메뉴 건너뛰기




Volumn 34, Issue , 2014, Pages 85-90

The roles and mechanism of ultradian oscillatory expression of the mouse Hes genes

Author keywords

Embryonic stem cell; Negative feedback; Neural stem cell; Oscillatory expression; Segmentation clock

Indexed keywords

FIBROBLAST GROWTH FACTOR; HELIX LOOP HELIX PROTEIN; NOTCH RECEPTOR; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; HES1 PROTEIN, MOUSE; HES7 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN;

EID: 84914117747     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2014.04.038     Document Type: Review
Times cited : (32)

References (50)
  • 1
    • 84874765320 scopus 로고    scopus 로고
    • Encoding and decoding cellular information through signaling dynamics
    • Purvis J.E., Lehav G. Encoding and decoding cellular information through signaling dynamics. Cell 2013, 152:945-956.
    • (2013) Cell , vol.152 , pp. 945-956
    • Purvis, J.E.1    Lehav, G.2
  • 2
    • 0027083415 scopus 로고
    • Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split
    • Sasai Y., Kageyama R., Tagawa Y., Shigemoto R., Nakanishi S. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev 1992, 6:2620-2634.
    • (1992) Genes Dev , vol.6 , pp. 2620-2634
    • Sasai, Y.1    Kageyama, R.2    Tagawa, Y.3    Shigemoto, R.4    Nakanishi, S.5
  • 3
    • 0035065732 scopus 로고    scopus 로고
    • Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm
    • Bessho Y., Miyoshi G., Sakata R., Kageyama R. Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. Genes Cells 2001, 6:175-185.
    • (2001) Genes Cells , vol.6 , pp. 175-185
    • Bessho, Y.1    Miyoshi, G.2    Sakata, R.3    Kageyama, R.4
  • 4
    • 0035887251 scopus 로고    scopus 로고
    • Dynamic expression and essential functions of Hes7 in somite segmentation
    • Bessho Y., Sakata R., Komatsu S., Shiota K., Yamada S., Kageyama R. Dynamic expression and essential functions of Hes7 in somite segmentation. Genes Dev 2001, 15:2642-2647.
    • (2001) Genes Dev , vol.15 , pp. 2642-2647
    • Bessho, Y.1    Sakata, R.2    Komatsu, S.3    Shiota, K.4    Yamada, S.5    Kageyama, R.6
  • 5
    • 0037174669 scopus 로고    scopus 로고
    • Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop
    • Hirata H., Yoshiura S., Ohtsuka T., Bessho Y., Harada T., Yoshikawa K., et al. Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science 2002, 298:840-843.
    • (2002) Science , vol.298 , pp. 840-843
    • Hirata, H.1    Yoshiura, S.2    Ohtsuka, T.3    Bessho, Y.4    Harada, T.5    Yoshikawa, K.6
  • 6
    • 79957580977 scopus 로고    scopus 로고
    • Vertebrate segmentation: from cyclic gene networks to scoliosis
    • Pourquié O. Vertebrate segmentation: from cyclic gene networks to scoliosis. Cell 2011, 145:650-663.
    • (2011) Cell , vol.145 , pp. 650-663
    • Pourquié, O.1
  • 8
    • 0038046204 scopus 로고    scopus 로고
    • Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock
    • Bessho Y., Hirata H., Masamizu Y., Kageyama R. Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock. Genes Dev 2003, 17:1451-1456.
    • (2003) Genes Dev , vol.17 , pp. 1451-1456
    • Bessho, Y.1    Hirata, H.2    Masamizu, Y.3    Kageyama, R.4
  • 9
    • 34547418278 scopus 로고    scopus 로고
    • The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and Notch signaling in the somite segmentation clock
    • Niwa Y., Masamizu Y., Liu T., Nakayama R., Deng C.-X., Kageyama R. The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and Notch signaling in the somite segmentation clock. Dev Cell 2007, 13:298-304.
    • (2007) Dev Cell , vol.13 , pp. 298-304
    • Niwa, Y.1    Masamizu, Y.2    Liu, T.3    Nakayama, R.4    Deng, C.-X.5    Kageyama, R.6
  • 10
    • 0041677612 scopus 로고    scopus 로고
    • Autoinhibition with transcriptional delay: a simple mechanism for the zebrafish somitogenesis oscillator
    • Lewis J. Autoinhibition with transcriptional delay: a simple mechanism for the zebrafish somitogenesis oscillator. Curr Biol 2003, 13:1398-1408.
    • (2003) Curr Biol , vol.13 , pp. 1398-1408
    • Lewis, J.1
  • 11
    • 0043180477 scopus 로고    scopus 로고
    • Oscillatory expression of Hes1, p53, and NF-κB driven by transcriptional time delays
    • Monk N.A.M. Oscillatory expression of Hes1, p53, and NF-κB driven by transcriptional time delays. Curr Biol 2003, 13:1409-1413.
    • (2003) Curr Biol , vol.13 , pp. 1409-1413
    • Monk, N.A.M.1
  • 12
    • 0037464494 scopus 로고    scopus 로고
    • Sustained oscillations and time delays in gene expression of protein Hes1
    • Jensen M.H., Sneppen K., Tiana G. Sustained oscillations and time delays in gene expression of protein Hes1. FEBS Lett 2003, 541:176-177.
    • (2003) FEBS Lett , vol.541 , pp. 176-177
    • Jensen, M.H.1    Sneppen, K.2    Tiana, G.3
  • 13
    • 3042842911 scopus 로고    scopus 로고
    • Instability of Hes7 protein is critical for the somite segmentation clock
    • Hirata H., Bessho Y., Kokubu H., Masamizu Y., Yamada S., Lewis J., et al. Instability of Hes7 protein is critical for the somite segmentation clock. Nat Genet 2004, 36:750-754.
    • (2004) Nat Genet , vol.36 , pp. 750-754
    • Hirata, H.1    Bessho, Y.2    Kokubu, H.3    Masamizu, Y.4    Yamada, S.5    Lewis, J.6
  • 15
    • 67349121585 scopus 로고    scopus 로고
    • Interfering with Wnt signalling alters the periodicity of the segmentation clock
    • Gibb S., Zagorska A., Melton K., Tenin G., Vacca I., Trainor P., et al. Interfering with Wnt signalling alters the periodicity of the segmentation clock. Dev Biol 2009, 330:21-31.
    • (2009) Dev Biol , vol.330 , pp. 21-31
    • Gibb, S.1    Zagorska, A.2    Melton, K.3    Tenin, G.4    Vacca, I.5    Trainor, P.6
  • 17
  • 18
    • 84873152971 scopus 로고    scopus 로고
    • Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene
    • Harima Y., Takashima Y., Ueda Y., Ohtsuka T., Kageyama R. Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene. Cell Rep 2013, 3:1-7.
    • (2013) Cell Rep , vol.3 , pp. 1-7
    • Harima, Y.1    Takashima, Y.2    Ueda, Y.3    Ohtsuka, T.4    Kageyama, R.5
  • 19
    • 0033561047 scopus 로고    scopus 로고
    • Why do almost all mammals have seven cervical vertebrae? Developmental constraints, Hox genes, and cancer
    • Galis F. Why do almost all mammals have seven cervical vertebrae? Developmental constraints, Hox genes, and cancer. J Exp Zool 1999, 285:19-26.
    • (1999) J Exp Zool , vol.285 , pp. 19-26
    • Galis, F.1
  • 20
    • 84887466041 scopus 로고    scopus 로고
    • Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes
    • Hoyle N.P., Ish-Horowicz D. Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes. Proc Natl Acad Sci USA 2013, 110:E4316-E4324.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. E4316-E4324
    • Hoyle, N.P.1    Ish-Horowicz, D.2
  • 21
    • 0030850751 scopus 로고    scopus 로고
    • Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation
    • Saga Y., Hata N., Koseki H., Taketo M.M. Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Genes Dev 1997, 11:1827-1839.
    • (1997) Genes Dev , vol.11 , pp. 1827-1839
    • Saga, Y.1    Hata, N.2    Koseki, H.3    Taketo, M.M.4
  • 22
    • 50649117174 scopus 로고    scopus 로고
    • Mesp2 and Tbx6 cooperatively create periodic patterns coupled with the clock machinery during mouse somitogenesis
    • Oginuma M., Niwa Y., Chapman D.L., Saga Y. Mesp2 and Tbx6 cooperatively create periodic patterns coupled with the clock machinery during mouse somitogenesis. Development 2008, 135:2555-2562.
    • (2008) Development , vol.135 , pp. 2555-2562
    • Oginuma, M.1    Niwa, Y.2    Chapman, D.L.3    Saga, Y.4
  • 23
    • 77951224757 scopus 로고    scopus 로고
    • The oscillation of Notch activation, but not its boundary, is required for somite border formation and rostral-caudal patterning within a somite
    • Oginuma M., Takahashi Y., Kitajima S., Kiso M., Kanno J., Kimura A., et al. The oscillation of Notch activation, but not its boundary, is required for somite border formation and rostral-caudal patterning within a somite. Development 2010, 137:1515-1522.
    • (2010) Development , vol.137 , pp. 1515-1522
    • Oginuma, M.1    Takahashi, Y.2    Kitajima, S.3    Kiso, M.4    Kanno, J.5    Kimura, A.6
  • 24
    • 79958056964 scopus 로고    scopus 로고
    • Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis
    • Niwa Y., Shimojo H., Isomura A., González A., Miyachi H., Kageyama R. Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis. Genes Dev 2011, 25:1115-1120.
    • (2011) Genes Dev , vol.25 , pp. 1115-1120
    • Niwa, Y.1    Shimojo, H.2    Isomura, A.3    González, A.4    Miyachi, H.5    Kageyama, R.6
  • 25
    • 0037448536 scopus 로고    scopus 로고
    • Periodic Notch inhibition by Lunatic Fringe underlies the chick segmentation clock
    • Dale J.K., Maroto M., Dequeant M.L., Malapert P., McGrew M., Pourquié O. Periodic Notch inhibition by Lunatic Fringe underlies the chick segmentation clock. Nature 2003, 421:275-278.
    • (2003) Nature , vol.421 , pp. 275-278
    • Dale, J.K.1    Maroto, M.2    Dequeant, M.L.3    Malapert, P.4    McGrew, M.5    Pourquié, O.6
  • 26
    • 84869422729 scopus 로고    scopus 로고
    • Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signalling
    • Okubo Y., Sugawara T., Abe-Koduka N., Kanno J., Kimura A., Saga Y. Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signalling. Nat Commun 2012, 3:1141.
    • (2012) Nat Commun , vol.3 , pp. 1141
    • Okubo, Y.1    Sugawara, T.2    Abe-Koduka, N.3    Kanno, J.4    Kimura, A.5    Saga, Y.6
  • 27
    • 17844390391 scopus 로고    scopus 로고
    • Analysis of Notch function in presomitic mesoderm suggests a γ-secretase-independent role for presenilins in somite differentiation
    • Huppert S.S., Ilagan M.X.G., De Strooper B., Kopan R. Analysis of Notch function in presomitic mesoderm suggests a γ-secretase-independent role for presenilins in somite differentiation. Dev Cell 2005, 8:677-688.
    • (2005) Dev Cell , vol.8 , pp. 677-688
    • Huppert, S.S.1    Ilagan, M.X.G.2    De Strooper, B.3    Kopan, R.4
  • 28
    • 19644371990 scopus 로고    scopus 로고
    • The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity
    • Morimoto M., Takahashi Y., Endo M., Saga Y. The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. Nature 2005, 435:354-359.
    • (2005) Nature , vol.435 , pp. 354-359
    • Morimoto, M.1    Takahashi, Y.2    Endo, M.3    Saga, Y.4
  • 29
    • 33845444174 scopus 로고    scopus 로고
    • A complex oscillating network of signaling genes underlies the mouse segmentation clock
    • Dequéant M.-L., Glynn E., Gaudenz K., Wahl M., Chen J., Mushegian A., et al. A complex oscillating network of signaling genes underlies the mouse segmentation clock. Science 2006, 314:1595-1598.
    • (2006) Science , vol.314 , pp. 1595-1598
    • Dequéant, M.-L.1    Glynn, E.2    Gaudenz, K.3    Wahl, M.4    Chen, J.5    Mushegian, A.6
  • 30
    • 70349682625 scopus 로고    scopus 로고
    • Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites
    • Ferjentsik Z., Hayashi S., Dale J.K., Bessho Y., Herreman A., De Strooper B., et al. Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites. PLoS Genet 2009, 5:e1000662.
    • (2009) PLoS Genet , vol.5 , pp. e1000662
    • Ferjentsik, Z.1    Hayashi, S.2    Dale, J.K.3    Bessho, Y.4    Herreman, A.5    De Strooper, B.6
  • 31
    • 0037344080 scopus 로고    scopus 로고
    • Wnt3a plays a major role in the segmentation clock controlling somitogenesis
    • Aulehla A., Wehrle C., Brand-Saberi B., Kemler R., Gossler A., Kanzler B., et al. Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell 2003, 4:395-406.
    • (2003) Dev Cell , vol.4 , pp. 395-406
    • Aulehla, A.1    Wehrle, C.2    Brand-Saberi, B.3    Kemler, R.4    Gossler, A.5    Kanzler, B.6
  • 32
    • 38849137768 scopus 로고    scopus 로고
    • A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation
    • Aulehla A., Wiegraebe W., Baubet V., Wahl M.B., Deng C., Taketo M., et al. A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation. Nat Cell Biol 2008, 10:186-193.
    • (2008) Nat Cell Biol , vol.10 , pp. 186-193
    • Aulehla, A.1    Wiegraebe, W.2    Baubet, V.3    Wahl, M.B.4    Deng, C.5    Taketo, M.6
  • 33
    • 31944447678 scopus 로고    scopus 로고
    • Real-time imaging of the somite segmentation clock: revelation of unstable oscillators in the individual presomitic mesoderm cell
    • Masamizu Y., Ohtsuka T., Takashima Y., Nagahara H., Takenaka Y., Yoshikawa K., et al. Real-time imaging of the somite segmentation clock: revelation of unstable oscillators in the individual presomitic mesoderm cell. Proc Natl Acad Sci USA 2006, 103:1313-1318.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1313-1318
    • Masamizu, Y.1    Ohtsuka, T.2    Takashima, Y.3    Nagahara, H.4    Takenaka, Y.5    Yoshikawa, K.6
  • 34
    • 41549140462 scopus 로고    scopus 로고
    • Oscillations in Notch signaling regulate maintenance of neural progenitors
    • Shimojo H., Ohtsuka T., Kageyama R. Oscillations in Notch signaling regulate maintenance of neural progenitors. Neuron 2008, 58:52-64.
    • (2008) Neuron , vol.58 , pp. 52-64
    • Shimojo, H.1    Ohtsuka, T.2    Kageyama, R.3
  • 35
    • 69249215528 scopus 로고    scopus 로고
    • The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells
    • Kobayashi T., Mizuno H., Imayoshi I., Furusawa C., Shirahige K., Kageyama R. The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells. Genes Dev 2009, 23:1870-1875.
    • (2009) Genes Dev , vol.23 , pp. 1870-1875
    • Kobayashi, T.1    Mizuno, H.2    Imayoshi, I.3    Furusawa, C.4    Shirahige, K.5    Kageyama, R.6
  • 37
    • 33746550363 scopus 로고    scopus 로고
    • Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system
    • Baek J.H., Hatakeyama J., Sakamoto S., Ohtsuka T., Kageyama R. Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system. Development 2006, 133:2467-2476.
    • (2006) Development , vol.133 , pp. 2467-2476
    • Baek, J.H.1    Hatakeyama, J.2    Sakamoto, S.3    Ohtsuka, T.4    Kageyama, R.5
  • 38
    • 50149117285 scopus 로고    scopus 로고
    • Control of the reversibility of cellular quiescence by the transcriptional repressor HES1
    • Sang L., Coller H.A., Roberts J.M. Control of the reversibility of cellular quiescence by the transcriptional repressor HES1. Science 2008, 321:1095-1100.
    • (2008) Science , vol.321 , pp. 1095-1100
    • Sang, L.1    Coller, H.A.2    Roberts, J.M.3
  • 39
    • 54949110207 scopus 로고    scopus 로고
    • Heterogeneity of embryonic and adult stem cells
    • Graf T., Stadtfeld M. Heterogeneity of embryonic and adult stem cells. Cell Stem Cell 2008, 3:480-483.
    • (2008) Cell Stem Cell , vol.3 , pp. 480-483
    • Graf, T.1    Stadtfeld, M.2
  • 40
    • 77954150150 scopus 로고    scopus 로고
    • Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling
    • Kobayashi T., Kageyama R. Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling. Genes Cells 2010, 15:689-698.
    • (2010) Genes Cells , vol.15 , pp. 689-698
    • Kobayashi, T.1    Kageyama, R.2
  • 41
    • 33746517512 scopus 로고    scopus 로고
    • Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling
    • Nemir M., Croquelois A., Pedrazzini T., Radtke F. Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling. Circ Res 2006, 98:1471-1478.
    • (2006) Circ Res , vol.98 , pp. 1471-1478
    • Nemir, M.1    Croquelois, A.2    Pedrazzini, T.3    Radtke, F.4
  • 42
    • 33646726733 scopus 로고    scopus 로고
    • Notch promotes neural lineage entry by pluripotent embryonic stem cells
    • Lowell S., Benchoua A., Heavey B., Smith A.G. Notch promotes neural lineage entry by pluripotent embryonic stem cells. PLoS Biol 2006, 4:e121.
    • (2006) PLoS Biol , vol.4 , pp. e121
    • Lowell, S.1    Benchoua, A.2    Heavey, B.3    Smith, A.G.4
  • 43
    • 10344264425 scopus 로고    scopus 로고
    • Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation
    • Hatakeyama J., Bessho Y., Katoh K., Ookawara S., Fujioka M., Guillemot F., et al. Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation. Development 2004, 131:5539-5550.
    • (2004) Development , vol.131 , pp. 5539-5550
    • Hatakeyama, J.1    Bessho, Y.2    Katoh, K.3    Ookawara, S.4    Fujioka, M.5    Guillemot, F.6
  • 44
    • 84889261444 scopus 로고    scopus 로고
    • Oscillatory control of factors determining multipotency and fate in mouse neural progenitors
    • Imayoshi I., Isomura A., Harima Y., Kawaguchi K., Kori H., Miyachi H., et al. Oscillatory control of factors determining multipotency and fate in mouse neural progenitors. Science 2013, 342:1203-1208.
    • (2013) Science , vol.342 , pp. 1203-1208
    • Imayoshi, I.1    Isomura, A.2    Harima, Y.3    Kawaguchi, K.4    Kori, H.5    Miyachi, H.6
  • 45
    • 0030974127 scopus 로고    scopus 로고
    • Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression
    • Chen H., Thiagalingam A., Chopra H., Borges M.W., Feder J.N., Nelkin B.D., et al. Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. Proc Natl Acad Sci USA 1997, 94:5355-5360.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 5355-5360
    • Chen, H.1    Thiagalingam, A.2    Chopra, H.3    Borges, M.W.4    Feder, J.N.5    Nelkin, B.D.6
  • 46
    • 79955676827 scopus 로고    scopus 로고
    • A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets
    • Castro D.S., Martynoga B., Parras C., Ramesh V., Pacary E., Johnston C., et al. A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets. Genes Dev 2011, 25:930-945.
    • (2011) Genes Dev , vol.25 , pp. 930-945
    • Castro, D.S.1    Martynoga, B.2    Parras, C.3    Ramesh, V.4    Pacary, E.5    Johnston, C.6
  • 47
    • 0037968010 scopus 로고    scopus 로고
    • Basic helix-loop-helix factors in cortical development
    • Ross S.E., Greenberg M.E., Stiles C.D. Basic helix-loop-helix factors in cortical development. Neuron 2003, 39:13-25.
    • (2003) Neuron , vol.39 , pp. 13-25
    • Ross, S.E.1    Greenberg, M.E.2    Stiles, C.D.3
  • 48
    • 0036631456 scopus 로고    scopus 로고
    • Proneural genes and the specification of neural cell types
    • Bertrand N., Castro D.S., Guillemot F. Proneural genes and the specification of neural cell types. Nat Rev Neurosci 2002, 3:517-530.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 517-530
    • Bertrand, N.1    Castro, D.S.2    Guillemot, F.3
  • 49
    • 84897417870 scopus 로고    scopus 로고
    • BHLH factors in self-renewal, multipotency, and fate choice of neural progenitor cells
    • Imayoshi I., Kageyama R. bHLH factors in self-renewal, multipotency, and fate choice of neural progenitor cells. Neuron 2014, 82:9-23.
    • (2014) Neuron , vol.82 , pp. 9-23
    • Imayoshi, I.1    Kageyama, R.2
  • 50
    • 54949151933 scopus 로고    scopus 로고
    • Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition
    • Kageyama R., Ohtsuka T., Shimojo H., Imayoshi I. Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition. Nat Neurosci 2008, 11:1247-1251.
    • (2008) Nat Neurosci , vol.11 , pp. 1247-1251
    • Kageyama, R.1    Ohtsuka, T.2    Shimojo, H.3    Imayoshi, I.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.