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Volumn 37, Issue 5, 2012, Pages 179-188

The spliceosome: A flexible, reversible macromolecular machine

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA PRECURSOR;

EID: 84860513145     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2012.02.009     Document Type: Review
Times cited : (192)

References (72)
  • 1
    • 75849145292 scopus 로고    scopus 로고
    • Expansion of the eukaryotic proteome by alternative splicing
    • Nilsen T.W., Graveley B.R. Expansion of the eukaryotic proteome by alternative splicing. Nature 2010, 463:457-463.
    • (2010) Nature , vol.463 , pp. 457-463
    • Nilsen, T.W.1    Graveley, B.R.2
  • 3
    • 0035949674 scopus 로고    scopus 로고
    • A computational analysis of sequence features involved in recognition of short introns
    • Lim L.P., Burge C.B. A computational analysis of sequence features involved in recognition of short introns. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:11193-11198.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 11193-11198
    • Lim, L.P.1    Burge, C.B.2
  • 4
    • 59649083526 scopus 로고    scopus 로고
    • Recognition of atypical 5' splice sites by shifted base-pairing to U1 snRNA
    • Roca X., Krainer A.R. Recognition of atypical 5' splice sites by shifted base-pairing to U1 snRNA. Nat. Struct. Mol. Biol. 2009, 16:176-182.
    • (2009) Nat. Struct. Mol. Biol. , vol.16 , pp. 176-182
    • Roca, X.1    Krainer, A.R.2
  • 5
    • 60349104299 scopus 로고    scopus 로고
    • The spliceosome: design principles of a dynamic RNP machine
    • Wahl M.C., et al. The spliceosome: design principles of a dynamic RNP machine. Cell 2009, 136:701-718.
    • (2009) Cell , vol.136 , pp. 701-718
    • Wahl, M.C.1
  • 6
    • 0042671357 scopus 로고    scopus 로고
    • Pre-mRNA splicing: awash in a sea of proteins
    • Jurica M.S., Moore M.J. Pre-mRNA splicing: awash in a sea of proteins. Mol. Cell 2003, 12:5-14.
    • (2003) Mol. Cell , vol.12 , pp. 5-14
    • Jurica, M.S.1    Moore, M.J.2
  • 7
    • 0344198459 scopus 로고    scopus 로고
    • The spliceosome: the most complex macromolecular machine in the cell?
    • Nilsen T.W. The spliceosome: the most complex macromolecular machine in the cell?. Bioessays 2003, 25:1147-1149.
    • (2003) Bioessays , vol.25 , pp. 1147-1149
    • Nilsen, T.W.1
  • 8
    • 70449625597 scopus 로고    scopus 로고
    • The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome
    • Fabrizio P., et al. The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. Mol. Cell 2009, 36:593-608.
    • (2009) Mol. Cell , vol.36 , pp. 593-608
    • Fabrizio, P.1
  • 9
    • 47249101070 scopus 로고    scopus 로고
    • Where in the cell is the minor spliceosome?
    • Steitz J.A., et al. Where in the cell is the minor spliceosome?. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:8485-8486.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 8485-8486
    • Steitz, J.A.1
  • 10
    • 60149110358 scopus 로고    scopus 로고
    • Pre-mRNA processing reaches back to transcription and ahead to translation
    • Moore M.J., Proudfoot N.J. Pre-mRNA processing reaches back to transcription and ahead to translation. Cell 2009, 136:688-700.
    • (2009) Cell , vol.136 , pp. 688-700
    • Moore, M.J.1    Proudfoot, N.J.2
  • 11
    • 77957285756 scopus 로고    scopus 로고
    • Cross-talk in transcription, splicing and chromatin: who makes the first call?
    • Alexander R., Beggs J.D. Cross-talk in transcription, splicing and chromatin: who makes the first call?. Biochem. Soc. Trans. 2010, 38:1251-1256.
    • (2010) Biochem. Soc. Trans. , vol.38 , pp. 1251-1256
    • Alexander, R.1    Beggs, J.D.2
  • 12
    • 77149180424 scopus 로고    scopus 로고
    • Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing
    • Lardelli R.M., et al. Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing. RNA 2010, 16:516-528.
    • (2010) RNA , vol.16 , pp. 516-528
    • Lardelli, R.M.1
  • 13
    • 0036948420 scopus 로고    scopus 로고
    • Allosteric cascade of spliceosome activation
    • Brow D.A. Allosteric cascade of spliceosome activation. Annu. Rev. Genet. 2002, 36:333-360.
    • (2002) Annu. Rev. Genet. , vol.36 , pp. 333-360
    • Brow, D.A.1
  • 14
    • 0027516055 scopus 로고
    • Mutational analysis of pre-mRNA splicing in Saccharomyces cerevisiae using a sensitive new reporter gene, CUP1
    • Lesser C.F., Guthrie C. Mutational analysis of pre-mRNA splicing in Saccharomyces cerevisiae using a sensitive new reporter gene, CUP1. Genetics 1993, 133:851-863.
    • (1993) Genetics , vol.133 , pp. 851-863
    • Lesser, C.F.1    Guthrie, C.2
  • 15
    • 0036270848 scopus 로고    scopus 로고
    • Yeast pre-mRNA splicing: methods, mechanisms, and machinery
    • Stevens S.W., Abelson J. Yeast pre-mRNA splicing: methods, mechanisms, and machinery. Methods Enzymol. 2002, 351:200-220.
    • (2002) Methods Enzymol. , vol.351 , pp. 200-220
    • Stevens, S.W.1    Abelson, J.2
  • 16
    • 0642346948 scopus 로고    scopus 로고
    • Ten commandments of enzymology, amended
    • Kornberg A. Ten commandments of enzymology, amended. Trends Biochem. Sci. 2003, 28:515-517.
    • (2003) Trends Biochem. Sci. , vol.28 , pp. 515-517
    • Kornberg, A.1
  • 17
    • 42249093677 scopus 로고    scopus 로고
    • Isolation of an active step I spliceosome and composition of its RNP core
    • Bessonov S., et al. Isolation of an active step I spliceosome and composition of its RNP core. Nature 2008, 452:846-850.
    • (2008) Nature , vol.452 , pp. 846-850
    • Bessonov, S.1
  • 18
    • 71449119694 scopus 로고    scopus 로고
    • Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components
    • Warkocki Z., et al. Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components. Nat. Struct. Mol. Biol. 2009, 16:1237-1243.
    • (2009) Nat. Struct. Mol. Biol. , vol.16 , pp. 1237-1243
    • Warkocki, Z.1
  • 19
    • 0030802754 scopus 로고    scopus 로고
    • Bimolecular exon ligation by the human spliceosome
    • Anderson K., Moore M.J. Bimolecular exon ligation by the human spliceosome. Science 1997, 276:1712-1716.
    • (1997) Science , vol.276 , pp. 1712-1716
    • Anderson, K.1    Moore, M.J.2
  • 20
    • 0022907583 scopus 로고
    • The yeast RNA gene products are essential for mRNA splicing in vitro
    • Lustig A.J., et al. The yeast RNA gene products are essential for mRNA splicing in vitro. Cell 1986, 47:953-963.
    • (1986) Cell , vol.47 , pp. 953-963
    • Lustig, A.J.1
  • 21
    • 0025941556 scopus 로고
    • U4 small nuclear RNA dissociates from a yeast spliceosome and does not participate in the subsequent splicing reaction
    • Yean S.L., Lin R.J. U4 small nuclear RNA dissociates from a yeast spliceosome and does not participate in the subsequent splicing reaction. Mol. Cell. Biol. 1991, 11:5571-5577.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 5571-5577
    • Yean, S.L.1    Lin, R.J.2
  • 22
    • 0034649666 scopus 로고    scopus 로고
    • Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome
    • Yean S.L., et al. Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome. Nature 2000, 408:881-884.
    • (2000) Nature , vol.408 , pp. 881-884
    • Yean, S.L.1
  • 23
    • 0034841844 scopus 로고    scopus 로고
    • The tandem affinity purification (TAP) method: a general procedure of protein complex purification
    • Puig O., et al. The tandem affinity purification (TAP) method: a general procedure of protein complex purification. Methods 2001, 24:218-229.
    • (2001) Methods , vol.24 , pp. 218-229
    • Puig, O.1
  • 24
    • 77955488349 scopus 로고    scopus 로고
    • The DEAH box ATPases Prp16 and Prp43 cooperate to proofread 5' splice site cleavage during pre-mRNA splicing
    • Koodathingal P., et al. The DEAH box ATPases Prp16 and Prp43 cooperate to proofread 5' splice site cleavage during pre-mRNA splicing. Mol. Cell 2010, 39:385-395.
    • (2010) Mol. Cell , vol.39 , pp. 385-395
    • Koodathingal, P.1
  • 25
    • 0000359208 scopus 로고
    • Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity
    • Hopfield J.J. Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity. Proc. Natl. Acad. Sci. U.S.A. 1974, 71:4135-4139.
    • (1974) Proc. Natl. Acad. Sci. U.S.A. , vol.71 , pp. 4135-4139
    • Hopfield, J.J.1
  • 26
    • 0027287852 scopus 로고
    • A mechanism to enhance mRNA splicing fidelity: the RNA-dependent ATPase Prp16 governs usage of a discard pathway for aberrant lariat intermediates
    • Burgess S.M., Guthrie C. A mechanism to enhance mRNA splicing fidelity: the RNA-dependent ATPase Prp16 governs usage of a discard pathway for aberrant lariat intermediates. Cell 1993, 73:1377-1391.
    • (1993) Cell , vol.73 , pp. 1377-1391
    • Burgess, S.M.1    Guthrie, C.2
  • 27
    • 0025233806 scopus 로고
    • A putative ATP binding protein influences the fidelity of branchpoint recognition in yeast splicing
    • Burgess S., et al. A putative ATP binding protein influences the fidelity of branchpoint recognition in yeast splicing. Cell 1990, 60:705-717.
    • (1990) Cell , vol.60 , pp. 705-717
    • Burgess, S.1
  • 28
    • 0027065506 scopus 로고
    • A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis
    • Schwer B., Guthrie C. A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis. EMBO J. 1992, 11:5033-5039.
    • (1992) EMBO J. , vol.11 , pp. 5033-5039
    • Schwer, B.1    Guthrie, C.2
  • 29
    • 77953408963 scopus 로고    scopus 로고
    • Spliceosome discards intermediates via the DEAH box ATPase Prp43p
    • Mayas R.M., et al. Spliceosome discards intermediates via the DEAH box ATPase Prp43p. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:10020-10025.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 10020-10025
    • Mayas, R.M.1
  • 30
    • 0030671163 scopus 로고    scopus 로고
    • Prp43: an RNA helicase-like factor involved in spliceosome disassembly
    • Arenas J.E., Abelson J.N. Prp43: an RNA helicase-like factor involved in spliceosome disassembly. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:11798-11802.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 11798-11802
    • Arenas, J.E.1    Abelson, J.N.2
  • 31
    • 30644465812 scopus 로고    scopus 로고
    • Prp43p is a DEAH-box spliceosome disassembly factor essential for ribosome biogenesis
    • Combs D.J., et al. Prp43p is a DEAH-box spliceosome disassembly factor essential for ribosome biogenesis. Mol. Cell. Biol. 2006, 26:523-534.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 523-534
    • Combs, D.J.1
  • 32
    • 70449686545 scopus 로고    scopus 로고
    • Prp43 bound at different sites on the pre-rRNA performs distinct functions in ribosome synthesis
    • Bohnsack M.T., et al. Prp43 bound at different sites on the pre-rRNA performs distinct functions in ribosome synthesis. Mol. Cell 2009, 36:583-592.
    • (2009) Mol. Cell , vol.36 , pp. 583-592
    • Bohnsack, M.T.1
  • 33
    • 0025097912 scopus 로고
    • Reverse self-splicing of group II intron RNAs in vitro
    • Augustin S., et al. Reverse self-splicing of group II intron RNAs in vitro. Nature 1990, 343:383-386.
    • (1990) Nature , vol.343 , pp. 383-386
    • Augustin, S.1
  • 34
    • 46449086933 scopus 로고    scopus 로고
    • Both catalytic steps of nuclear pre-mRNA splicing are reversible
    • Tseng C.-K., Cheng S.-C. Both catalytic steps of nuclear pre-mRNA splicing are reversible. Science 2008, 320:1782-1784.
    • (2008) Science , vol.320 , pp. 1782-1784
    • Tseng, C.-K.1    Cheng, S.-C.2
  • 35
    • 52949135935 scopus 로고    scopus 로고
    • Mechanistic insights from reversible splicing catalysis
    • Smith D.J., Konarska M.M. Mechanistic insights from reversible splicing catalysis. RNA 2008, 14:1975-1978.
    • (2008) RNA , vol.14 , pp. 1975-1978
    • Smith, D.J.1    Konarska, M.M.2
  • 36
    • 65549090941 scopus 로고    scopus 로고
    • Insights into branch nucleophile positioning and activation from an orthogonal pre-mRNA splicing system in yeast
    • Smith D.J., et al. Insights into branch nucleophile positioning and activation from an orthogonal pre-mRNA splicing system in yeast. Mol. Cell 2009, 34:333-343.
    • (2009) Mol. Cell , vol.34 , pp. 333-343
    • Smith, D.J.1
  • 37
    • 44949246374 scopus 로고    scopus 로고
    • Nought may endure but mutability": spliceosome dynamics and the regulation of splicing
    • Smith D.J., et al. Nought may endure but mutability": spliceosome dynamics and the regulation of splicing. Mol. Cell 2008, 30:657-666.
    • (2008) Mol. Cell , vol.30 , pp. 657-666
    • Smith, D.J.1
  • 38
    • 2342522014 scopus 로고    scopus 로고
    • Suppression of multiple substrate mutations by spliceosomal prp8 alleles suggests functional correlations with ribosomal ambiguity mutants
    • Query C.C., Konarska M.M. Suppression of multiple substrate mutations by spliceosomal prp8 alleles suggests functional correlations with ribosomal ambiguity mutants. Mol. Cell 2004, 14:343-354.
    • (2004) Mol. Cell , vol.14 , pp. 343-354
    • Query, C.C.1    Konarska, M.M.2
  • 39
    • 34249890532 scopus 로고    scopus 로고
    • Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing
    • Liu L., et al. Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing. Nat. Struct. Mol. Biol. 2007, 14:519-526.
    • (2007) Nat. Struct. Mol. Biol. , vol.14 , pp. 519-526
    • Liu, L.1
  • 40
    • 32444443532 scopus 로고    scopus 로고
    • Repositioning of the reaction intermediate within the catalytic center of the spliceosome
    • Konarska M.M., et al. Repositioning of the reaction intermediate within the catalytic center of the spliceosome. Mol. Cell 2006, 21:543-553.
    • (2006) Mol. Cell , vol.21 , pp. 543-553
    • Konarska, M.M.1
  • 41
    • 34250314386 scopus 로고    scopus 로고
    • Trans-Splicing to spliceosomal U2 snRNA suggests disruption of branch site-U2 pairing during pre-mRNA splicing
    • Smith D.J., et al. trans-Splicing to spliceosomal U2 snRNA suggests disruption of branch site-U2 pairing during pre-mRNA splicing. Mol. Cell 2007, 26:883-890.
    • (2007) Mol. Cell , vol.26 , pp. 883-890
    • Smith, D.J.1
  • 42
    • 44449097780 scopus 로고    scopus 로고
    • Do-it-yourself guide: how to use the modern single-molecule toolkit
    • Walter N.G., et al. Do-it-yourself guide: how to use the modern single-molecule toolkit. Nat. Methods 2008, 5:475-489.
    • (2008) Nat. Methods , vol.5 , pp. 475-489
    • Walter, N.G.1
  • 43
    • 84861854858 scopus 로고    scopus 로고
    • Single molecule enzymology: watching the reaction
    • Gershenson A. Single molecule enzymology: watching the reaction. Curr. Opin. Chem. Biol. 2009, 13:1-7.
    • (2009) Curr. Opin. Chem. Biol. , vol.13 , pp. 1-7
    • Gershenson, A.1
  • 44
    • 33746743013 scopus 로고    scopus 로고
    • Viewing dynamic assembly of molecular complexes by multi-wavelength single-molecule fluorescence
    • Friedman L.J., et al. Viewing dynamic assembly of molecular complexes by multi-wavelength single-molecule fluorescence. Biophys. J. 2006, 91:1023-1031.
    • (2006) Biophys. J. , vol.91 , pp. 1023-1031
    • Friedman, L.J.1
  • 45
    • 79952504644 scopus 로고    scopus 로고
    • Ordered and dynamic assembly of single spliceosomes
    • Hoskins A.A., et al. Ordered and dynamic assembly of single spliceosomes. Science 2011, 331:1289-1295.
    • (2011) Science , vol.331 , pp. 1289-1295
    • Hoskins, A.A.1
  • 46
    • 0023695462 scopus 로고
    • Early commitment of yeast pre-mRNA to the spliceosome pathway
    • Legrain P., et al. Early commitment of yeast pre-mRNA to the spliceosome pathway. Mol. Cell. Biol. 1988, 8:3755-3760.
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 3755-3760
    • Legrain, P.1
  • 47
    • 0024325159 scopus 로고
    • Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing
    • Seraphin B., Rosbash M. Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing. Cell 1989, 59:349-358.
    • (1989) Cell , vol.59 , pp. 349-358
    • Seraphin, B.1    Rosbash, M.2
  • 48
    • 0030841913 scopus 로고    scopus 로고
    • Dynamics of the U1 small nuclear ribonucleoprotein during yeast spliceosome assembly
    • Ruby S.W. Dynamics of the U1 small nuclear ribonucleoprotein during yeast spliceosome assembly. J. Biol. Chem. 1997, 272:17333-17341.
    • (1997) J. Biol. Chem. , vol.272 , pp. 17333-17341
    • Ruby, S.W.1
  • 49
    • 77950516144 scopus 로고    scopus 로고
    • Conformational dynamics of single pre-mRNA molecules during in vitro splicing
    • Abelson J., et al. Conformational dynamics of single pre-mRNA molecules during in vitro splicing. Nat. Struct. Mol. Biol. 2010, 17:504-512.
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 504-512
    • Abelson, J.1
  • 50
    • 77957066363 scopus 로고    scopus 로고
    • Preparation of fluorescent pre-mRNA substrates for an smFRET study of pre-mRNA splicing in yeast
    • Abelson J., et al. Preparation of fluorescent pre-mRNA substrates for an smFRET study of pre-mRNA splicing in yeast. Methods Enzymol. 2010, 472:31-40.
    • (2010) Methods Enzymol. , vol.472 , pp. 31-40
    • Abelson, J.1
  • 51
    • 38049077956 scopus 로고    scopus 로고
    • Visualizing the splicing of single pre-mRNA molecules in whole cell extract
    • Crawford D.J., et al. Visualizing the splicing of single pre-mRNA molecules in whole cell extract. RNA 2008, 14:170-179.
    • (2008) RNA , vol.14 , pp. 170-179
    • Crawford, D.J.1
  • 52
    • 0037012922 scopus 로고    scopus 로고
    • Genome-wide analysis of mRNA processing in yeast using splicing-specific microarrays
    • Clark T.A., et al. Genome-wide analysis of mRNA processing in yeast using splicing-specific microarrays. Science 2002, 296:907-910.
    • (2002) Science , vol.296 , pp. 907-910
    • Clark, T.A.1
  • 53
    • 34247255773 scopus 로고    scopus 로고
    • Transcript specificity in yeast pre-mRNA splicing revealed by mutations in core spliceosomal components
    • Pleiss J.A., et al. Transcript specificity in yeast pre-mRNA splicing revealed by mutations in core spliceosomal components. PLoS Biol. 2007, 5:e90.
    • (2007) PLoS Biol. , vol.5
    • Pleiss, J.A.1
  • 54
    • 34748855702 scopus 로고    scopus 로고
    • Rapid, transcript-specific changes in splicing in response to environmental stress
    • Pleiss J.A., et al. Rapid, transcript-specific changes in splicing in response to environmental stress. Mol. Cell 2007, 27:928-937.
    • (2007) Mol. Cell , vol.27 , pp. 928-937
    • Pleiss, J.A.1
  • 55
    • 79960456464 scopus 로고    scopus 로고
    • Diverse environmental stresses elicit distinct responses at the level of pre-mRNA processing in yeast
    • Bergkessel M., et al. Diverse environmental stresses elicit distinct responses at the level of pre-mRNA processing in yeast. RNA 2011, 17:1461-1478.
    • (2011) RNA , vol.17 , pp. 1461-1478
    • Bergkessel, M.1
  • 56
    • 80053008165 scopus 로고    scopus 로고
    • Deciphering 3'ss selection in the yeast genome reveals an RNA thermosensor that mediates alternative splicing
    • Meyer M., et al. Deciphering 3'ss selection in the yeast genome reveals an RNA thermosensor that mediates alternative splicing. Mol. Cell 2011, 43:1033-1039.
    • (2011) Mol. Cell , vol.43 , pp. 1033-1039
    • Meyer, M.1
  • 57
    • 0026088747 scopus 로고
    • Requirement of the RNA helicase-like protein PRP22 for release of messenger RNA from spliceosomes
    • Company M., et al. Requirement of the RNA helicase-like protein PRP22 for release of messenger RNA from spliceosomes. Nature 1991, 349:487-493.
    • (1991) Nature , vol.349 , pp. 487-493
    • Company, M.1
  • 58
    • 4143078172 scopus 로고    scopus 로고
    • Commitment to splice site pairing coincides with A complex formation
    • Lim S.R., Hertel K.J. Commitment to splice site pairing coincides with A complex formation. Mol. Cell 2004, 15:477-483.
    • (2004) Mol. Cell , vol.15 , pp. 477-483
    • Lim, S.R.1    Hertel, K.J.2
  • 59
    • 59449100357 scopus 로고    scopus 로고
    • Spliceosome assembly pathways for different types of alternative splicing converge during commitment to splice site pairing in the A complex
    • Kotlajich M.V., et al. Spliceosome assembly pathways for different types of alternative splicing converge during commitment to splice site pairing in the A complex. Mol. Cell. Biol. 2009, 29:1072-1082.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 1072-1082
    • Kotlajich, M.V.1
  • 60
    • 53149145051 scopus 로고    scopus 로고
    • RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition
    • Bonnal S., et al. RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition. Mol. Cell 2008, 32:81-95.
    • (2008) Mol. Cell , vol.32 , pp. 81-95
    • Bonnal, S.1
  • 61
    • 70350569286 scopus 로고    scopus 로고
    • Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches
    • Chen M., Manley J.L. Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nat. Rev. Mol. Cell Biol. 2009, 10:741-754.
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 741-754
    • Chen, M.1    Manley, J.L.2
  • 62
    • 8644278829 scopus 로고    scopus 로고
    • Identification of alternative splicing regulators by RNA interference in Drosophila
    • Park J.W., et al. Identification of alternative splicing regulators by RNA interference in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:15974-15979.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 15974-15979
    • Park, J.W.1
  • 64
    • 70350542582 scopus 로고    scopus 로고
    • The role of exon sequences in C complex spliceosome structure
    • Ilagan J., et al. The role of exon sequences in C complex spliceosome structure. J. Mol. Biol. 2009, 394:363-375.
    • (2009) J. Mol. Biol. , vol.394 , pp. 363-375
    • Ilagan, J.1
  • 65
    • 68249149579 scopus 로고    scopus 로고
    • Exon, intron and splice site locations in the spliceosomal B complex
    • Wolf E., et al. Exon, intron and splice site locations in the spliceosomal B complex. EMBO J. 2009, 28:2283-2292.
    • (2009) EMBO J. , vol.28 , pp. 2283-2292
    • Wolf, E.1
  • 66
    • 36749080450 scopus 로고    scopus 로고
    • Competition between the ATPase Prp5 and branch region-U2 snRNA pairing modulates the fidelity of spliceosome assembly
    • Xu Y.-Z., Query C.C. Competition between the ATPase Prp5 and branch region-U2 snRNA pairing modulates the fidelity of spliceosome assembly. Mol. Cell 2007, 28:838-849.
    • (2007) Mol. Cell , vol.28 , pp. 838-849
    • Xu, Y.-Z.1    Query, C.C.2
  • 67
    • 0033010430 scopus 로고    scopus 로고
    • An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p
    • Staley J.P., Guthrie C. An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p. Mol. Cell 1999, 3:55-64.
    • (1999) Mol. Cell , vol.3 , pp. 55-64
    • Staley, J.P.1    Guthrie, C.2
  • 68
    • 33744937919 scopus 로고    scopus 로고
    • Exon ligation is proofread by the DExD/H-box ATPase Prp22p
    • Mayas R.M., et al. Exon ligation is proofread by the DExD/H-box ATPase Prp22p. Nat. Struct. Mol. Biol. 2006, 13:482-490.
    • (2006) Nat. Struct. Mol. Biol. , vol.13 , pp. 482-490
    • Mayas, R.M.1
  • 69
    • 79959450181 scopus 로고    scopus 로고
    • Real-time imaging of cotranscriptional splicing reveals a kinetic model that reduces noise: implications for alternative splicing regulation
    • Schmidt U., et al. Real-time imaging of cotranscriptional splicing reveals a kinetic model that reduces noise: implications for alternative splicing regulation. J. Cell Biol. 2011, 193:819-829.
    • (2011) J. Cell Biol. , vol.193 , pp. 819-829
    • Schmidt, U.1
  • 70
    • 81855183655 scopus 로고    scopus 로고
    • Single-molecule imaging of transcriptionally coupled and uncoupled splicing
    • Vargas D.Y., et al. Single-molecule imaging of transcriptionally coupled and uncoupled splicing. Cell 2011, 147:1054-1065.
    • (2011) Cell , vol.147 , pp. 1054-1065
    • Vargas, D.Y.1
  • 71
    • 79955407832 scopus 로고    scopus 로고
    • Real-time observation of transcription initiation and elongation on an endogenous yeast gene
    • Larson D.R., et al. Real-time observation of transcription initiation and elongation on an endogenous yeast gene. Science 2011, 332:475-478.
    • (2011) Science , vol.332 , pp. 475-478
    • Larson, D.R.1
  • 72
    • 77957747157 scopus 로고    scopus 로고
    • The differential interaction of snRNPs with pre-mRNA reveals splicing kinetics in living cells
    • Huranová M., et al. The differential interaction of snRNPs with pre-mRNA reveals splicing kinetics in living cells. J. Cell Biol. 2010, 191:75-86.
    • (2010) J. Cell Biol. , vol.191 , pp. 75-86
    • Huranová, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.