Proteolytic control of neurite outgrowth inhibitor NOGO-A by the cAMP/PKA pathway

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 44, 2014, Pages 15729-15734

  Sepe, Maria ^a   Lignitto, Luca ^a   Porpora, Monia ^a   Donne, Rossella Delle ^a   Rinaldi, Laura ^a   Belgianni, Giuseppe ^a   Colucci, Gianna ^a   Cuomo, Ornella ^a   Viggiano, Davide ^a,b   Scorziello, Antonella ^a   Garbi, Corrado ^a   Annunziato, Lucio ^a   Feliciello, Antonio ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF MOLISE   (Italy)

Author keywords

CAMP; NOGO A; PKA; Proteasome; Ubiquitin

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; LIGASE; NEUROTROPHIN; PROTEIN NOGO A; RING LIGASE PRAJA2; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; MYELIN PROTEIN; NEURODEGENERATION ASSOCIATED PROTEIN 1, RAT; PJA2 PROTEIN, HUMAN; PROTEIN NOGO; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ARTICLE; BRAIN; BRAIN DEVELOPMENT; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; DOWN REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; MESENCEPHALON; NERVE CELL; NERVE CELL DIFFERENTIATION; NERVE FIBER; NERVE FIBER GROWTH; NERVE SPROUTING; NEUROBLASTOMA CELL; NONHUMAN; PRESYNAPTIC NERVE; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN STABILITY; RAT; SIGNAL TRANSDUCTION; SYNAPTOSOME; ANIMAL; CYTOLOGY; GENETICS; HEK293 CELL LINE; METABOLISM; NEURITE; TUMOR CELL LINE; WISTAR RAT;

MAMMALIA; RATTUS;

ANIMALS; AXONS; CELL LINE, TUMOR; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA-BINDING PROTEINS; HEK293 CELLS; HUMANS; MESENCEPHALON; MYELIN PROTEINS; NEURITES; PROTEOLYSIS; RATS; RATS, WISTAR; UBIQUITIN-PROTEIN LIGASES;

EID: 84914706588     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1410274111     Document Type: Article

References (33)

1. Karnezis T, et al. (2004) The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination. Nat Neurosci 7(7):736-744.
2. Horner PJ, Gage FH (2000) Regenerating the damaged central nervous system. Nature 407(6807):963-970.
3. Huang EJ, Reichardt LF (2001) Neurotrophins: Roles in neuronal development and function. Annu Rev Neurosci 24:677-736.
4. Poo MM (2001) Neurotrophins as synaptic modulators. Nat Rev Neurosci 2(1):24-32.
5. Taskén K, Aandahl EM (2004) Localized effects of cAMP mediated by distinct routes of protein kinase A. Physiol Rev 84(1):137-167.
6. Feliciello A, Gottesman ME, Avvedimento EV (2001) The biological functions of A-kinase anchor proteins. J Mol Biol 308(2):99-114.
7. Beene DL, Scott JD (2007) A-kinase anchoring proteins take shape. Curr Opin Cell Biol 19(2):192-198.
8. Taylor SS, et al. (2005) Dynamics of signaling by PKA. Biochim Biophys Acta 1754(1-2):25-37.
9. Lignitto L, et al. (2011) Control of PKA stability and signalling by the RING ligase praja2. Nat Cell Biol 13(4):412-422.
10. GrandPré T, Nakamura F, Vartanian T, Strittmatter SM (2000) Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 403(6768):439-444.
11. Iwahashi J, Hamada N, Watanabe H (2007) Two hydrophobic segments of the RTN1 family determine the ER localization and retention. Biochem Biophys Res Commun 355(2):508-512.
12. Bongiorno D, Petratos S (2010) Molecular regulation of Nogo-A in neural cells: Novel insights into structure and function. Int J Biochem Cell Biol 42(7):1072-1075.
13. Ahmed Z, et al. (2006) Schwann cell-derived factor-induced modulation of the NgR/ p75NTR/EGFR axis disinhibits axon growth through CNS myelin in vivo and in vitro. Brain 129(Pt 6):1517-1533.
14. Encinas M, et al. (2000) Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J Neurochem 75(3):991-1003.
15. Beyer C, Karolczak M (2000) Estrogenic stimulation of neurite growth in midbrain dopaminergic neurons depends on cAMP/protein kinase A signalling. J Neurosci Res 59(1):107-116.
16. Sánchez S, et al. (2004) A cAMP-activated pathway, including PKA and PI3K, regulates neuronal differentiation. Neurochem Int 44(4):231-242.
17. Aglah C, Gordon T, Posse de Chaves EI (2008) cAMP promotes neurite outgrowth and extension through protein kinase A but independently of Erk activation in cultured rat motoneurons. Neuropharmacology 55(1):8-17.
18. Cunha C, Brambilla R, Thomas KL (2010) A simple role for BDNF in learning and memory? Front Mol Neurosci 3:1.
19. Cheng PL, et al. (2011) Self-amplifying autocrine actions of BDNF in axon development. Proc Natl Acad Sci USA 108(45):18430-18435.
20. Yoshii A, Constantine-Paton M (2010) Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease. Dev Neurobiol 70(5):304-322.
21. Wang Q, Zheng JQ (1998) cAMP-mediated regulation of neurotrophin-induced collapse of nerve growth cones. J Neurosci 18(13):4973-4984.
22. Gao Y, Nikulina E, Mellado W, Filbin MT (2003) Neurotrophins elevate cAMP to reach a threshold required to overcome inhibition by MAG through extracellular signalregulated kinase-dependent inhibition of phosphodiesterase. J Neurosci 23(37): 11770-11777.
23. Spencer TK, Mellado W, Filbin MT (2008) BDNF activates CaMKIV and PKA in parallel to block MAG-mediated inhibition of neurite outgrowth. Mol Cell Neurosci 38(1): 110-116.
24. Shabb JB (2001) Physiological substrates of cAMP-dependent protein kinase. Chem Rev 101(8):2381-2411.
25. Tojima T, Kobayashi S, Ito E (2003) Dual role of cyclic AMP-dependent protein kinase in neuritogenesis and synaptogenesis during neuronal differentiation. J Neurosci Res 74(6):829-837.
26. Wang KC, et al. (2002) Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature 417(6892):941-944.
27. Edsjö A, Holmquist L, Påhlman S (2007) Neuroblastoma as an experimental model for neuronal differentiation and hypoxia-induced tumor cell dedifferentiation. Semin Cancer Biol 17(3):248-256.
28. Scorziello A, et al. (2001) Differential vulnerability of cortical and cerebellar neurons in primary culture to oxygen glucose deprivation followed by reoxygenation. J Neurosci Res 63(1):20-26.
29. Fath T, Ke YD, Gunning P, Götz J, Ittner LM (2009) Primary support cultures of hippocampal and substantia nigra neurons. Nat Protoc 4(1):78-85.
30. Simonen M, et al. (2003) Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury. Neuron 38(2):201-211.
31. Tarazi FI, Tomasini EC, Baldessarini RJ (1998) Postnatal development of dopamine and serotonin transporters in rat caudate-putamen and nucleus accumbens septi. Neurosci Lett 254(1):21-24.
32. Lee JP, McKercher S, Muller FJ, Snyder EY (2008) Neural stem cell transplantation in mouse brain. Curr Protoc Neurosci Chapter 3:Unit 3.10.
33. Kume H, Konishi Y, Murayama KS, Kametani F, ArakiW(2009) Expression of reticulon 3 in Alzheimer's disease brain. Neuropathol Appl Neurobiol 35(2):178-188.