Impact of cocoa polyphenol extracts on the immune system and microbiota in two strains of young rats

British Journal of Nutrition

Volumn 112, Issue 12, 2014, Pages 1944-1954

  Massot Cladera, Malen ^a   Abril Gil, Mar ^a   Torres, Sandra ^a   Franch, Àngels ^a   Castell, Margarida ^a   Pérez Cano, Francisco J ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Cocoa; Immune system; Immunoglobulins; Intestinal immune system; Microbiota

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; POLYPHENOL; THEOBROMINE; FLAVONOID; PLANT EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BROWN NORWAY RAT; CACAO; CELL ISOLATION; CONTROLLED STUDY; DIET; ENZYME LINKED IMMUNOSORBENT ASSAY; FECES LEVEL; FEMALE; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; IMMUNE SYSTEM; IMMUNOFLUORESCENCE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOMODULATION; INTESTINE FLORA; LYMPHOCYTE; MESENTERY LYMPH NODE; NONHUMAN; PEYER PATCH; RAT; RAT STRAIN; WISTAR RAT; ANIMAL; CHEMISTRY; DIETARY FIBER; DRUG EFFECTS; FECES; IMMUNOLOGY; INTESTINE MUCOSA; LYMPH NODE; MESENTERY; METABOLISM; MICROBIOLOGY; MICROFLORA; PHARMACOLOGY;

RATTUS; THEOBROMA CACAO;

ANIMALS; CACAO; DIET; DIETARY FIBER; FECES; FEMALE; FLAVONOIDS; IMMUNOGLOBULIN A; INTESTINAL MUCOSA; LYMPH NODES; LYMPHOCYTES; MESENTERY; MICROBIOTA; PEYER'S PATCHES; PLANT EXTRACTS; POLYPHENOLS; RATS, WISTAR; THEOBROMINE;

EID: 84915788329     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114514003080     Document Type: Article

References (43)

1. Katz DL, Doughty K & Ali A (2011) Cocoa and chocolate inhuman health and disease. Antioxid Redox Signal 15,2779-2811.
2. Tomas-Berberan FA, Cienfuegos-Jovellanos E, Marn A, et al.(2007) A new process to develop a cocoa powder withhigher flavonoid monomer content and enhanced bioavailabilityin healthy humans. J Agric Food Chem 55, 3926-3935.
3. Sehm J, Lindermayer H, Dummer C, et al. (2007) The influenceof polyphenol rich apple pomare or red-winepomace diet on the gut morphology in weaning piglets.J Anim Physiol Anim Nutr (Berl) 91, 289-296.
4. Pérez-Cano FJ, Massot-Cladera M, Franch A, et al. (2013)The effects of cocoa on the immune system. Front Pharmacol4, 1-12.
5. Ramiro-Puig E, Pérez-Cano FJ, Ramos-Romero S, et al. (2008)Intestinal immune system of young rats influenced bycocoa-enriched diet. J Nutr Biochem 19, 555-565.
6. Mora JR & von Andrian UH (2008) Differentiation andhoming of IgA-secreting cells. Mucosal Immunol 1, 96-109.
7. Corthésy B (2007) Roundtrip ticket for secretory IgA: role inmucosal homeostasis J Immunol 178, 27-32.
8. MacPherson AJ, McCoy KD, Johansen FE, et al. (2008) Theimmune geography of IgA induction and function. MucosalImmunol 1, 11-22.
9. Chen CM, Li SC, Lin YL, et al. (2005) Consumption ofpurple sweet potato leaves modulates human immuneresponse: T-lymphocyte functions, lytic activity of naturalkiller cell and antibody production. World J Gastroenterol11, 5777-5781.
10. Okazaki Y, Han Y, Kayahata M, et al. (2010) Consumption ofcurcumin elevates fecal immunoglobulin A, an index ofintestinal immune function, in rats fed a high-fat diet. J NutrSci Vitaminol (Tokyo) 56, 68-71.
11. Pérez-Berezo T, Franch A, Ramos-Romero S, et al. (2011)Cocoa-enriched diets modulate intestinal and systemichumoral immune response in young adult rats. Mol NutrFood Res 55, S56-S66.
12. Massot-Cladera M, Pérez-Berezo T, Franch A, et al. (2012)Cocoa modulatory effect on rat faecal microbiota and coloniccrosstalk. Arch Biochem Biophys 527, 105-112.
13. Abreu MT (2010) Toll-like receptor signaling in the intestinalepithelium: how bacterial recognition shapes intestinal function.Nat Rev Immunol 10, 131-144.
14. Hill DA & Artis D (2010) Intestinal bacteria and the regulationof immune cell homeostasis. Annu Rev Immunol 28,623-667.
15. Etxeberria U, Fernandez-Quintela A, Milagro FI, et al. (2013)Impact of polyphenols and polyphenol-rich dietary sourceson gut microbiota composition. J Agric Food Chem 61,9517-9533.
16. Van Duynhoven J, Vaughan EE, van Dorsten F, et al. (2013)Interactions of black tea polyphenols with human gut microbiota:implications for gut and cardiovascular health. Am JClin Nutr 98, 1631S-1641S.
17. Tzounis X, Rodrguez-Mateos A, Vulevic J, et al. (2011) Prebioticevaluation of cocoa-derived flavanols in healthyhumans by using a randomized, controlled, double-blind,crossover intervention study. Am J Clin Nutr 93, 62-72.
18. Pérez-Berezo T, Ramiro-Puig E, Pérez-Cano FJ, et al. (2009)Influence of a cocoa-enriched diet on specific immuneresponse in ovalbumin-sensitized rats. Mol Nutr Food Res53, 389-397.
19. Cienfuentes-Jovellanos E, Pasamar MA, Fritz J, et al. (2007)Method for Obtaining Polyphenol-Rich Cocoa Powder with aLow Fat Content and Cocoa thus Obtained. Patent CooperationTreaty (PCT)WO2007/096449A1. Spain: Natraceutical Industrial.
20. Ramiro-Puig E, Pérez-Cano FJ, Ramrez-Santana C, et al.(2007) Spleen lymphocyte function modulated by a cocoaenricheddiet. Clin Exp Immunol 149, 535-542.
21. Massot-Cladera M, Franch A, Castellote C, et al. (2013) Cocoaflavonoid-enriched diet modulates systemic and intestinalimmunoglobulin synthesis in adult Lewis rats. Nutrients 5,3272-3286.
22. Dulloo AG (2011) The search for compounds that stimulatethermogenesis in obesity management: from pharmaceuticalsto functional food ingredients. Obes Rev 12, 866-883.
23. Singh A, Holvoet S & Mercenier A (2011) Dietary polyphenolsin the prevention and treatment of allergic diseases.Clin Exp Allergy 41, 1346-1359.
24. Castell M, Pérez-Cano FJ, Abril-Gil M, et al. (2014)Flavonoids on allergy. Curr Pharm Des 20, 972-987.
25. Pérez-Berezo T, Franch A, Castellote C, et al. (2012) Mechanismsinvolved in down-regulation of intestinal IgA in rats byhigh cocoa intake. J Nutr Biochem 23, 838-844.
26. Akiyama H, Sato Y, Watanable T, et al. (2005) Dietary unripeapple polyphenols inhibits the development of foodallergies in murine models. FEBS Lett 579, 4485-4491.
27. Hara H, Orita N, Hatano S, et al. (1995) Effect of tea polyphenolson fecal flora and fecal metabolic products ofpigs. J Vet Med Sci 57, 45-49.
28. Tzounis X, Vulevic J, Kuhnle GG, et al. (2008) Flavanolmonomer-induced changes to the human faecal microflora.Br J Nutr 99, 782-792.
29. Bialonska D, Kasimsetty SG, Schrader KK, et al. (2009) Theeffect of pomegranate (Punica granatum L.) by productsand ellagitannins on the growth of human gut bacteria.J Agric Food Chem 57, 8344-8349.
30. Cueva C, Sanchez-Patan F, Monagas M, et al. (2013) In vitrofermentation of grape seed flavan-3-ol fractions by humanfaecal microbiota: changes in microbial groups and phenolicmetabolites. FEMS Microbiol Ecol 83, 792-805.
31. Dolara P, Luceri C, De Filippo C, et al. (2005) Red winepolyphenols influence carcinogenesis, intestinal microflora,oxidative damage and gene expression profiles of colonicmucosa in F344 rats. Mutat Res 591, 237-246.
32. Sembries S, Dongowski G, Mehrlander K, et al. (2006) Physiologicaleffects of extraction juices from apple, grape, andred beet pomaces in rats. J Agric Food Chem 54,10269-10280.
33. Selma MV, Espn JC & Tomas-Barberan FA (2009) Interactionbetween phenolics and gut microbiota: role in humanhealth. J Agric Food Chem 57, 6485-6501.
34. Puupponen-Pimia R, Nohynek L, Hartmann-Schmidlin S,et al. (2005) Berry phenolics selectively inhibit the growthof intestinal pathogens. J Appl Microbiol 98, 991-1000.
35. Duda-Chodak A (2012) The inhibitory effect of polyphenolson human gut microbiota. J Physiol Pharmacol 63, 497-503.
36. Daims H, Bruhl A, Amann R, et al. (1999) The domainspecificprobe EUB338 is insufficient for the detection ofall bacteria: development and evaluation of a more comprehensiveprobe set. Syst Appl Microbiol 22, 434-444.
37. Manz W, Amann R, Ludwig W, et al. (1996) Application of asuite of 16S rRNA-specific oligonucleotide probes designedto investigate bacteria of the phylum Cytophaga-Flavobacter-Bacteroides in the natural environment. Microbiology142, 1097-1106.
38. Langendijk PS, Schut F, Jansen GJ, et al. (1995) Quantitativefluorescent in situ hybridisation of Bifidobacterium spp.with genus specific 16S rRNA targeted probes and its applicationin fecal samples. Appl Environ Micriobiol 61,3069-3075.
39. Harmsen HJM, Elfferich P, Schut F, et al. (1999) A 16S rRNAtargetedprobe for detection of lactobacilli and enterococciin faecal samples by fluorescent in situ hybridization.Microb Ecol Health Dis 11, 3-12.
40. Poulsen LK, Lan F, Kristensen CS, et al. (1994) Free in PMCspatial distribution of Escherichia coli in the mouse largeintestine inferred from rRNA in situ hybridization. InfectImmun 62, 5191-5194.
41. Franks AH, Harmsen HJM, Raangs GC, et al. (1995)Variations of bacterial populations in human feces measuredby fluorescent in situ hybridization with group specific16S rRNA-targeted oligonucleotide probes. Appl EnvironMicrobiol 64, 3336-3345.
42. Trebesius K, Leitritz L, Adler K, et al. (2000) Culture independentand rapid identification of bacterial pathogens innecrotizing fasciitis and streptococcal toxic shock syndromeby fluorescence in situ hybridisation. Med MicrobiolImmunol 188, 169-175.
43. Wallner G, Amann R & Beisket W (1993) Optimizingfluorescent in situ hybridization with rRNA-targeted oligonucleotideprobes for flow cytometric identification ofmicroorganisms. Cytometry 14, 136-143.