Engineering the isoelectric point of a renal cell carcinoma targeting antibody greatly enhances scFv solubility

Immunotechnology

Volumn 4, Issue 2, 1998, Pages 107-114

  Tan, Philip H ^a   Chu, Vano ^a   Stray, James E ^b   Hamlin, Donald K ^b   Pettit, Dean ^a   Wilbur, D Scott ^b   Vessella, Robert L ^b   Stayton, Patrick S ^a  

^a University of Washington   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Antibody engineering; Renal cell carcinoma; Single chain Fv; Targeted delivery

Indexed keywords

CYSTEINE; GLUTAMIC ACID; HISTIDINE; IMMUNOGLOBULIN FRAGMENT; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY A6H; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOENGINEERING; CARBOXY TERMINAL SEQUENCE; DRUG TARGETING; ISOELECTRIC POINT; KIDNEY CARCINOMA; NONHUMAN; PRIORITY JOURNAL; SOLUBILITY;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEOPLASM; CARCINOMA, RENAL CELL; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; ISOELECTRIC POINT; KIDNEY NEOPLASMS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; PROTEIN ENGINEERING; SOLUBILITY;

EID: 0031732556     PISSN: 13802933     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1380-2933(98)00011-6     Document Type: Article

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