Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones

Neuropathology and Applied Neurobiology

Volumn 40, Issue 6, 2014, Pages 670-685

  Highley, J Robin ^a   Kirby, Janine ^a   Jansweijer, Joeri A ^b   Webb, Philip S ^a   Hewamadduma, Channa A ^a,c   Heath, Paul R ^a   Higginbottom, Adrian ^a   Raman, Rohini ^a   Ferraiuolo, Laura ^a   Cooper Knock, Johnathan ^a   Mcdermott, Christopher J ^a   Wharton, Stephen B ^a   Shaw, Pamela J ^a   Ince, Paul G ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Amyotrophic lateral sclerosis; Microarray; mRNA; post mortem; Splicing; TDP 43

Indexed keywords

DNA BINDING PROTEIN; NUCLEAR PROTEIN; PROTEIN TDP-43;

AGED; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL; FEMALE; GENE EXPRESSION; GENETICS; HUMAN; MALE; METABOLISM; MIDDLE AGED; MOTONEURON; MOUSE; RNA SPLICING; SPINAL CORD;

AGED; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION; HUMANS; MALE; MICE; MIDDLE AGED; MOTOR NEURONS; NUCLEAR PROTEINS; RNA SPLICING; SPINAL CORD;

EID: 84913597051     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/nan.12148     Document Type: Article

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