Scalable production of highly concentrated chitosan/TPP nanoparticles in different pHs and evaluation of the in vitro transfection efficiency

Biochemical Engineering Journal

Volumn 94, Issue , 2015, Pages 65-73

  Sipoli, Caroline Casagrande ^a   Santana, Nathalia ^a   Shimojo, Andrea Arruda Martins ^a   Azzoni, Adriano ^b   de la Torre, Lucimara Gaziola ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Chitosan nanoparticles; Gene delivery; Ionotropic gelation; Nanotechnology; Scalable process; Stability

Indexed keywords

BATCH DATA PROCESSING; CHEMICAL STABILITY; CHITOSAN; CONVERGENCE OF NUMERICAL METHODS; DNA; GENE TRANSFER; IONOTROPIC GELATION; MEDICAL APPLICATIONS; NANOTECHNOLOGY; PH; POLYDISPERSITY;

BIOMEDICAL APPLICATIONS; CHITOSAN NANOPARTICLES; GENE DELIVERY; NANO-PARTICLE PRODUCTION; NANOPARTICLE PROPERTIES; PHYSICO-CHEMICAL STABILITY; PHYSICOCHEMICAL PROPERTY; POLYDISPERSITY INDICES;

NANOPARTICLES;

CHITOSAN DERIVATIVE; NANOPARTICLE; TRIPOLYPHOSPHATE NANOPARTICLE; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; ARTICLE; BATCH PROCESS; CONTROLLED STUDY; FEMALE; HELA CELL LINE; HUMAN; HUMAN CELL; HYDRODYNAMICS; IN VITRO GENE TRANSFER; IN VITRO STUDY; LIGHT SCATTERING; MACROMOLECULE; MOLECULAR WEIGHT; PARTICLE SIZE; PH; PHOTON CORRELATION SPECTROSCOPY; PHYSICAL CHEMISTRY; STATIC ELECTRICITY; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

EID: 84913572999     PISSN: 1369703X     EISSN: 1873295X     Source Type: Journal    
DOI: 10.1016/j.bej.2014.11.008     Document Type: Article

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