Photoredox catalysis in a complex pharmaceutical setting: Toward the preparation of JAK2 inhibitor LY2784544

Journal of Organic Chemistry

Volumn 79, Issue 23, 2014, Pages 11631-11643

  Douglas, James J ^a,b   Cole, Kevin P ^b   Stephenson, Corey R J ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; CATALYSIS; CHEMICAL BONDS; LIGHT;

C-N BOND CLEAVAGES; DIRECT COUPLING; FUNCTIONALIZATIONS; MEDICINAL CHEMISTRY; METHYLATION REACTION; N-METHYL-MORPHOLINE; PHOTOREDOX CATALYSIS; PHOTOREDOX REACTIONS;

SYNTHESIS (CHEMICAL);

GANDOTINIB; MORPHOLINE DERIVATIVE; N METHYLMORPHOLINE; PYRIDAZINE; TERTIARY AMINE; UNCLASSIFIED DRUG; IMIDAZOLE DERIVATIVE; JAK2 PROTEIN, HUMAN; JANUS KINASE 2; PYRAZOLE DERIVATIVE; PYRIDAZINE DERIVATIVE;

ARTICLE; CHEMICAL BOND; CRYSTALLIZATION; DRUG SYNTHESIS; MEDICINAL CHEMISTRY; METHYLATION; OXIDATION REDUCTION REACTION; PHOTOCATALYSIS; PHOTOREDOX CATALYSIS; REACTION OPTIMIZATION; ANTAGONISTS AND INHIBITORS; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; LIGHT; PHOTOCHEMISTRY; SYNTHESIS;

CATALYSIS; IMIDAZOLES; JANUS KINASE 2; LIGHT; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PHOTOCHEMICAL PROCESSES; PYRAZOLES; PYRIDAZINES;

EID: 84916214381     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo502288q     Document Type: Article

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