Validation of a genomics-based hypothetical adverse outcome pathway: 2,4-Dinitrotoluene perturbs PPAR signaling thus impairing energy metabolism and exercise endurance

Toxicological Sciences

Volumn 141, Issue 1, 2014, Pages 44-58

  Wilbanks, Mitchell S ^a   Gust, Kurt A ^a   Atwa, Sahar ^b   Sunesara, Imran ^c   Johnson, David ^a,d   Ang, Choo Yaw ^e   Meyer, Sharon A ^b   Perkins, Edward J ^a  

^a US ARMY ENGINEER RESEARCH AND DEVELOPMENT CENTER   (United States)

^b UNIVERSITY OF LOUISIANA AT MONROE   (United States)

^c UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^d Conestoga Rovers and Associates ^*  (United States)

^e Badger Technical Services   (United States)

Author keywords

Adverse outcome pathway; Dinitrotoluene; Energy; PPAR

Indexed keywords

2,4 DINITROTOLUENE; CARBOHYDRATE; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; 2,4-DINITROTOLUENE; GLYCOGEN; NITROBENZENE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; POLLUTANT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOASSAY; CONTROLLED STUDY; ENDURANCE; ENERGY METABOLISM; ENERGY YIELD; EXERCISE; EXHAUSTION; FATTY ACID TRANSPORT; FEMALE; FORCED SWIM TEST; GENE; GENE EXPRESSION; MOUSE; NONHUMAN; WEIGHT REDUCTION; WILD TYPE; ANIMAL; BODY WEIGHT; C57BL MOUSE; DOSE RESPONSE; DRUG EFFECTS; GENETICS; GENOMICS; KNOCKOUT MOUSE; LIVER; METABOLISM; PATHOLOGY; POLLUTANT; SIGNAL TRANSDUCTION; SWIMMING; TOXICITY;

MUS;

ANIMALS; BODY WEIGHT; DINITROBENZENES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENERGY METABOLISM; ENVIRONMENTAL POLLUTANTS; GENOMICS; GLYCOGEN; LIVER; MICE, INBRED C57BL; MICE, KNOCKOUT; PHYSICAL ENDURANCE; PPAR ALPHA; PPAR GAMMA; SIGNAL TRANSDUCTION; SWIMMING;

EID: 84913617160     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu104     Document Type: Article

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