CrossTalk proposal: The dominant mechanism causing disuse muscle atrophy is decreased protein synthesis

Journal of Physiology

Volumn 592, Issue 24, 2014, Pages 5341-5343

  Phillips, Stuart M ^a   Mcglory, Chris ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSPORT; AMINOACIDEMIA; ARTICLE; BED REST; CYTOKINE STORM; HUMAN; HYPERCORTISOLISM; IMMOBILITY; MUSCLE ATROPHY; MUSCLE CELL; MUSCLE CONTRACTION; MUSCLE MASS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; SPECIES DIFFERENCE; GENETICS; METABOLISM; MUSCULAR DISORDERS, ATROPHIC;

MUSCLE PROTEIN;

HUMANS; MUSCLE PROTEINS; MUSCULAR DISORDERS, ATROPHIC; PROTEIN BIOSYNTHESIS;

EID: 84916624254     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2014.273615     Document Type: Article

References (25)

1. Adams GR, Caiozzo VJ & Baldwin KM (2003). Skeletal muscle unweighting: spaceflight and ground-based models. J Appl Physiol (1985) 95, 2185-2201.
2. Bohe J, Low JF, Wolfe RR & Rennie MJ (2001). Latency and duration of stimulation of human muscle protein synthesis during continuous infusion of amino acids. J Physiol 532, 575-579.
3. Breen L, Stokes KA, Churchward-Venne TA, Moore DR, Baker SK, Smith K, Atherton PJ & Phillips SM (2013). Two weeks of reduced activity decreases leg lean mass and induces 'anabolic resistance' of myofibrillar protein synthesis in healthy elderly. J Clin Endocrinol Metab 98, 2604-2612.
4. de Boer MD, Selby A, Atherton P, Smith K, Seynnes OR, Maganaris CN, Maffulli N, Movin T, Narici MV & Rennie MJ (2007). The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse. J Physiol 585, 241-251.
5. Drummond MJ, Dickinson JM, Fry CS, Walker DK, Gundermann DM, Reidy PT, Timmerman KL, Markofski MM, Paddon-Jones D, Rasmussen BB & Volpi E (2012). Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults. Am J Physiol Endocrinol Metab 302, E1113-E1122.
6. Ferrando AA, Lane HW, Stuart CA, vis-Street J & Wolfe RR (1996). Prolonged bed rest decreases skeletal muscle and whole body protein synthesis. Am J Physiol Endocrinol Metab 270, E627-E633.
7. Fujita S, Dreyer HC, Drummond MJ, Glynn EL, Cadenas JG, Yoshizawa F, Volpi E & Rasmussen BB (2007). Nutrient signalling in the regulation of human muscle protein synthesis. J Physiol 582, 813-823.
8. Garlick PJ, Maltin CA, Baillie AG, Delday MI & Grubb DA (1989). Fiber-type composition of nine rat muscles. II. Relationship to protein turnover. Am J Physiol Endocrinol Metab 257, E828-E832.
9. Gibson JN, Halliday D, Morrison WL, Stoward PJ, Hornsby GA, Watt PW, Murdoch G & Rennie MJ (1987). Decrease in human quadriceps muscle protein turnover consequent upon leg immobilization. Clin Sci (Lond) 72, 503-509.
10. Gibson JN, Smith K & Rennie MJ (1988). Prevention of disuse muscle atrophy by means of electrical stimulation: maintenance of protein synthesis. Lancet 2, 767-770.
11. Glover EI, Phillips SM, Oates BR, Tang JE, Tarnopolsky MA, Selby A, Smith K & Rennie MJ (2009). Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion. J Physiol 586, 6049-6061.
12. Koopman R, Gleeson BG, Gijsen AP, Groen B, Senden JM, Rennie MJ & van Loon LJ (2011). Post-exercise protein synthesis rates are only marginally higher in type I compared with type II muscle fibres following resistance-type exercise. Eur J Appl Physiol 111, 1871-1878.
13. Krogh-Madsen R, Thyfault JP, Broholm C, Mortensen OH, Olsen RH, Mounier R, Plomgaard P, van Hall G, Booth FW & Pedersen BK (2010). A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity. J Appl Physiol (1985) 108, 1034-1040.
14. Lecker SH, Jagoe RT, Gilbert A, Gomes M, Baracos V, Bailey J, Price SR, Mitch WE & Goldberg AL (2004). Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. FASEB J 18, 39-51.
15. Mittendorfer B, Andersen JL, Plomgaard P, Saltin B, Babraj JA, Smith K & Rennie MJ (2005). Protein synthesis rates in human muscles: neither anatomical location nor fibre-type composition are major determinants. J Physiol 563, 203-211.
16. Oates BR, Glover EI, West DW, Fry JL, Tarnopolsky MA & Phillips SM (2010). Low-volume resistance exercise attenuates the decline in strength and muscle mass associated with immobilization. Muscle Nerve 42, 539-546.
17. Paddon-Jones D, Sheffield-Moore M, Cree MG, Hewlings SJ, Aarsland A, Wolfe RR & Ferrando AA (2006). Atrophy and impaired muscle protein synthesis during prolonged inactivity and stress. J Clin Endocrinol Metab 91, 4836-4841.
18. Paddon-Jones D, Sheffield-Moore M, Urban RJ, Aarsland A, Wolfe RR & Ferrando AA (2005). The catabolic effects of prolonged inactivity and acute hypercortisolemia are offset by dietary supplementation. J Clin Endocrinol Metab 90, 1453-1459.
19. Paddon-Jones D, Sheffield-Moore M, Urban RJ, Sanford AP, Aarsland A, Wolfe RR & Ferrando AA (2004). Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest. J Clin Endocrinol Metab 89, 4351-4358.
20. Pasini E, Aquilani R, Dioguardi FS, D'Antona G, Gheorghiade M & Taegtmeyer H (2008). Hypercatabolic syndrome: molecular basis and effects of nutritional supplements with amino acids. Am J Cardiol 101, 11E-15E.
21. Phillips SM, Glover EI & Rennie MJ (2009). Alterations of protein turnover underlying disuse atrophy in human skeletal muscle. J Appl Physiol 107, 643-654.
22. Symons TB, Sheffield-Moore M, Chinkes DL, Ferrando AA & Paddon-Jones D (2009). Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravity. J Appl Physiol 107, 34-38.
23. Thomason DB, Biggs RB & Booth FW (1989). Protein metabolism and beta-myosin heavy-chain mRNA in unweighted soleus muscle. Am J Physiol Regul Integr Comp Physiol 257, R300-R305.
24. Wall BT, Snijders T, Senden JM, Ottenbros CL, Gijsen AP, Verdijk LB & van Loon LJ (2013). Disuse impairs the muscle protein synthetic response to protein ingestion in healthy men. J Clin Endocrinol Metab 98, 4872-4881.
25. 2O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein sub-fraction synthesis in humans. Am J Physiol Endocrinol Metab 306, E571-E579.