Mechanism of KATP hyperactivity and sulfonylurea tolerance due to a diabetogenic mutation in L0 helix of sulfonylurea receptor 1 (ABCC8)

FEBS Letters

Volumn 585, Issue 22, 2011, Pages 3555-3559

  Babenko, Andrey P ^a   Vaxillaire, Martine ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b CNRS   (France)

Author keywords

ABC protein; Diabetes; Gating mutation; Potassium channel; Sulfonylurea therapy

Indexed keywords

GLIBENCLAMIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; SULFONYLUREA RECEPTOR; TOLBUTAMIDE;

ABCC8 GENE; ARTICLE; BINDING SITE; CHANNEL GATING; CONTROLLED STUDY; DIABETES MELLITUS; DIABETOGENESIS; ELECTROPHYSIOLOGY; GENE; GENE MUTATION; HUMAN; HUMAN CELL; HYDROPHILICITY; INSULIN RELEASE; KINETICS; MOLECULAR DYNAMICS; MUTAGENESIS; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN BINDING;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CRICETINAE; DIABETES MELLITUS; HUMANS; ION CHANNEL GATING; KATP CHANNELS; KINETICS; LIGANDS; MODELS, MOLECULAR; MUTATION; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN CONFORMATION; RECEPTORS, DRUG; SULFONYLUREA COMPOUNDS;

EID: 80855148259     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.10.020     Document Type: Article

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