메뉴 건너뛰기




Volumn 54, Issue 1, 2015, Pages 9-23

Inhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma

Author keywords

C4; FAK; FLT 4; SK N AS; SK N BE(2)

Indexed keywords

CHLOROPYRAMINE; DOXORUBICIN; FOCAL ADHESION KINASE; VASCULOTROPIN RECEPTOR 3; ANTINEOPLASTIC AGENT; ETHYLENEDIAMINE DERIVATIVE; FOCAL ADHESION KINASE 1; PTK2 PROTEIN, HUMAN; VEGFR3 PROTEIN, HUMAN;

EID: 84914676536     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22070     Document Type: Article
Times cited : (18)

References (49)
  • 1
    • 0035161845 scopus 로고    scopus 로고
    • Neuroblastoma: Changing incidence and survival in young people aged 0-24 years. A report from the North of England Young Persons' Malignant Disease Registry
    • Cotterill S, Parker L, More L, Craft A. Neuroblastoma: Changing incidence and survival in young people aged 0-24 years. A report from the North of England Young Persons' Malignant Disease Registry. Med Pediatr Oncol 2001; 36:231-234.
    • (2001) Med Pediatr Oncol , vol.36 , pp. 231-234
    • Cotterill, S.1    Parker, L.2    More, L.3    Craft, A.4
  • 2
    • 0031081425 scopus 로고
    • Signaling through focal adhesion kinase
    • Hanks S, Polte T. Signaling through focal adhesion kinase. Bioessays 1977; 19:137-145.
    • (1977) Bioessays , vol.19 , pp. 137-145
    • Hanks, S.1    Polte, T.2
  • 3
  • 4
    • 0038048222 scopus 로고    scopus 로고
    • FAK regulates biological processes important for the pathogenesis of cancer
    • Gabarra-Niecko V, Schaller M, Dunty J. FAK regulates biological processes important for the pathogenesis of cancer. Cancer Metastasis Rev 2003; 22:359-374.
    • (2003) Cancer Metastasis Rev , vol.22 , pp. 359-374
    • Gabarra-Niecko, V.1    Schaller, M.2    Dunty, J.3
  • 5
  • 6
    • 20344393365 scopus 로고    scopus 로고
    • The tyrosine kinase pyk2 promotes migration and invasion of glioma cells
    • Lipinski C, Tran N, Menashi E, et al. The tyrosine kinase pyk2 promotes migration and invasion of glioma cells. Neoplasia 2005; 7:435-445.
    • (2005) Neoplasia , vol.7 , pp. 435-445
    • Lipinski, C.1    Tran, N.2    Menashi, E.3
  • 7
    • 0034730632 scopus 로고    scopus 로고
    • The focal adhesion kinase suppresses transformation associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways
    • Xu L, Yang X, Bradham C, et al. The focal adhesion kinase suppresses transformation associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways. J Biol Chem 2000; 275:30597-30604.
    • (2000) J Biol Chem , vol.275 , pp. 30597-30604
    • Xu, L.1    Yang, X.2    Bradham, C.3
  • 8
    • 0032443850 scopus 로고    scopus 로고
    • The COOH-terminal domain of the focal adhesion kinase induces loss of adhesion and cell death in human tumor cells
    • Xu L, Yang X, Craven R, Cance W. The COOH-terminal domain of the focal adhesion kinase induces loss of adhesion and cell death in human tumor cells. Cell Growth Differ 1998; 9:999-1005.
    • (1998) Cell Growth Differ , vol.9 , pp. 999-1005
    • Xu, L.1    Yang, X.2    Craven, R.3    Cance, W.4
  • 9
    • 0029848157 scopus 로고    scopus 로고
    • Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells
    • Xu L, Owens L, Sturge G, et al. Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells. Cell Growth Differ 1996; 7:413-418.
    • (1996) Cell Growth Differ , vol.7 , pp. 413-418
    • Xu, L.1    Owens, L.2    Sturge, G.3
  • 10
    • 0037064030 scopus 로고    scopus 로고
    • Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor mediated apoptosis in human breast cancer cells
    • Golubovskaya V, Beviglia L, Xu L, Earp Hr, Craven R, Cance W. Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor mediated apoptosis in human breast cancer cells. J Biol Chem 2002; 277:38978-38987.
    • (2002) J Biol Chem , vol.277 , pp. 38978-38987
    • Golubovskaya, V.1    Beviglia, L.2    Xu, L.3    Earp, H.4    Craven, R.5    Cance, W.6
  • 11
    • 29344471438 scopus 로고    scopus 로고
    • Focal adhesion kinase silencing augments docetaxel mediated apoptosis in ovarian cancer cells
    • Halder J, Landen CJ, Lutgendorf S, et al. Focal adhesion kinase silencing augments docetaxel mediated apoptosis in ovarian cancer cells. Clin Cancer Res 2005; 11:8829-8836.
    • (2005) Clin Cancer Res , vol.11 , pp. 8829-8836
    • Halder, J.1    Landen, C.J.2    Lutgendorf, S.3
  • 12
    • 34250163937 scopus 로고    scopus 로고
    • A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth
    • Shi Q, Hjelmeland AB, Keir ST, et al. A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth. Mol Carcinog 2007; 46:488-496.
    • (2007) Mol Carcinog , vol.46 , pp. 488-496
    • Shi, Q.1    Hjelmeland, A.B.2    Keir, S.T.3
  • 13
    • 50349092365 scopus 로고    scopus 로고
    • Focal adhesion kinase expression in human neuroblastoma: Immunohistochemical and real-time PCR analyses
    • Beierle E, Massoll N, Hartwich J, et al. Focal adhesion kinase expression in human neuroblastoma: Immunohistochemical and real-time PCR analyses. Clin Cancer Res 2008; 14:3299-3305.
    • (2008) Clin Cancer Res , vol.14 , pp. 3299-3305
    • Beierle, E.1    Massoll, N.2    Hartwich, J.3
  • 14
    • 34250359928 scopus 로고    scopus 로고
    • N-MYC regulates focal adhesion kinase expression in human neuroblastoma
    • Beierle E, Trujillo A, Nagaram A, et al. N-MYC regulates focal adhesion kinase expression in human neuroblastoma. J Biol Chem 2007; 282:12503-12516.
    • (2007) J Biol Chem , vol.282 , pp. 12503-12516
    • Beierle, E.1    Trujillo, A.2    Nagaram, A.3
  • 16
    • 77953526787 scopus 로고    scopus 로고
    • Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma
    • Beierle E, Ma X, Stewart J, et al. Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma. Cell Cycle 2010; 9:1005-1015.
    • (2010) Cell Cycle , vol.9 , pp. 1005-1015
    • Beierle, E.1    Ma, X.2    Stewart, J.3
  • 17
    • 1142299737 scopus 로고    scopus 로고
    • Expression and significance of VEGF-C and FLT-4 in gastric cancer
    • Liu X, Sun X, Wu J. Expression and significance of VEGF-C and FLT-4 in gastric cancer. World J Gastroenterol 2004; 10:352-355.
    • (2004) World J Gastroenterol , vol.10 , pp. 352-355
    • Liu, X.1    Sun, X.2    Wu, J.3
  • 18
    • 36249027630 scopus 로고    scopus 로고
    • VEGF-D in association with VEGFR-3 promotes nodal metastasis in human invasive lobular breast cancer
    • van Iterson V, Leidenius M, von Smitten K, Bono P, Heikkilä P. VEGF-D in association with VEGFR-3 promotes nodal metastasis in human invasive lobular breast cancer. Am J Clin Pathol 2007; 128:759-766.
    • (2007) Am J Clin Pathol , vol.128 , pp. 759-766
    • van Iterson, V.1    Leidenius, M.2    von Smitten, K.3    Bono, P.4    Heikkilä, P.5
  • 19
    • 34848908049 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C and its receptor VEGFR-3 in non-small-cell lung cancer: Concurrent expression in cancer cells from primary tumour and metastatic lymph node
    • Saintigny P, Kambouchner M, Ly M, et al. Vascular endothelial growth factor-C and its receptor VEGFR-3 in non-small-cell lung cancer: Concurrent expression in cancer cells from primary tumour and metastatic lymph node. Lung Cancer 2007; 58:205-213.
    • (2007) Lung Cancer , vol.58 , pp. 205-213
    • Saintigny, P.1    Kambouchner, M.2    Ly, M.3
  • 20
    • 35348944486 scopus 로고    scopus 로고
    • VEGF-C, VEGF-D and Flt-4 in transitional bladder cancer: Relationships to clinicopathological parameters and long-term survival
    • Herrmann E, Eltze E, Bierer S, et al. VEGF-C, VEGF-D and Flt-4 in transitional bladder cancer: Relationships to clinicopathological parameters and long-term survival. Anticancer Res 2007; 27:3127-3133.
    • (2007) Anticancer Res , vol.27 , pp. 3127-3133
    • Herrmann, E.1    Eltze, E.2    Bierer, S.3
  • 21
    • 68049098116 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-3 promotes breast cancer cell proliferation, motility and survival in vitro and tumor formation in vivo
    • Kurenova EV, Hunt DL, He D, et al. Vascular endothelial growth factor receptor-3 promotes breast cancer cell proliferation, motility and survival in vitro and tumor formation in vivo. Cell Cycle 2009; 8:2266-2280.
    • (2009) Cell Cycle , vol.8 , pp. 2266-2280
    • Kurenova, E.V.1    Hunt, D.L.2    He, D.3
  • 22
    • 33846688115 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth
    • Laakkonen P, Waltari M, Holopainen T, et al. Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth. Cancer Res 2007; 67:593-599.
    • (2007) Cancer Res , vol.67 , pp. 593-599
    • Laakkonen, P.1    Waltari, M.2    Holopainen, T.3
  • 23
    • 0037370288 scopus 로고    scopus 로고
    • VEGF receptors are differentially expressed by neuroblastoma cells in culture
    • Beierle EA, Dai W, Langham MJ, Copeland ER, Chen M. VEGF receptors are differentially expressed by neuroblastoma cells in culture. J Pediatr Surg 2003; 38:514-521.
    • (2003) J Pediatr Surg , vol.38 , pp. 514-521
    • Beierle, E.A.1    Dai, W.2    Langham, M.J.3    Copeland, E.R.4    Chen, M.5
  • 24
  • 26
    • 79953312505 scopus 로고    scopus 로고
    • The selective VEGFR 1-3 in hibitor axitinib (AG-013736) shows antitumor activity in human neuroblastoma xenografts
    • Rössler J, Monnet Y, Farace F, et al. The selective VEGFR 1-3 in hibitor axitinib (AG-013736) shows antitumor activity in human neuroblastoma xenografts. Int J Cancer 2011; 128:2748-2758.
    • (2011) Int J Cancer , vol.128 , pp. 2748-2758
    • Rössler, J.1    Monnet, Y.2    Farace, F.3
  • 27
    • 32944475609 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells
    • Garces C, Kurenova E, Golubovskaya V, Cance W. Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells. Cancer Res 2006; 66:1446-1454.
    • (2006) Cancer Res , vol.66 , pp. 1446-1454
    • Garces, C.1    Kurenova, E.2    Golubovskaya, V.3    Cance, W.4
  • 28
    • 68549120961 scopus 로고    scopus 로고
    • Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo
    • Kurenova E, Hunt D, He D, Magis A, Ostrov D, Cance W. Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo. J Med Chem 2009; 52:4716-4724.
    • (2009) J Med Chem , vol.52 , pp. 4716-4724
    • Kurenova, E.1    Hunt, D.2    He, D.3    Magis, A.4    Ostrov, D.5    Cance, W.6
  • 29
    • 84894241649 scopus 로고    scopus 로고
    • Inhibition of the focal adhesion kinase and vascular endothelial growth factor receptor-3 interaction leads to decreased survival in human neuroblastoma cell lines
    • [Epub ahead of print].
    • Beierle EA, Ma X, Stewart JE, Megison M, Cance WG, Kurenova EV. Inhibition of the focal adhesion kinase and vascular endothelial growth factor receptor-3 interaction leads to decreased survival in human neuroblastoma cell lines. Mol Carcinog 2012; doi: 10.1002/mc.21969. [Epub ahead of print].
    • (2012) Mol Carcinog
    • Beierle, E.A.1    Ma, X.2    Stewart, J.E.3    Megison, M.4    Cance, W.G.5    Kurenova, E.V.6
  • 30
    • 0027418205 scopus 로고
    • Measurement of colocalization of objects in dual-color confocal images
    • Manders EMM, Verbeek FJ, Aten JA. Measurement of colocalization of objects in dual-color confocal images. J Microsc 1993; 169:375-382.
    • (1993) J Microsc , vol.169 , pp. 375-382
    • Manders, E.M.M.1    Verbeek, F.J.2    Aten, J.A.3
  • 31
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994; 124:619-626.
    • (1994) J Cell Biol , vol.124 , pp. 619-626
    • Frisch, S.M.1    Francis, H.2
  • 32
    • 0029739950 scopus 로고    scopus 로고
    • Control of adhesion-dependent cell survival by focal adhesion kinase
    • Frisch SM, Vuori K, Ruoslahti E, Chan-Hui PY. Control of adhesion-dependent cell survival by focal adhesion kinase. J Cell Biol 1996; 134:793-799.
    • (1996) J Cell Biol , vol.134 , pp. 793-799
    • Frisch, S.M.1    Vuori, K.2    Ruoslahti, E.3    Chan-Hui, P.Y.4
  • 33
    • 0030046955 scopus 로고    scopus 로고
    • The association of focal adhesion kinase with a 200-kDa protein that is tyrosine phosphorylated in response to platelet-derived growth factor
    • Chen HC, Guan JL. The association of focal adhesion kinase with a 200-kDa protein that is tyrosine phosphorylated in response to platelet-derived growth factor. Eur J Biochem 1996; 235:495-500.
    • (1996) Eur J Biochem , vol.235 , pp. 495-500
    • Chen, H.C.1    Guan, J.L.2
  • 34
    • 0033772308 scopus 로고    scopus 로고
    • FAK integrates growth-factor and integrin signals to promote cell migration
    • Sieg DJ, Hauck CR, Ilic D, et al. FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol 2000; 2:249-256.
    • (2000) Nat Cell Biol , vol.2 , pp. 249-256
    • Sieg, D.J.1    Hauck, C.R.2    Ilic, D.3
  • 35
    • 46949105858 scopus 로고    scopus 로고
    • FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells
    • Liu W, Bloom D, Cance W, Kurenova E, Golubovskaya V, Hochwald S. FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis 2008; 29:1096-1107.
    • (2008) Carcinogenesis , vol.29 , pp. 1096-1107
    • Liu, W.1    Bloom, D.2    Cance, W.3    Kurenova, E.4    Golubovskaya, V.5    Hochwald, S.6
  • 36
    • 33745468872 scopus 로고    scopus 로고
    • Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion
    • Chen SY, Chen HC. Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion. Mol Cell Biol 2006; 26:5155-5167.
    • (2006) Mol Cell Biol , vol.26 , pp. 5155-5167
    • Chen, S.Y.1    Chen, H.C.2
  • 37
    • 21644466387 scopus 로고    scopus 로고
    • Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53
    • Golubovskaya VM, Finch R, Cance WG. Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. J Biol Chem 2005; 80:25008-25021.
    • (2005) J Biol Chem , vol.80 , pp. 25008-25021
    • Golubovskaya, V.M.1    Finch, R.2    Cance, W.G.3
  • 38
    • 33847387601 scopus 로고    scopus 로고
    • Disrupting Skp2-cyclin A interaction with a blocking peptide induces selective cancer cell killing
    • Ji P, Sun D, Wang H, Bauzon F, Zhu L. Disrupting Skp2-cyclin A interaction with a blocking peptide induces selective cancer cell killing. Mol Cancer Ther 2007; 6:684-691.
    • (2007) Mol Cancer Ther , vol.6 , pp. 684-691
    • Ji, P.1    Sun, D.2    Wang, H.3    Bauzon, F.4    Zhu, L.5
  • 39
    • 6344245673 scopus 로고    scopus 로고
    • Disruption of the Rb-Raf-1 interaction inhibits tumor growth and angiogenesis
    • Dasgupta P, Sun J, Wang S, et al. et al. Disruption of the Rb-Raf-1 interaction inhibits tumor growth and angiogenesis. Mol Cell Biol 2004; 24:9527-9541.
    • (2004) Mol Cell Biol , vol.24 , pp. 9527-9541
    • Dasgupta, P.1    Sun, J.2    Wang, S.3
  • 40
    • 10744221485 scopus 로고    scopus 로고
    • In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    • Vassilev LT, Vu BT, Graves B, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004; 303:844-848.
    • (2004) Science , vol.303 , pp. 844-848
    • Vassilev, L.T.1    Vu, B.T.2    Graves, B.3
  • 41
    • 67650447477 scopus 로고    scopus 로고
    • A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma
    • Erkizan HV, Kong Y, Merchant M, et al. A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma. Nat Med 2009; 15:750-756.
    • (2009) Nat Med , vol.15 , pp. 750-756
    • Erkizan, H.V.1    Kong, Y.2    Merchant, M.3
  • 42
    • 33645059697 scopus 로고    scopus 로고
    • The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death
    • Manero F, Gautier F, Gallenne T, et al. The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death. Cancer Res 2006; 66:2757-2764.
    • (2006) Cancer Res , vol.66 , pp. 2757-2764
    • Manero, F.1    Gautier, F.2    Gallenne, T.3
  • 43
    • 0021261878 scopus 로고
    • Amplification of N-myc in untreated human neuroblastomas correlates with advanced stage disease
    • Brodeur GM, Seeger RC, Schwab M, Varmus HE, Bishop JM. Amplification of N-myc in untreated human neuroblastomas correlates with advanced stage disease. Science 1984; 224:1121-1124.
    • (1984) Science , vol.224 , pp. 1121-1124
    • Brodeur, G.M.1    Seeger, R.C.2    Schwab, M.3    Varmus, H.E.4    Bishop, J.M.5
  • 44
    • 0022388606 scopus 로고
    • Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas
    • Seeger RC, Brodeur GM, Sather H, et al. Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl J Med 1985; 313:1111-1116.
    • (1985) N Engl J Med , vol.313 , pp. 1111-1116
    • Seeger, R.C.1    Brodeur, G.M.2    Sather, H.3
  • 45
    • 17644438571 scopus 로고
    • Sustained cytokine production and immunophenotypic changes in human neuroblastoma cell lines transduced with a human gamma interferon vector
    • Uçar K, Seeger R, Challita P, et al. Sustained cytokine production and immunophenotypic changes in human neuroblastoma cell lines transduced with a human gamma interferon vector. Cancer Gene Ther 1995; 2:171-181.
    • (1995) Cancer Gene Ther , vol.2 , pp. 171-181
    • Uçar, K.1    Seeger, R.2    Challita, P.3
  • 46
    • 0037436820 scopus 로고    scopus 로고
    • Combined RAR alpha- and RXR-specific ligands overcome N-myc-associated retinoid resistance in neuroblastoma cells
    • Nguyen T, Hocker JE, Thomas W, et al. Combined RAR alpha- and RXR-specific ligands overcome N-myc-associated retinoid resistance in neuroblastoma cells. Biochem Biophys Res Commun 2003; 302:462-468.
    • (2003) Biochem Biophys Res Commun , vol.302 , pp. 462-468
    • Nguyen, T.1    Hocker, J.E.2    Thomas, W.3
  • 47
    • 0037025173 scopus 로고    scopus 로고
    • Cancer. Addiction to oncogenes-The Achilles heal of cancer
    • Weinstein IB. Cancer. Addiction to oncogenes-The Achilles heal of cancer. Science 2002; 297:63-64.
    • (2002) Science , vol.297 , pp. 63-64
    • Weinstein, I.B.1
  • 48
    • 0242493171 scopus 로고    scopus 로고
    • RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity
    • Duxbury MS, Ito H, Benoit E, Zinner MJ, Ashley SW, Whang EE. RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity. Biochem Biophys Res Commun 2003; 311:786-792.
    • (2003) Biochem Biophys Res Commun , vol.311 , pp. 786-792
    • Duxbury, M.S.1    Ito, H.2    Benoit, E.3    Zinner, M.J.4    Ashley, S.W.5    Whang, E.E.6
  • 49
    • 70149087281 scopus 로고    scopus 로고
    • Knockdown of focal adhesion kinase reverses colon carcinoma multicellular resistance
    • Chen YY, Wang ZX, Chang PA, et al. Knockdown of focal adhesion kinase reverses colon carcinoma multicellular resistance. Cancer Sci 2009; 100:1708-1713.
    • (2009) Cancer Sci , vol.100 , pp. 1708-1713
    • Chen, Y.Y.1    Wang, Z.X.2    Chang, P.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.