Quercetin enhances adriamycin cytotoxicity through induction of apoptosis and regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase/c-Jun N-terminal kinase signaling in multidrug-resistant leukemia K562 cells

Molecular Medicine Reports

Volumn 11, Issue 1, 2015, Pages 341-348

  Chen, Fang Yuan ^a   Cao, Lan Fang ^a   Wan, Hai Xia ^a   Zhang, Min Yue ^a   Cai, Jia Yi ^a   Shen, Li Jing ^a   Zhong, Ji Hua ^a   Zhong, Hua ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Human leukemia; Multidrug resistance; Quercetin

Indexed keywords

BIM PROTEIN; CASPASE 3; CASPASE 8; CASPASE 9; DOXORUBICIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MULTIDRUG RESISTANCE PROTEIN; PROCASPASE 9; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; QUERCETIN; RHODAMINE 123; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; CANCER RESISTANCE; CELL COUNTING; CELL PROLIFERATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC50; K562 CELL LINE; LEUKEMIA; MITOCHONDRIAL MEMBRANE POTENTIAL; MULTIDRUG RESISTANCE; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WESTERN BLOTTING; DRUG EFFECTS; DRUG RESISTANCE; METABOLISM;

APOPTOSIS; CELL PROLIFERATION; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; HUMANS; K562 CELLS; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; P-GLYCOPROTEINS; QUERCETIN;

EID: 84916237923     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2734     Document Type: Article

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