Carboxyamidotriazole ameliorates experimental colitis by inhibition of cytokine production, nuclear factor-κB activation, and colonic fibrosis

Journal of Pharmacology and Experimental Therapeutics

Volumn 342, Issue 2, 2012, Pages 356-365

  Guo, Lei ^a   Ye, Caiying ^a   Hao, Xiaojian ^b   Zheng, Ru ^a   Ju, Rui ^a   Wu, Danwei ^a   Luo, Lifeng ^a   Wang, Conghui ^a   Li, Juan ^a   Yu, Xiaoli ^a   Zhu, Lei ^a   Zhang, Dechang ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 1 [3,5 DICHLORO 4 (4 CHLOROBENZOYL)BENZYL] 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; CYTOKINE; DEXTRAN SULFATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; SALAZOSULFAPYRIDINE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CHEMICAL ANALYSIS; COLITIS; COLON; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG MECHANISM; ENTERITIS; ENZYME INHIBITION; ENZYME REPRESSION; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTESTINAL FIBROSIS; LAMINA PROPRIA; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SCORING SYSTEM; TRANSCRIPTION INITIATION; TREATMENT RESPONSE;

ANIMALS; COLITIS; COLON; DEXTRAN SULFATE; FIBROSIS; INFLAMMATION; INFLAMMATORY BOWEL DISEASES; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-1BETA; INTERLEUKIN-6; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; MUCOUS MEMBRANE; NF-KAPPA B; PHOSPHORYLATION; PROTEOLYSIS; TRIAZOLES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84864135049     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.112.192849     Document Type: Article

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