Renoprotective effect of myricetin restrains dyslipidemia and renal mesangial cell proliferation by the suppression of sterol regulatory element binding proteins in an experimental model of diabetic nephropathy

European Journal of Pharmacology

Volumn 743, Issue , 2014, Pages 53-62

  Kandasamy, Neelamegam ^a   Ashokkumar, Natarajan ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Cadmium; Diabetic nephropathy; Lipid metabolism; Myricetin; Steptozotocin

Indexed keywords

ALBUMIN; CADMIUM CHLORIDE; CHOLESTEROL; COLLAGEN TYPE 4; FATTY ACID; FIBRONECTIN; HIGH DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN; MYRICETIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE; PHOSPHOLIPID; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1A; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSFORMING GROWTH FACTOR BETA1; TRIACYLGLYCEROL; VASCULOTROPIN; VERY LOW DENSITY LIPOPROTEIN; FLAVONOID; PROTECTIVE AGENT; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DYSLIPIDEMIA; ENZYME ACTIVITY; FATTY ACID BLOOD LEVEL; GLOMERULOSCLEROSIS; HISTOPATHOLOGY; KIDNEY FIBROSIS; LIPID METABOLISM; LIPOPROTEIN BLOOD LEVEL; MALE; MESANGIUM CELL; NEPHROTOXICITY; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; RAT; RENAL PROTECTION; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; ANIMAL; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DRUG EFFECTS; DYSLIPIDEMIAS; KIDNEY; METABOLISM; WISTAR RAT;

ANIMALS; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DYSLIPIDEMIAS; FATTY ACIDS, NONESTERIFIED; FLAVONOIDS; KIDNEY; LIPID METABOLISM; LIPOPROTEIN LIPASE; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; MALE; MESANGIAL CELLS; PHOSPHATIDYLCHOLINE-STEROL O-ACYLTRANSFERASE; PPAR ALPHA; PROTECTIVE AGENTS; RATS; RATS, WISTAR; STEROL REGULATORY ELEMENT BINDING PROTEINS; TRIGLYCERIDES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84915731724     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.09.014     Document Type: Article

References (50)

1. E.M. Alissa, and G.A. Ferns Heavy metal poisoning and cardiovascular disease J. Toxicol. 2011 2011 870125
2. G. Assmann, A. vonEckerdstein, and H. Funke Lecithin: cholesterol acyltransferase deficiency and fish eye disease Curr. Opin. Lipidol. 2 1991 110 117
3. R.H. Bell, and R.J. Hye Animal models of diabetes mellitus physiology and pathology J. Surg. Res. 35 1983 433 460
4. E.P. Bottinger TGF-beta in renal injury and disease Semin. Nephrol. 27 2007 309 320
5. M.S. Brown, and J.L. Goldstein The SREBP pathway: regu-lation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor Cell 89 1997 331 340
6. N.D.J.A. Catanzaro, and M.T.R. Suen Clinical laboratory indicators of cardiovascular disease risk Altern. Med. Rev. 1 1996 185 194
7. J. Chen, P. Muntner, and L.L. Hamm The metabolic syndrome and chronic kidney disease in US adults Ann. Intern. Med. 140 2004 167 174
8. M.E. Choi Mechanism of transforming growth factor-beta 1 signaling: role of the mitogen activated protein kinase Kidney Int. Suppl. 77 2000 53 58
9. D. de Zeeuw, G. Remuzzi, H.H. Parving, W.F. Keane, Z. Zhang, and S. Shahinfar Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL Kidney Int. 65 2004 2309 2320
10. B.T. Doumas, W.A. Watson, and H.G. Biggs Albumin standards and the measurement of serum albumin with bromcresol green Clin. Chem. Acta 31 1971 87 96
11. S. Dronavalli, I. Duka, and G. Bakris The pathogenesis of diabetic nephropathy Nat. Clin. Pract. Endocrinol. Metab. 4 2008 444 452
12. H. Easterbauer, J. Gebick, H. Phal, and G. Jurgens The role of lipidperoxidation and antioxidants in the oxidative modifications of LDL Free Radic. Biol. Med. 13 1992 341 390
13. K. Falholt, W. Falholt, and B. Lund An easy colorimetric micromethod for routine determination of free fatty acids in plasma Clin. Chim. Acta 46 1973 105 111
14. J. Folch, M. Lees, and S.G.H. Solane A simple method for isolation and purification of total lipids from animal tissues J. Biol. Chem. 226 1957 497 509
15. P. Fossati, and P. Lorenzo Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide Clin. Chem. 28 1982 2077 2080
16. L. Gadola, O. Noboa, M.N. Marquez, M.J. Rodriguez, N. Nin, J. Boggia, A. Ferreiro, S. Garcia, V. Ortega, M.L. Musto, P. Ponte, P. Sesser, C. Pizarrosa, S. Ravaglio, and A. Vallega Calcium citrate ameliorates the progression of chronic renal injury Kidney Int. 65 2004 1224 1230
17. A.G. Garfinkel, P. Nilsson-Ehle, and M.C. Schotz Regulation of lipoprotein lipase. Induction by insulin Biochim. Biophys. Acta 424 1976 264 273
18. J.L. Goldstein, and M.S. Brown Regulation of the mevalonate pathway Nature 343 1990 425 430
19. J. Hitz, J. Steinmetz, and G. Siest Plasma lecithin: cholesterol acyltransferase reference values and effects of xenobiotics Clin. Chim. Acta 133 1983 85 96
20. J.D. Horton, J.L. Goldstein, and M.S. Brown SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J. Clin. Investig. 109 2002 1125 1131
21. J.D. Horton, N.A. Shah, J.A. Warrington, N.N. Anderson, S.W. Park, M.S. Brown, and J.L. Goldstein Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes Proc. Natl. Acad. Sci. USA 100 2003 12027 12032
22. K. Jandeleit-Dahm, Z. Cao, A.J. Cox, D.J. Kelly, R.E. Gilbert, and M.E. Cooper Role of hyperlipidemia in progressive renal disease: focus on diabetic nephropathy Kidney Int. Suppl. 71 1999 31 36
23. L. Jarup Hazards of heavy metal contamination Br. Med. Bull. 68 2003 167 182
24. T. Jin, G. Nordberg, J. Sehlin, H. Wallin, and S. Sandberg The susceptibility to nephrotoxicity of STZ-induced diabetic rats subchronically exposed to Cd chloride in drinking water Toxicology 142 1999 69 75
25. N. Kandasamy, and N. Ashokkumar Myricetin, a natural flavonoid, normalizes hyperglycemia in streptozotocin-cadmium-induced experimental diabetic nephrotoxic rats Biomed. Prev. Nutr. 2 2012 246 251
26. N. Kandasamy, and N. Ashokkumar Myricetin modulates streptozotocin-cadmium induced oxidative stress in long term experimental diabetic nephrotoxic rats J. Funct. Foods 5 2013 1466 1477
27. N. Kandasamy, and N. Ashokkumar Protective effect of bioflavonoid myricetin enhances carbohydrate metabolic enzymes and insulin signaling molecules in streptozotocin-cadmium induced diabetic nephrotoxic rats Toxicol. Appl. Pharmacol. 279 2014 173 185
28. Y.S. Kanwar, J. Wada, L. Sun, P. Xie, E.I. Wallner, and S. Chen Diabetic nephropathy: mechanisms of renal disease progression Exp. Biol. Med. 233 2008 4 11
29. M. Kashgarian, S. Oshima, A. Takeuchi, D. Throckmorton, and H. Rasmussen The contribution of mesangial cell collagen synthesis to the pathogenesis of diabetic nephropathy Contrib. Nephrol. 107 1994 132 139
30. E.D. Korn Clearing factor: a heparin activated lipoprotein lipase: isolation and characterization of enzyme from normal rats J. Biol. Chem. 215 1955 1 26
31. U.K. Laemmli Cleavge of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
32. E. Lopez, C. Arce, and M.J. Oset-Gasque Cadmium induces reactive oxygen species generation and lipid peroxidation in cortical neurons in culture Free Radic. Biol. Med. 40 2006 940 951
33. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the folin-phenol reagent J. Biol. Chem. 193 1951 265 275
34. A. Menditto, F. Chiodo, M. Patriarca, G. Morisi, A. Menotti, A. Spagnolo The NRF Project Research Group Blood cadmium levels in non-exposed male subjects living in the rome area: relationship to selected cardiovascular risk factors Microchem. J. 59 1998 173 179
35. P. Murugavel, and L. Pari Diallyl tetrasulfide protects cadmium-induced alterations in lipids and plasma lipoproteins in rats Nutr. Res. 27 2007 356 361
36. P.A. Nilsson-Ehle, A.S. Garfinkel, and M.C. Shotz Lipolytic enzymes and plasma lipoprotein metabolism Annu. Rev. Biochem. 49 1980 667 693
37. K.C. Ong, and H.E. Khoo Biological effects of myricetin Gen. Pharmacol. 29 1997 121 126
38. J.T. Pai, O. Guryev, M.S. Brown, and J.L. Goldstein Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins J. Biol. Chem. 273 1998 26138 26148
39. B. Philipp, and D.J. Shapiro Improved methods for the assay and activation of 3-hydroxy-3-methyl glutaryl coenzyme A reductase J. Lipid Res. 20 1970 588 593
40. J. Prakash Dyslipidemia in diabetic kidney disease Clin. Queries: Nephrol. 0102 2012 115 118
41. G. Proctor, T. Jiang, M. Iwahashi, Z. Wang, J. Li, and M. Levi Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes Diabetes 55 2006 2502 2509
42. S. Satarug, and M.R. Moore Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke Environ. Health Perspect. 112 2004 1099 1103
43. B.F. Schrijvers, A.S. De Vriese, and A. Flyvbjerg From hyperglycemia to diabetic kidney disease: the role of metabolic, hemodynamic, intracellular factors and growth factors/cytokines Endocr. Rev. 25 2004 971 1010
44. O. Siddique, Y. Sun, J.C. Lin, and Y.W. Chein Facilitated transdermal transport of insulin J. Pharmacol. Sci. 76 1987 341 345
45. G.H. Tesch, and T.J. Allen Rodent models of streptozotocin-induced diabetic nephropathy Nephrology 12 2007 261 266
46. R. Tobias, and S. Stellan The protective effect of simvastatin against low dose streptozotocin induced type 1 diabetes in mice is independent of inhibition of HmgCoA reductase Biochem. Biophys. Res. Commun. 379 2009 1076 1079
47. X. Wen, Y. Zeng, L. Liu, H. Zhang, W. Xu, N. Li, and X. Jia Zhenqing recipe alleviates diabetic nephropathy in experimental type 2 diabetic rats through suppression of SREBP-1c J. Ethnopharmacol. 142 2012 144 150
48. S. Wild, G. Roglic, A. Green, R. Sicree, and H. King Global prevalence of diabetes: estimates for the year 2000 and projections for 2030 Diabetes Care 27 2004 1047 1053
49. D.B. Zilversmit, and A.K. Davis Microdetermination of phospholipids by TCA precipitation J. Lab. Clin. Med. 35 1950 155 159
50. A. Zlatkis, B. Zak, and A.J. Boyle A new method for the direct determination of serum cholesterol J. Lab. Clin. Med. 41 1953 486 492