Carboxyamidotriazole: A novel inhibitor of both cAMP-phosphodiesterases and cGMP-phosphodiesterases

European Journal of Pharmacology

Volumn 746, Issue , 2015, Pages 14-21

  Guo, Lei ^a   Luo, Lifeng ^a   Ju, Rui ^a   Chen, Chen ^a   Zhu, Lei ^a   Li, Juan ^a   Yu, Xiaoli ^a   Ye, Caiying ^a   Zhang, Dechang ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Carboxyamidotriazole; Phosphodiesterase inhibitor

Indexed keywords

5 AMINO 1 [3,5 DICHLORO 4 (4 CHLOROBENZOYL)BENZYL] 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; CYCLIC AMP PHOSPHODIESTERASE; CYCLIC GMP PHOSPHODIESTERASE; ISOBUTYLMETHYLXANTHINE; PHOSPHODIESTERASE INHIBITOR; SILDENAFIL; ANTINEOPLASTIC AGENT; CARBOXYAMIDO-TRIAZOLE; CYCLIC AMP; CYCLIC GMP; NONSTEROID ANTIINFLAMMATORY AGENT; TRIAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CANCER CELL LINE; CELL LEVEL; CELL LINE; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME ISOLATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; IC50; LEWIS LUNG CARCINOMA CELL; LUNG PARENCHYMA; LYMPHATIC LEUKEMIA; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; RAT; RAW264 CELL LINE; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; INTRACELLULAR SPACE; METABOLISM; TUMOR CELL LINE;

3',5'-CYCLIC-AMP PHOSPHODIESTERASES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CYCLIC AMP; CYCLIC GMP; INTRACELLULAR SPACE; MALE; MICE; PHOSPHODIESTERASE INHIBITORS; RATS; SIGNAL TRANSDUCTION; TRIAZOLES;

EID: 84913539984     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.10.018     Document Type: Article

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