Evaluation of a multimodal resin for selective capture of CHO-derived monoclonal antibodies directly from harvested cell culture fluid

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 969, Issue , 2014, Pages 256-263

  Kaleas, Kimberly A ^a   Tripodi, Margaret ^a   Revelli, Scott ^a   Sharma, Vikas ^a   Pizarro, Shelly A ^a  

^a GENENTECH INC   (United States)

Author keywords

Capto MMC; Mammalian cell culture fluid; Monoclonal antibody; Multimodal chromatography; Selective capture

Indexed keywords

ANIMAL CELL CULTURE; BINDING ENERGY; BINS; CELL CULTURE; CHROMATOGRAPHY; FEEDSTOCKS; LIGANDS; MAMMALS; MONOCLONAL ANTIBODIES; RESINS; SURFACE PLASMON RESONANCE;

CAPTO MMC; DOWNSTREAM-PROCESSING; DYNAMIC BINDING CAPACITY; MAMMALIAN CELL CULTURE; MOLECULAR PROPERTIES; MONOCLONAL ANTIBODIES (MAB); MULTIMODAL CHROMATOGRAPHIES; SELECTIVE CAPTURE;

ANTIBODIES;

AGAROSE; HYDROGEN; LIGAND; MONOCLONAL ANTIBODY; RESIN;

ADSORPTION; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CHO CELL LINE; CHROMATOGRAPHY; COMPLEMENTARITY DETERMINING REGION; CULTURE MEDIUM; DESORPTION; DOWNSTREAM PROCESSING; FEMALE; HYDROGEN BOND; HYDROPHOBICITY; ION EXCHANGE; ION EXCHANGE CHROMATOGRAPHY; LIGAND BINDING; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION; AFFINITY CHROMATOGRAPHY; ANIMAL; CHEMISTRY; CRICETULUS; CULTURE TECHNIQUE; DEVICES; HAMSTER; ISOLATION AND PURIFICATION; PROCEDURES;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL CULTURE TECHNIQUES; CHO CELLS; CHROMATOGRAPHY, AFFINITY; CRICETINAE; CRICETULUS; HYDROGEN-ION CONCENTRATION;

EID: 84916199353     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.08.026     Document Type: Article

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