Nutritional assessment and therapy in COPD: A European respiratory society statement

European Respiratory Journal

Volumn 44, Issue 6, 2014, Pages 1504-1520

  Schols, Annemie M ^a   Ferreira, Ivone M ^b,c   Franssen, Frits M ^d   Gosker, Harry R ^a   Janssens, Wim ^e   Muscaritoli, Maurizio ^f   Pison, Christophe ^g,h,i,j   Rutten Van Mölken, Maureen ^k   Slinde, Frode ^l   Steiner, Michael C ^m   Tkacova, Ruzena ^n,o   Singh, Sally J ^m  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b TORONTO WESTERN HOSPITAL   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

^d Centre of Expertise for Chronic Organ Failure   (Netherlands)

^e UNIVERSITY OF LEUVEN   (Belgium)

^f SAPIENZA UNIVERSITY OF ROME   (Italy)

^g GRENOBLE UNIVERSITY HOSPITAL   (France)

^h Domaine Universitaire   (France)

ⁱ UNIV GRENOBLE ALPES   (France)

^j European Institute of Systems Biology and Medicine   (France)

^k ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^l UNIVERSITY OF GOTHENBURG   (Sweden)

^m GLENFIELD HOSPITAL   (United Kingdom)

ⁿ Med Faculty of Safarik University   (Slovakia)

^o L PASTEUR UNIVERSITY HOSPITAL   (Slovakia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

OSTEOCLAST DIFFERENTIATION FACTOR; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B;

ABDOMINAL FAT; ARTICLE; AWARENESS; BODY COMPOSITION; BONE DENSITY; BONE MASS; CACHEXIA; CHRONIC OBSTRUCTIVE LUNG DISEASE; COST EFFECTIVENESS ANALYSIS; DIETARY INTAKE; DUAL ENERGY X RAY ABSORPTIOMETRY; ENERGY EXPENDITURE; EUROPEAN; EXERCISE; FAT FREE MASS; FEEDING BEHAVIOR; HEALTH CARE DELIVERY; HEALTH PROGRAM; HUMAN; HYDRODYNAMICS; INTRAABDOMINAL FAT; LIFESTYLE MODIFICATION; MEDICAL SOCIETY; MORTALITY; MUSCLE ATROPHY; MUSCLE CONTRACTION; MUSCLE MASS; MUSCLE STRENGTH; MUSCLE WEAKNESS; NUTRITIONAL ASSESSMENT; OBESITY; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PHENOTYPE; PHYSICAL PERFORMANCE; PRACTICE GUIDELINE; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; REIMBURSEMENT; SARCOPENIA; SYSTEMATIC REVIEW; ADVISORY COMMITTEE; COMPLICATION; DIET THERAPY; EUROPE; NUTRITION DISORDERS; NUTRITIONAL STATUS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RISK FACTOR;

ADVISORY COMMITTEES; BODY COMPOSITION; CACHEXIA; EUROPE; EXERCISE; HUMANS; NUTRITION ASSESSMENT; NUTRITION DISORDERS; NUTRITIONAL STATUS; OBESITY; PHENOTYPE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RISK FACTORS; SARCOPENIA; SOCIETIES, MEDICAL;

EID: 84916234213     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00070914     Document Type: Article

References (128)

1. Vestbo J, Hurd SS, Agusti AG, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2013; 187: 347-365.
2. Vanfleteren LE, Spruit MA, Groenen M, et al. Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013; 187: 728-735.
3. Burgel PR, Paillasseur JL, Peene B, et al. Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality. PLoS One 2012; 7: e51048.
4. Filley GF, Beckwitt HJ, Reeves JT, et al. Chronic obstructive bronchopulmonary disease. II. Oxygen transport in two clinical types. Am J Med 1968; 44: 26-38.
5. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010; 39: 412-423.
6. Evans WJ, Morley JE, Argiles J, et al. Cachexia: a new definition. Clin Nutr 2008; 27: 793-799.
7. Muscaritoli M, Anker SD, Argiles J, et al. Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) ''cachexia-anorexia in chronic wasting diseases'' and ''nutrition in geriatrics''. Clin Nutr 2010; 29: 154-159.
8. Berrington de Gonzalez A, Hartge P, Cerhan JR, et al. Body-mass index and mortality among 1.46 million white adults. N Engl J Med 2010; 363: 2211-2219.
9. Whitlock G, Lewington S, Sherliker P, et al. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 2009; 373: 1083-1096.
10. Vestbo J, Prescott E, Almdal T, et al. Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study. Am J Respir Crit Care Med 2006; 173: 79-83.
11. Morley JE, Abbatecola AM, Argiles JM, et al. Sarcopenia with limited mobility: an international consensus. J Am Med Dir Assoc 2011; 12: 403-409.
12. Stratton RJ, Hackston A, Longmore D, et al. Malnutrition in hospital outpatients and inpatients: prevalence, concurrent validity and ease of use of the ''malnutrition universal screening tool'' (''MUST'') for adults. Br J Nutr 2004; 92: 799-808.
13. Vellas B, Villars H, Abellan G, et al. Overview of the MNA -its history and challenges. J Nutr Health Aging 2006; 10: 456-463.
14. Landbo C, Prescott E, Lange P, et al. Prognostic value of nutritional status in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999; 160: 1856-1861.
15. Schols AM, Slangen J, Volovics L, et al. Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 157: 1791-1797.
16. Lainscak M, von Haehling S, Doehner W, et al. Body mass index and prognosis in patients hospitalized with acute exacerbation of chronic obstructive pulmonary disease. J Cachexia Sarcopenia Muscle 2011; 2: 81-86.
17. Ora J, Laveneziana P, Wadell K, et al. Effect of obesity on respiratory mechanics during rest and exercise in COPD. J Appl Physiol (1985) 2011; 111: 10-19.
18. Schols AM, Broekhuizen R, Weling-Scheepers CA, et al. Body composition and mortality in chronic obstructive pulmonary disease. Am J Clin Nutr 2005; 82: 53-59.
19. Engelen MP, Schols AM, Lamers RJ, et al. Different patterns of chronic tissue wasting among patients with chronic obstructive pulmonary disease. Clin Nutr 1999; 18: 275-280.
20. van den Borst B, Gosker HR, Koster A, et al. The influence of abdominal visceral fat on inflammatory pathways and mortality risk in obstructive lung disease. Am J Clin Nutr 2012; 96: 516-526.
21. Bolton CE, Ionescu AA, Shiels KM, et al. Associated loss of fat-free mass and bone mineral density in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2004; 170: 1286-1293.
22. Maltais F, Decramer M, Casaburi R, et al. An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2014; 189: e15-e62.
23. Schols A, Mostert R, Cobben N, et al. Transcutaneous oxygen saturation and carbon dioxide tension during meals in patients with chronic obstructive pulmonary disease. Chest 1991; 100: 1287-1292.
24. Gronberg AM, Slinde F, Engstrom CP, et al. Dietary problems in patients with severe chronic obstructive pulmonary disease. J Hum Nutr Diet 2005; 18: 445-452.
25. Goris AH, Vermeeren MA, Wouters EF, et al. Energy balance in depleted ambulatory patients with chronic obstructive pulmonary disease: the effect of physical activity and oral nutritional supplementation. Br J Nutr 2003; 89: 725-731.
26. Schols AM, Soeters PB, Mostert R, et al. Energy balance in chronic obstructive pulmonary disease. Am Rev Respir Dis 1991; 143: 1248-1252.
27. Kao CC, Hsu JW, Bandi V, et al. Resting energy expenditure and protein turnover are increased in patients with severe chronic obstructive pulmonary disease. Metabolism 2011; 60: 1449-1455.
28. Layec G, Haseler LJ, Hoff J, et al. Evidence that a higher ATP cost of muscular contraction contributes to the lower mechanical efficiency associated with COPD: preliminary findings. Am J Physiol Regul Integr Comp Physiol 2011; 300: R1142-R1147.
29. Baarends EM, Schols AM, Akkermans MA, et al. Decreased mechanical efficiency in clinically stable patients with COPD. Thorax 1997; 52: 981-986.
30. Baarends EM, Schols AM, Pannemans DL, et al. Total free living energy expenditure in patients with severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1997; 155: 549-554.
31. Kim V, Kretschman DM, Sternberg AL, et al. Weight gain after lung reduction surgery is related to improved lung function and ventilatory efficiency. Am J Respir Crit Care Med 2012; 186: 1109-1116.
32. Efthimiou J, Mounsey PJ, Benson DN, et al. Effect of carbohydrate rich versus fat rich loads on gas exchange and walking performance in patients with chronic obstructive lung disease. Thorax 1992; 47: 451-456.
33. Rutten EP, Franssen FM, Engelen MP, et al. Greater whole-body myofibrillar protein breakdown in cachectic patients with chronic obstructive pulmonary disease. Am J Clin Nutr 2006; 83: 829-834.
34. Langen RC, Gosker HR, Remels AH, et al. Triggers and mechanisms of skeletal muscle wasting in chronic obstructive pulmonary disease. Int J Biochem Cell Biol 2013; 45: 2245-2256.
35. Guo Y, Gosker HR, Schols AM, et al. Autophagy in locomotor muscles of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013; 188: 1313-1320.
36. Jonker R, Deutz NE, Erbland ML, et al. Hydrolyzed casein and whey protein meals comparably stimulate net whole-body protein synthesis in COPD patients with nutritional depletion without an additional effect of leucine co-ingestion. Clin Nutr 2014; 33: 211-220.
37. Engelen MP, Wouters EF, Deutz NE, et al. Factors contributing to alterations in skeletal muscle and plasma amino acid profiles in patients with chronic obstructive pulmonary disease. Am J Clin Nutr 2000; 72: 1480-1487.
38. Engelen MP, De Castro CL, Rutten EP, et al. Enhanced anabolic response to milk protein sip feeding in elderly subjects with COPD is associated with a reduced splanchnic extraction of multiple amino acids. Clin Nutr 2012; 31: 616-624.
39. Rutten EP, Lenaerts K, Buurman WA, et al. Disturbed intestinal integrity in patients with COPD; effects of activities of daily living. Chest 2013; 145: 245-252.
40. Engelen MP, Rutten EP, De Castro CL, et al. Supplementation of soy protein with branched-chain amino acids alters protein metabolism in healthy elderly and even more in patients with chronic obstructive pulmonary disease. Am J Clin Nutr 2007; 85: 431-439.
41. Engelen MP, Deutz NE, Mostert R, et al. Response of whole-body protein and urea turnover to exercise differs between patients with chronic obstructive pulmonary disease with and without emphysema. Am J Clin Nutr 2003; 77: 868-874.
42. Sambrook P, Cooper C. Osteoporosis. Lancet 2006; 367: 2010-2018.
43. Lehouck A, Boonen S, Decramer M, et al. COPD, bone metabolism, and osteoporosis. Chest 2011; 139: 648-657.
44. Graat-Verboom L, Wouters EF, Smeenk FW, et al. Current status of research on osteoporosis in COPD: a systematic review. Eur Respir J 2009; 34: 209-218.
45. Graat-Verboom L, Smeenk FW, van den Borne BE, et al. Risk factors for osteoporosis in Caucasian patients with moderate chronic obstructive pulmonary disease: a case control study. Bone 2012; 50: 1234-1239.
46. Bon J, Fuhrman CR, Weissfeld JL, et al. Radiographic emphysema predicts low bone mineral density in a tobaccoexposed cohort. Am J Respir Crit Care Med 2011; 183: 885-890.
47. Makita H, Nasuhara Y, Nagai K, et al. Characterisation of phenotypes based on severity of emphysema in chronic obstructive pulmonary disease. Thorax 2007; 62: 932-937.
48. Ohara T, Hirai T, Muro S, et al. Relationship between pulmonary emphysema and osteoporosis assessed by CT in patients with COPD. Chest 2008; 134: 1244-1249.
49. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 2001; 22: 477-501.
50. Franco CB, Paz-Filho G, Gomes PE, et al. Chronic obstructive pulmonary disease is associated with osteoporosis and low levels of vitamin D. Osteoporos Int 2009; 20: 1881-1887.
51. Rachner TD, Khosla S, Hofbauer LC. Osteoporosis: now and the future. Lancet 2011; 377: 1276-1287.
52. McGarvey LP, John M, Anderson JA, et al. Ascertainment of cause-specific mortality in COPD: operations of the TORCH Clinical Endpoint Committee. Thorax 2007; 62: 411-415.
53. van den Borst B, Gosker HR, Wesseling G, et al. Low-grade adipose tissue inflammation in patients with mild-tomoderate chronic obstructive pulmonary disease. Am J Clin Nutr 2011; 94: 1504-1512.
54. van den Borst B, Gosker HR, Schols AM. Central fat and peripheral muscle: partners in crime in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013; 187: 8-13.
55. Bautista J, Ehsan M, Normandin E, et al. Physiologic responses during the six minute walk test in obese and nonobese COPD patients. Respir Med 2011; 105: 1189-1194.
56. Chaston TB, Dixon JB. Factors associated with percent change in visceral versus subcutaneous abdominal fat during weight loss: findings from a systematic review. Int J Obes (Lond) 2008; 32: 619-628.
57. Schols AM. Translating nutritional potential of metabolic remodelling to disease-modifying nutritional management. Curr Opin Clin Nutr Metab Care 2013; 16: 617-618.
58. Vermeeren MA, Schols AM, Wouters EF. Effects of an acute exacerbation on nutritional and metabolic profile of patients with COPD. Eur Respir J 1997; 10: 2264-2269.
59. Ehsan M, Khan R, Wakefield D, et al. A longitudinal study evaluating the effect of exacerbations on physical activity in patients with chronic obstructive pulmonary disease. Ann Am Thorac Soc 2013; 10: 559-564.
60. Creutzberg EC, Wouters EF, Vanderhoven-Augustin IM, et al. Disturbances in leptin metabolism are related to energy imbalance during acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2000; 162: 1239-1245.
61. Saudny-Unterberger H, Martin JG, Gray-Donald K. Impact of nutritional support on functional status during an acute exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1997; 156: 794-799.
62. Pouw EM, Ten Velde GP, Croonen BH, et al. Early non-elective readmission for chronic obstructive pulmonary disease is associated with weight loss. Clin Nutr 2000; 19: 95-99.
63. Lainscak M, Gosker HR, Schols AM. Chronic obstructive pulmonary disease patient journey: hospitalizations as window of opportunity for extra-pulmonary intervention. Curr Opin Clin Nutr Metab Care 2013; 16: 278-283.
64. Broekhuizen R, Creutzberg EC, Weling-Scheepers CA, et al. Optimizing oral nutritional drink supplementation in patients with chronic obstructive pulmonary disease. Br J Nutr 2005; 93: 965-971.
65. Weekes CE, Emery PW, Elia M. Dietary counselling and food fortification in stable COPD: a randomised trial. Thorax 2009; 64: 326-331.
66. Ferreira IM, Brooks D, White J, et al. Nutritional supplementation for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2012; 12: CD000998.
67. DeLetter MC. A nutritional intervention for persons with chronic airflow limitation. PhD thesis. University of Kentucky, Lexington, KY, USA, 1991.
68. Efthimiou J, Felming J, Gomes C, et al. The effect of supplementary oral nutrition in poorly nourished patients with chronic obstructive pulmonary disease. Am Rev Respir Dis 1988; 137: 1075-1082.
69. Fuenzalida CE, Petty TL, Jones ML. The immune response to short nutritional intervention in advanced COPD. Am Rev Respir Dis 1990; 142: 49-56.
70. Lewis MI, Belman MJ, Dorr Uyemura J. Nutritional supplementation in ambulatory patients with COPD. Am Rev Respir Dis 1987; 135: 1062-1068.
71. Otte KE, Ahlburg P, D'Amore F, et al. Nutritional repletion in malnourished patients with emphysema. JPEN J Parenter Enteral Nutr 1989; 13: 152-156.
72. Rogers RM, Donahoe M, Constantino J. Physiologic effects of oral supplementation feeding in malnourished patients with COPD - a randomized control study. Am Rev Respir Dis 1992; 146: 1511-1517.
73. Schols AM, Soeters PB, Mostert R, et al. Physiologic effects of nutritional support and anabolic steroids in patients with chronic obstructive pulmonary disease. A placebo-controlled randomized trial. Am J Respir Crit Care Med 1995; 152: 1268-1274.
74. Sugawara K, Takahashi H, Kasai C, et al. Effects of nutritional supplementation combined with low-intensity exercise in malnourished patients with COPD. Respir Med 2010; 104: 1883-1889.
75. Hoogendoorn M, van Wetering CR, Schols AM, et al. Is INTERdisciplinary COMmunitybased COPD management (INTERCOM) cost-effective? Eur Respir J 2010; 35: 79-87.
76. van Wetering CR, Hoogendoorn M, Broekhuizen R, et al. Efficacy and costs of nutritional rehabilitation in musclewasted patients with chronic obstructive pulmonary disease in a community-based setting: a prespecified subgroup analysis of the INTERCOM trial. J Am Med Dir Assoc 2010; 11: 179-187.
77. van Wetering CR, Hoogendoorn M, Geraerts-Keeris AJ, et al. Effectiveness and costs of nutritional intervention integrated in an INTERdisciplinary COMmunity-based COPD management program (INTERCOM) in patients with less advanced COPD. Am J Respir Crit Care Med 2009; 179: A5375.
78. Van Wetering CR, Hoogendoorn M, Mol SJM, et al. Short-and long-term efficacy of a community-based COPD management programme in less advanced COPD: a randomised controlled trial. Thorax 2010; 65: 7-13.
79. van Wetering CR, van Nooten FE, Mol SJ, et al. Systemic impairment in relation to disease burden in patients with moderate COPD eligible for a lifestyle program. Findings from the INTERCOM trial. Int J COPD 2008; 3: 443-451.
80. Weekes CE, Bateman NT, Elia M, et al. Tailored dietary advice and food fortification results in weight gain and clinical benefit in malnourished patients with chronic obstructive pulmonary disease. Thorax 2004; 59: Suppl. 2, ii4.
81. Ryan CF, Road JD, Buckley PA, et al. Energy balance in stable malnourished patients with chronic obstructive pulmonary disease. Chest 1993; 103: 1038-1044.
82. Whittaker JS, Ryan CF, Buckley PA, et al. The effects of refeeding on peripheral respiratory muscle function in malnourished chronic obstructive disease patients. Am Rev Respir Dis 1990; 142: 283-288.
83. Knowles JB, Fairbarn MS, Wiggs BJ, et al. Dietary supplementation and respiratory muscle performance in patients with COPD. Chest 1988; 93: 977-983.
84. Steiner MC, Barton RL, Singh SJ, et al. Nutritional enhancement of exercise performance in chronic obstructive pulmonary disease: a randomised controlled trial. Eur Respir J 2002; 20: Suppl. 38, 262s.
85. Steiner MC, Barton RL, Singh SJ, et al. Nutritional enhancement of exercise performance in chronic obstructive pulmonary disease: a randomised controlled trial. Thorax 2003; 58: 745-751.
86. Steiner MC, Barton RL, Singh SJ, et al. The effect of nutritional supplementation on body weight and composition in COPD patients participating in rehabilitation. Eur Respir J 2002; 20: Suppl. 38, 211s.
87. Sugawara K, Shioya T, Satake M, et al. Anti-inflammatory nutritional support enhances exercise performance and QOL in patients with stable COPD. Eur Respir J 2011; 38: Suppl. 55, 326s.
88. Sugawara K, Takahashi H, Kashiwagura T, et al. Effect of anti-inflammatory supplementation with whey peptide and exercise therapy in patients with COPD. Respir Med 2012; 106: 1526-1534.
89. Atkins D, Best D, Briss PA, et al. Grading quality of evidence and strength of recommendations. BMJ 2004; 328: 1490.
90. Puhan MA, Chandra D, Mosenifar Z, et al. The minimal important difference of exercise tests in severe COPD. Eur Respir J 2011; 37: 784-790.
91. Polkey MI, Spruit MA, Edwards LD, et al. Six-minute-walk test in chronic obstructive pulmonary disease: minimal clinically important difference for death or hospitalization. Am J Respir Crit Care Med 2013; 187: 382-386.
92. Collins PF, Stratton RJ, Elia M. Nutritional support in chronic obstructive pulmonary disease: a systematic review and meta-analysis. Am J Clin Nutr 2012; 95: 1385-1395.
93. Collins PF, Elia M, Stratton RJ. Nutritional support and functional capacity in chronic obstructive pulmonary disease: a systematic review and meta-analysis. Respirology 2013; 18: 616-629.
94. van Loon LJ. Is there a need for protein ingestion during exercise? Sport Med 2014; 44: Suppl. 1, S105-S111.
95. Devries MC, Phillips SM. Creatine supplementation during resistance training in older adults - a meta-analysis. Med Sci Sports Exerc 2014; 46: 1194-1203.
96. van de Bool C, Steiner MC, Schols AM. Nutritional targets to enhance exercise performance in chronic obstructive pulmonary disease. Curr Opin Clin Nutr Metab Care 2012; 15: 553-560.
97. Mickleborough TD. Omega-3 polyunsaturated fatty acids in physical performance optimization. Int J Sport Nutr Exerc Metab 2013; 23: 83-96.
98. Cermak NM, Gibala MJ, van Loon LJ. Nitrate supplementation's improvement of 10-km time-trial performance in trained cyclists. Int J Sport Nutr Exerc Metab 2012; 22: 64-71.
99. Schols AM. Nutrition as a metabolic modulator in COPD. Chest 2013; 144: 1340-1345.
100. Baldi S, Aquilani R, Pinna GD, et al. Fat-free mass change after nutritional rehabilitation in weight losing COPD: role of insulin, C-reactive protein and tissue hypoxia. Int J Chron Obstruct Pulmon Dis 2010; 5: 29-39.
101. Deacon SJ, Vincent EE, Greenhaff PL, et al. Randomized controlled trial of dietary creatine as an adjunct therapy to physical training in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008; 178: 233-239.
102. Fuld JP, Kilduff LP, Neder JA, et al. Creatine supplementation during pulmonary rehabilitation in chronic obstructive pulmonary disease. Thorax 2005; 60: 531-537.
103. Faager G, Soderlund K, Skold CM, et al. Creatine supplementation and physical training in patients with COPD: a double blind, placebo-controlled study. Int J Chron Obstruct Pulmon Dis 2006; 1: 445-453.
104. Broekhuizen R, Wouters EF, Creutzberg EC, et al. Polyunsaturated fatty acids improve exercise capacity in chronic obstructive pulmonary disease. Thorax 2005; 60: 376-382.
105. Al-Ghimlas F, Todd DC. Creatine supplementation for patients with COPD receiving pulmonary rehabilitation: a systematic review and meta-analysis. Respirology 2010; 15: 785-795.
106. Constantin D, Menon MK, Houchen-Wolloff L, et al. Skeletal muscle molecular responses to resistance training and dietary supplementation in COPD. Thorax 2013; 68: 625-633.
107. Giron R, Matesanz C, Garcia-Rio F, et al. Nutritional state during COPD exacerbation: clinical and prognostic implications. Ann Nutr Metab 2009; 54: 52-58.
108. Gupta B, Kant S, Mishra R, et al. Nutritional status of chronic obstructive pulmonary disease patients admitted in hospital with acute exacerbation. J Clin Med Res 2010; 2: 68-74.
109. Hallin R, Koivisto-Hursti UK, Lindberg E, et al. Nutritional status, dietary energy intake and the risk of exacerbations in patients with chronic obstructive pulmonary disease (COPD). Respir Med 2006; 100: 561-567.
110. Odencrants S, Ehnfors M, Ehrenberg A. Nutritional status and patient characteristics for hospitalised older patients with chronic obstructive pulmonary disease. J Clin Nurs 2008; 17: 1771-1778.
111. Edington J, Barnes R, Bryan F, et al. A prospective randomised controlled trial of nutritional supplementation in malnourished elderly in the community: clinical and health economic outcomes. Clin Nutr 2004; 23: 195-204.
112. Janssens W, Lehouck A, Carremans C, et al. Vitamin D beyond bones in chronic obstructive pulmonary disease: time to act. Am J Respir Crit Care Med 2009; 179: 630-636.
113. Black PN, Scragg R. Relationship between serum 25-hydroxyvitamin D and pulmonary function in the third national health and nutrition examination survey. Chest 2005; 128: 3792-3798.
114. Ginde AA, Mansbach JM, Camargo CA Jr. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med 2009; 169: 384-390.
115. Kunisaki KM, Niewoehner DE, Singh RJ, et al. Vitamin D status and longitudinal lung function decline in the Lung Health Study. Eur Respir J 2011; 37: 238-243.
116. Lange NE, Sparrow D, Vokonas P, et al. Vitamin D deficiency, smoking, and lung function in the Normative Aging Study. Am J Respir Crit Care Med 2012; 186: 616-621.
117. Afzal S, Lange P, Bojesen SE, et al. Plasma 25-hydroxyvitamin D, lung function and risk of chronic obstructive pulmonary disease. Thorax 2014; 69: 24-31.
118. Lehouck A, Mathieu C, Carremans C, et al. High doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med 2012; 156: 105-114.
119. Agler AH, Kurth T, Gaziano JM, et al. Randomised vitamin E supplementation and risk of chronic lung disease in the Women's Health Study. Thorax 2011; 66: 320-325.
120. Varraso R, Jiang R, Barr RG, et al. Prospective study of cured meats consumption and risk of chronic obstructive pulmonary disease in men. Am J Epidemiol 2007; 166: 1438-1445.
121. Varraso R, Fung TT, Barr RG, et al. Prospective study of dietary patterns and chronic obstructive pulmonary disease among US women. Am J Clin Nutr 2007; 86: 488-495.
122. Varraso R, Willett WC, Camargo CA Jr. Prospective study of dietary fiber and risk of chronic obstructive pulmonary disease among US women and men. Am J Epidemiol 2010; 171: 776-784.
123. Fonseca Wald EL, van den Borst B, Gosker HR, et al. Dietary fibre and fatty acids in chronic obstructive pulmonary disease risk and progression: a systematic review. Respirology 2014; 19: 176-184.
124. Jiang R, Camargo CA Jr, Varraso R, et al. Consumption of cured meats and prospective risk of chronic obstructive pulmonary disease in women. Am J Clin Nutr 2008; 87: 1002-1008.
125. Chow CK. Consumption of cured meats and risk of chronic obstructive pulmonary disease. Am J Clin Nutr 2008; 88: 1703.
126. de Batlle J, Mendez M, Romieu I, et al. Cured meat consumption increases risk of readmission in COPD patients. Eur Respir J 2012; 40: 555-560.
127. Silverberg DS, Mor R, Weu MT, et al. Anemia and iron deficiency in COPD patients: prevalence and the effects of correction of the anemia with erythropoiesis stimulating agents and intravenous iron. BMC Pulm Med 2014; 14: 24.
128. Pison CM, Cano NJ, Cherion C, et al. Multimodal nutritional rehabilitation improves clinical outcomes of malnourished patients with chronic respiratory failure: a randomised controlled trial. Thorax 2011; 66: 953-960.