Impaired bone formation in pdia3 deficient mice

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Wang, Yun ^a   Nizkorodov, Alexandr ^a   Riemenschneider, Kelsie ^a   Lee, Christopher S D ^a   Navarrete, Rene Olivares ^b   Schwartz, Zvi ^b   Boyan, Barbara D ^a,b  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b Virginia Commonwealth University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; PROTEIN DISULFIDE ISOMERASE; PROTEIN DISULFIDE ISOMERASE FAMILY A MEMBER 3; UNCLASSIFIED DRUG; PDIA3 PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; ENZYME DEFICIENCY; GENE DELETION; GROWTH PLATE; HETEROZYGOTE; HOMOZYGOSITY; KNOCKOUT MOUSE; LETHALITY; METAPHYSIS; MICRO-COMPUTED TOMOGRAPHY; MORPHOMETRICS; MOUSE; MOUSE EMBRYO; NONHUMAN; OSSIFICATION; OSTEOBLAST; PHENOTYPE; SIGNAL TRANSDUCTION; TIBIA; TRABECULAR BONE; ANIMAL; C57BL MOUSE; CELL CULTURE; EMBRYOLOGY; GENETICS; METABOLISM;

MUS;

ANIMALS; CELLS, CULTURED; GENE DELETION; GROWTH PLATE; HETEROZYGOTE; MICE; MICE, INBRED C57BL; OSTEOGENESIS; PROTEIN DISULFIDE-ISOMERASES;

EID: 84913556412     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0112708     Document Type: Article

References (41)

1. St-Arnaud R, Naja RP (2011) Vitamin D metabolism, cartilage and bone fracture repair. Mol Cell Endocrinol 347: 48-54.
2. Schwartz Z, Ehland H, Sylvia VL, Larsson D, Hardin RR, et al. (2002) 1alpha, 25-dihydroxyvitamin D(3) and 24R, 25-dihydroxyvitamin D(3) modulate growth plate chondrocyte physiology via protein kinase C-dependent phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase. Endocrinology 143: 2775-2786.
3. Vertino AM, Bula CM, Chen JR, Almeida M, Han L, et al. (2005) Nongenotropic, anti-apoptotic signaling of 1alpha, 25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases. J Biol Chem 280: 14130-14137.
4. Norman AW (2006) Minireview: vitamin D receptor: new assignments for an already busy receptor. Endocrinology 147: 5542-5548.
5. Nemere I, Farach-Carson MC, Rohe B, Sterling TM, Norman AW, et al. (2004) Ribozyme knockdown functionally links a 1, 25(OH)2D3 membrane binding protein (1, 25D3-MARRS) and phosphate uptake in intestinal cells. Proc Natl Acad Sci U S A 101: 7392-7397.
6. Khanal RC, Nemere I (2007) The ERp57/GRp58/1, 25D3-MARRS receptor: multiple functional roles in diverse cell systems. Curr Med Chem 14: 1087- 1093.
7. Garbi N, Tanaka S, Momburg F, Hammerling GJ (2006) Impaired assembly of the major histocompatibility complex class I peptide-loading complex in mice deficient in the oxidoreductase ERp57. Nat Immunol 7: 93-102.
8. Hoffstrom BG, Kaplan A, Letso R, Schmid RS, Turmel GJ, et al. (2010) Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins. Nat Chem Biol 6: 900-906.
9. Nemere I (2005) The 1, 25D3-MARRS protein: contribution to steroid stimulated calcium uptake in chicks and rats. Steroids 70: 455-457.
10. Boyan BD, Sylvia VL, Dean DD, Pedrozo H, Del Toro F, et al. (1999) 1, 25- (OH)2D3 modulates growth plate chondrocytes via membrane receptormediated protein kinase C by a mechanism that involves changes in phospholipid metabolism and the action of arachidonic acid and PGE2. Steroids 64: 129-136.
11. Doroudi M, Schwartz Z, Boyan BD (2012) Phospholipase A2 activating protein is required for 1alpha, 25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via Pdia3. J Steroid Biochem Mol Biol 132: 48-56.
12. Chen J, Olivares-Navarrete R, Wang Y, Herman TR, Boyan BD, et al. (2010) Protein-disulfide isomerase-associated 3 (Pdia3) mediates the membrane response to 1, 25-dihydroxyvitamin D3 in osteoblasts. J Biol Chem 285: 37041-37050.
13. Boyan BD, Chen J, Schwartz Z (2012) Mechanism of Pdia3-dependent 1alpha, 25-dihydroxy vitamin D3 signaling in musculoskeletal cells. Steroids 77: 892-896.
14. Boyan BD, Sylvia VL, McKinney N, Schwartz Z (2003) Membrane actions of vitamin D metabolites 1alpha, 25(OH)2D3 and 24R, 25(OH)2D3 are retained in growth plate cartilage cells from vitamin D receptor knockout mice. J Cell Biochem 90: 1207-1223.
15. Boyan BD, Wong KL, Wang L, Yao H, Guldberg RE, et al. (2006) Regulation of growth plate chondrocytes by 1, 25-dihydroxyvitamin D3 requires caveolae and caveolin-1. J Bone Miner Res 21: 1637-1647.
16. Rubin J, Schwartz Z, Boyan BD, Fan X, Case N, et al. (2007) Caveolin-1 knockout mice have increased bone size and stiffness. J Bone Miner Res 22: 1408-1418.
17. Akyay A, Solmaz OA (2012) Myelofibrosis associated with vitamin d deficiency rickets in an older aged child. Pediatr Hematol Oncol 29: 691-693.
18. Yoshizawa T, Handa Y, Uematsu Y, Takeda S, Sekine K, et al. (1997) Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet 16: 391-396.
19. Li YC, Pirro AE, Amling M, Delling G, Baron R, et al. (1997) Targeted ablation of the vitamin D receptor: An animal model of vitamin D-dependent rickets type II with alopecia. Proc Natl Acad Sci U S A 94: 9831-9835.
20. hormone Mpabcorcfatal-ttwbhg, Van Cromphaut SJ, Dewerchin M, Hoenderop JG, Stockmans I, et al. (2001) Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc Natl Acad Sci U S A 98: 13324-13329.
21. Amling M, Priemel M, Holzmann T, Chapin K, Rueger JM, et al. (1999) Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology 140: 4982-4987.
22. Chen J, Lee CS, Coleman RM, Yoon JY, Lohmann CH, et al. (2009) Formation of tethers linking the epiphysis and metaphysis is regulated by vitamin d receptor-mediated signaling. Calcif Tissue Int 85: 134-145.
23. Nemere I, Garbi N, Hammerling GJ, Khanal RC (2010) Intestinal cell calcium uptake and the targeted knockout of the 1, 25D3-MARRS (membraneassociated, rapid response steroid-binding) receptor/PDIA3/Erp57. J Biol Chem 285: 31859-31866.
24. Kinney MA, Saeed R, McDevitt TC (2012) Systematic analysis of embryonic stem cell differentiation in hydrodynamic environments with controlled embryoid body size. Integr Biol (Camb) 4: 641-650.
25. Wilson JL, Najia MA, Saeed R, McDevitt TC (2013) Alginate encapsulation parameters influence the differentiation of microencapsulated embryonic stem cell aggregates. Biotechnol Bioeng.
26. Wang Y, Chen J, Lee CS, Nizkorodov A, Riemenschneider K, et al. (2010) Disruption of Pdia3 gene results in bone abnormality and affects 1alpha, 25- dihydroxy-vitamin D3-induced rapid activation of PKC. J Steroid Biochem Mol Biol 121: 257-260.
27. Nolan RL, Teller JK (2006) Diethylamine extraction of proteins and peptides isolated with a mono-phasic solution of phenol and guanidine isothiocyanate. J Biochem Biophys Methods 68: 127-131.
28. Lee CS, Chen J, Wang Y, Williams JK, Ranly DM, et al. (2011) Coordinated tether formation in anatomically distinct mice growth centers is dependent on a functional vitamin D receptor and is tightly linked to three-dimensional tissue morphology. Bone 49: 419-427.
29. Olivares-Navarrete R, Sutha K, Hyzy SL, Hutton DL, Schwartz Z, et al. (2012) Osteogenic differentiation of stem cells alters vitamin D receptor expression. Stem Cells Dev 21: 1726-1735.
30. Shapiro F (2008) Bone development and its relation to fracture repair. The role of mesenchymal osteoblasts and surface osteoblasts. Eur Cell Mater 15: 53-76.
31. Jorgensen PH, Bak B, Andreassen TT (1991) Mechanical properties and biochemical composition of rat cortical femur and tibia after long-term treatment with biosynthetic human growth hormone. Bone 12: 353-359.
32. Martens M, Van Audekercke R, De Meester P, Mulier JC (1981) The geometrical properties of human femur and tibia and their importance for the mechanical behaviour of these bone structures. Arch Orthop Trauma Surg 98: 113-120.
33. Sooy K, Sabbagh Y, Demay MB (2005) Osteoblasts lacking the vitamin D receptor display enhanced osteogenic potential in vitro. J Cell Biochem 94: 81- 87.
34. Galbiati F, Volonte D, Brown AM, Weinstein DE, Ben-Ze'ev A, et al. (2000) Caveolin-1 expression inhibits Wnt/beta-catenin/Lef-1 signaling by recruiting beta-catenin to caveolae membrane domains. J Biol Chem 275: 23368-23377.
35. Baron R, Rawadi G (2007) Wnt signaling and the regulation of bone mass. Curr Osteoporos Rep 5: 73-80.
36. Xiang W, Kong J, Chen S, Cao LP, Qiao G, et al. (2005) Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac reninangiotensin systems. Am J Physiol Endocrinol Metab 288: E125-132.
37. Simpson RU, Hershey SH, Nibbelink KA (2007) Characterization of heart size and blood pressure in the vitamin D receptor knockout mouse. J Steroid Biochem Mol Biol 103: 521-524.
38. Coe H, Jung J, Groenendyk J, Prins D, Michalak M (2010) ERp57 modulates STAT3 signaling from the lumen of the endoplasmic reticulum. J Biol Chem 285: 6725-6738.
39. Doroudi M, Olivares-Navarrete R, Hyzy SL, Boyan BD, Schwartz Z (2014) Signaling components of the 1alpha, 25(OH)D-dependent Pdia3 receptor complex are required for Wnt5a calcium-dependent signaling. Biochim Biophys Acta 1843: 2365-2375.
40. Masuyama R, Stockmans I, Torrekens S, Van Looveren R, Maes C, et al. (2006) Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts. J Clin Invest 116: 3150-3159.
41. Brameld JM, Buttery PJ, Dawson JM, Harper JM (1998) Nutritional and hormonal control of skeletal-muscle cell growth and differentiation. Proc Nutr Soc 57: 207-217.