Utilising an LC-MS/MS-based multi-biomarker approach to assess mycotoxin exposure in the Bangkok metropolitan area and surrounding provinces

Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment

Volumn 31, Issue 12, 2014, Pages 2040-2046

  Warth, Benedikt ^a   Petchkongkaew, Awanwee ^a,b   Sulyok, Michael ^a   Krska, Rudolf ^a  

^a UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^b THAMMASAT UNIVERSITY   (Thailand)

Author keywords

biomonitoring; exposure assessment; human urine; LC MS MS; mycotoxin metabolite; Thailand; xenobiotic

Indexed keywords

AFLATOXINS; HEALTH HAZARDS; METABOLITES; RISK ASSESSMENT; TOXIC MATERIALS;

BIOMONITORING; EXPOSURE ASSESSMENT; HUMAN URINE; LC/MS/MS; THAILAND; XENOBIOTIC;

BIOMARKERS;

AFLATOXIN B1; BIOLOGICAL MARKER; FUMONISIN; HT 2 TOXIN; MYCOTOXIN; NIVALENOL; OCHRATOXIN; T 2 TOXIN; TRICHOTHECENE DERIVATIVE; VOMITOXIN; ZEARALENONE; ZERANOL; CARCINOGEN; GLUCURONIDE;

ADOLESCENT; ADULT; AGED; ARTICLE; BODY WEIGHT; CHILD; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HUMAN; HUMAN EXPERIMENT; KIDNEY CONCENTRATING CAPACITY; MALE; METABOLITE; NORMAL HUMAN; TANDEM MASS SPECTROMETRY; THAILAND; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS; URINARY EXCRETION; DEVELOPING COUNTRY; ENVIRONMENTAL MONITORING; FOOD CONTAMINATION; HEALTH; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; PILOT STUDY; PROCEDURES; REPRODUCIBILITY; RISK ASSESSMENT; URINE; VALIDATION STUDY;

ADULT; BIOLOGICAL MARKERS; CARCINOGENS, ENVIRONMENTAL; CHILD; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEVELOPING COUNTRIES; ENVIRONMENTAL MONITORING; FEMALE; FOOD CONTAMINATION; GLUCURONIDES; HUMANS; MALE; MYCOTOXINS; PILOT PROJECTS; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; RURAL HEALTH; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; THAILAND; TRICHOTHECENES; URBAN HEALTH;

EID: 84914173574     PISSN: 19440049     EISSN: 19440057     Source Type: Journal    
DOI: 10.1080/19440049.2014.969329     Document Type: Article

References (46)

1. Abia WA, Warth B, Sulyok M, Krska R, Tchana A, Njobeh PB, Turner PC, Kouanfack C, Mbu Eyongetah M, Dutton M, Moundipa PF. 2013. Bio-monitoring of mycotoxin exposure in Cameroon using a urinary multi-biomarker approach. Food Chem Toxicol. 62:927–934.
2. Ahn J, Kim D, Kim H, Jahng K-Y. 2010. Quantitative determination of mycotoxins in urine by LC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 27:1674–1682.
3. Anukul N, Vangnai K, Mahakarnchanakul W. 2013. Significance of regulation limits in mycotoxin contamination in Asia and risk management programs at the national level. J Food Drug Anal. 21:227–241.
4. Bansal J, Pantazopoulos P, Tama J, Cavlovic P, Kwong K, Turcotte A-M, Lau BP-Y, Scott PM. 2011. Surveys of rice sold in Canada for aflatoxins, ochratoxin A and fumonisins. Food Addit Contam: Part A. 28:767–774.
5. Bezerra da Rocha ME, Oliveira Freire FC, Maia FFF, Guedes MIF, Rondina D. 2014. Mycotoxins and their effects on human and animal health. Food Contr. 36:159–165.
6. [CAST] Council for Agricultural Science and Technology. 2003. Mycotoxins: risks in plant, animal, and human systems. Task Force Report No. 139. Ames (IA): CAST.
7. Chinaphuti A, Suttayakorn R. 2011. Monitoring of mycotoxins in agricultural products using DOA-aflatoxin ELISA test kit. Proceedings of FFTC-KU 2011 conference. International seminar on risk assessment and risk management of mycotoxins for food safety in Asia; Sep 5–9; Pattaya. Kasetsart University.
8. [EFSA] European Food Safety Authority. 2006. Opinion of the Scientific Panel on contaminants in the Food Chain of the EFSA on a request from the Commission related to ochratoxin A in food. EFSA J. 365:1–56.
9. Ezekiel C, Warth B, Ogara IM, Abia WA, Ezekiel VC, Atehnkeng J, Sulyok M, Turner P, Tayo GO, Krska R, Bandyopadhyay R. 2014. Mycotoxin exposure in rural residents in northern Nigeria: a pilot study using multi-urinary biomarkers. Environ Int. 66:138–145.
10. FAO/WHO. 2010. Summary Report of the 72nd Meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Rome/Geneva: FAO/WHO.
11. Fruhmann P, Warth B, Hametner C, Berthiller F, Horkel E, Adam G, Sulyok M, Krska R, Fröhlich J. 2012. Synthesis of deoxynivalenol-3-ß-D-O-glucuronide for its use as biomarker for dietary deoxynivalenol exposure. World Mycotoxin J. 5:127–132.
12. Gilbert J, Brereton P, MacDonald S. 2001. Assessment of dietary exposure to ochratoxin A in the UK using a duplicate diet approach and analysis of urine and plasma samples. Food Addit Contam. 18:1088–1093.
13. Groopman JD, Kensler TW. 1999. The light at the end of the tunnel for chemical-specific biomarkers: daylight or headlight? Carcinogenesis. 20:1–11.
14. [IARC] International Agency for Research on Cancer. 2002. IARC Monographs on the evaluation of carcinogenic risks to humans: Some Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene. 82.
15. Leong Y-H, Latiff AA, Ahmad NI, Rosma A. 2012. Exposure measurement of aflatoxins and aflatoxin metabolites in human body fluids. A short review. Mycotoxin Res. 28:79–87.
16. Malir F, Ostry V, Grosse Y, Roubal T, Skarkova J, Ruprich J. 2006. Monitoring the mycotoxins in food and their biomarkers in the Czech Republic. Mol Nutr Food Res. 50:513–518.
17. Meky FA, Turner PC, Ashcroft AE, Miller JD, Qiao Y-L, Roth MJ, Wild CP. 2003. Development of a urinary biomarker of human exposure to deoxynivalenol. Food Chem Toxicol. 41:265–273.
18. Mikula H, Hametner C, Berthiller F, Warth B, Krska R, Adam G, Fröhlich J. 2012. Fast and reproducible chemical synthesis of zearalenone-14-β, D-glucuronide. World Mycotoxin J. 5:289–296.
19. Pitt JI, Wild CP, Baan RA, Gelderblom WCA, Miller JD, Riley RT, Wu F. 2012. Improving public health through mycotoxin control. The International Agency for Research on Cancer. Geneva: WHO Press.
20. Poapolathep A, Poapolathep S, Klangkaew N, Sugita-Konishi Y, Kumagai S. 2008. Detection of deoxynivalenol contamination in wheat products in Thailand. J Food Prot. 71:1931–1933.
21. Polychronaki N, Wild CP, Mykkänen H, Amra H, Wahhab MA, Sylla A, Diallo M, El-Nezami H, Turner PC. 2008. Urinary biomarkers of aflatoxin exposure in young children from Egypt and Guinea. Food Chem Toxicol. 46:519–526.
22. 1 excretion in humans consuming maize-based diets. Mol Nutr Food Res. 56:1445–1455.
23. Šarkanj B, Warth B, Uhlig S, Abia WA, Sulyok M, Klapec T, Krska R, Banjari I. 2013. Urinary analysis reveals high deoxynivalenol exposure in pregnant women from Croatia. Food Chem Toxicol. 62:231–237.
24. Shephard GS, Burger H-M, Gambacorta L, Gong YY, Krska R, Rheeder JP, Solfrizzo M, Srey C, Sulyok M, Visconti A, et al. 2013. Multiple mycotoxin exposure determined by urinary biomarkers in rural subsistence farmers in the former Transkei, South Africa. Food Chem Toxicol. 62:217–225.
25. Singkong W, Ratanapol H, Liamkaew W. 2013. Zearalenone contamination in corn for human consumption in Kamphaengphet, Thailand. Chiang Mai J Sci. 40:534–539.
26. 1 in urine as a multi-biomarker method to assess exposure to mycotoxins. Anal Bioanal Chem. 401:2831–2841.
27. Solfrizzo M, Gambacorta L, Visconti A. 2014. Assessment of multi-mycotoxin exposure in Southern Italy by urinary multi-biomarker determination. Toxins. 6:523–538.
28. Solfrizzo M, Gambacorta L, Warth B, White K, Srey C, Sulyok M, Krska R, Gong YY. 2013. Comparison of single and multi-analyte methods based on LC-MS/MS for mycotoxin biomarker determination in human urine. World Mycotoxin J. 6:355–366.
29. Srivatanakul P, Parkin DM, Jiang Y-Z, Khlat M, Kao-Ian U, Sontipong S, Wild CP. 1991. The role of infection by opisthorchis viverrini, hepatitis B virus, and aflatoxin exposure in the etiology of liver cancer in thailand. A correlation study. Cancer. 68:2411–2417.
30. Srivatanakul P, Parkin DM, Khlat M, Chenvidhya D, Chotiwan P, Insiripong S, L’Abbé KA, Wild CP. 1991. Liver cancer in Thailand II. A case-control study of hepatocellular carcinoma. Int J Cancer. 48:329–332.
31. Tangkijvanich P, Hirsch, P, Theamboonlers A, Nuchprayoon I, Poovorawan Y. 1999. Association of hepatitis viruses with hepatocellular carcinoma in Thailand. J Gastroenterol. 34:227–233.
32. Turner PC, Flannery B, Isitt C, Ali M, Pestka J. 2012. The role of biomarkers in evaluating human health concerns from fungal contaminants in food. Nutr Res Rev. 25:162–179.
33. Turner PC, Hopton RP, White KL, Fisher J, Cade JE, Wild CP. 2011. Assessment of deoxynivalenol metabolite profiles in UK adults. Food Chem Toxicol. 49:132–135.
34. Turner PC, White KLM, Burley VJ, Hopton RP, Rajendram A, Fisher J, Cade JE, Wild CP. 2010. A comparison of deoxynivalenol intake and urinary deoxynivalenol in UK adults. Biomarkers. 15:553–562.
35. 1 as a urinary biomarker of exposure in a maize intervention study among South African subsistence farmers. Cancer Epidemiol Biomar. 20:483–489.
36. Waenlor W, Wiwanitkit V. 2003. Aflatoxin contamination of food and food products in Thailand: an overview. Southeast Asian J Trop Med Public Health. 34:184–190.
37. Warth B, Sulyok M, Berthiller F, Schuhmacher R, Fruhmann P, Hametner C, Adam G, Fröhlich J, Krska R. 2011. Direct quantification of deoxynivalenol glucuronide in human urine as biomarker of exposure to the Fusarium mycotoxin deoxynivalenol. Anal Bioanal Chem. 401:195–200.
38. Warth B, Sulyok M, Berthiller F, Schuhmacher R, Krska R. 2013. New insights into the human metabolism of the fusarium mycotoxins deoxynivalenol and zearalenone. Toxicol Lett. 220:88–94.
39. Warth B, Sulyok M, Fruhmann P, Berthiller F, Schuhmacher R, Hametner C, Adam G, Fröhlich J, Krska R. 2012. Assessment of human deoxynivalenol exposure using an LC-MS/MS based biomarker method. Toxicol Lett. 211:85–90.
40. Warth B, Sulyok M, Fruhmann P, Mikula H, Berthiller F, Schuhmacher R, Hametner C, Abia WA, Adam G, Fröhlich J, Krska R. 2012. Development and validation of a rapid multi-biomarker liquid chromatography/tandem mass spectrometry method to assess human exposure to mycotoxins. Rapid Commun Mass Spectrom. 26:1533–1540.
41. Warth B, Sulyok M, Krska R. 2013. LC–MS/MS based multi-biomarker approaches for the assessment of human exposure to mycotoxins. Anal Bioanal Chem. 405:5687–5695.
42. Wild CP, Jiang Y-Z, Allen SJ, Jansen LAM, Hall AJ, Montesano R. 1990. Aflatoxin-albumin adducts in human sera from different regions of the world. Carcinogenesis. 11:2271–2274.
43. Wild CP, Shrestha SM, Anwar WA, Montesano R. 1992. Field studies of aflatoxin exposure, metabolism and induction of genetic alterations in relation to HBV infection and hepatocellular carcinoma in The Gambia and Thailand. Toxicol Lett. 64–65:455–461.
44. Williams J. 2004. Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions. Am J Clin Nutr. 80:1106–1122.
45. Yoshizawa T, Yamashita A, Chokethaworn N. 1996. Occurrence of fumonisins and aflatoxins in corn from Thailand. Food Addit Contam. 13:163–168.
46. 1 in human urine. Cancer Res. 47:1848–1852.