-
1
-
-
79959376326
-
Click-generated triazole ureas as ultrapotent invivo-active serine hydrolase inhibitors
-
Adibekian A., Martin B.R., Wang C., Hsu K.L., Bachovchin D.A., Niessen S., Hoover H., Cravatt B.F. Click-generated triazole ureas as ultrapotent invivo-active serine hydrolase inhibitors. Nat. Chem. Biol. 2011, 7:469-478.
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 469-478
-
-
Adibekian, A.1
Martin, B.R.2
Wang, C.3
Hsu, K.L.4
Bachovchin, D.A.5
Niessen, S.6
Hoover, H.7
Cravatt, B.F.8
-
2
-
-
70350536563
-
Brown adipose tissue and seasonal variation in humans
-
Au-Yong I.T., Thorn N., Ganatra R., Perkins A.C., Symonds M.E. Brown adipose tissue and seasonal variation in humans. Diabetes 2009, 58:2583-2587.
-
(2009)
Diabetes
, vol.58
, pp. 2583-2587
-
-
Au-Yong, I.T.1
Thorn, N.2
Ganatra, R.3
Perkins, A.C.4
Symonds, M.E.5
-
3
-
-
78650495439
-
Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening
-
Bachovchin D.A., Ji T., Li W., Simon G.M., Blankman J.L., Adibekian A., Hoover H., Niessen S., Cravatt B.F. Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening. Proc. Natl. Acad. Sci. USA 2010, 107:20941-20946.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 20941-20946
-
-
Bachovchin, D.A.1
Ji, T.2
Li, W.3
Simon, G.M.4
Blankman, J.L.5
Adibekian, A.6
Hoover, H.7
Niessen, S.8
Cravatt, B.F.9
-
4
-
-
0035847001
-
Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell
-
Barbera M.J., Schluter A., Pedraza N., Iglesias R., Villarroya F., Giralt M. Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell. J.Biol. Chem. 2001, 276:1486-1493.
-
(2001)
J.Biol. Chem.
, vol.276
, pp. 1486-1493
-
-
Barbera, M.J.1
Schluter, A.2
Pedraza, N.3
Iglesias, R.4
Villarroya, F.5
Giralt, M.6
-
5
-
-
79751503329
-
Brown adipose tissue activity controls triglyceride clearance
-
Bartelt A., Bruns O.T., Reimer R., Hohenberg H., Ittrich H., Peldschus K., Kaul M.G., Tromsdorf U.I., Weller H., Waurisch C., et al. Brown adipose tissue activity controls triglyceride clearance. Nat. Med. 2011, 17:200-205.
-
(2011)
Nat. Med.
, vol.17
, pp. 200-205
-
-
Bartelt, A.1
Bruns, O.T.2
Reimer, R.3
Hohenberg, H.4
Ittrich, H.5
Peldschus, K.6
Kaul, M.G.7
Tromsdorf, U.I.8
Weller, H.9
Waurisch, C.10
-
6
-
-
0037009880
-
Individual variation of adipose gene expression and identification of covariated genes by cDNA microarrays
-
Boeuf S., Keijer J., Franssen-Van Hal N.L., Klaus S. Individual variation of adipose gene expression and identification of covariated genes by cDNA microarrays. Physiol. Genomics 2002, 11:31-36.
-
(2002)
Physiol. Genomics
, vol.11
, pp. 31-36
-
-
Boeuf, S.1
Keijer, J.2
Franssen-Van Hal, N.L.3
Klaus, S.4
-
7
-
-
0027300035
-
Tissue-specific and β-adrenergic regulation of the mitochondrial uncoupling protein gene: control by cis-acting elements in the 5'-flanking region
-
Cassard-Doulcier A.M., Gelly C., Fox N., Schrementi J., Raimbault S., Klaus S., Forest C., Bouillaud F., Ricquier D. Tissue-specific and β-adrenergic regulation of the mitochondrial uncoupling protein gene: control by cis-acting elements in the 5'-flanking region. Mol. Endocrinol. 1993, 7:497-506.
-
(1993)
Mol. Endocrinol.
, vol.7
, pp. 497-506
-
-
Cassard-Doulcier, A.M.1
Gelly, C.2
Fox, N.3
Schrementi, J.4
Raimbault, S.5
Klaus, S.6
Forest, C.7
Bouillaud, F.8
Ricquier, D.9
-
8
-
-
64349105205
-
Identification and importance of brown adipose tissue in adult humans
-
Cypess A.M., Lehman S., Williams G., Tal I., Rodman D., Goldfine A.B., Kuo F.C., Palmer E.L., Tseng Y.H., Doria A., et al. Identification and importance of brown adipose tissue in adult humans. N.Engl. J. Med. 2009, 360:1509-1517.
-
(2009)
N.Engl. J. Med.
, vol.360
, pp. 1509-1517
-
-
Cypess, A.M.1
Lehman, S.2
Williams, G.3
Tal, I.4
Rodman, D.5
Goldfine, A.B.6
Kuo, F.C.7
Palmer, E.L.8
Tseng, Y.H.9
Doria, A.10
-
9
-
-
84877331455
-
Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
-
Cypess A.M., White A.P., Vernochet C., Schulz T.J., Xue R., Sass C.A., Huang T.L., Roberts-Toler C., Weiner L.S., Sze C., et al. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat. Med. 2013, 19:635-639.
-
(2013)
Nat. Med.
, vol.19
, pp. 635-639
-
-
Cypess, A.M.1
White, A.P.2
Vernochet, C.3
Schulz, T.J.4
Xue, R.5
Sass, C.A.6
Huang, T.L.7
Roberts-Toler, C.8
Weiner, L.S.9
Sze, C.10
-
10
-
-
84897107752
-
Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes
-
Dominguez E., Galmozzi A., Chang J.W., Hsu K.L., Pawlak J., Li W., Godio C., Thomas J., Partida D., Niessen S., et al. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nat. Chem. Biol. 2014, 10:113-121.
-
(2014)
Nat. Chem. Biol.
, vol.10
, pp. 113-121
-
-
Dominguez, E.1
Galmozzi, A.2
Chang, J.W.3
Hsu, K.L.4
Pawlak, J.5
Li, W.6
Godio, C.7
Thomas, J.8
Partida, D.9
Niessen, S.10
-
11
-
-
1842409029
-
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
-
Enerbäck S., Jacobsson A., Simpson E.M., Guerra C., Yamashita H., Harper M.E., Kozak L.P. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 1997, 387:90-94.
-
(1997)
Nature
, vol.387
, pp. 90-94
-
-
Enerbäck, S.1
Jacobsson, A.2
Simpson, E.M.3
Guerra, C.4
Yamashita, H.5
Harper, M.E.6
Kozak, L.P.7
-
12
-
-
84867564026
-
Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria
-
Fedorenko A., Lishko P.V., Kirichok Y. Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria. Cell 2012, 151:400-413.
-
(2012)
Cell
, vol.151
, pp. 400-413
-
-
Fedorenko, A.1
Lishko, P.V.2
Kirichok, Y.3
-
13
-
-
58749091645
-
UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
-
Feldmann H.M., Golozoubova V., Cannon B., Nedergaard J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 2009, 9:203-209.
-
(2009)
Cell Metab.
, vol.9
, pp. 203-209
-
-
Feldmann, H.M.1
Golozoubova, V.2
Cannon, B.3
Nedergaard, J.4
-
14
-
-
84888042813
-
The nuclear receptor Rev-erbα controls circadian thermogenic plasticity
-
Gerhart-Hines Z., Feng D., Emmett M.J., Everett L.J., Loro E., Briggs E.R., Bugge A., Hou C., Ferrara C., Seale P., et al. The nuclear receptor Rev-erbα controls circadian thermogenic plasticity. Nature 2013, 503:410-413.
-
(2013)
Nature
, vol.503
, pp. 410-413
-
-
Gerhart-Hines, Z.1
Feng, D.2
Emmett, M.J.3
Everett, L.J.4
Loro, E.5
Briggs, E.R.6
Bugge, A.7
Hou, C.8
Ferrara, C.9
Seale, P.10
-
15
-
-
0035462378
-
Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold
-
Golozoubova V., Hohtola E., Matthias A., Jacobsson A., Cannon B., Nedergaard J. Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold. FASEB J. 2001, 15:2048-2050.
-
(2001)
FASEB J.
, vol.15
, pp. 2048-2050
-
-
Golozoubova, V.1
Hohtola, E.2
Matthias, A.3
Jacobsson, A.4
Cannon, B.5
Nedergaard, J.6
-
16
-
-
79961167173
-
2,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity and risk of death
-
Grundlingh J., Dargan P.I., El-Zanfaly M., Wood D.M. 2,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity and risk of death. J.Med. Toxicol. 2011, 7:205-212.
-
(2011)
J.Med. Toxicol.
, vol.7
, pp. 205-212
-
-
Grundlingh, J.1
Dargan, P.I.2
El-Zanfaly, M.3
Wood, D.M.4
-
17
-
-
0032528169
-
Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity
-
Guerra C., Koza R.A., Yamashita H., Walsh K., Kozak L.P. Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J.Clin. Invest. 1998, 102:412-420.
-
(1998)
J.Clin. Invest.
, vol.102
, pp. 412-420
-
-
Guerra, C.1
Koza, R.A.2
Yamashita, H.3
Walsh, K.4
Kozak, L.P.5
-
18
-
-
84894132767
-
A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis
-
Kajimura S., Saito M. A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis. Annu. Rev. Physiol. 2014, 76:225-249.
-
(2014)
Annu. Rev. Physiol.
, vol.76
, pp. 225-249
-
-
Kajimura, S.1
Saito, M.2
-
19
-
-
69349088117
-
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex
-
Kajimura S., Seale P., Kubota K., Lunsford E., Frangioni J.V., Gygi S.P., Spiegelman B.M. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature 2009, 460:1154-1158.
-
(2009)
Nature
, vol.460
, pp. 1154-1158
-
-
Kajimura, S.1
Seale, P.2
Kubota, K.3
Lunsford, E.4
Frangioni, J.V.5
Gygi, S.P.6
Spiegelman, B.M.7
-
20
-
-
84890919810
-
Antiobesity pharmacotherapy: new drugs and emerging targets
-
Kim G.W., Lin J.E., Blomain E.S., Waldman S.A. Antiobesity pharmacotherapy: new drugs and emerging targets. Clin. Pharmacol. Ther. 2014, 95:53-66.
-
(2014)
Clin. Pharmacol. Ther.
, vol.95
, pp. 53-66
-
-
Kim, G.W.1
Lin, J.E.2
Blomain, E.S.3
Waldman, S.A.4
-
21
-
-
0028865142
-
Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
-
Kopecky J., Clarke G., Enerbäck S., Spiegelman B., Kozak L.P. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J.Clin. Invest. 1995, 96:2914-2923.
-
(1995)
J.Clin. Invest.
, vol.96
, pp. 2914-2923
-
-
Kopecky, J.1
Clarke, G.2
Enerbäck, S.3
Spiegelman, B.4
Kozak, L.P.5
-
22
-
-
0034602264
-
Synergistic gene interactions control the induction of the mitochondrial uncoupling protein (Ucp1) gene in white fat tissue
-
Koza R.A., Hohmann S.M., Guerra C., Rossmeisl M., Kozak L.P. Synergistic gene interactions control the induction of the mitochondrial uncoupling protein (Ucp1) gene in white fat tissue. J.Biol. Chem. 2000, 275:34486-34492.
-
(2000)
J.Biol. Chem.
, vol.275
, pp. 34486-34492
-
-
Koza, R.A.1
Hohmann, S.M.2
Guerra, C.3
Rossmeisl, M.4
Kozak, L.P.5
-
23
-
-
84877340732
-
Evidence for two types of brown adipose tissue in humans
-
Lidell M.E., Betz M.J., Dahlqvist Leinhard O., Heglind M., Elander L., Slawik M., Mussack T., Nilsson D., Romu T., Nuutila P., et al. Evidence for two types of brown adipose tissue in humans. Nat. Med. 2013, 19:631-634.
-
(2013)
Nat. Med.
, vol.19
, pp. 631-634
-
-
Lidell, M.E.1
Betz, M.J.2
Dahlqvist Leinhard, O.3
Heglind, M.4
Elander, L.5
Slawik, M.6
Mussack, T.7
Nilsson, D.8
Romu, T.9
Nuutila, P.10
-
24
-
-
84900325394
-
A smooth muscle-like origin for beige adipocytes
-
Long J.Z., Svensson K.J., Tsai L., Zeng X., Roh H.C., Kong X., Rao R.R., Lou J., Lokurkar I., Baur W., et al. A smooth muscle-like origin for beige adipocytes. Cell Metab. 2014, 19:810-820.
-
(2014)
Cell Metab.
, vol.19
, pp. 810-820
-
-
Long, J.Z.1
Svensson, K.J.2
Tsai, L.3
Zeng, X.4
Roh, H.C.5
Kong, X.6
Rao, R.R.7
Lou, J.8
Lokurkar, I.9
Baur, W.10
-
25
-
-
77950237717
-
The changed metabolic world with human brown adipose tissue: therapeutic visions
-
Nedergaard J., Cannon B. The changed metabolic world with human brown adipose tissue: therapeutic visions. Cell Metab. 2010, 11:268-272.
-
(2010)
Cell Metab.
, vol.11
, pp. 268-272
-
-
Nedergaard, J.1
Cannon, B.2
-
26
-
-
84858039282
-
PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein
-
Ohno H., Shinoda K., Spiegelman B.M., Kajimura S. PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab. 2012, 15:395-404.
-
(2012)
Cell Metab.
, vol.15
, pp. 395-404
-
-
Ohno, H.1
Shinoda, K.2
Spiegelman, B.M.3
Kajimura, S.4
-
27
-
-
84889604511
-
EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex
-
Ohno H., Shinoda K., Ohyama K., Sharp L.Z., Kajimura S. EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature 2013, 504:163-167.
-
(2013)
Nature
, vol.504
, pp. 163-167
-
-
Ohno, H.1
Shinoda, K.2
Ohyama, K.3
Sharp, L.Z.4
Kajimura, S.5
-
28
-
-
84858037735
-
Pten positively regulates brown adipose function, energy expenditure, and longevity
-
Ortega-Molina A., Efeyan A., Lopez-Guadamillas E., Muñoz-Martin M., Gómez-López G., Cañamero M., Mulero F., Pastor J., Martinez S., Romanos E., et al. Pten positively regulates brown adipose function, energy expenditure, and longevity. Cell Metab. 2012, 15:382-394.
-
(2012)
Cell Metab.
, vol.15
, pp. 382-394
-
-
Ortega-Molina, A.1
Efeyan, A.2
Lopez-Guadamillas, E.3
Muñoz-Martin, M.4
Gómez-López, G.5
Cañamero, M.6
Mulero, F.7
Pastor, J.8
Martinez, S.9
Romanos, E.10
-
29
-
-
84869173668
-
Aging leads to a programmed loss of brown adipocytes in murine subcutaneous white adipose tissue
-
Rogers N.H., Landa A., Park S., Smith R.G. Aging leads to a programmed loss of brown adipocytes in murine subcutaneous white adipose tissue. Aging Cell 2012, 11:1074-1083.
-
(2012)
Aging Cell
, vol.11
, pp. 1074-1083
-
-
Rogers, N.H.1
Landa, A.2
Park, S.3
Smith, R.G.4
-
30
-
-
67650242165
-
High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity
-
Saito M., Okamatsu-Ogura Y., Matsushita M., Watanabe K., Yoneshiro T., Nio-Kobayashi J., Iwanaga T., Miyagawa M., Kameya T., Nakada K., et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 2009, 58:1526-1531.
-
(2009)
Diabetes
, vol.58
, pp. 1526-1531
-
-
Saito, M.1
Okamatsu-Ogura, Y.2
Matsushita, M.3
Watanabe, K.4
Yoneshiro, T.5
Nio-Kobayashi, J.6
Iwanaga, T.7
Miyagawa, M.8
Kameya, T.9
Nakada, K.10
-
32
-
-
0029941669
-
Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: regulation by peroxisome proliferator-activated receptor gamma
-
Sears I.B., MacGinnitie M.A., Kovacs L.G., Graves R.A. Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: regulation by peroxisome proliferator-activated receptor gamma. Mol. Cell. Biol. 1996, 16:3410-3419.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 3410-3419
-
-
Sears, I.B.1
MacGinnitie, M.A.2
Kovacs, L.G.3
Graves, R.A.4
-
33
-
-
84869233588
-
Human BAT possesses molecular signatures that resemble beige/brite cells
-
Sharp L.Z., Shinoda K., Ohno H., Scheel D.W., Tomoda E., Ruiz L., Hu H., Wang L., Pavlova Z., Gilsanz V., Kajimura S. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS ONE 2012, 7:e49452.
-
(2012)
PLoS ONE
, vol.7
, pp. e49452
-
-
Sharp, L.Z.1
Shinoda, K.2
Ohno, H.3
Scheel, D.W.4
Tomoda, E.5
Ruiz, L.6
Hu, H.7
Wang, L.8
Pavlova, Z.9
Gilsanz, V.10
Kajimura, S.11
-
34
-
-
64349095231
-
Cold-activated brown adipose tissue in healthy men
-
van Marken Lichtenbelt W.D., Vanhommerig J.W., Smulders N.M., Drossaerts J.M., Kemerink G.J., Bouvy N.D., Schrauwen P., Teule G.J. Cold-activated brown adipose tissue in healthy men. N.Engl. J. Med. 2009, 360:1500-1508.
-
(2009)
N.Engl. J. Med.
, vol.360
, pp. 1500-1508
-
-
van Marken Lichtenbelt, W.D.1
Vanhommerig, J.W.2
Smulders, N.M.3
Drossaerts, J.M.4
Kemerink, G.J.5
Bouvy, N.D.6
Schrauwen, P.7
Teule, G.J.8
-
35
-
-
64349123664
-
Functional brown adipose tissue in healthy adults
-
Virtanen K.A., Lidell M.E., Orava J., Heglind M., Westergren R., Niemi T., Taittonen M., Laine J., Savisto N.J., Enerbäck S., Nuutila P. Functional brown adipose tissue in healthy adults. N.Engl. J. Med. 2009, 360:1518-1525.
-
(2009)
N.Engl. J. Med.
, vol.360
, pp. 1518-1525
-
-
Virtanen, K.A.1
Lidell, M.E.2
Orava, J.3
Heglind, M.4
Westergren, R.5
Niemi, T.6
Taittonen, M.7
Laine, J.8
Savisto, N.J.9
Enerbäck, S.10
Nuutila, P.11
-
36
-
-
34247626853
-
The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression
-
Waki H., Park K.W., Mitro N., Pei L., Damoiseaux R., Wilpitz D.C., Reue K., Saez E., Tontonoz P. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression. Cell Metab. 2007, 5:357-370.
-
(2007)
Cell Metab.
, vol.5
, pp. 357-370
-
-
Waki, H.1
Park, K.W.2
Mitro, N.3
Pei, L.4
Damoiseaux, R.5
Wilpitz, D.C.6
Reue, K.7
Saez, E.8
Tontonoz, P.9
-
37
-
-
26644453335
-
Simple and highly efficient BAC recombineering using galK selection
-
Warming S., Costantino N., Court D.L., Jenkins N.A., Copeland N.G. Simple and highly efficient BAC recombineering using galK selection. Nucleic Acids Res. 2005, 33:e36.
-
(2005)
Nucleic Acids Res.
, vol.33
, pp. e36
-
-
Warming, S.1
Costantino, N.2
Court, D.L.3
Jenkins, N.A.4
Copeland, N.G.5
-
38
-
-
84864287504
-
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
-
Wu J., Boström P., Sparks L.M., Ye L., Choi J.H., Giang A.H., Khandekar M., Virtanen K.A., Nuutila P., Schaart G., et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012, 150:366-376.
-
(2012)
Cell
, vol.150
, pp. 366-376
-
-
Wu, J.1
Boström, P.2
Sparks, L.M.3
Ye, L.4
Choi, J.H.5
Giang, A.H.6
Khandekar, M.7
Virtanen, K.A.8
Nuutila, P.9
Schaart, G.10
-
39
-
-
33845977987
-
Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat
-
Xue B., Rim J.S., Hogan J.C., Coulter A.A., Koza R.A., Kozak L.P. Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat. J.Lipid Res. 2007, 48:41-51.
-
(2007)
J.Lipid Res.
, vol.48
, pp. 41-51
-
-
Xue, B.1
Rim, J.S.2
Hogan, J.C.3
Coulter, A.A.4
Koza, R.A.5
Kozak, L.P.6
|