A β-catenin gradient links the clock and wavefront systems in mouse embryo segmentation

Nature Cell Biology

Volumn 10, Issue 2, 2008, Pages 186-193

  Aulehla, Alexander ^a   Wiegraebe, Winfried ^a   Baubet, Valerie ^b   Wahl, Matthias B ^a   Deng, Chuxia ^c   Taketo, Makoto ^d   Lewandoski, Mark ^e   Pourquié, Olivier ^a,f  

^a STOWERS INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b WISTAR INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d KYOTO UNIVERSITY   (Japan)

^e NATIONAL CANCER INSTITUTE   (United States)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; NUCLEAR PROTEIN; WNT PROTEIN; YELLOW FLUORESCENT PROTEIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO SEGMENTATION; IMAGE ANALYSIS; MATURATION; MESODERM; MOLECULAR CLOCK; MOUSE; NONHUMAN; OSCILLATOR; OSCILLATORY POTENTIAL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALS; BETA CATENIN; BIOLOGICAL CLOCKS; BODY PATTERNING; CELL NUCLEUS; MESODERM; MICE; MICE, TRANSGENIC; MUTATION; SIGNAL TRANSDUCTION; SOMITES; WNT PROTEINS;

EID: 38849137768     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1679     Document Type: Article

References (35)

1. Palmeirim, I., Henrique, D., Ish-Horowicz, & Fourquié, O. Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesiss. Cell 91, 639-648 (1997).
2. Aulehla, A. et al. Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev. Cell 4, 395-406 (2003).
3. Dequeant, M. L. et al. A complex oscillating network of signalling genes underlies the mouse segmentation clock. Science 314, 1595-1596 (2006).
4. Nakaya, M. A. et al. Wnt3a links left-right determination with segmentation and anteroposterior axis elongation. Development 132, 5425-5436 (2005).
5. Satoh, W., Gotoh, T., Tsunematsu, Y., Aizawa, S. & Shimono, A. Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryo-genesis. Development 133, 989-999 (2006).
6. Dubrulle, J., McGrew, M. J. & Pourquie, O. FGF signalling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation. Cell 106, 219-232 (2001).
7. Diez del Corral, R. et al. Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension. Neuron 40, 65-79 (2003).
8. Saga, Y., Hata, N., Koseki, H. & Taketo, M. M. Mesp2: A novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Genes Dev. 11, 1827-1839 (1997).
9. Morimoto, M., Takahashi, Y., Endo, M. & Saga, Y. The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. Nature 435, 354-359 (2005).
10. Lustig, B. et al. Negative feedback loop of Wnt signalling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol. Cell. Biol. 22, 1184-1193 (2002).
11. Jho, E. H. et al. Wnt/β-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol. Cell. Biol. 22, 1172-1183 (2002).
12. Brault, V. et al. Inactivation of the β-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128, 1253-1264 (2001).
13. Gordon, M. D. & Nusse, R. Wnt signaling: Multiple pathways, multiple receptors, and multiple transcription factors. J. Biol. Chem. 281, 22429-22433 (2006).
14. Maretto, S. et al. Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors. Proc. Natl Acad. Sci. USA 100, 3299-3304 (2003).
15. White, P. H., Farkas, D. R., McFadden, E. E. & Chapman, D. L. Defective somite patterning in mouse embryos with reduced levels of Tbx6. Development 130, 1681-1690 (2003).
16. Wittier, L. et al. Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling-and Tbx6. EMBO Rep. 8, 784-789 (2007).
17. Hofmann, M. et al. WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos. Genes Dev. 18, 2712-2717 (2004).
18. Galceran, J., Sustmann, C., Hsu, S. C., Folberth, S. & Grosschedl, R. LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes Dev. 18, 2718-2723 (2004).
19. Roehl, H. & Nusslein-Volhard, C. Zebrafish pea3 and erm are general targets of FGF8 signaling. Curr. Biol. 11, 503-507 (2001).
20. Burgess, R., Rawls, A., Brown, M, Bradley, A. & Olson, E. N. Requirement of the paraxis gene for somite formation and musculoskeletal patterning. Nature 314, 570-573 (1996).
21. Niederreither, K., Subbarayan, V., Dolle, P. & Chambon, P. Embryonic retinoic acid synthesis is essentail for early mouse post-implantation development. Nature Genet. 21, 444-448 (1999).
22. Nakajima, Y., Morimoto, M., Takahashi, Y., Koseki, H. & Saga, Y. Identification of Epha4 enhancer required for segmental-expression and the regulation by Mesp2. Development 133, 2517-2525 (2006).
23. Bessho, Y., Miyoshi, G., Sakata, R. & Kageyama, R. Hes7: A bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. Genes Cells 6, 175-185 (2001).
24. Morales, A. V., Yasuda, Y. & Ish-Horowicz, D. Periodic lunatic fringe expression is controlled during segmentation by a cyclic transcriptional enhancer responsive to notch signaling. Dev. Cell 3, 63-74 (2002).
25. Cole, S. E., Levorse, J. M., Tilghman, S. M. & Vogt, T. F. Clock regulatory elements control cyclic expression of lunatic fringe during somitogenesis. Dev. Cell, 3 75-84 (2002).
26. Sawada, A. et al. Fgf/MAPK signalfing is a crucial positional cue in somite boundary formation. Develppment, 128, 4873-4880 (2001).
27. Delfini, M. C., Dubrulle, J., Malapert, P., Chal, J. & Pourquie, O. Control of the segmentation process by graded MAPK/ERK activation in the chick embryo. Proc. Natl Acad. Sci. USA 102, 11343-11348 (2005).
28. Morkel, M. et al. β-catenin regulates Cripto- and Wnt3 dependent gene expression programs in mouse axis and mesoderm formation. Development 130, 6283-6294 (2003).
29. Niwa, Y. et al. The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock. Dev. Cell 13, 298-304 (2007).
30. Wahl, M. B., Deng, C., Lewandoski, M. & Pourquie, O. FGF signaling acts upstream of the NOTCH and WNT signaling pathways to control segmentation clock oscillations in mouse somitogenesis. Development 134, 4033-4041 (2007).
31. Hecht, A. & Kemler, R. Curbing the nuclear activities of β-catenin. Control over Wnt target gene expression. EMBO Rep 1, 24-28 (2000).
32. Wang, S. & Jones, K. A. CK2 controls the recruitment of Wnt regulators to target genes in vivo. Curr. Biol. 16, 2239-2244 (2006).
33. Masamizu, Y. et al. Real-time imaging of the somite segmentation clock: Revelation of unstable oscillators in the individual presomitic mesoderm cells. Proc. Natl Acad. Sci. USA 103, 1313-1318 (2006).
34. Nagai, T. et al. A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications. Nature Biotechnol. 20, 87-90 (2002).
35. Jones, E. A. et al. Dynamic in vivo imaging of postimplantation mammalian embryos using whole embryo culture. Genesis 34, 228-235 (2002).