A general approach to antibody thermostabilization

mAbs

Volumn 6, Issue 5, 2014, Pages 1274-1282

  McConnell, Audrey D ^a   Zhang, Xue ^a   Macomber, John L ^a   Chau, Betty ^a   Sheffer, Joseph C ^a   Rahmanian, Sorena ^a   Hare, Eric ^a   Spasojevic, Vladimir ^a   Horlick, Robert A ^a   King, David J ^a   Bowers, Peter M ^a  

^a AnaptysBio Inc   (United States)

Author keywords

Affinity maturation; Monoclonal antibodies; Protein engineering; Solubility; Somatic hypermutation; Thermostability

Indexed keywords

ADALIMUMAB; CETUXIMAB; DENOSUMAB; HEMAGGLUTININ 33 ANTIBODY; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; TRASTUZUMAB; UNCLASSIFIED DRUG;

ANTIBODY ENGINEERING; ARTICLE; CELL MATURATION; COMPLEMENTARITY DETERMINING REGION; DRUG STABILITY; HUMAN; IN VITRO STUDY; MAMMAL CELL; SOMATIC HYPERMUTATION; TEMPERATURE STRESS; THERMOSTABILITY;

EID: 84913555775     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.29680     Document Type: Article

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