메뉴 건너뛰기




Volumn 9783642399688, Issue , 2014, Pages 307-326

Bacterial topoisomerase inhibitors: Quinolones and beyond

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84913554744     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-39968-8_16     Document Type: Chapter
Times cited : (6)

References (69)
  • 2
    • 3042536020 scopus 로고    scopus 로고
    • In vitro and bactericidal activities of ABT-492, a novel fluoroquinolone, against Gram-positive and Gram-negative organisms
    • Almer LS, Hoffrage JB, Keller EJ, Flamm RK, Shortridge VD (2004) In vitro and bactericidal activities of ABT-492, a novel fluoroquinolone, against Gram-positive and Gram-negative organisms. Antimicrob Agents Chemother 48:2771-2777
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 2771-2777
    • Almer, L.S.1    Hoffrage, J.B.2    Keller, E.J.3    Flamm, R.K.4    Shortridge, V.D.5
  • 4
    • 79953768958 scopus 로고    scopus 로고
    • A new DNA gyrase inhibitor subclass of the cyclothialidine family based on a bicyclic dilactam-lactone scaffold synthesis and antibacterial properties
    • Angehrn P, Goetschi E, Gmuender H et al (2011) A new DNA gyrase inhibitor subclass of the cyclothialidine family based on a bicyclic dilactam-lactone scaffold synthesis and antibacterial properties. J Med Chem 54:2207-2224
    • (2011) J Med Chem , vol.54 , pp. 2207-2224
    • Angehrn, P.1    Goetschi, E.2    Gmuender, H.3
  • 5
    • 0036952196 scopus 로고    scopus 로고
    • In vitro antibacterial activity of prulifloxacin, a new oral fluoroquinolone
    • Araake M, Hara T, Watabe H, Nishino T (2002) In vitro antibacterial activity of prulifloxacin, a new oral fluoroquinolone. Jpn J Antibiot 55:778-790
    • (2002) Jpn J Antibiot , vol.55 , pp. 778-790
    • Araake, M.1    Hara, T.2    Watabe, H.3    Nishino, T.4
  • 7
    • 77955917935 scopus 로고    scopus 로고
    • Type IIA topoisomerase inhibition by a new class of antibacterial agents
    • Bax BD, Chan PF, Eggleston DS et al (2010) Type IIA topoisomerase inhibition by a new class of antibacterial agents. Nature 466:935-940
    • (2010) Nature , vol.466 , pp. 935-940
    • Bax, B.D.1    Chan, P.F.2    Eggleston, D.S.3
  • 8
    • 68649122111 scopus 로고    scopus 로고
    • New inhibitors of bacterial topoisomerase GyrA/ParC subunits
    • Black MT, Coleman K (2009) New inhibitors of bacterial topoisomerase GyrA/ParC subunits. Curr Opin Investig Drugs 10:804-810
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 804-810
    • Black, M.T.1    Coleman, K.2
  • 10
    • 54849420897 scopus 로고    scopus 로고
    • Recent advances in bacterial topoisomerase inhibitors
    • Bradbury BJ, Pucci MJ (2008) Recent advances in bacterial topoisomerase inhibitors. Curr Opin Pharmacol 8:574-581
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 574-581
    • Bradbury, B.J.1    Pucci, M.J.2
  • 12
    • 51849112827 scopus 로고    scopus 로고
    • Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: Intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships
    • Charifson PS, Grillot AL, Grossman TH et al (2008) Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships. J Med Chem 51:5243-5263
    • (2008) J Med Chem , vol.51 , pp. 5243-5263
    • Charifson, P.S.1    Grillot, A.L.2    Grossman, T.H.3
  • 13
    • 0023684775 scopus 로고
    • Structure-activity relationships in quinolone antibacterials: Design, synthesis and biological activities of novel isothiazoloquinolones
    • Chu DT, Fernandes PB, Claiborne AK, Shen L, Pernet AG (1988) Structure-activity relationships in quinolone antibacterials: design, synthesis and biological activities of novel isothiazoloquinolones. Drugs Exp Clin Res 14:379-383
    • (1988) Drugs Exp Clin Res , vol.14 , pp. 379-383
    • Chu, D.T.1    Fernandes, P.B.2    Claiborne, A.K.3    Shen, L.4    Pernet, A.G.5
  • 14
    • 73849145677 scopus 로고    scopus 로고
    • Multiple-dose safety, tolerability, and pharmacokinetics of oral nemonoxacin (TG-873870) in healthy volunteers
    • Chung DT, Tsai TY, Chen SJ et al (2009) Multiple-dose safety, tolerability, and pharmacokinetics of oral nemonoxacin (TG-873870) in healthy volunteers. Antimicrob Agents Chemother 54:411-417
    • (2009) Antimicrob Agents Chemother , vol.54 , pp. 411-417
    • Chung, D.T.1    Tsai, T.Y.2    Chen, S.J.3
  • 15
    • 82355173219 scopus 로고    scopus 로고
    • Exploiting bacterial DNA gyrase as a drug target: Current state and perspectives
    • Collin F, Karkare S, Maxwell A (2011) Exploiting bacterial DNA gyrase as a drug target: Current state and perspectives. Appl Microbiol Biotechnol 92:479-497
    • (2011) Appl Microbiol Biotechnol , vol.92 , pp. 479-497
    • Collin, F.1    Karkare, S.2    Maxwell, A.3
  • 16
    • 81555200433 scopus 로고    scopus 로고
    • Randomized, double-blind, phase II, multicenter study evaluating the safety/ tolerability and efficacy of JNJ-Q2, a novel fluoroquinolone, compared with linezolid for treatment of acute bacterial skin and skin structure infection
    • Covington P, Davenport JM, Andrae D, O'Riordan W, Liverman L, McIntyre G, Almenoff J (2011) Randomized, double-blind, phase II, multicenter study evaluating the safety/ tolerability and efficacy of JNJ-Q2, a novel fluoroquinolone, compared with linezolid for treatment of acute bacterial skin and skin structure infection. Antimicrob Agents Chemother 55:5790-5797
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 5790-5797
    • Covington, P.1    Davenport, J.M.2    Andrae, D.3    O'riordan, W.4    Liverman, L.5    McIntyre, G.6    Almenoff, J.7
  • 17
    • 15944421641 scopus 로고    scopus 로고
    • Structure-activity relationships of the quinolone antibacterials in the new millennium: Some things change and some do not
    • Hooper DC, Rubenstein E (eds) , 3rd edn. ASM Press, Washington, DC
    • Domogala JM, Hagen SE (2003) Structure-activity relationships of the quinolone antibacterials in the new millennium: Some things change and some do not. In: Hooper DC, Rubenstein E (eds) Quinolone antimicrobial agents, 3rd edn. ASM Press, Washington, DC
    • (2003) Quinolone Antimicrobial Agents
    • Domogala, J.M.1    Hagen, S.E.2
  • 20
    • 84863393500 scopus 로고    scopus 로고
    • Pyrrolamide DNA gyrase inhibitors: Fragment-based nuclear magnetic resonance screening to identify antibacterial agents
    • Eakin AE, Green O, Hales N et al (2012) Pyrrolamide DNA gyrase inhibitors: fragment-based nuclear magnetic resonance screening to identify antibacterial agents. Antimicrob Agents Chemother 56:1240-1246
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 1240-1246
    • Eakin, A.E.1    Green, O.2    Hales, N.3
  • 21
    • 58549111375 scopus 로고    scopus 로고
    • DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity
    • East SP, White CB, Barker O et al (2009) DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity. Bioor Med Chem Lett 19:894-899
    • (2009) Bioor Med Chem Lett , vol.19 , pp. 894-899
    • East, S.P.1    White, C.B.2    Barker, O.3
  • 22
    • 33750436245 scopus 로고    scopus 로고
    • 3-Aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organisms
    • Ellsworth EL, Tran TP, Showalter HDH et al (2006) 3-Aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organisms. J Med Chem 49:6435-6438
    • (2006) J Med Chem , vol.49 , pp. 6435-6438
    • Ellsworth, E.L.1    Tran, T.P.2    Showalter, H.D.H.3
  • 23
    • 0038778607 scopus 로고    scopus 로고
    • The quinolones: Decades of development and use
    • Emmerson AM, Jones AM (2003) The quinolones: decades of development and use. J Antimicrob Chemother 51(Suppl S1):13-20
    • (2003) J Antimicrob Chemother , vol.51 , pp. 13-20
    • Emmerson, A.M.1    Jones, A.M.2
  • 24
    • 78149471908 scopus 로고    scopus 로고
    • Antibacterial activity of finafloxacin under different pH conditions against isogenic strains of Escherichia coli expressing combinations
    • Emrich NC, Heisig A, Stubbings W, Labischinski H, Heisig P (2010) Antibacterial activity of finafloxacin under different pH conditions against isogenic strains of Escherichia coli expressing combinations. J Antimicrob Chemother 65:2530-2533
    • (2010) J Antimicrob Chemother , vol.65 , pp. 2530-2533
    • Emrich, N.C.1    Heisig, A.2    Stubbings, W.3    Labischinski, H.4    Heisig, P.5
  • 25
    • 81555206710 scopus 로고    scopus 로고
    • Efficacy of a new fluoroquinolone, JNJ-Q2, in murine models of Staphylococcus aureus and Streptococcus pneumoniae skin, respiratory, and systemic infections
    • Fernandez J, Hilliard JJ, Morrow BJ, Melton JL, Flamm RK, Barron AM, Lynch AS (2011) Efficacy of a new fluoroquinolone, JNJ-Q2, in murine models of Staphylococcus aureus and Streptococcus pneumoniae skin, respiratory, and systemic infections. Antimicrob Agents Chemother 55:5522-5528
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 5522-5528
    • Fernandez, J.1    Hilliard, J.J.2    Morrow, B.J.3    Melton, J.L.4    Flamm, R.K.5    Barron, A.M.6    Lynch, A.S.7
  • 26
    • 62949084685 scopus 로고    scopus 로고
    • Antimicrobial activity of prulifloxacin tested against a worldwide collection of gastroenteritis-producing pathogens, including those causing traveler's diarrhea
    • Fritsche TR, Biedenbach DJ, Jones RN (2009) Antimicrobial activity of prulifloxacin tested against a worldwide collection of gastroenteritis-producing pathogens, including those causing traveler's diarrhea. Antimicrob Agents Chemother 53:1221-1224
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 1221-1224
    • Fritsche, T.R.1    Biedenbach, D.J.2    Jones, R.N.3
  • 27
    • 61749102100 scopus 로고    scopus 로고
    • Prulifloxacin: Clinical studies of a broad-spectrum quinolone agent
    • Giannarini G, Tascini C, Selli C (2009) Prulifloxacin: Clinical studies of a broad-spectrum quinolone agent. Future Microbiol 4:13-24
    • (2009) Future Microbiol , vol.4 , pp. 13-24
    • Giannarini, G.1    Tascini, C.2    Selli, C.3
  • 28
    • 33846582343 scopus 로고    scopus 로고
    • Dual targeting of GyrB and ParE by a novel aminobenzimidazole class of antibacterial compounds
    • Grossman TH, Bartels DJ, Mullin S (2007) Dual targeting of GyrB and ParE by a novel aminobenzimidazole class of antibacterial compounds. Antimicrob Agents Chemother 5:657-666
    • (2007) Antimicrob Agents Chemother , vol.5 , pp. 657-666
    • Grossman, T.H.1    Bartels, D.J.2    Mullin, S.3
  • 29
    • 67749108274 scopus 로고    scopus 로고
    • Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria
    • Haas W, Pillar CM, Zurenko GM, Lee JC, Brunner LS, Morris TW (2009) Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. Antimicrob Agents Chemother 53:3552-3560
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 3552-3560
    • Haas, W.1    Pillar, C.M.2    Zurenko, G.M.3    Lee, J.C.4    Brunner, L.S.5    Morris, T.W.6
  • 30
    • 70349780552 scopus 로고    scopus 로고
    • Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins
    • Heide L (2009) Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins. Biotechnol Adv 27:1006-1014
    • (2009) Biotechnol Adv , vol.27 , pp. 1006-1014
    • Heide, L.1
  • 31
    • 77950106718 scopus 로고    scopus 로고
    • Activity of the investigational fluoroquinolone finafloxacin against ciprofloxacin-sensitive and-resistant Acinetobacter baumannii
    • Higgins PG, Stubbings W, Wisplinghoff H, Seifert H (2010) Activity of the investigational fluoroquinolone finafloxacin against ciprofloxacin-sensitive and-resistant Acinetobacter baumannii. Antimicrob Agents Chemother 54:1613-1615
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 1613-1615
    • Higgins, P.G.1    Stubbings, W.2    Wisplinghoff, H.3    Seifert, H.4
  • 33
    • 34247169863 scopus 로고    scopus 로고
    • In vitro and in vivo activities of PD 0305970 and PD 0326448, new bacterial gyrase/topoisomerase inhibitors with potent antibacterial activities versus multidrug-resistant Gram-positive and fastidious organism groups
    • Huband MD, Cohen MA, Zurack M et al (2007) In vitro and in vivo activities of PD 0305970 and PD 0326448, new bacterial gyrase/topoisomerase inhibitors with potent antibacterial activities versus multidrug-resistant Gram-positive and fastidious organism groups. Antimicrob Agents Chemother 51:1191-1201
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 1191-1201
    • Huband, M.D.1    Cohen, M.A.2    Zurack, M.3
  • 34
    • 54049132913 scopus 로고    scopus 로고
    • Antimicrobial activity of DC-159a, a new fluoroquinolone, against 1, 149 recently collected clinical isolates
    • Jones RN, Fritsche TR, Sader HS (2008) Antimicrobial activity of DC-159a, a new fluoroquinolone, against 1, 149 recently collected clinical isolates. Antimicrob Agents Chemother 52:3763-3775
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 3763-3775
    • Jones, R.N.1    Fritsche, T.R.2    Sader, H.S.3
  • 35
    • 6044275650 scopus 로고    scopus 로고
    • Prulifloxacin
    • Keam SJ, Perry CM (2004) Prulifloxacin. Drugs 64:2221-2234
    • (2004) Drugs , vol.64 , pp. 2221-2234
    • Keam, S.J.1    Perry, C.M.2
  • 36
    • 8644227083 scopus 로고    scopus 로고
    • Safety pharmacology of DW-224a, a novel fluoroquinolone antibiotic agent
    • Kim EJ, Shin WH, Kim KS, Han SS (2004) Safety pharmacology of DW-224a, a novel fluoroquinolone antibiotic agent. Drug Chem Toxicol 27:295-307
    • (2004) Drug Chem Toxicol , vol.27 , pp. 295-307
    • Kim, E.J.1    Shin, W.H.2    Kim, K.S.3    Han, S.S.4
  • 37
    • 0038078076 scopus 로고    scopus 로고
    • A novel antibacterial 8-chloroquinolone with a distorted orientation of the N1-(5-amino-2, 4-difluorophenyl) group
    • Kuramoto Y, Ohshita Y, Yoshida J, Yazaki A, Shiro M, Koike T (2003) A novel antibacterial 8-chloroquinolone with a distorted orientation of the N1-(5-amino-2, 4-difluorophenyl) group. J Med Chem 46:1905-1917
    • (2003) J Med Chem , vol.46 , pp. 1905-1917
    • Kuramoto, Y.1    Ohshita, Y.2    Yoshida, J.3    Yazaki, A.4    Shiro, M.5    Koike, T.6
  • 41
    • 84930263679 scopus 로고    scopus 로고
    • Minimum inhibitory concentrations (MIC) and mutation prevention concentrations (MPC) of NXL101, a novel topoisomerase IV inhibitor, against Staphylococcus aureus including multi-resistant strains
    • abstr F-507
    • Levasseur, P, Delachaume C, Lowther J, Hodgson J (2005) Minimum inhibitory concentrations (MIC) and mutation prevention concentrations (MPC) of NXL101, a novel topoisomerase IV inhibitor, against Staphylococcus aureus including multi-resistant strains. In: 45th interscience conference on antimicrobial agents and chemotherapy, abstr F-507
    • (2005) 45th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Levasseur, P.1    Delachaume, C.2    Lowther, J.3    Hodgson, J.4
  • 42
    • 85192405927 scopus 로고    scopus 로고
    • Efficacy of oral NXL101, a novel topoisomerase inhibitor, against fluoroquinolone-susceptible (FQS) and-resistant (FQR) Streptococcus pneumoniae (Sp) strains in a mouse pneumonia model
    • abstr F1-2125
    • Levasseur, P, Girard AM, Lowther J (2007) Efficacy of oral NXL101, a novel topoisomerase inhibitor, against fluoroquinolone-susceptible (FQS) and-resistant (FQR) Streptococcus pneumoniae (Sp) strains in a mouse pneumonia model. In: 47th interscience conference on antimicrobial agents and chemotherapy, abstr F1-2125
    • (2007) 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Levasseur, P.1    Girard, A.M.2    Lowther, J.3
  • 43
    • 73849121375 scopus 로고    scopus 로고
    • Dose escalation study of the safety, tolerability, and pharmacokinetics of nemonoxacin (TG-873870), a novel potent broad-spectrum nonfluorinated quinolone, in healthy volunteers
    • Lin L, Chang LW, Tsai CY, Hsu CH, Chung DT, Aronstein WS, Ajayi F, Kuzmak B, Lyon RA (2010) Dose escalation study of the safety, tolerability, and pharmacokinetics of nemonoxacin (TG-873870), a novel potent broad-spectrum nonfluorinated quinolone, in healthy volunteers. Antimicrob Agents Chemother 54:405-410
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 405-410
    • Lin, L.1    Chang, L.W.2    Tsai, C.Y.3    Hsu, C.H.4    Chung, D.T.5    Aronstein, W.S.6    Ajayi, F.7    Kuzmak, B.8    Lyon, R.A.9
  • 45
    • 33645791657 scopus 로고    scopus 로고
    • In vitro characterization of the antibacterial spectrum of novel bacterial type II topoisomerase inhibitors of the aminobenzimidazole class
    • Mani N, Gross CH et al (2006) In vitro characterization of the antibacterial spectrum of novel bacterial type II topoisomerase inhibitors of the aminobenzimidazole class. Antimicrob Agents Chemother 50:1228-1237
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 1228-1237
    • Mani, N.1    Gross, C.H.2
  • 46
    • 30344478219 scopus 로고    scopus 로고
    • Pharmacologic characteristics of prulifloxacin
    • Matera MG (2006) Pharmacologic characteristics of prulifloxacin. Pulm Pharmacol Ther 19(Suppl 1):20-29
    • (2006) Pulm Pharmacol Ther , vol.19 , pp. 20-29
    • Matera, M.G.1
  • 47
    • 14844347928 scopus 로고    scopus 로고
    • Bacterial topoisomerase inhibitors: Quinolone and pyridone antibacterial agents
    • Mitscher LA (2005) Bacterial topoisomerase inhibitors: quinolone and pyridone antibacterial agents. Chem Rev 105:559-592
    • (2005) Chem Rev , vol.105 , pp. 559-592
    • Mitscher, L.A.1
  • 52
    • 0033659828 scopus 로고    scopus 로고
    • Clinical use of the fluoroquinolones
    • Owens RC Jr, Ambrose PG (2000) Clinical use of the fluoroquinolones. Med Clin North Am 84:1447-1469
    • (2000) Med Clin North Am , vol.84 , pp. 1447-1469
    • Owens, R.C.1    Ambrose, P.G.2
  • 53
    • 21844444791 scopus 로고    scopus 로고
    • Antimicrobial safety: Focus on quinolones
    • Owens RC Jr, Ambrose PG (2005) Antimicrobial safety: focus on quinolones. Clin Infect Dis 41(Suppl 2):S144-S157
    • (2005) Clin Infect Dis , vol.41 , pp. S144-S157
    • Owens, R.C.1    Ambrose, P.G.2
  • 54
    • 70349126269 scopus 로고    scopus 로고
    • Probing the differential interactions of quinazolinedione PD 0305970 and quinolones with gyrase and topoisomerase IV
    • Pan XS, Gould KA, Fisher LM (2009) Probing the differential interactions of quinazolinedione PD 0305970 and quinolones with gyrase and topoisomerase IV. Antimicrob Agents Chemother 53:3822-3831
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 3822-3831
    • Pan, X.S.1    Gould, K.A.2    Fisher, L.M.3
  • 58
    • 79952786510 scopus 로고    scopus 로고
    • Prulifloxacin: A review focusing on its use beyond respiratory and urinary tract infections
    • Rafailidis PI, Polyzos KA, Sgouros K, Falagas ME (2011) Prulifloxacin: A review focusing on its use beyond respiratory and urinary tract infections. Int J Antimicrob Agents 37:283-290
    • (2011) Int J Antimicrob Agents , vol.37 , pp. 283-290
    • Rafailidis, P.I.1    Polyzos, K.A.2    Sgouros, K.3    Falagas, M.E.4
  • 59
    • 81555223850 scopus 로고    scopus 로고
    • Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II: Broad-spectrum antibacterial agents with reduced hERG activity
    • Reck F, Alm R, Brassil P et al (2011) Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II: broad-spectrum antibacterial agents with reduced hERG activity. J Med Chem 54:7834-7847
    • (2011) J Med Chem , vol.54 , pp. 7834-7847
    • Reck, F.1    Alm, R.2    Brassil, P.3
  • 60
    • 0034840669 scopus 로고    scopus 로고
    • History of quinolones and their side effects
    • Rubenstein E (2001) History of quinolones and their side effects. Chemother 47(Suppl 3):3-8
    • (2001) Chemother , vol.47 , pp. 3-8
    • Rubenstein, E.1
  • 61
    • 72049128109 scopus 로고    scopus 로고
    • Discontinued drugs in 2008: Anti-infectives
    • Ryder NS (2010) Discontinued drugs in 2008: Anti-infectives. Expert Opin Investig Drugs 19:1-21
    • (2010) Expert Opin Investig Drugs , vol.19 , pp. 1-21
    • Ryder, N.S.1
  • 62
    • 81255154494 scopus 로고    scopus 로고
    • Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy
    • Sherer BA et al (2011) Pyrrolamide DNA gyrase inhibitors: optimization of antibacterial activity and efficacy. Bioorg Med Chem Lett 21:7416-7420
    • (2011) Bioorg Med Chem Lett , vol.21 , pp. 7416-7420
    • Sherer, B.A.1
  • 63
    • 84930263682 scopus 로고    scopus 로고
    • The discovery of potent, dual targeting pyrrolopyrimidine inhibitors of bacterial DNA gyrase B and topoisomerase IV with broad spectrum antibacterial activity
    • abstr F1-1837
    • Tari LW, Bensen D, Tzross M et al (2011a) The discovery of potent, dual targeting pyrrolopyrimidine inhibitors of bacterial DNA gyrase B and topoisomerase IV with broad spectrum antibacterial activity. In: 51st interscience conference on antimicrobial agents and chemotherapy, abstr F1-1837
    • (2011) 51st Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Tari, L.W.1    Bensen, D.2    Tzross, M.3
  • 64
    • 84930263682 scopus 로고    scopus 로고
    • The discovery of novel, dual targeting inhibitors of bacterial DNA gyrase B and topoisomerase IV using pharmacophore-based crystallographic fragment screening
    • abstr F2-1872
    • Tari LW, Bensen D, Tzross M et al (2011b) The discovery of novel, dual targeting inhibitors of bacterial DNA gyrase B and topoisomerase IV using pharmacophore-based crystallographic fragment screening. In: 51st interscience conference on antimicrobial agents and chemotherapy, abstr F2-1872
    • (2011) 51st Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Tari, L.W.1    Bensen, D.2    Tzross, M.3
  • 67
    • 33846445306 scopus 로고    scopus 로고
    • Isothiazoloquinolones with enhanced antistaphylococcal activities against multi-drug resistant strains: Effects of structural modifications at the 6-, 7-, and 8-positions
    • Wang Q, Lucien E, Hashimoto A et al (2007) Isothiazoloquinolones with enhanced antistaphylococcal activities against multi-drug resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions. J Med Chem 50:199-210
    • (2007) J Med Chem , vol.50 , pp. 199-210
    • Wang, Q.1    Lucien, E.2    Hashimoto, A.3
  • 68
    • 77950325093 scopus 로고    scopus 로고
    • Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death
    • Wang X, Zhao X, Malik M, Drlica K (2010) Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death. J Antimicrob Chemother 65:520-524
    • (2010) J Antimicrob Chemother , vol.65 , pp. 520-524
    • Wang, X.1    Zhao, X.2    Malik, M.3    Drlica, K.4
  • 69
    • 77956697514 scopus 로고    scopus 로고
    • New quinolone antibiotics: A survey of the literature from 2005 to 2010
    • Wiles JA, Bradbury BJ, Pucci MJ (2010) New quinolone antibiotics: A survey of the literature from 2005 to 2010. Expert Opin Ther Patents 20:1295-1319
    • (2010) Expert Opin Ther Patents , vol.20 , pp. 1295-1319
    • Wiles, J.A.1    Bradbury, B.J.2    Pucci, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.