Dual mode fluorescent 18F-PET tracers: Efficient modular synthesis of rhodamine-[cRGD]2-[18F]-organotrifluoroborate, rapid, and high yielding one-step 18F-labeling at high specific activity, and correlated in vivo PET imaging and ex vivo fluorescence

Bioconjugate Chemistry

Volumn 25, Issue 11, 2014, Pages 1951-1962

  Liu, Zhibo ^a   Radtke, Mark Alex ^a   Wong, May Q ^b   Lin, Kuo Shyan ^b   Yapp, Donald T ^b   Perrin, David M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORINE COMPOUNDS; FLUOROPHORES; GRAFTING (CHEMICAL); TUMORS;

DUAL MODES; EX-VIVO; FLUORIDE ION; HIGH SPECIFIC ACTIVITIES; IN-VIVO; MODULAR APPROACH; PET IMAGES; PET TRACER; RHODAMINE; USER FRIENDLY;

PEPTIDES;

ALKYNE; AMMONIOMETHYLTRIFLUOROBORATE; CYCLIC RGD; FLUORINE 18; ORGANOTRIFLUOROBORATE; PENTAERYTHRITOL; RHODAMINE; TRACER; UNCLASSIFIED DRUG; WATER; BORIC ACID; CYCLIC ARGININE-GLYCINE-ASPARTIC ACID PEPTIDE; CYCLOPEPTIDE; FLUORESCENT DYE; FLUORINE; FLUOROBORIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE UPTAKE; CHEMICAL PROCEDURES; CLICK CHEMISTRY; CONJUGATION; CONTROLLED STUDY; DRUG SYNTHESIS; DRUG UPTAKE; EX VIVO STUDY; FLUORESCENCE IMAGING; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; ISOTOPE EXCHANGE; ISOTOPE LABELING; LIMIT OF DETECTION; MOLECULAR IMAGING; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOCHEMISTRY; ANIMAL; CHEMISTRY; HT 29 CELL LINE; HUMAN; PROCEDURES; SYNTHESIS;

ANIMALS; BORATES; CHEMISTRY TECHNIQUES, SYNTHETIC; FLUORESCENT DYES; FLUORINE RADIOISOTOPES; HT29 CELLS; HUMANS; ISOTOPE LABELING; MICE; PEPTIDES, CYCLIC; POSITRON-EMISSION TOMOGRAPHY; RHODAMINES;

EID: 84913530443     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc5003357     Document Type: Article

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