Novel roles for actin in mitochondrial fission

Journal of Cell Science

Volumn 127, Issue 21, 2014, Pages 4549-4560

  Hatch, Anna L ^a   Gurel, Pinar S ^a   Higgs, Henry N ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Actin; Mitochondrial fission; Myosin

Indexed keywords

ACTIN; ADAPTOR PROTEIN; DRP1 PROTEIN; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; INF2 PROTEIN; MDV1 PROTEIN; MITOCHONDRIAL PROTEIN; MYOSIN II; MYOSIN IIA; NEURAL WISKOTT ALDRICH SYNDROME PROTEIN; UNCLASSIFIED DRUG; DYNAMIN; MYOSIN;

ACTIN FILAMENT; ACTIN POLYMERIZATION; CRYSTAL STRUCTURE; ENDOPLASMIC RETICULUM; HYDROLYSIS; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NOTE; PROTEIN STRUCTURE; ANIMAL; BIOLOGICAL MODEL; HUMAN; METABOLISM; PHYSIOLOGY;

ACTINS; ANIMALS; DYNAMINS; HUMANS; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; MODELS, BIOLOGICAL; MYOSINS;

EID: 84913582205     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.153791     Document Type: Note

References (119)

1. Anand, R., Wai, T., Baker, M. J., Kladt, N., Schauss, A. C., Rugarli, E. and Langer, T. (2014). The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission. J. Cell Biol. 204, 919-929.
2. Archer, S. L. (2013). Mitochondrial dynamics -mitochondrial fission and fusion in human diseases. N. Engl. J. Med. 369, 2236-2251.
3. Beck, H., Flynn, K., Lindenberg, K. S., Schwarz, H., Bradke, F., Di Giovanni, S. and Knöll, B. (2012). Serum Response Factor (SRF)-cofilin-actin signaling axis modulates mitochondrial dynamics. Proc. Natl. Acad. Sci. USA 109, E2523-E2532.
4. Belin, B. J. and Mullins, R. D. (2013). What we talk about when we talk about nuclear actin. Nucleus 4, 291-297.
5. Benda, C. (1898). Arch. Anat. Physiol. 73, 393-398.
6. Berg, J. S., Powell, B. C. and Cheney, R. E. (2001). A millennial myosin census. Mol. Biol. Cell 12, 780-794.
7. Billington, N., Wang, A., Mao, J., Adelstein, R. S. and Sellers, J. R. (2013). Characterization of three full-length human nonmuscle myosin II paralogs. J. Biol. Chem. 288, 33398-33410.
8. Blanchoin, L., Boujemaa-Paterski, R., Sykes, C. and Plastino, J. (2014). Actin dynamics, architecture, and mechanics in cell motility. Physiol. Rev. 94, 235-263.
9. Bleazard, W., McCaffery, J. M., King, E. J., Bale, S., Mozdy, A., Tieu, Q., Nunnari, J. and Shaw, J. M. (1999). The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast. Nat. Cell Biol. 1, 298-304.
10. Block, J., Breitsprecher, D., Kühn, S., Winterhoff, M., Kage, F., Geffers, R., Duwe, P., Rohn, J. L., Baum, B., Brakebusch, C. et al. (2012). FMNL2 drives actin-based protrusion and migration downstream of Cdc42. Curr. Biol. 22, 1005-1012.
11. Boldogh, I., Vojtov, N., Karmon, S. and Pon, L. A. (1998). Interaction between mitochondria and the actin cytoskeleton in budding yeast requires two integral mitochondrial outer membrane proteins, Mmm1p and Mdm10p. J. Cell Biol. 141, 1371-1381.
12. Boldogh, I. R., Yang, H. C., Nowakowski, W. D., Karmon, S. L., Hays, L. G., Yates, J. R., 3rd and Pon, L. A. (2001). Arp2/3 complex and actin dynamics are required for actin-based mitochondrial motility in yeast. Proc. Natl. Acad. Sci. USA 98, 3162-3167.
13. Boldogh, I. R., Nowakowski, D.W., Yang, H. C., Chung, H., Karmon, S., Royes, P. and Pon, L. A. (2003). A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery. Mol. Biol. Cell 14, 4618-4627.
14. Boyer, O., Nevo, F., Plaisier, E., Funalot, B., Gribouval, O., Benoit, G., Cong, E. H., Arrondel, C., Tête, M. J., Montjean, R. et al. (2011). INF2 mutations in Charcot-Marie-Tooth disease with glomerulopathy. N. Engl. J. Med. 365, 2377-2388.
15. Braschi, E., Zunino, R. and McBride, H. M. (2009). MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission. EMBO Rep. 10, 748-754.
16. Brown, E. J., Schlöndorff, J. S., Becker, D. J., Tsukaguchi, H., Tonna, S. J., Uscinski, A. L., Higgs, H. N., Henderson, J. M. and Pollak, M. R. (2010). Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis. Nat. Genet. 42, 72-76.
17. Bui, H. T. and Shaw, J. M. (2013). Dynamin assembly strategies and adaptor proteins in mitochondrial fission. Curr. Biol. 23, R891-R899.
18. Burgess, S. M., Delannoy, M. and Jensen, R. E. (1994). MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria. J. Cell Biol. 126, 1375-1391.
19. Chan, D. C. (2012). Fusion and fission: interlinked processes critical for mitochondrial health. Annu. Rev. Genet. 46, 265-287.
20. Chang, C. R. and Blackstone, C. (2010). Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1. Ann. N. Y. Acad. Sci. 1201, 34-39.
21. Chang, D. T. and Reynolds, I. J. (2006). Differences in mitochondrial movement and morphology in young and mature primary cortical neurons in culture. Neuroscience 141, 727-736.
22. Chen, H. and Chan, D. C. (2009). Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases. Hum. Mol. Genet. 18 R2, R169-R176.
23. Chen, Q. and Pollard, T. D. (2011). Actin filament severing by cofilin is more important for assembly than constriction of the cytokinetic contractile ring. J. Cell Biol. 195, 485-498.
24. Chen, C. T., Hehnly, H. and Doxsey, S. J. (2012). Orchestrating vesicle transport, ESCRTs and kinase surveillance during abscission. Nat. Rev. Mol. Cell Biol. 13, 483-488.
25. Chesarone, M. A., DuPage, A. G. and Goode, B. L. (2010). Unleashing formins to remodel the actin and microtubule cytoskeletons. Nat. Rev. Mol. Cell Biol. 11, 62-74.
26. Chhabra, E. S. and Higgs, H. N. (2006). INF2 Is a WASP homology 2 motifcontaining formin that severs actin filaments and accelerates both polymerization and depolymerization. J. Biol. Chem. 281, 26754-26767.
27. Chhabra, E. S., Ramabhadran, V., Gerber, S. A. and Higgs,H. N. (2009). INF2 is an endoplasmic reticulum-associated formin protein. J. Cell Sci. 122, 1430-1440.
28. Cogswell, A. M., Stevens, R. J. and Hood, D. A. (1993). Properties of skeletal muscle mitochondria isolated from subsarcolemmal and intermyofibrillar regions. Am. J. Physiol. 264, C383-C389.
29. Collins, T. J. and Bootman, M. D. (2003). Mitochondria are morphologically heterogeneous within cells. J. Exp. Biol. 206, 1993-2000.
30. Craig, R., Smith, R. and Kendrick-Jones, J. (1983). Light-chain phosphorylation controls the conformation of vertebrate non-muscle and smooth muscle myosin molecules. Nature 302, 436-439.
31. de Brito, O. M. and Scorrano, L. (2008). Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 456, 605-610.
32. De Vos, K. J., Allan, V. J., Grierson, A. J. and Sheetz, M. P. (2005). Mitochondrial function and actin regulate dynamin-related protein 1-dependent mitochondrial fission. Curr. Biol. 15, 678-683.
33. DuBoff, B., Götz, J. and Feany, M. B. (2012). Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron 75, 618-632.
34. Friedman, J. R. and Nunnari, J. (2014). Mitochondrial form and function. Nature 505, 335-343.
35. Friedman, J. R., Lackner, L. L., West, M., DiBenedetto, J. R., Nunnari, J. and Voeltz, G. K. (2011). ER tubules mark sites of mitochondrial division. Science 334, 358-362.
36. Fröhlich, C., Grabiger, S., Schwefel, D., Faelber, K., Rosenbaum, E., Mears, J., Rocks, O. and Daumke, O. (2013). Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein. EMBO J. 32, 1280-1292.
37. Gaillard, J., Ramabhadran, V., Neumanne, E., Gurel, P., Blanchoin, L., Vantard, M. and Higgs, H. N. (2011). Differential interactions of the formins INF2, mDia1, and mDia2 with microtubules. Mol. Biol. Cell 22, 4575-4587.
38. Gandre-Babbe, S. and van der Bliek, A. M. (2008). The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Mol. Biol. Cell 19, 2402-2412.
39. Goldstein, S., Moerman, E. J. and Porter, K. (1984). High-voltage electron microscopy of human diploid fibroblasts during ageing in vitro. Morphometric analysis of mitochondria. Exp. Cell Res. 154, 101-111.
40. Goyal, U. and Blackstone, C. (2013). Untangling the web: mechanisms underlying ER network formation. Biochim. Biophys. Acta 1833, 2492-2498.
41. Griffin, E. E., Graumann, J. and Chan, D. C. (2005). The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria. J. Cell Biol. 170, 237-248.
42. Gu, C., Yaddanapudi, S., Weins, A., Osborn, T., Reiser, J., Pollak, M., Hartwig, J. and Sever, S. (2010). Direct dynamin-actin interactions regulate the actin cytoskeleton. EMBO J. 29, 3593-3606.
43. Guo, Q., Koirala, S., Perkins, E. M., McCaffery, J. M. and Shaw, J. M. (2012). The mitochondrial fission adaptors Caf4 and Mdv1 are not functionally equivalent. PLoS ONE 7, e53523.
44. Gurel, P. S., Ge, P., Grintsevich, E. E., Shu, R., Blanchoin, L., Zhou, Z. H., Reisler, E. and Higgs, H. N. (2014). INF2-mediated severing through actin filament encirclement and disruption. Curr. Biol. 24, 156-164.
45. Higgs, H. N. (2005). Formin proteins: a domain-based approach. Trends Biochem. Sci. 30, 342-353.
46. Hollenbeck, P. J. and Saxton, W. M. (2005). The axonal transport of mitochondria. J. Cell Sci. 118, 5411-5419.
47. Hoppins, S. and Nunnari, J. (2012). Cell Biology. Mitochondrial dynamics and apoptosis-the ER connection. Science 337, 1052-1054.
48. Hu, M., Crawford, S. A., Henstridge, D. C., Ng, I. H., Boey, E. J., Xu, Y., Febbraio, M. A., Jans, D. A. and Bogoyevitch, M. A. (2013). p32 protein levels are integral to mitochondrial and endoplasmic reticulum morphology, cell metabolism and survival. Biochem. J. 453, 381-391.
49. Ingerman, E., Perkins, E. M., Marino, M., Mears, J. A., McCaffery, J. M., Hinshaw, J. E. and Nunnari, J. (2005). Dnm1 forms spirals that are structurally tailored to fit mitochondria. J. Cell Biol. 170, 1021-1027.
50. Jans, D. C., Wurm, C. A., Riedel, D., Wenzel, D., Stagge, F., Deckers, M., Rehling, P. and Jakobs, S. (2013). STED super-resolution microscopy reveals an array of MINOS clusters along human mitochondria. Proc. Natl. Acad. Sci. USA 110, 8936-8941.
51. Kavanagh, E., Vlachos, P., Emourgeon, V., Rodhe, J. and Joseph, B. (2012). P57 (KIP2) control of actin cytoskeleton dynamics is responsible for its mitochondrial pro-apoptotic effect. Cell Death Dis. 3, e311.
52. Kim, H. W., Oh, S. H., Kim, J. W., Cho, B., Park, I. S., Sun, W. and Rhyu, I. J. (2012). Efficient and accurate analysis of mitochondrial morphology in a whole cell with a high-voltage electron microscopy. J. Electron Microsc. (Tokyo) 61, 127-131.
53. Koch, A., Schneider, G., Lüers, G. H. and Schrader, M. (2004). Peroxisome elongation and constriction but not fission can occur independently of dynaminlike protein 1. J. Cell Sci. 117, 3995-4006.
54. Koirala, S., Guo, Q., Kalia, R., Bui, H. T., Eckert, D. M., Frost, A. and Shaw, J. M. (2013). Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proc. Natl. Acad. Sci. USA 110, E1342-E1351.
55. Korobova, F., Ramabhadran, V. and Higgs, H. N. (2013). An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2. Science 339, 464-467.
56. Korobova, F., Gauvin, T. J. and Higgs, H. N. (2014). A role for myosin II in mammalian mitochondrial fission. Curr. Biol. 24, 409-414.
57. Kudryashev, M., Lepper, S., Baumeister, W., Cyrklaff, M. and Frischknecht, F. (2010). Geometric constrains for detecting short actin filaments by cryogenic electron tomography. PMC Biophys 3, 6.
58. Kuroiwa, T. and Kuroiwa, H. (1980). Inhibition of Physarum mitochondrial division by cytochalasin B. Experientia 36, 193-194.
59. Labrousse, A. M., Zappaterra, M. D., Rube, D. A. and van der Bliek, A. M. (1999). C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. Mol. Cell 4, 815-826.
60. Lackner, L. L., Horner, J. S. and Nunnari, J. (2009). Mechanistic analysis of a dynamin effector. Science 325, 874-877.
61. Laporte, D., Coffman, V. C., Lee, I. J. and Wu, J. Q. (2011). Assembly and architecture of precursor nodes during fission yeast cytokinesis. J. Cell Biol. 192, 1005-1021.
62. Lee, I. J., Coffman, V. C. and Wu, J. Q. (2012). Contractile-ring assembly in fission yeast cytokinesis: Recent advances and new perspectives. Cytoskeleton 69, 751-763.
63. Legesse-Miller, A., Massol, R. H. and Kirchhausen, T. (2003). Constriction and Dnm1p recruitment are distinct processes in mitochondrial fission. Mol. Biol. Cell 14, 1953-1963.
64. Lehrer, S. S. (1981). Damage to actin filaments by glutaraldehyde: protection by tropomyosin. J. Cell Biol. 90, 459-466.
65. Lewis, M. R. and Lewis, W. H. (1914). Mitochondria in Tissue Culture. Science 39, 330-333.
66. Li, F. and Higgs, H. N. (2003). The mouse Formin mDia1 is a potent actin nucleation factor regulated by autoinhibition. Curr. Biol. 13, 1335-1340.
67. Li, F. and Higgs, H. N. (2005). Dissecting requirements for auto-inhibition of actin nucleation by the formin, mDia1. J. Biol. Chem. 280, 6986-6992.
68. Li, G. B, Cheng, Q., Liu, L., Zhou, T., Shan, C. Y., Hu, X. Y., Zhou, J., Liu, E. H., Li, P. and Gao, N. (2013). Mitochondrial translocation of cofilin is required for allyl isothiocyanate-mediated cell death bia ROCK1/PTEN/PI3K signaling pathway. Cell Commun. Signal. 11, 50.
69. Limouze, J., Straight, A. F., Mitchison, T. and Sellers, J. R. (2004). Specificity of blebbistatin, an inhibitor of myosin II. J. Muscle Res. Cell Motil. 25, 337-341.
70. Liu, X., Weaver, D., Shirihai, O. and Hajnóczky, G. (2009). Mitochondrial 'kissand-run': interplay between mitochondrial motility and fusion-fission dynamics. EMBO J. 28, 3074-3089.
71. Losón, O. C., Song, Z., Chen, H. and Chan, D. C. (2013). Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. Mol. Biol. Cell 24, 659-667.
72. Losón, O. C., Liu, R., Rome, M. E., Meng, S., Kaiser, J. T., Shan, S. O. and Chan, D. C. (2014). The mitochondrial fission receptor MiD51 requires ADP as a cofactor. Structure 22, 367-377.
73. Lu, Z., Ma, X. N., Zhang, H. M., Ji, H. H., Ding, H., Zhang, J., Luo, D., Sun, Y. and Li, X. D. (2014). Mouse Myosin-19 Is a Plus-end-directed, High-duty Ratio Molecular Motor. J. Biol. Chem. 289, 18535-18548.
74. Macdonald, P. J., Stepanyants, N., Mehrotra, N., Mears, J. A., Qi, X., Sesaki, H. and Ramachandran, R. (2014). A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission. Mol. Biol. Cell 25, 1905-1915.
75. Maupin, P. and Pollard, T. D. (1983). Improved preservation and staining of HeLa cell actin filaments, clathrin-coated membranes, and other cytoplasmic structures by tannic acid-glutaraldehyde-saponin fixation. J. Cell Biol. 96, 51-62.
76. Mears, J. A., Lackner, L. L., Fang, S., Ingerman, E., Nunnari, J. and Hinshaw, J. E. (2011). Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission. Nat. Struct. Mol. Biol. 18, 20-26.
77. Mileykovskaya, E. and Dowhan, W. (2009). Cardiolipin membrane domains in prokaryotes and eukaryotes. Biochim. Biophys. Acta 1788, 2084-2091.
78. Milton, D. L., Schneck, A. N., Ziech, D. A., Ba, M., Facemyer, K. C., Halayko, A. J., Baker, J. E., Gerthoffer, W. T. and Cremo, C. R. (2011). Direct evidence for functional smooth muscle myosin II in the 10S self-inhibited monomeric conformation in airway smooth muscle cells. Proc. Natl. Acad. Sci. USA 108, 1421-1426.
79. Murley, A., Lackner, L. L., Osman, C., West, M., Voeltz, G. K., Walter, P. and Nunnari, J. (2013). ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast. eLife 2, e00422.
80. Niemann, A., Ruegg, M., La Padula, V., Schenone, A. and Suter, U. (2005). Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network: new implications for Charcot-Marie-Tooth disease. J. Cell Biol. 170, 1067-1078.
81. Niemann, A., Wagner, K. M., Ruegg, M. and Suter, U. (2009). GDAP1 mutations differ in their effects on mitochondrial dynamics and apoptosis depending on the mode of inheritance. Neurobiol. Dis. 36, 509-520.
82. Noske, A. B., Costin, A. J., Morgan, G. P. and Marsh, B. J. (2008). Expedited approaches to whole cell electron tomography and organelle mark-up in situ in high-pressure frozen pancreatic islets. J. Struct. Biol. 161, 298-313.
83. Nunnari, J. and Suomalainen, A. (2012). Mitochondria: in sickness and in health. Cell 148, 1145-1159.
84. Osteryoung, K. W. and Pyke, K. A. (2014). Division and dynamic morphology of plastids. Annu. Rev. Plant Biol. 65, 443-472.
85. Otera, H., Wang, C., Cleland, M. M., Setoguchi, K., Yokota, S., Youle, R. J. and Mihara, K. (2010). Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J. Cell Biol. 191, 1141-1158.
86. Otsuga, D., Keegan, B. R., Brisch, E., Thatcher, J. W., Hermann, G. J., Bleazard, W. and Shaw, J. M. (1998). The dynamin-related GTPase, Dnm1p, controls mitochondrial morphology in yeast. J. Cell Biol. 143, 333-349.
87. Palmer, C. S., Osellame, L. D., Laine, D., Koutsopoulos, O. S., Frazier, A. E. and Ryan, M. T. (2011). MiD49 and MiD51, new components of the mitochondrial fission machinery. EMBO Rep. 12, 565-573.
88. Palmer, C. S., Elgass, K. D., Parton, R. G., Osellame, L. D., Stojanovski, D. and Ryan, M. T. (2013). Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. J. Biol. Chem. 288, 27584-27593.
89. Pathak, D., Sepp, K. J. and Hollenbeck, P. J. (2010). Evidence that myosin activity opposes microtubule-based axonal transport of mitochondria. J. Neurosci. 30, 8984-8992.
90. Paul, A. S. and Pollard, T. D. (2009). Review of the mechanism of processive actin filament elongation by formins. Cell Motil. Cytoskeleton 66, 606-617.
91. Perkins, G. A. and Ellisman, M. H. (2011). Mitochondrial configurations in peripheral nerve suggest differential ATP production. J. Struct. Biol. 173, 117-127.
92. Pollard, T. D. (2010). Mechanics of cytokinesis in eukaryotes. Curr. Opin. Cell Biol. 22, 50-56.
93. Prehoda, K. E. and Lim, W. A. (2002). How signaling proteins integrate multiple inputs: a comparison of N-WASP and Cdk2. Curr. Opin. Cell Biol. 14, 149-154.
94. Prehoda, K. E., Scott, J. A., Mullins, R. D. and Lim, W. A. (2000). Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. Science 290, 801-806.
95. Proctor, S. A., Minc, N., Boudaoud, A. and Chang, F. (2012). Contributions of turgor pressure, the contractile ring, and septum assembly to forces in cytokinesis in fission yeast. Curr. Biol. 22, 1601-1608.
96. Quinlan, M. E. (2013). Direct interaction between two actin nucleators is required in Drosophila oogenesis. Development 140, 4417-4425.
97. Quinlan, M. E., Hilgert, S., Bedrossian, A., Mullins, R. D. and Kerkhoff, E. (2007). Regulatory interactions between two actin nucleators, Spire and Cappuccino. J. Cell Biol. 179, 117-128.
98. Quintero, O. A., DiVito, M. M., Adikes, R. C., Kortan, M. B., Case, L. B., Lier, A. J., Panaretos, N. S., Slater, S. Q.,Rengarajan, M., Feliu,M. et al. (2009).Human Myo19 is a novel myosin that associates with mitochondria. Curr. Biol. 19, 2008-2013.
99. Ramabhadran, V., Korobova, F., Rahme, G. J. and Higgs, H. N. (2011). Splice variant-specific cellular function of the formin INF2 in maintenance of Golgi architecture. Mol. Biol. Cell 22, 4822-4833.
100. Ramabhadran, V., Hatch, A. L. and Higgs, H. N. (2013). Actin monomers activate inverted formin 2 by competing with its autoinhibitory interaction. J. Biol. Chem. 288, 26847-26855.
101. Roh, S. E., Woo, J. A., Lakshmana, M. K., Uhlar, C., Ankala, V., Boggess, T., Liu, T., Hong, Y. H., Mook-Jung, I., Kim, S. J. and Kang, D. E. (2013). Mitochondrial dysfunction and calcium deregulation by the RanBP9-cofilin pathway. FASEB J. 27, 4776-4789.
102. Shen, Q., Yamano, K., Head, B. P., Kawajiri, S., Cheung, J. T., Wang, C., Cho, J. H., Hattori, N., Youle, R. J. and van der Bliek, A. M. (2014). Mutations in Fis1 disrupt orderly disposal of defective mitochondria. Mol. Biol. Cell 25, 145-159.
103. Shutova, M. S., Spessott, W. A., Giraudo, C. G. and Svitkina, T. (2014). Endogenous species of mammalian nonmuscle myosin IIA and IIB include activated monomers and heteropolymers. Curr. Biol. Epub ahead of print.
104. Simmen, T., Aslan, J. E., Blagoveshchenskaya, A. D., Thomas, L., Wan, L., Xiang, Y., Feliciangeli, S. F., Hung, C. H., Crump, C. M. and Thomas, G. (2005). PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. EMBO J. 24, 717-729.
105. Sogo, L. F. and Yaffe, M. P. (1994). Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane. J. Cell Biol. 126, 1361-1373.
106. Strack, S., Wilson, T. J. and Cribbs, J. T. (2013). Cyclin-dependent kinases regulate splice-specific targeting of dynamin-related protein 1 to microtubules. J. Cell Biol. 201, 1037-1051.
107. Sun, M. G., Williams, J., Munoz-Pinedo, C., Perkins, G. A., Brown, J. M., Ellisman, M. H., Green, D. R. and Frey, T. G. (2007). Correlated threedimensional light and electron microscopy reveals transformation of mitochondria during apoptosis. Nat. Cell Biol. 9, 1057-1065.
108. Tieu, Q., Okreglak, V., Naylor, K. and Nunnari, J. (2002). The WD repeat protein, Mdv1p, functions as a molecular adaptor by interacting with Dnm1p and Fis1p during mitochondrial fission. J. Cell Biol. 158, 445-452.
109. Unbekandt, M. and Olson, M. F. (2014). The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer. J. Mol. Med. 92, 217-225.
110. Vafai, S. B. and Mootha, V. K. (2012). Mitochondrial disorders as windows into an ancient organelle. Nature 491, 374-383.
111. Vicente-Manzanares, M., Ma, X., Adelstein, R. S. and Horwitz, A. R. (2009). Non-muscle myosin II takes centre stage in cell adhesion and migration. Nat. Rev. Mol. Cell Biol. 10, 778-790.
112. Voeltz, G. K. and Prinz, W. A. (2007). Sheets, ribbons and tubules-how organelles get their shape. Nat. Rev. Mol. Cell Biol. 8, 258-264.
113. Wang, C., Zhou, G. L., Vedantam, S. and Field, J. (2008). Mitochondrial shuttling of CAP1 promotes actin-and cofilin-dependent apoptosis. J. Cell. Sci. 121, 2913-2920.
114. Wang, W., Wang, Y., Long, J., Wang, J., Haudek, S. B., Overbeek, P., Chang, B. H., Schumacker, P. T. and Danesh, F. R. (2012). Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells. Cell Metab. 15, 186-200.
115. Yamano, K., Fogel, A. I., Wang, C., van der Bliek, A. M. and Youle, R. J. (2014). Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy. eLife 3, e01612.
116. Ydenberg, C. A., Smith, B. A., Breitsprecher, D., Gelles, J. and Goode, B. L. (2011). Cease-fire at the leading edge: new perspectives on actin filament branching, debranching, and cross-linking. Cytoskeleton 68, 596-602.
117. Yoon, Y., Pitts, K. R., Dahan, S. and McNiven, M. A. (1998). A novel dynaminlike protein associates with cytoplasmic vesicles and tubules of the endoplasmic reticulum in mammalian cells. J. Cell Biol. 140, 779-793.
118. Yoshida, Y., Miyagishima, S. Y., Kuroiwa, H. and Kuroiwa, T. (2012). The plastid-dividing machinery: formation, constriction and fission. Curr. Opin. Plant Biol. 15, 714-721.
119. Youle, R. J. and van der Bliek, A. M. (2012). Mitochondrial fission, fusion, and stress. Science 337, 1062-1065.