Quantitative determination of mycotoxins in urine by LC-MS/MS

Food Additives and Contaminants - Part A

Volumn 27, Issue 12, 2010, Pages 1674-1682

  Ahna, J ^a   Kima, D ^a   Kima, H ^a   Jahngb, K Y ^b  

^a Ministry of Agriculture and Forestry Korea   (South Korea)

^b Chonbuk National University   (South Korea)

Author keywords

Affinity columns; Liquid chromatography mass spectrometry (LC MS); Mycotoxins

Indexed keywords

ANTIGEN-ANTIBODY REACTIONS; BIOMOLECULES; COLUMN CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

ACCURATE ANALYTICAL METHODS; AFFINITY COLUMN; IMMUNOAFFINITY COLUMNS; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (LC MS/MS); LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY; MULTIPLE REACTION MONITORING; MYCOTOXINS; QUANTITATIVE DETERMINATIONS;

METABOLITES;

AFLATOXIN M1; FUMONISIN B1; FUMONISIN B2; MYCOTOXIN; OCHRATOXIN;

ARTICLE; CLINICAL TRIAL; DILUTION; FEMALE; HUMAN; IMMUNOAFFINITY CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MALE; MASS FRAGMENTOGRAPHY; PRIORITY JOURNAL; URINALYSIS; URINE;

EID: 78649552505     PISSN: 19440049     EISSN: 14645122     Source Type: Journal    
DOI: 10.1080/19440049.2010.505201     Document Type: Article

References (25)

1. Blank R, Rolfs JP, Sudekum KH, Frohlich AA, Marquardt RR, Wolffram S. 2003. Effects of chronic ingestion of ochratoxin A on blood levels and excretion of the mycotoxin in sheep. J Agricult Food Chem. 51: 6899-6905.
2. 1 in human urine. Nature. 227:403-404.
3. Gilbert J, Brereton P, MacDonald S. 2001. Assessment of dietary exposure to ochratoxin A in the UK using a duplicate diet approach and analysis of urine and plasma samples. Food Addit Contam. 18:1088-1093.
4. 1 levels in a Mexican population. Cancer Epidemiol Biomark Prevent. 17:688-694.
5. Groopman JD, Donahue PR, Zhu JQ, Chen JS, Wogan GN. 1985. Aflatoxin metabolism in humans: detection of metabolites and nucleic acid adducts in urine by affinity chromatography. Proc Natl Acad Sci USA. 82:6492-6496.
6. Groopman JD, Zhu JQ, Donahue PR, Pikul A, Zhang LS, Chen JS, Wogan GN. 1992. Molecular dosimetry of urinary aflatoxin-DNA adducts in people living in Guangxi Autonomous Region, People's Republic of China. Cancer Res. 52:45-52.
7. Jackson PE, Groopman JD. 1999. Aflatoxin and liver cancer. Bailliere's Clin Gastroenterol. 13:545-555.
8. Kuiper-Goodman T. 1996. Risk assessment of the mycotoxin ochratoxin; an update. Food Addit Contam. 13:53-57.
9. Manique R, Pena A, Lino CM, Molto JC, Manes J. 2008. Ochratoxin A in the morning and afternoon portions of urine from Coimbra and Valencian populations. Toxicon. 51:1281-1287.
10. Mantle PG. 2008. Interpretation of the pharmacokinetics of ochratoxinAin blood plasma of rats, during and after acute or chronic ingestion. Food Chem Toxicol. 46:1808-1816.
11. Munoz K, Blaszkewicz M, Degen GH. 2009. Simultaneous analysis of ochratoxin A and its major metabolite ochratoxin α in plasma and urine for and an advanced biomonitoring of the mycotoxin. J Chromatogr B [Epub ahead of print].
12. Qian GS, Ross RK, Yu MC, Yuan JM, Gao YT, Henderson BE, Wogan GN, Groopman JD. 1994. A follow-up study of urinary marker of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China. Cancer Epidemiol Biomark Prevent. 3:3-10.
13. Scott PM. 2005. Biomarkers of human exposure to ochratoxin A. Food Addit Contam. 22(Suppl 1):99-107.
14. Shephard GS. 2009. Aflatoxin analysis at the beginning of the twenty-first century. Analyt Bioanalyt Chem. 395:1215-1224.
15. 1 in a non-human primate. Toxicon. 32:735-741.
16. 2 in rats. Food Chem Toxicol. 33:591-595.
17. 1 in human urine. J Chromatogr B. 705:171-173.
18. Silva LJ, Pena A, Lino CM, Fernandez MF, Manes J. 2010. Fumonisins determination in urine by LC-MS-MS. Analyt Bioanalyt Chem. 396:809-816.
19. Stander MA, Steyn PS, van der Westhuizen FH, Payne BE. 2001. A kinetic study into the hydrolysis of the ochratoxins and analogues by carboxypeptidase A. Chem Res Toxicol. 14:302-304.
20. Studer-Rohr I, Schlatter J, Dietrich DR. 2000. Kinetic parameters and intraindividual fluctuations of ochratoxin A plasma levels in humans. Archiv Toxicol. 74:499-510.
21. Walton M, Egner P, Shcoll PF, Walker J, Kensler TW, Groopman JD. 2001. Liquid chromatography electrospray- mass spectrometry of urinary aflatoxin biomarkers: characterization and application to dosimetry and chemoprevention in rats. Chem Res Toxicol. 14:919-926.
22. Xiao H, Marquardt RR, Abramson D, Frohlich AA. 1996. Metabolites of ochratoxins in rat urine and in a culture of Aspergillus ochraceus. Appl Environ Microbiol. 62:648-655.
23. Zepnik H, Pahler A, Schauer U, Dekant W. 2001. Ochratoxin A-induced tumor formation: is there a role of reactive ochratoxin A metabolites? Toxicol Sci. 59:59-67.
24. Zepnik H, Volkel W, Dekant W. 2003. Toxicokinetics of the mycotoxin ochratoxin A in F344 rats after oral administration. Toxicol Appl Pharmacol. 192:36-44.
25. 1 in human urine. Cancer Res. 47:1848-1852.