Formation of tethers linking the epiphysis and metaphysis is regulated by vitamin D receptor-mediated signaling

Calcified Tissue International

Volumn 85, Issue 2, 2009, Pages 134-145

  Chen, Jida ^a,b   Lee, Christopher S D ^a   Coleman, Rhima M ^a   Yoon, John Y ^a   Lohmann, Christoph H ^c   Zustin, Jozef ^c   Guldberg, Robert E ^a   Schwartz, Zvi ^a   Boyan, Barbara D ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b CHONGQING UNIVERSITY   (China)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

1,25 Dihydroxyvitamin D3; Bone development; Micro computed tomography; Rat femoral growth plate tether; Rescue diet; Rickets; Vitamin D receptor knockout mice

Indexed keywords

CALCIUM; LACTOSE; PHOSPHORUS; VITAMIN D RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE MATRIX; CALCIUM BONE LEVEL; CONTROLLED STUDY; DIETARY INTAKE; EPIPHYSIS; FEMALE; GROWTH PLATE; MALE; METAPHYSIS; MICRO-COMPUTED TOMOGRAPHY; MORPHOMETRICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; RICKETS; SIGNAL TRANSDUCTION;

ANIMALS; DIAPHYSES; EPIPHYSES; FEMALE; FEMUR; GENE SILENCING; GROWTH PLATE; MALE; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; RECEPTORS, CALCITRIOL; SIGNAL TRANSDUCTION; TOMOGRAPHY, X-RAY COMPUTED;

EID: 69249212215     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-009-9259-1     Document Type: Article

References (23)

1. Boyan BD, Schwartz Z, Howell DS, Naski M, Ranly DM, Sylvia VL, Dean DD (2001) The biology, chemistry, and biochemistry of the mammalian growth plate. In: Coe FL, Favus MJ (eds) Disorders of bone and mineral metabolism. Lippincott, Williams, and Wilkins, Philadelphia, pp 498-532
2. CH Chen Y Sakai MB Demay 2001 Targeting expression of the human vitamin D receptor to the keratinocytes of vitamin D receptor null mice prevents alopecia Endocrinology 142 5386 5389
3. 3 1α-hydroxylase gene causes vitamin D-dependent rickets type I Mol Cell Endocrinol 156 7 12
4. YC Li M Amling AE Pirro M Priemel J Meuse R Baron G Delling MB Demay 1998 Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice Endocrinology 139 4391 4396
5. M Amling M Priemel T Holzmann K Chapin JM Rueger R Baron MB Demay 1999 Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses Endocrinology 140 4982 4987 (Pubitemid 30687103)
6. DeLuca HF (1985) The metabolism and functions of vitamin D. In: Norman AW, Schaefer K, Grigoleit HG, Herrath DV (eds) Vitamin D: chemical, biochemical and clinical update. Walter de Gruyter, New York, pp 361-375
7. Boyan BD, Dean DD, Sylvia VL, Schwartz Z (1998) Role of vitamin D: genomic and nongenomic regulation of cartilage by 1, 25-(OH)2D3 and 24, 25-(OH)2D3. In: Buckwalter JA, Ehrlich MG, Sandell LJ, Trippel SB (eds) Skeletal growth and development: clinical issues and basic science advances. American Academy of Orthopaedic Surgeons, Chicago, pp 333-359
8. Boyan BD, Schwartz Z (2005) Cartilage and vitamin D: genomic and nongenomic regulation by 1, 25(OH)2D3. In: Feldman D, Pike JW, Glorieux FH (eds) Vitamin D, 2nd edn. Elsevier Academic Press, Burlington, MA, pp 575-597
9. EA Martin EL Ritman RT Turner 2003 Time course of epiphyseal growth plate fusion in rat tibiae Bone 32 261 267
10. RW Haines 1975 The histology of epiphyseal union in mammals J Anat 120 1 25
11. LF Rogers AK Poznanski 1994 Imaging of epiphyseal injuries Radiology 191 297 308
12. F Sailhan F Chotel AL Guibal S Gollogly P Adam J Berard L Guibaud 2004 Three-dimensional MR imaging in the assessment of physeal growth arrest Eur Radiol 14 1600 1608
13. A Reich A Sharir E Zelzer L Hacker E Monsonego-Ornan R Shahar 2008 The effect of weight loading and subsequent release from loading on the postnatal skeleton Bone 43 766 774
14. K Sergerie MO Lacoursière M Lévesque I Villemure 2009 Mechanical properties of the porcine growth plate and its three zones from unconfined compression tests J Biomech 42 510 516
15. I Villemure L Cloutier JR Matyas NA Duncan 2007 Non-uniform strain distribution within rat cartilaginous growth plate under uniaxial compression J Biomech 40 149 156
16. YC Li AE Pirro M Amling G Delling R Baron R Bronson MB Demay 1997 Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia Proc Natl Acad Sci USA 94 9831 9835
17. MM Donohue MB Demay 2002 Rickets in VDR null mice is secondary to decreased apoptosis of hypertrophic chondrocytes Endocrinology 143 3691 3694
18. BD Boyan VL Sylvia N McKinney Z Schwartz 2003 Membrane actions of vitamin D metabolites 1α, 25(OH)2D3 and 24R, 25(OH)2D3 are retained in growth plate cartilage cells from vitamin D receptor knockout mice J Cell Biochem 90 1207 1223
19. Zar JH (1984) Biostatistical analysis, 2nd edn. Prentice-Hall, Englewood Cliffs, NJ
20. I Nemere MC Farach-Carson B Rohe TM Sterling AW Norman BD Boyan SE Safford 2004 Ribozyme knockdown functionally links a 1, 25(OH)2D3 membrane binding protein (1, 25D3-MARRS) and phosphate uptake in intestinal cells Proc Natl Acad Sci USA 101 7392 7397
21. I Nemere Z Schwartz H Pedrozo VL Sylvia DD Dean BD Boyan 1998 Identification of a membrane receptor for 1, 25-dihydroxyvitamin D3 which mediates rapid activation of protein kinase C J Bone Miner Res 13 1353 1359
22. O Dardenne J Prud'homme SA Hacking FH Glorieux R St-Arnaud 2003 Correction of the abnormal mineral ion homeostasis with a high-calcium, high-phosphorus, high-lactose diet rescues the PDDR phenotype of mice deficient for the 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) Bone 32 332 340
23. A Aszódi EB Hunziker BR Olsen R Fässler 2001 The role of collagen II and cartilage fibril-associated molecules in skeletal development Osteoarthr Cartil Suppl A S150 S159