Urinary biomarkers of aflatoxin exposure in young children from Egypt and Guinea

Food and Chemical Toxicology

Volumn 46, Issue 2, 2008, Pages 519-526

  Polychronaki, Nektaria ^a   Wild, Christopher P ^b   Mykkänen, Hannu ^a   Amra, Hassan ^c   Abdel Wahhab, Mosaad ^c   Sylla, Abdoulaye ^d   Diallo, Mamadou ^d   El Nezami, Hani ^a   Turner, Paul C ^b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c NATIONAL RESEARCH CENTRE   (Egypt)

^d Institut Pasteur de Guinée IPG   (Guinea)

Author keywords

Aflatoxins; Children; Egypt; Guinea; Urine; Weaning

Indexed keywords

AFLATOXIN; AFLATOXIN B1; AFLATOXIN B2; AFLATOXIN G1; AFLATOXIN G2; AFLATOXIN M1; BIOLOGICAL MARKER;

ANTIBODY AFFINITY; ARTICLE; CANCER RISK; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; EGYPT; ENVIRONMENTAL EXPOSURE; FEMALE; FLUORESCENCE; GEOMETRY; GUINEA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIVER CELL CARCINOMA; MALE; METABOLITE; PRESCHOOL CHILD; QUANTITATIVE ANALYSIS; URINALYSIS; URINE LEVEL;

AFLATOXINS; BIOLOGICAL MARKERS; CHILD, PRESCHOOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-SECTIONAL STUDIES; EGYPT; FEMALE; GUINEA; HEPATITIS B VIRUS; HUMANS; INFANT; MALE; MILK, HUMAN; POISONS; RURAL HEALTH;

EID: 37449022597     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.08.034     Document Type: Article

References (51)

1. Allen S.J., Wild C.P., Wheeler J.G., Riley E.M., Montesano R., Bennett S., Whittle H.C., Hall A.J., and Greenwood B.M. Aflatoxin exposure, malaria and hepatitis B infection in rural Gambian children. Trans. R Soc. Trop. Med. Hyg. 86 (1992) 426-430
2. Barker D.J. The developmental origins of chronic adult disease. Acta Paediatr. Suppl. 93 (2004) 26-33
3. Barrett J. Liver cancer and aflatoxin: New information from the Kenyan outbreak. Environ. Health Perspect. 113 (2005) A837-A838
4. 1. J. Org. Chem. 40 (1975) 3458-3459
5. Delisle H. Foetal programming of nutrition-related chronic diseases. Sante 12 (2002) 56-63
6. Diallo M.S., Sylla A., Sidibe K., Sylla B.S., Trepo C.R., and Wild C.P. Prevalence of exposure to aflatoxin and hepatitis B and C viruses in Guinea, West Africa. Nat. Toxins 3 (1995) 6-9
7. El-Nezami H., Mykkänen H., Kankaanpaa P., Suomalainen T., Salminen S., and Ahokas J. Ability of a mixture of lactobacillus and propionibacterium to influence the faecal aflatoxin content in healthy Egyptian volunteers: a pilot clinical study. Biosci. Microflora 19 (2000) 41-45
8. Ezzat S., Abdel-Hamid M., Abdel-Latif E., Mokhtar N., Labib N.A., El-Ghorory L., Mikhail N.N., Abdel-Hamid A., Hifnawy T., Stickland G.T., et al. Associations of pesticides, HCV, HBV, and hepatocellular carcinoma in Egypt. Int. J. Hyg. Environ. Health 208 (2005) 329-339
9. Firestone M.P., and Amler R.W. Children's environmental health -- an international perspective. Int. J. Hyg. Environ. Health 206 (2003) 395-400
10. Gong Y., Cardwell K., Hounsa A., Egal S., Turner P.C., Hall A.J., and Wild C.P. Dietary aflatoxin exposure and impaired growth in young children from Benin and Togo: cross sectional study. BMJ 325 (2002) 20-21
11. Gong Y., Egal S., Hounsa A., Turner P.C., Hall A.J., Cardwell K.F., and Wild C.P. Determinants of aflatoxin exposure in young children from Benin and Togo, West Africa: the critical role of weaning. Int. J. Epidemiol. 32 (2003) 556-562
12. Gong Y., Hounsa A., Egal S., Turner P.C., Sutcliffe A.E., Hall A.J., Cardwell K., and Wild C.P. Postweaning exposure to aflatoxin results in impaired child growth: a longitudinal study in Benin, West Africa. Environ. Health Perspect. 112 (2004) 1334-1338
13. Groopman J.D., Donahue P.R., Zhu J.Q., Chen J.S., and Wogan G.N. Aflatoxin metabolism in humans: detection of metabolites and nucleic acid adducts in urine by affinity chromatography. Proc. Natl. Acad. Sci. USA 82 (1985) 6492-6496
14. Groopman J.D., Hall A.J., Whittle H., Hudson G.J., Wogan G.N., Montesano R., and Wild C.P. Molecular dosimetry of aflatoxin-N7-guanine in human urine obtained in The Gambia, West Africa. Cancer Epidemiol. Biomarkers Prev. 1 (1992) 221-227
15. Groopman J.D., Zhu J.Q., Donahue P.R., Pikul A., Zhang L.S., Chen J.S., and Wogan G.N. Molecular dosimetry of urinary aflatoxin-DNA adducts in people living in Guangxi Autonomous Region, People's Republic of China. Cancer Res. 52 (1992) 45-52
16. Guengerich F.P., Johnson W.W., Shimada T., Ueng Y.F., Yamazaki H., and Langouet S. Activation and detoxication of aflatoxin B1. Mutat. Res. 402 (1998) 121-128
17. Guengerich F.P., Arneson K.O., Williams K.M., Deng Z., and Harris T.M. Reaction of aflatoxin b(1) oxidation products with lysine. Chem. Res. Toxicol. 15 (2002) 780-792
18. Hatem N.L., Hassab H.M., Abd Al-Rahman E.M., El-Deeb S.A., and El-Sayed Ahmed R.L. Prevalence of aflatoxins in blood and urine of Egyptian infants with protein-energy malnutrition. Food Nutr. Bull. 26 (2005) 49-56
19. IARC. 2002. Some Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene. World Health Organization, International Agency for Research on Cancer, Lyon, France. Report No. 82. pp. 1--556.
20. JEFCA. 1998. Safety Evaluation of Certain Food Additives and Contaminants (JEFCA Evaluation). Joint FAO/WHO Expert Committee on Food Additives, Geneva. Report No. 40.
21. Jonsyn-Ellis F.E. Seasonal variation in exposure frequency and concentration levels of aflatoxins and ochratoxins in urine samples of boys and girls. Mycopathologia 152 (2001) 35-40
22. Mykkänen H., Zhu H., Salminen E., Juvonen R.O., Ling W., Ma J., Polychronaki N., Kemilainen H., Mykkanen O., Salminen S., et al. Fecal and urinary excretion of aflatoxin B1 metabolites (AFQ1, AFM1 and AFB-N7-guanine) in young Chinese males. Int. J. Cancer 115 (2005) 879-884
23. Neal G.E., Eaton D.L., Judah D.J., and Verma A. Metabolism and toxicity of aflatoxins m1 and B1 in human-derived in vitro systems. Toxicol. Appl. Pharmacol. 151 (1998) 152-158
24. Ngindu A., Johnson B.K., Kenya P.R., Ngira J.A., Ocheng D.M., Nandwa H., Omondi T.N., Jansen A.J., Ngare W., Kaviti J.N., et al. Outbreak of acute hepatitis caused by aflatoxin poisoning in Kenya. Lancet 1 (1982) 1346-1348
25. Polychronaki N., Turner P.C., Mykkanen H., Gong Y., Amra H., Abdel-Wahhab M., and El-Nezami H. Determinants of aflatoxin M1 in breast milk in a selected group of Egyptian mothers. Food Addit. Contam. 23 (2006) 700-708
26. 1 excretion in breast milk of selected Egyptian mothers. Food Chem. Toxicol. 45 (2007) 1210-1215
27. Qian G.S., Ross R.K., Yu M.C., Yuan J.M., Gao Y.T., Henderson B.E., Wogan G.N., and Groopman J.D. A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China. Cancer Epidemiol. Biomarkers Prev. 3 (1994) 3-10
28. Serck-Hanssen A. Aflatoxin-induced fatal hepatitis? A case report from Uganda. Arch. Environ. Health 20 (1970) 729-731
29. Sun Z., Lu P., Gail M.H., Pee D., Zhang Q., Ming L., Wang J., Wu Y., Liu G., and Zhu Y. Increased risk of hepatocellular carcinoma in male hepatitis B surface antigen carriers with chronic hepatitis who have detectable urinary aflatoxin metabolite M1. Hepatology 30 (1999) 379-383
30. Sylla A., Diallo M.S., Castegnaro J., and W C.P. Interactions between hepatitis B virus infection and exposure to aflatoxins in the development of hepatocellular carcinoma: a molecular epidemiology approach. Mutat. Res. 428 (1999) 187-196
31. Turner P.C., Mendy M., Whittle H., Fortuin M., Hall A.J., and Wild C.P. Hepatitis B infection and aflatoxin biomarker levels in Gambian children. Trop. Med. Int. Health 5 (2000) 837-841
32. Turner P.C., Moore S.E., Hall A.J., Prentice A.M., and Wild C.P. Modification of immune function through exposure to dietary aflatoxin in Gambian children. Environ. Health Perspect. 111 (2003) 217-220
33. Turner P.C., Sylla A., Gong Y.Y., Diallo M.S., Sutcliffe A.E., Hall A.J., and Wild C.P. Reduction in exposure to carcinogenic aflatoxins by post-harvest intervention measures in west Africa: a community-based intervention study. Lancet 365 (2005) 1950-1956
34. Turner P.C., Sylla A., Kuang S.Y., Marchant C.L., Diallo M.S., Hall A.J., Groopman J.D., and Wild C.P. Absence of TP53 codon 249 mutations in young Guinean children with high aflatoxin exposure. Cancer Epidemiol. Biomarkers Prev. 14 (2005) 2053-2055
35. Turner, P.C., Collinson, A.C., Cheung, Y.B., Gong, Y.Y., Hall, A.J., Prentice, A.M., Wild, C.P., in press. Aflatoxin exposure in utero causes growth faltering in Gambian infants. Int. J. Epidemiol. doi:10.1093/ije/dym122.
36. Wang J.S., and Groopman J.D. DNA damage by mycotoxins. Mutat. Res. 424 (1999) 167-181
37. Wang H., Dick R., Yin H., Licad-Coles E., Kroetz D.L., Szklarz G., Harlow G., Halpert J.R., and Correia M.A. Structure-function relationships of human liver cytochromes P450 3A: aflatoxin B1 metabolism as a probe. Biochemistry 37 36 (1998) 12536-12545
38. Wang J.S., Huang T., Su J., Liang F., Wei Z., Liang Y., Luo H., Kuang S.Y., Qian G.S., Sun G., et al. Hepatocellular carcinoma and aflatoxin exposure in Zhuqing Village, Fusui County, People's Republic of China. Cancer Epidemiol. Biomarkers Prev. 10 (2001) 143-146
39. WHO. 2003. Global strategy for infant and young child feeding. Geneva.
40. Wild C.P., and Hall A.J. Primary prevention of hepatocellular carcinoma in developing countries. Mutat. Res. 462 (2000) 381-393
41. Wild C.P., and Kleinjans J. Children and increased susceptibility to environmental carconogens: evidence or empathy?. Cancer Epidemiol. Biomarkers Prev. 12 (2003) 1389-1394
42. Wild C.P., Pionneau F.A., Montesano R., Mutiro C.F., and Chetsanga C.J. Aflatoxin detected in human breast milk by immunoassay. Int. J. Cancer 40 (1987) 328-333
43. Wild C.P., Jiang Y.Z., Allen S.J., Jansen L.A., Hall A.J., and Montesano R. Aflatoxin-albumin adducts in human sera from different regions of the world. Carcinogenesis 11 (1990) 2271-2274
44. Wild C.P., Rasheed F.N., Jawla M.F., Hall A.J., Jansen L.A., and Montesano R. In-utero exposure to aflatoxin in west Africa. Lancet 337 (1991) 1602
45. Wild C.P., Hudson G.J., Sabbioni G., Chapot B., Hall A.J., Wogan G.N., Whittle H., Montesano R., and Groopman J.D. Dietary intake of aflatoxins and the level of albumin-bound aflatoxin in peripheral blood in The Gambia, West Africa. Cancer Epidemiol. Biomarkers Prev. 1 (1992) 229-234
46. Wild, C.P., Shrestha, S.M., Anwar, W.A., Montesano, R., 1992b. Field studies of aflatoxin exposure, metabolism and induction of genetic alterations in relation to HBV infection and hepatocellular carcinoma in The Gambia and Thailand. Toxicol. Lett. 64-65. Spec No. 455-461.
47. Wild C.P., Fortuin M., Donato F., Whittle H.C., Hall A.J., Wolf C.R., and Montesano R. Aflatoxin, liver enzymes, and hepatitis B virus infection in Gambian children. Cancer Epidemiol. Biomarkers Prev. 2 (1993) 555-561
48. Wild C.P., Jansen L.A., Cova L., and Montesano R. Molecular dosimetry of aflatoxin exposure: contribution to understanding the multifactorial etiopathogenesis of primary hepatocellular carcinoma with particular reference to hepatitis B virus. Environ. Health Perspect. 99 (1993) 115-122
49. Wild C.P., Yin F., Turner P.C., Chemin I., Chapot B., Mendy M., Whittle H., Kirk G.D., and Hall A.J. Environmental and genetic determinants of aflatoxin-albumin adducts in the Gambia. Int. J. Cancer 86 (2000) 1-7
50. Zarba A., Wild C.P., Hall A.J., Montesano R., Hudson G.J., and Groopman J.D. Aflatoxin M1 in human breast milk from The Gambia, west Africa, quantified by combined monoclonal antibody immunoaffinity chromatography and HPLC. Carcinogenesis 13 (1992) 891-894
51. Zhu J.Q., Zhang L.S., Hu X., Xiao Y., Chen J.S., Xu Y.C., Fremy J., and Chu F.S. Correlation of dietary aflatoxin B1 levels with excretion of aflatoxin M1 in human urine. Cancer Res. 47 (1987) 1848-1852