A novel antibacterial 8-chloroquinolone with a distorted orientation of the N1-(5-amino-2,4-difluorophenyl) group

Journal of Medicinal Chemistry

Volumn 46, Issue 10, 2003, Pages 1905-1917

  Kuramoto, Yasuhiro ^a,b   Ohshita, Yoshihiro ^b   Yoshida, Jiro ^b   Yazaki, Akira ^b   Shiro, Motoo ^c   Koike, Tohru ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b WAKUNAGA PHARMACEUTICAL CO LTD   (Japan)

^c RIGAKU CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7 (3 AMINOAZETIDIN 1 YL) 1 (5 AMINO 2,4 DIFLUOROPHENYL) 8 CHLORO 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; ANTIINFECTIVE AGENT; AROMATIC COMPOUND; AZETIDINE DERIVATIVE; BROMINE; CHLORINE; CIPROFLOXACIN; METHYL GROUP; METICILLIN; NAPHTHYRIDONE DERIVATIVE; NORFLOXACIN; OFLOXACIN; PHENYL GROUP; QUINOLINE DERIVED ANTIINFECTIVE AGENT; QUINOLONE DERIVATIVE; TOSUFLOXACIN; TROVAFLOXACIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIUM ISOLATE; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR MODEL; NONHUMAN; STEREOCHEMISTRY; STEREOSPECIFICITY; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; AZETIDINES; CRYSTALLOGRAPHY, X-RAY; FLUOROQUINOLONES; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUINOLINES; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0038078076     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0205090     Document Type: Article

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