Physiology 2002 92 5 1970 1977 2-s2.0-0036085668 (Pubitemid 34666424)
38. Teixeira V. H., Valente H. F., Casal S. I., Marques A. F., Moreira P. A., Antioxidants do not prevent postexercise peroxidation and may delay muscle recovery. Medicine and Science in Sports and Exercise 2009 41 9 1752 1760 2-s2.0-69349095111 10.1249/MSS.0b013e31819fe8e3
39. Thompson D., Williams C., Garcia-Roves P., McGregor S. J., McArdle F., Jackson M. J., Post-exercise vitamin C supplementation and recovery from demanding exercise. European Journal of Applied Physiology 2003 89 3-4 393 400 2-s2.0-0038650491 (Pubitemid 36748701)
40. Thompson D., Williams C., Kingsley M., Nicholas C. W., Lakomy H. K. A., McArdle F., Jackson M. J., Muscle soreness and damage parameters after prolonged intermittent shuttle-running following acute vitamin C supplementation. International Journal of Sports Medicine 2001 22 1 68 75 2-s2.0-0035131772 10.1055/s-2001-11358 (Pubitemid 32147446)
41. Avery N. G., Kaiser J. L., Sharman M. J., Scheett T. P., Barnes D. M., Gomez A. L., Effects of vitamin E supplementation on recovery from repeated bouts of resistance exercise. Journal of Strength and Conditioning Research 2003 17 4 801 809 (Pubitemid 37524267)
42. Bryer S. C., Goldfarb A. H., Effect of high dose vitamin C supplementation on muscle soreness, damage, function, and oxidative stress to eccentric exercise. International Journal of Sport Nutrition and Exercise Metabolism 2006 16 3 270 280 2-s2.0-33745447391 (Pubitemid 43953298)
43. Maxwell S. R. J., Jakeman P., Thomason H., Leguen C., Thorpe G. H. G., Changes in plasma antioxidant status during eccentric exercise and the effect of vitamin supplementation. Free Radical Research Communications 1993 19 3 191 202 2-s2.0-0027331072
44. McBride J. M., Kraemer W. J., Triplett-McBride T., Sebastianelli W., Effect of resistance exercise on free radical production. Medicine and Science in Sports and Exercise 1998 30 1 67 72 2-s2.0-0031917043 10.1097/00005768- 199801000-00010 (Pubitemid 28071385)
45. Sacheck J. M., Milbury P. E., Cannon J. G., Roubenoff R., Blumberg J. B., Effect of vitamin E and eccentric exercise on selected biomarkers of oxidative stress in young and elderly men. Free Radical Biology and Medicine 2003 34 12 1575 1588 2-s2.0-0037683669 10.1016/S0891-5849(03)00187-4 (Pubitemid 36638717)
46. Lamprecht M., Hofmann P., Greilberger J. F., Schwaberger G., Increased lipid peroxidation in trained men after 2 weeks of antioxidant supplementation. International Journal of Sport Nutrition and Exercise Metabolism 2009 19 4 385 399 2-s2.0-68249116840
47. Nieman D. C., Henson D. A., McAnulty S. R., McAnulty L. S., Morrow J. D., Ahmed A., Heward C. B., Vitamin E and immunity after the Kona Triathlon World Championship. Medicine and Science in Sports and Exercise 2004 36 8 1328 1335 2-s2.0-3543021462 10.1249/01.MSS.0000135778.57355.CA (Pubitemid 39014816)
48. Bloomer R. J., Falvo M. J., Fry A. C., Schilling B. K., Smith W. A., Moore C. A., Oxidative stress response in trained men following repeated squats or sprints. Medicine and Science in Sports and Exercise 2006 38 8 1436 1442 2-s2.0-33747073796 10.1249/01.mss.0000227408.91474.77 (Pubitemid 44215752)
49. Farney T. M., McCarthy C. G., Canale R. E., Schilling B. K., Whitehead P. N., Bloomer R. J., Absence of blood oxidative stress in trained men following strenuous exercise. Medicine and Science in Sports and Exercise. In press
50. Shin Y. A., Lee J. H., Song W., Jun T. W., Exercise training improves the antioxidant enzyme activity with no changes of telomere length. Mechanisms of Ageing and Development 2008 129 5 254 260 2-s2.0-41249100160 10.1016/j.mad.2008.01.001
51. Ayres S., Baer J., Subbiah M. T. R., Exercised-induced increase in lipid peroxidation parameters in amenorrheic female athletes. Fertility and Sterility 1998 69 1 73 77 2-s2.0-0031905758 10.1016/S0015-0282(97)00428-7 (Pubitemid 28072996)
52. Petersen A. C., McKenna M. J., Medved I., Murphy K. T., Brown M. J., Della Gatta P., Infusion with the antioxidant N-acetylcysteine attenuates early adaptive responses to exercise in human skeletal muscle. Acta Physiologica 2012 204 3 382 392 10.1111/j.1748-1716.2011.02344.x
53. Kalafati M., Jamurtas A. Z., Nikolaidis M. G., Paschalis V., Theodorou A. A., Sakellariou G. K., Koutedakis Y., Kouretas D., Ergogenic and antioxidant effects of spirulina supplementation in humans. Medicine and Science in Sports and Exercise 2010 42 1 142 151 2-s2.0-73449122238 10.1249/MSS.0b013e3181ac7a45
54. Nieman D. C., Williams A. S., Shanely R. A., Jin F., McAnulty S. R., Triplett N. T., Austin M. D., Henson D. A., Quercetin's influence on exercise performance and muscle mitochondrial biogenesis. Medicine and Science in Sports and Exercise 2010 42 2 338 345 2-s2.0-75149152490 10.1249/MSS.0b013e3181b18fa3
55. Eichenberger P., Mettler S., Arnold M., Colombani P. C., No effects of three-week consumption of a green tea extract on time trial performance in endurance-trained men. International Journal for Vitamin and Nutrition Research 2010 80 1 54 64 2-s2.0-77953483917 10.1024/0300-9831/a000006
56. Ostojic S. M., Stojanovic M. D., Djordjevic B., Jourkesh M., Vasiljevic N., The effects of a 4-week coffeeberry supplementation on antioxidant status, endurance, and anaerobic performance in college athletes. Research in Sports Medicine 2008 16 4 281 294 2-s2.0-57749098989 10.1080/15438620802523345
57. Fortes C., Virgili F., Antioxidant vitamins are not 'just antioxidants': not necessarily harmful when targeted to the right population. BioFactors 2008 33 3 177 180 2-s2.0-67650674099 10.1002/biof.5520330303
58. Calabrese E. J., Baldwin L. A., Hormesis: U-shaped dose responses and their centrality in toxicology. Trends in Pharmacological Sciences 2001 22 6 285 291 2-s2.0-0035365892 10.1016/S0165-6147(00)01719-3 (Pubitemid 32536728)
59. Radak Z., Chung H. Y., Goto S., Exercise and hormesis: oxidative stress-related adaptation for successful aging. Biogerontology 2005 6 1 71 75 2-s2.0-20044379872 10.1007/s10522-004-7386-7 (Pubitemid 41583294)
60. Radak Z., Chung H. Y., Koltai E., Taylor A. W., Goto S., Exercise, oxidative stress and hormesis. Ageing Research Reviews 2008 7 1 34 42 2-s2.0-37749053882 10.1016/j.arr.2007.04.004