Exercise training in Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus: Effects on the B-cell mass, insulin content and fibrosis in the pancreas

Diabetes Research and Clinical Practice

Volumn 35, Issue 1, 1997, Pages 11-19

  Shima, Kenji ^a   Min, Zhu ^a   Noma, Yoshihiko ^a   Mizuno, Akira ^a   Murakami, Takashi ^a   Sano, Toshiaki ^a   Kuwajima, Masamichi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

B cell mass; exercise; fibrosis and OLETF rat; insulin content

Indexed keywords

INSULIN;

ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CYSTIC FIBROSIS; EXERCISE; HISTOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS; RAT;

EID: 0031079718     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8227(96)01357-5     Document Type: Article

References (23)

1. [1] Tan, M.H., Bonen, A., Garner, J.B. and Belcastro, A.N. (1982) Physical training in diabetic rats: effects on glucose tolerance and serum lipids. J. Appl. Physiol. 52, 1514-1518.
2. [2] Laurie, J.G., Michael, F.H. and Elizabeth, D.H. (1991) Exercise training normalizes glucose metabolism in a rat model of impaired glucose tolerance. Metabolism 40, 455-464.
3. [3] Tancrede, G., Rousseau-Migneron, S. and Nadeau, A. (1982) Beneficial effects of physical training in rats with a mild streptozotocin-induced diabetes mellitus. Diabetes 31, 406-409.
4. [4] Dall'aglio, E., Chang, F., Chang, H., Wright, D. and Reaven, G.M. (1983) Effect of exercise training and sucrose feeding on insulin stimulated glucose uptake in rats with streptozotocin-induced insulin-deficient diabetes. Diabetes 32, 165-168.
5. [5] Reaven, G.M. and Chang, F. (1981) Effect of exercise-training on the metabolic manifestations of streptozotocin-induced diabetes in the rat. Diabetologia 21, 415-417.
6. [6] Goodyear, L.J., Hirshman, M.F., Knutson, S.M., Horton, E.D. and Horton, E.S. (1988) Effect of exercise training on glucose homeostasis in normal and insulin deficient diabetic rats. J. Appl. Physiol. 65, 844-851.
7. [7] Vallerand, A.L., Lupien, J., Deshaies, Y. and Bukowiecki, L.J. (1986) Intensive exercise training does not improve glucose tolerance in severely diabetic rats. Horm. Metab. Res. 18, 79-81.
8. [8] Berger, M., Kemmer, F.W., Becker, K. Herberg, L., Schwenen, M., Gjinavci, A. and Berchtold, P. (1979) Effect of physical training on glucose tolerance and on glucose metabolism of skeletal muscle in anesthetized normal rats. Diabetologia 16, 179-184.
9. [9] Mondon, C.E., Dolkas, C.B. and Reaven, G.M. (1980) Site of enhanced insulin sensitivity in exercise-training rats at rest. Am. J. Physiol. 239, E169-E177.
10. [10] Ivy. J.L., Young, J.C., McLane, J.A., Fell, R.D. and Holloszy, J.O. (1983) Exercise training and glucose uptake by skeletal muscle in rats. J. Appl. Physiol. 55, 1393-1396.
11. [11] Shima, K., Shi, K., Sano, T., Iwami. T., Mizuno, A. and Noma, Y. (1993) Is exercise training effective in preventing diabetes mellitus in the Otsuka-Eong-Evans-Tokushima Fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus? Metabolism 42, 971-977.
12. [12] Shima, K., Shi. K., Mizuno, A., Sano, T., Ishida, K. and Yoshimoto, S. (1994) Effects of difference in amount of exercise training on prevention diabetes mellitus in the Otsuka-Long-Evans-Tokushima Fatty rats, a model of spontaneous non-insulin-dcpcndent diabetes mellitus. Diabetes Res. Clin. Pract. 23, 147-154.
13. [13] Weir, G.C., Bonner-Weir, S. and Leahy, J.E. (1990) Islet mass and function in diabetes and transplantation. Diabetes 39, 401-405.
14. [14] Zhu, M., Noma, Y., Mizuno, A., Sano, T. and Shima, K. (1996) Poor capacity for proliferation of pancreatic B-cells in Otsuka-Eong-Evans-Tokushima Fatty rat: a model of spontaneous NIDDM. Diabetes 45: 941-946.
15. [15] Kawano, K., Hirashima, T., Mori, S., Saitoh, Y., Kurosumi, M. and Notori, T. (1992) Spontaneous long-term hyperglycemic rat with diabetic complications: Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 41, 1422-1428.
16. [16] Weibel, E.R. (1963) Principles and methods for the morphometric studies of the lung and other organs. Lab. Invest. 12, 131-155.
17. [17] Swenne, I. (1982) The role of glucose in the in vitro regulation of cell cycle kinetics and proliferation of fetal pancreatic B-cells. Diabetes 31, 754-760.
18. [18] McDowell, E.M., DeSanti, A.M. and Strum, J.M. (1989) Correlations between blood glucose levels and bromodeoxyuridine labeling indices of pancreatic islet cells following streptozotocin administration to pregnant Syrian golden hamsters. Virchows Archiv. B Cell Pathol. 57, 223-230.
19. [19] Bonner-Weir, S., Deery, D., Leahy, J.L. and Weir G.C. (1989) Compensatory growth of pancreatic B-cells in adult rats after short-term glucose infusion. Diabetes 38, 49-53.
20. [20] Bonner-Weir, S., Trent, D.F. and Weir. G.C. (1983) Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J. Clin. Invest, 71: 1544-1553.
21. [21] Shima, K., Hirota, M., Sano, T., Iwami, T. and Oshima, I. (1987) Effect of exercise training on insulin and glucagon release from perfused rat pancreas. Horm. Metabol. Res. 19, 395-452.
22. [22] Ishida, K., Mizuno, A., Zhu, M., Sano, T. and Shima, K. (1995) Which is the primary euologic event in Otsuka Long-Evans-Tokushima Fatty rats, a model of spontaneous, non-insulin-dependent diabetes mellitus, insulin resistance or impaired insulin secretion? Metabolism 44, 940-945.
23. [23] Legg, M.A. and Harawi, S.J. (1985) The pathology of diabetes mellitus. In: A.L. Marble, P. Krall, R.F. Bradley, A.R. Christlieb, J.S. Soeldner, E. (Eds.), Lea and Febigen, Philadelphia, Joslin's Diabetes Mellitus, pp. 298-307