A novel role of SIRT1 in gammaherpesvirus latency and replication

Cell Cycle

Volumn 13, Issue 21, 2014, Pages 3328-3330

  He, Meilan ^a   Gao, Shou Jiang ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Epigenetics; H3K4me3 and H3K27me3; Kaposi's Sarcoma; Kaposi's Sarcoma Associated Herpesvirus (KSHV); KSHV Latency and Reactivation; Metabolism; Nicotinamide; Primary effusion lymphoma; SIRT1

Indexed keywords

HISTONE H3; SIRTUIN 1; HISTONE; NICOTINAMIDE ADENINE DINUCLEOTIDE; SIRT1 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; VIRUS PROTEIN;

ARTICLE; GAMMAHERPESVIRINAE; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; LATENT PERIOD; LIFE CYCLE; NONHUMAN; PROMOTER REGION; TRANSACTIVATION; VIRUS REPLICATION; ANTAGONISTS AND INHIBITORS; CALORIC RESTRICTION; CELL LINE; DNA REPLICATION; GENETICS; HUMAN; HUMAN HERPESVIRUS 8; METABOLISM; PHYSIOLOGY; TRANSCRIPTION INITIATION; VIRUS LATENCY;

HUMAN HERPESVIRUS 8;

CALORIC RESTRICTION; CELL LINE; DNA REPLICATION; HERPESVIRUS 8, HUMAN; HISTONES; HUMANS; NAD; PROMOTER REGIONS, GENETIC; SIRTUIN 1; TRANS-ACTIVATORS; TRANSCRIPTIONAL ACTIVATION; VIRAL PROTEINS; VIRUS LATENCY;

EID: 84914689416     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/15384101.2014.968431     Document Type: Article

References (14)

1. Guarente L. Sir2 links chromatin silencing, metabolism, and aging. Genes Dev 2000; 14:1021-6; PMID:10809662
2. Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000; 403:795-800; PMID:10693811; http://dx.doi.org/ 10.1038/35001622
3. Yuan H, Su L, Chen WY. The emerging and diverse roles of sirtuins in cancer: a clinical perspective. Onco Targets Ther 2013; 6:1399-416; PMID:24133372.
4. Canto C, Auwerx J. Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD(C)? Pharmacol Rev 2012; 64:166-87; PMID:22106091; http://dx.doi. org/10.1124/pr.110.003905
5. Pagans S, Pedal A, North BJ, Kaehlcke K, Marshall BL, Dorr A, Hetzer-Egger C, Henklein P, Frye R, McBurney MW, et al. SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol 2005; 3:e41; PMID:15719057
6. Ren JH, Tao Y, Zhang ZZ, Chen WX, Cai XF, Chen K, Ko BC, Song CL, Ran LK, Li WY, et al. Sirtuin 1 regulates hepatitis B virus transcription and replication by targeting transcription factor AP-1. J Virol 2014; 88:2442-51; PMID:24335313; http://dx.doi.org/ 10.1128/JVI.02861-13
7. Picchione KE, Bhattacharjee A. Viral genome silencing by neuronal sirtuin 1. J Neurovirol 2011; 17:184-8; PMID:21165789; http://dx.doi.org/10.1007/s13365- 010-0012-3
8. Ye F, Lei X, Gao SJ. Mechanisms of Kaposi's Sarcoma- Associated Herpesvirus Latency and Reactivation. Adv Virol 2011; 2011; PMID:21625290; http://dx.doi.org/ 10.1155/2011/193860
9. Ganem D. KSHV infection and the pathogenesis of Kaposi's sarcoma. Annu Rev Pathol 2006; 1:273-96; PMID:18039116; http://dx.doi.org/10.1146/annurev. pathol.1.110304.100133
10. Gunther T, Grundhoff A. The epigenetic landscape of latent Kaposi sarcoma-associated herpesvirus genomes. PLoS Pathog 2010; 6:e1000935; PMID:20532208; http://dx.doi.org/10.1371/journal. ppat.1000935
11. Toth Z, Maglinte DT, Lee SH, Lee HR, Wong LY, Brulois KF, Lee S, Buckley JD, Laird PW, Marquez VE, et al. Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathog 2010; 6:e1001013; PMID:20661424
12. Sun R, Lin SF, Gradoville L, Yuan Y, Zhu F, Miller G. A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proc Natl Acad Sci U S A 1998; 95:10866-71; PMID:9724796; http://dx.doi.org/10.1073/pnas.95.18.10866
13. Li Q, He M, Zhou F, Ye F, Gao SJ. Activation of Kaposi's sarcoma-associated herpesvirus (KSHV) by inhibitors of class III histone deacetylases: identification of sirtuin 1 as a regulator of the KSHV life cycle. J Virol 2014; 88:6355-67; PMID:24672028; http://dx.doi. org/10.1128/JVI.00219-14
14. Li X. SIRT1 and energy metabolism. Acta Biochim Biophys Sin (Shanghai) 2013; 45:51-60; PMID:23257294; http://dx.doi.org/10.1093/abbs/