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Volumn 15, Issue 12, 2014, Pages 21992-22010

Identification of a plastid-localized bifunctional nerolidol/linalool synthase in relation to linalool biosynthesis in young grape berries

Author keywords

Gene expression; Grape berries; Linalool synthase; Subcellular localization

Indexed keywords

ENZYME; LINALOOL; LINALOOL SYNTHASE; NEROLIDOL SYNTHASE; UNCLASSIFIED DRUG; GREEN FLUORESCENT PROTEIN; HYDROLYASE; NEROLIDOL; RECOMBINANT PROTEIN; S-LINALOOL SYNTHASE; SESQUITERPENE; TERPENE;

EID: 84914680474     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms151221992     Document Type: Article
Times cited : (45)

References (50)
  • 1
    • 0343294293 scopus 로고    scopus 로고
    • Monoterpenes in grape juice and wines
    • Mateo, J.; Jiménez, M. Monoterpenes in grape juice and wines. J. Chromatogr. 2000, 881, 557-567.
    • (2000) J. Chromatogr. , vol.881 , pp. 557-567
    • Mateo, J.1    Jiménez, M.2
  • 2
    • 59049098660 scopus 로고    scopus 로고
    • Changes in the aromatic composition of the Vitis vinifera grape muscat hamburg during ripening
    • Fenoll, J.; Manso, A.; Hellin, P.; Ruiz, L.; Flores, P. Changes in the aromatic composition of the Vitis vinifera grape muscat hamburg during ripening. Food Chem. 2009, 114, 420-428.
    • (2009) Food Chem. , vol.114 , pp. 420-428
    • Fenoll, J.1    Manso, A.2    Hellin, P.3    Ruiz, L.4    Flores, P.5
  • 3
    • 48249125841 scopus 로고    scopus 로고
    • Seasonal variation of flavour content of English vineyard grapes, determined by stir-bar sorptive extraction-gas chromatography-mass spectrometry
    • Caven-Quantrill, D.J.; Buglass, A.J. Seasonal variation of flavour content of English vineyard grapes, determined by stir-bar sorptive extraction-gas chromatography-mass spectrometry. Flavour Fragr. J. 2008, 23, 239-248.
    • (2008) Flavour Fragr. J. , vol.23 , pp. 239-248
    • Caven-Quantrill, D.J.1    Buglass, A.J.2
  • 5
    • 0035594238 scopus 로고    scopus 로고
    • Analytical chemistry: Unlocking the secrets of wine flavor
    • Ebeler, S.E. Analytical chemistry: Unlocking the secrets of wine flavor. Food Rev. Int. 2001, 17, 45-64.
    • (2001) Food Rev. Int. , vol.17 , pp. 45-64
    • Ebeler, S.E.1
  • 6
    • 57949103155 scopus 로고    scopus 로고
    • Comparison of monoterpene constituents in Traminette, Gewürztraminer, and Riesling winegrapes
    • Skinkis, P.A.; Bordelon, B.P.; Wood, K.V. Comparison of monoterpene constituents in Traminette, Gewürztraminer, and Riesling winegrapes. Am. J. Enol. Vitic. 2008, 59, 440-445.
    • (2008) Am. J. Enol. Vitic. , vol.59 , pp. 440-445
    • Skinkis, P.A.1    Bordelon, B.P.2    Wood, K.V.3
  • 7
    • 32444433426 scopus 로고    scopus 로고
    • Biosynthesis of plant volatiles: Nature's diversity and ingenuity
    • Pichersky, E.; Noel, J.P.; Dudareva, N. Biosynthesis of plant volatiles: Nature's diversity and ingenuity. Science 2006, 311, 808-811.
    • (2006) Science , vol.311 , pp. 808-811
    • Pichersky, E.1    Noel, J.P.2    Dudareva, N.3
  • 8
    • 84856585187 scopus 로고    scopus 로고
    • A raison d'êtrefor two distinct pathways in the early steps of plant isoprenoid biosynthesis?
    • Hemmerlin, A.; Harwood, J.L.; Bach, T.J. A raison d'êtrefor two distinct pathways in the early steps of plant isoprenoid biosynthesis? Prog. Lipid Res. 2012, 51, 95-148.
    • (2012) Prog. Lipid Res. , vol.51 , pp. 95-148
    • Hemmerlin, A.1    Harwood, J.L.2    Bach, T.J.3
  • 10
    • 79953251042 scopus 로고    scopus 로고
    • The family of terpene synthases in plants: A mid-size family of genes for specialized metabolism that is highly diversified throughout the kingdom
    • Chen, F.; Tholl, D.; Bohlmann, J.; Pichersky, E. The family of terpene synthases in plants: A mid-size family of genes for specialized metabolism that is highly diversified throughout the kingdom. Plant J. 2011, 66, 212-229.
    • (2011) Plant J. , vol.66 , pp. 212-229
    • Chen, F.1    Tholl, D.2    Bohlmann, J.3    Pichersky, E.4
  • 11
    • 0032516004 scopus 로고    scopus 로고
    • Plant terpenoid synthases: Molecular biology and phylogenetic analysis
    • Bohlmann, J.; Meyer-Gauen, G.; Croteau, R. Plant terpenoid synthases: Molecular biology and phylogenetic analysis. Proc. Natl. Acad. Sci. USA 1998, 95, 4126-4133.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 4126-4133
    • Bohlmann, J.1    Meyer-Gauen, G.2    Croteau, R.3
  • 12
    • 0037877924 scopus 로고    scopus 로고
    • (E)-β-Ocimene and myrcene synthase genes of floral scent biosynthesis in snapdragon: Function and expression of three terpene synthase genes of a new terpene synthase subfamily
    • Dudareva, N.; Martin, D.; Kish, C.M.; Kolosova, N.; Gorenstein, N.; Fäldt, J.; Miller, B.; Bohlmann, J. (E)-β-Ocimene and myrcene synthase genes of floral scent biosynthesis in snapdragon: Function and expression of three terpene synthase genes of a new terpene synthase subfamily. Plant Cell 2003, 15, 1227-1241.
    • (2003) Plant Cell , vol.15 , pp. 1227-1241
    • Dudareva, N.1    Martin, D.2    Kish, C.M.3    Kolosova, N.4    Gorenstein, N.5    Fäldt, J.6    Miller, B.7    Bohlmann, J.8
  • 14
    • 77958058409 scopus 로고    scopus 로고
    • Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, flcDNA cloning, and enzyme assays
    • Martin, D.; Aubourg, S.; Schouwey, M.; Daviet, L.; Schalk, M.; Toub, O.; Lund, S.; Bohlmann, J. Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, flcDNA cloning, and enzyme assays. BMC Plant Biol. 2010, 10, 226.
    • (2010) BMC Plant Biol. , vol.10 , pp. 226
    • Martin, D.1    Aubourg, S.2    Schouwey, M.3    Daviet, L.4    Schalk, M.5    Toub, O.6    Lund, S.7    Bohlmann, J.8
  • 15
    • 55249088798 scopus 로고    scopus 로고
    • Two nearly identical terpene synthases catalyze the formation of nerolidol and linalool in snapdragon flowers
    • Nagegowda, D.A.; Gutensohn, M.; Wilkerson, C.G.; Dudareva, N. Two nearly identical terpene synthases catalyze the formation of nerolidol and linalool in snapdragon flowers. Plant J. 2008, 55, 224-239.
    • (2008) Plant J. , vol.55 , pp. 224-239
    • Nagegowda, D.A.1    Gutensohn, M.2    Wilkerson, C.G.3    Dudareva, N.4
  • 16
    • 0036629116 scopus 로고    scopus 로고
    • Differential incorporation of 1-deoxy-D-xylulose into (3S)-linalool and geraniol in grape berry exocarp and mesocarp
    • Luan, F.; Wüst, M. Differential incorporation of 1-deoxy-D-xylulose into (3S)-linalool and geraniol in grape berry exocarp and mesocarp. Phytochemistry 2002, 60, 451-459.
    • (2002) Phytochemistry , vol.60 , pp. 451-459
    • Luan, F.1    Wüst, M.2
  • 17
    • 0030198839 scopus 로고    scopus 로고
    • Evolution of floral scent in clarkia: Novel patterns of S-linalool synthase gene expression in the c. Breweri flower
    • Dudareva, N.; Cseke, L.; Blanc, V.M.; Pichersky, E. Evolution of floral scent in clarkia: Novel patterns of S-linalool synthase gene expression in the c. Breweri flower. Plant Cell 1996, 8, 1137-1148.
    • (1996) Plant Cell , vol.8 , pp. 1137-1148
    • Dudareva, N.1    Cseke, L.2    Blanc, V.M.3    Pichersky, E.4
  • 19
    • 47749108717 scopus 로고    scopus 로고
    • Molecular and genomic basis of volatile-mediated indirect defense against insects in rice
    • Yuan, J.S.; Köllner, T.G.; Wiggins, G.; Grant, J.; Degenhardt, J.; Chen, F. Molecular and genomic basis of volatile-mediated indirect defense against insects in rice. Plant J. 2008, 55, 491-503.
    • (2008) Plant J. , vol.55 , pp. 491-503
    • Yuan, J.S.1    Köllner, T.G.2    Wiggins, G.3    Grant, J.4    Degenhardt, J.5    Chen, F.6
  • 20
    • 84892460516 scopus 로고    scopus 로고
    • Characterization of S-(+)-linalool synthase from several provenances of Cinnamomum osmophloeum
    • Lin, Y.L.; Lee, Y.R.; Huang, W.K.; Chang, S.T.; Chu, F.H. Characterization of S-(+)-linalool synthase from several provenances of Cinnamomum osmophloeum. Tree Genet. Genomes 2014, 10, 75-86.
    • (2014) Tree Genet. Genomes , vol.10 , pp. 75-86
    • Lin, Y.L.1    Lee, Y.R.2    Huang, W.K.3    Chang, S.T.4    Chu, F.H.5
  • 21
    • 77954177309 scopus 로고    scopus 로고
    • Plant volatile terpenoid metabolism: Biosynthetic genes, transcriptional regulation and subcellular compartmentation
    • Nagegowda, D.A. Plant volatile terpenoid metabolism: Biosynthetic genes, transcriptional regulation and subcellular compartmentation. FEBS Lett. 2010, 584, 2965-2973.
    • (2010) FEBS Lett. , vol.584 , pp. 2965-2973
    • Nagegowda, D.A.1
  • 22
    • 84893802095 scopus 로고    scopus 로고
    • Biosynthesis of sesquiterpenes in grape berry exocarp of Vitis vinifera L.: Evidence for a transport of farnesyl diphosphate precursors from plastids to the cytosol
    • May, B.; Lange, B.M.; Wüst, M. Biosynthesis of sesquiterpenes in grape berry exocarp of Vitis vinifera L.: Evidence for a transport of farnesyl diphosphate precursors from plastids to the cytosol. Phytochemistry 2013, 95, 135-144.
    • (2013) Phytochemistry , vol.95 , pp. 135-144
    • May, B.1    Lange, B.M.2    Wüst, M.3
  • 23
    • 77649280393 scopus 로고    scopus 로고
    • Characterisation of an (S)-linalool synthase from kiwifruit (Actinidia arguta) that catalyses the first committed step in the production of floral lilac compounds
    • Chen, X.; Yauk, Y.K.; Nieuwenhuizen, N.J.; Matich, A.J.; Wang, M.Y.; Perez, R.L.; Atkinson, R.G.; Beuning, L.L. Characterisation of an (S)-linalool synthase from kiwifruit (Actinidia arguta) that catalyses the first committed step in the production of floral lilac compounds. Funct. Plant Biol. 2010, 37, 232-243.
    • (2010) Funct. Plant Biol. , vol.37 , pp. 232-243
    • Chen, X.1    Yauk, Y.K.2    Nieuwenhuizen, N.J.3    Matich, A.J.4    Wang, M.Y.5    Perez, R.L.6    Atkinson, R.G.7    Beuning, L.L.8
  • 24
    • 0036042698 scopus 로고    scopus 로고
    • Genomic analysis of the terpenoid synthase (AtTPS) gene family of Arabidopsis thaliana
    • Aubourg, S.; Lecharny, A.; Bohlmann, J. Genomic analysis of the terpenoid synthase (AtTPS) gene family of Arabidopsis thaliana. Mol. Genet. Genomics 2002, 267, 730-745.
    • (2002) Mol. Genet. Genomics , vol.267 , pp. 730-745
    • Aubourg, S.1    Lecharny, A.2    Bohlmann, J.3
  • 25
    • 2942525373 scopus 로고    scopus 로고
    • Identification of vitis vinifera (-)-α-terpineol synthase by in silico screening of full-length cdna ests and functional characterization of recombinant terpene synthase
    • Martin, D.M.; Bohlmann, J. Identification of vitis vinifera (-)-α-terpineol synthase by in silico screening of full-length cdna ests and functional characterization of recombinant terpene synthase. Phytochemistry 2004, 65, 1223-1229.
    • (2004) Phytochemistry , vol.65 , pp. 1223-1229
    • Martin, D.M.1    Bohlmann, J.2
  • 26
    • 4644297519 scopus 로고    scopus 로고
    • Vitis vinifera terpenoid cyclases: Functional identification of two sesquiterpene synthase cDNAs encoding (+)-valencene synthase and (-)-germacrene D synthase and expression of mono- and sesquiterpene synthases in grapevine flowers and berries
    • Lücker, J.;Bowen, P.; Bohlmann, J. Vitis vinifera terpenoid cyclases: Functional identification of two sesquiterpene synthase cDNAs encoding (+)-valencene synthase and (-)-germacrene D synthase and expression of mono- and sesquiterpene synthases in grapevine flowers and berries. Phytochemistry 2004, 65, 2649-2659.
    • (2004) Phytochemistry , vol.65 , pp. 2649-2659
    • Lücker, J.1    Bowen, P.2    Bohlmann, J.3
  • 27
    • 0001507420 scopus 로고
    • Evidence for a geranyl-diphosphate synthase located within the plastids of Vitis vinifera L. Cultivated in vitro
    • Soler, E.; Feron, G.; Clastre, M.; Dargent, R.; Gleizes, M.; Ambid, C. Evidence for a geranyl-diphosphate synthase located within the plastids of Vitis vinifera L. Cultivated in vitro. Planta 1992, 187, 171-175.
    • (1992) Planta , vol.187 , pp. 171-175
    • Soler, E.1    Feron, G.2    Clastre, M.3    Dargent, R.4    Gleizes, M.5    Ambid, C.6
  • 29
    • 84865585138 scopus 로고    scopus 로고
    • Biosynthesis of wine aroma: Transcript profiles of hydroxymethylbutenyl diphosphate reductase, geranyl diphosphate synthase, and linalool/nerolidol synthase parallel monoterpenol glycoside accumulation in Gewürztraminer grapes
    • Martin, D.M.; Chiang, A.; Lund, S.T.; Bohlmann, J. Biosynthesis of wine aroma: Transcript profiles of hydroxymethylbutenyl diphosphate reductase, geranyl diphosphate synthase, and linalool/nerolidol synthase parallel monoterpenol glycoside accumulation in Gewürztraminer grapes. Planta 2012, 236, 919-929.
    • (2012) Planta , vol.236 , pp. 919-929
    • Martin, D.M.1    Chiang, A.2    Lund, S.T.3    Bohlmann, J.4
  • 30
    • 66149091603 scopus 로고    scopus 로고
    • Evolution of volatile compounds during the development of cabernet sauvignon grapes (Vitis viniferaL.)
    • Kalua, C.M.; Boss, P.K. Evolution of volatile compounds during the development of cabernet sauvignon grapes (Vitis viniferaL.). J. Agric. Food Chem. 2009, 57, 3818-3830.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 3818-3830
    • Kalua, C.M.1    Boss, P.K.2
  • 31
    • 0001573225 scopus 로고
    • Changes in free and glycosidically bound monoterpenes in developing muscat grapes
    • Wilson, B.; Strauss, C.R.; Williams, P.J. Changes in free and glycosidically bound monoterpenes in developing muscat grapes. J. Agric. Food Chem. 1984, 32, 919-924.
    • (1984) J. Agric. Food Chem. , vol.32 , pp. 919-924
    • Wilson, B.1    Strauss, C.R.2    Williams, P.J.3
  • 32
    • 70349319667 scopus 로고    scopus 로고
    • Wine chemistry and flavor: Looking into the crystal glass
    • Ebeler, S.E.; Thorngate, J.H. Wine chemistry and flavor: Looking into the crystal glass. J. Agric. Food Chem. 2009, 57, 8098-8108.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 8098-8108
    • Ebeler, S.E.1    Thorngate, J.H.2
  • 33
    • 12844261769 scopus 로고    scopus 로고
    • Temporal expression of the lis gene from vitis vinifera L., cv. Muscat de frontignan
    • Proceedings of the 10th Weurman Flavour Research Symposium, Beaune, France, 25-28 June 2002; Editions Tec & Doc, Lavoisier Intercept: London, UK
    • Ebang-Oke, J.; Billerbeck, G.D.; Ambid, C.; le Quéré, J.; Étiévant, P. Temporal expression of the lis gene from vitis vinifera L., cv. Muscat de frontignan. In Flavour Research at the Dawn of the Twenty-first Century. Proceedings of the 10th Weurman Flavour Research Symposium, Beaune, France, 25-28 June 2002; Editions Tec & Doc, Lavoisier Intercept: London, UK, 2003; pp. 321-325.
    • (2003) Flavour Research at the Dawn of the Twenty-first Century , pp. 321-325
    • Ebang-Oke, J.1    Billerbeck, G.D.2    Ambid, C.3    le Quéré, J.4    Étiévant, P.5
  • 34
    • 84879655529 scopus 로고    scopus 로고
    • Analysis of the expression of terpene synthase genes in relation to aroma content in two aromatic Vitis vinifera varieties
    • Matarese, F.; Scalabrelli, G.; D'Onofrio, C. Analysis of the expression of terpene synthase genes in relation to aroma content in two aromatic Vitis vinifera varieties. Funct. Plant Biol. 2013, 40, 552-565.
    • (2013) Funct. Plant Biol. , vol.40 , pp. 552-565
    • Matarese, F.1    Scalabrelli, G.2    D'Onofrio, C.3
  • 35
    • 67049156725 scopus 로고    scopus 로고
    • Preparation and biological application of antibodies against leucoanthocyanidin reductase and anthocyanidin reductase from grape berry
    • He, F.; Fang, X.X.; Hu, M.; Pan, Q.H.; Shi, Y.; Duan, C.Q. Preparation and biological application of antibodies against leucoanthocyanidin reductase and anthocyanidin reductase from grape berry. Vitis J. Grapevine Res. 2009, 48, 69-75.
    • (2009) Vitis J. Grapevine Res. , vol.48 , pp. 69-75
    • He, F.1    Fang, X.X.2    Hu, M.3    Pan, Q.H.4    Shi, Y.5    Duan, C.Q.6
  • 39
    • 84914701804 scopus 로고    scopus 로고
    • ChloroP. (accessed on 10 July 2010)
    • ChloroP. Available online: http://www.cbs.dtu.dk/services/ChloroP (accessed on 10 July 2010).
  • 40
    • 84914701803 scopus 로고    scopus 로고
    • TargetP. (accessed on 10 July 2010)
    • TargetP. Available online: http://www.cbs.dtu.dk/services/TargetP (accessed on 10 July 2010).
  • 41
    • 84914701802 scopus 로고    scopus 로고
    • SignalP. (accessed on 10 July 2010)
    • SignalP. Available online: http://www.cbs.dtu.dk/services/SignalP (accessed on 10 July 2010).
  • 42
    • 38849128565 scopus 로고    scopus 로고
    • (accessed on 20 June 2010)
    • DFCI Grape gene index. Available online: http://compbio.dfci.harvard.edu/tgi/cgi-bin/tgi/gimain. pl?gudb=grape (accessed on 20 June 2010).
    • DFCI Grape gene index.
  • 43
    • 0037266613 scopus 로고    scopus 로고
    • Traumatic resin defense in norway spruce (Picea abies): Methyl jasmonate-induced terpene synthase gene expression, and cDNA cloning and functional characterization of (+)-3-carene synthase
    • Fäldt, J.; Martin, D.; Miller, B.; Rawat, S.; Bohlmann, J. Traumatic resin defense in norway spruce (Picea abies): Methyl jasmonate-induced terpene synthase gene expression, and cDNA cloning and functional characterization of (+)-3-carene synthase. Plant Mol. Biol. 2003, 51, 119-133.
    • (2003) Plant Mol. Biol. , vol.51 , pp. 119-133
    • Fäldt, J.1    Martin, D.2    Miller, B.3    Rawat, S.4    Bohlmann, J.5
  • 44
    • 84914701801 scopus 로고    scopus 로고
    • (accessed on 1 August 2010)
    • The Map of p-EZS-NL Vector. Available online: https://deepgreen.dpb.carnegiescience.edu (accessed on 1 August 2010).
    • The Map of p-EZS-NL Vector.
  • 45
    • 68249140338 scopus 로고    scopus 로고
    • Apple sucrose transporter SUT1 and sorbitol transporter SOT6 interact with cytochrome b5 to regulate their affinity for substrate sugars
    • Fan, R.C.; Peng, C.C.; Xu, Y.H.; Wang, X.F.; Li, Y.; Shang, Y.; Du, S.Y.; Zhao, R.; Zhang, X.Y.; Zhang, L.Y.; et al. Apple sucrose transporter SUT1 and sorbitol transporter SOT6 interact with cytochrome b5 to regulate their affinity for substrate sugars. Plant Physiol. 2009, 150, 1880-1901.
    • (2009) Plant Physiol. , vol.150 , pp. 1880-1901
    • Fan, R.C.1    Peng, C.C.2    Xu, Y.H.3    Wang, X.F.4    Li, Y.5    Shang, Y.6    Du, S.Y.7    Zhao, R.8    Zhang, X.Y.9    Zhang, L.Y.10
  • 47
    • 7244257594 scopus 로고    scopus 로고
    • Perlprimer: Cross-platform, graphical primer design for standard, bisulphite and real-time PCR
    • Marshall, O.J. Perlprimer: Cross-platform, graphical primer design for standard, bisulphite and real-time PCR. Bioinformatics 2004, 20, 2471-2472.
    • (2004) Bioinformatics , vol.20 , pp. 2471-2472
    • Marshall, O.J.1
  • 48
    • 80052472692 scopus 로고    scopus 로고
    • Molecular characterization and expression analysis on two isogenes encoding 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase in grapes
    • Zhang, Z.Z.; Li, X.X.; Zhu, B.Q.; Wen, Y.Q.; Duan, C.Q.; Pan, Q.H. Molecular characterization and expression analysis on two isogenes encoding 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase in grapes. Mol. Biol. Rep. 2011, 38, 4739-4747.
    • (2011) Mol. Biol. Rep. , vol.38 , pp. 4739-4747
    • Zhang, Z.Z.1    Li, X.X.2    Zhu, B.Q.3    Wen, Y.Q.4    Duan, C.Q.5    Pan, Q.H.6
  • 49
    • 71349085673 scopus 로고    scopus 로고
    • Evolution of the aroma composition of wines supplemented with grape flavour precursors from different varietals during accelerated wine ageing
    • Loscos, N.; Hernandez-Orte, P.; Cacho, J.; Ferreira, V. Evolution of the aroma composition of wines supplemented with grape flavour precursors from different varietals during accelerated wine ageing. Food Chem. 2010, 120, 205-216.
    • (2010) Food Chem. , vol.120 , pp. 205-216
    • Loscos, N.1    Hernandez-Orte, P.2    Cacho, J.3    Ferreira, V.4
  • 50
    • 70350333878 scopus 로고    scopus 로고
    • Comparison of volatile profiles of nine litchi (litchi chinensis sonn.) cultivars from southern china
    • Wu, Y.; Pan, Q.; Qu, W.; Duan, C. Comparison of volatile profiles of nine litchi (litchi chinensis sonn.) cultivars from southern china. J. Agric. Food Chem. 2009, 57, 9676-9681.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 9676-9681
    • Wu, Y.1    Pan, Q.2    Qu, W.3    Duan, C.4


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