Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach

Nature Communications

Volumn 5, Issue , 2014, Pages

  Weiss, Jason T ^a   Dawson, John C ^a   Macleod, Kenneth G ^a   Rybski, Witold ^a,b   Fraser, Craig ^a   Torres Sánchez, Carmen ^c   Patton, E Elizabeth ^a,b   Bradley, Mark ^a   Carragher, Neil O ^a   Unciti Broceta, Asier ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c LOUGHBOROUGH UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 FLUORO 1 PROPARGYL URACIL; CYTOTOXIC AGENT; FLUOROURACIL; MACROGOL; PALLADIUM; POLYSTYRENE; PRODRUG; RESIN; UNCLASSIFIED DRUG; 5-FLUORO-1-PROPARGYLURACIL; ANTINEOPLASTIC ANTIMETABOLITE;

CANCER; CATALYSIS; CYPRINID; DISEASE TREATMENT; DRUG; EMBRYO; PALLADIUM; RESIN;

ALKYLATION; ANIMAL EXPERIMENT; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOCOMPATIBILITY; CATALYSIS; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; DEALKYLATION; DRUG CYTOTOXICITY; DRUG EFFICACY; EMBRYO; EXTRACELLULAR SPACE; IMMUNOASSAY; IN VITRO STUDY; MOLECULAR IMAGING; NONHUMAN; PANCREATIC CANCER CELL LINE; YOLK SAC; ZEBRA FISH; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DRUG SCREENING; HCT116 CELL LINE; HUMAN;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; DEALKYLATION; DRUG EVALUATION, PRECLINICAL; FLUOROURACIL; HCT116 CELLS; HUMANS; PALLADIUM; PRODRUGS; ZEBRAFISH;

EID: 84913533758     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms4277     Document Type: Article

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